Effect of mechanical forces on cellular response to radiation

Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways

(2021) Anne-Clémence Vion et al.   Frontiers in Physiology

Physiology and Pathophysiology of Mechanically Activated PIEZO Channels

(2021) Ruhma Syeda   Annual Review of Neuroscience

Fluid shear stress activates YAP to promote epithelial–mesenchymal transition in hepatocellular carcinoma

(2021) Hongchi Yu et al.   Molecular Oncology

Radiation-induced YAP activation confers glioma radioresistance via promoting FGF2 transcription and DNA damage repair

(2021) Yu Zhang et al.   ONCOGENE

Wnt/β-catenin inhibitor ICG-001 enhances the antitumor efficacy of radiotherapy by increasing radiation-induced DNA damage and improving tumor immune microenvironment in hepatocellular carcinoma

(2021) Yan Huang et al.   RADIOTHERAPY AND ONCOLOGY

Substrate stiffness affects the morphology, proliferation, and radiosensitivity of cervical squamous carcinoma cells

(2021) Bixia Jin et al.   TISSUE & CELL

The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins

(2021) Ren Jie Tuieng et al.   Cells

YAP/TAZ functions and their regulation at a glance

(2020) Arianna Pocaterra et al.   JOURNAL OF CELL SCIENCE

Integrin αvβ3‐Akt signalling plays a role in radioresistance of melanoma

(2020) Hyuntaik Im et al.   EXPERIMENTAL DERMATOLOGY

Adhesion and Migration Response to Radiation Therapy of Mammary Epithelial and Adenocarcinoma Cells Interacting with Different Stiffness Substrates

(2020) Valeria Panzetta et al.   Cancers

Extracellular matrix stiffness and Wnt/β-catenin signaling in physiology and disease

(2020) Pablo Astudillo   BIOCHEMICAL SOCIETY TRANSACTIONS

Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures

(2020) Sophie Massou et al.   NATURE CELL BIOLOGY

Nucleosomes effectively shield DNA from radiation damage in living cells

(2020) Francesca Brambilla et al.   NUCLEIC ACIDS RESEARCH

Fluid Shear Stress Sensing by the Endothelial Layer

(2020) Etienne Roux et al.   Frontiers in Physiology

Laminar Flow Protects Vascular Endothelial Tight Junctions and Barrier Function via Maintaining the Expression of Long Non-coding RNA MALAT1

(2020) Fangfang Yang et al.   Frontiers in Bioengineering and Biotechnology

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanical Control of Cell Proliferation Increases Resistance to Chemotherapeutic Agents

(2020) Ilaria Francesca Rizzuti et al.   PHYSICAL REVIEW LETTERS

Evaluation of different sterilization methods for decellularized kidney tissue

(2020) Lida Moradi et al.   TISSUE & CELL

Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents

(2020) Min Deng et al.   Science Advances

Influence of chromatin compaction on simulated early radiation-induced DNA damage using Geant4-DNA

(2019) N. Tang et al.   MEDICAL PHYSICS

The extracellular matrix as a multitasking player in disease

(2019) Achilleas D. Theocharis et al.   FEBS Journal

Low shear stress induces ERK nuclear localization and YAP activation to control the proliferation of breast cancer cells

(2019) Xiang Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer

(2019) Scott H. Medina et al.   BIOMATERIALS

Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts

(2019) Mohammad Mirazul Islam et al.   Acta Biomaterialia

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility

(2019) Ryan S. Stowers et al.   Nature Biomedical Engineering

Cyclic stretch-induced mechanical stress to the cell nucleus inhibits ultraviolet radiation-induced DNA damage

(2019) Kazuaki Nagayama et al.   Biomechanics and Modeling in Mechanobiology

Effects of ex vivo ionizing radiation on collagen structure and whole-bone mechanical properties of mouse vertebrae

(2019) Megan M. Pendleton et al.   BONE

Collective cancer invasion forms an integrin-dependent radioresistant niche

(2019) Anna Haeger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models

(2019) Ludivine C. Delon et al.   BIOMATERIALS

The Hippo Pathway, YAP/TAZ, and the Plasma Membrane

(2019) Valentina Rausch et al.   TRENDS IN CELL BIOLOGY

The Extracellular, Cellular, and Nuclear Stiffness, a Trinity in the Cancer Resistome—A Review

(2019) Sara Sofia Deville et al.   Frontiers in Oncology

Biomechanical regulation of drug sensitivity in an engineered model of human tumor

(2018) A. Marturano-Kruik et al.   BIOMATERIALS

Circuit Design Features of a Stable Two-Cell System

(2018) Xu Zhou et al.   CELL

GPR68 Senses Flow and Is Essential for Vascular Physiology

(2018) Jie Xu et al.   CELL

Mechanobiology of Tumor Growth

(2018) Parthiv Kant Chaudhuri et al.   CHEMICAL REVIEWS

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

Proinvasive extracellular matrix remodeling in tumor microenvironment in response to radiation

(2018) Ki-Chun Yoo et al.   ONCOGENE

Fluid shear stress impacts ovarian cancer cell viability, subcellular organization, and promotes genomic instability

(2018) Alexandra R. Hyler et al.   PLoS One

β-Catenin–dependent mechanotransduction dates back to the common ancestor of Cnidaria and Bilateria

(2018) Ekaterina Pukhlyakova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

αvβ3 INTEGRIN MEDIATES RADIORESISTANCE OF PROSTATE CANCER CELLS THROUGH REGULATION OF SURVIVIN

(2018) Tao Wang et al.   MOLECULAR CANCER RESEARCH

The Hippo Pathway: Biology and Pathophysiology

(2018) Shenghong Ma et al.   Annual Review of Biochemistry

Role of Extracellular Matrix in Development and Cancer Progression

(2018) Cameron Walker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of TAZ contributes radiation-induced senescence and growth arrest in glioma cells

(2018) Lei Zhang et al.   ONCOGENE

Small Force, Big Impact: Next Generation Organ-on-a-Chip Systems Incorporating Biomechanical Cues

(2018) Ece Ergir et al.   Frontiers in Physiology

Extended Exposure to Stiff Microenvironments Leads to Persistent Chromatin Remodeling in Human Mesenchymal Stem Cells

(2018) Anouk R. Killaars et al.   Advanced Science

A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma

(2017) Shumei Song et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of genome organization and gene expression by nuclear mechanotransduction

(2017) Caroline Uhler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CAF-secreted CXCL1 conferred radioresistance by regulating DNA damage response in a ROS-dependent manner in esophageal squamous cell carcinoma

(2017) Hongfang Zhang et al.   Cell Death & Disease

Fluid shear stress activates YAP1 to promote cancer cell motility

(2017) Hyun Jung Lee et al.   Nature Communications

YAP1 inhibition radiosensitizes triple negative breast cancer cells by targeting the DNA damage response and cell survival pathways

(2017) Daniel Andrade et al.   Oncotarget

Two views of the same stimulus

(2017) Wayne A Johnson   eLife

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

(2017) Nicole Scholz et al.   eLife

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Effects of shear stress on endothelial cells: go with the flow

(2016) D. A. Chistiakov et al.   Acta Physiologica

Microfluidics as a new tool in radiation biology

(2016) Jerome Lacombe et al.   CANCER LETTERS

Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves

(2016) Boksik Cha et al.   GENES & DEVELOPMENT

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Endothelial fluid shear stress sensing in vascular health and disease

(2016) Nicolas Baeyens et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell stretching devices as research tools: engineering and biological considerations

(2016) Harshad Kamble et al.   LAB ON A CHIP

Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow

(2016) Idil Orhon et al.   NATURE CELL BIOLOGY

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

(2016) Kuei-Chun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemodynamic Flow-Induced Mechanotransduction Signaling Influences the Radiation Response of the Vascular Endothelium

(2016) Mohan Natarajan et al.   RADIATION RESEARCH

Endothelial cell alignment as a result of anisotropic strain and flow induced shear stress combinations

(2016) Ravi Sinha et al.   Scientific Reports

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling

(2016) Claudio A Franco et al.   eLife

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

(2016) Su-Jin Heo et al.   eLife

Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis

(2016) Blair W Benham-Pyle et al.   eLife

Extracellular matrix stiffness dictates Wnt expression through integrin pathway

(2016) Jing Du et al.   Scientific Reports

Circulatory shear flow alters the viability and proliferation of circulating colon cancer cells

(2016) Rong Fan et al.   Scientific Reports

Fluid shear, intercellular stress, and endothelial cell alignment

(2015) Robert Steward et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of ion channels in ionizing radiation-induced cell death

(2015) Stephan M. Huber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Comparison of four decontamination treatments on porcine renal decellularized extracellular matrix structure, composition, and support of renal tubular epithelium cells

(2015) Nafiseh Poornejad et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Optimal compressive force accelerates osteoclastogenesis in RAW264.7 cells

(2015) TAKAKO HAYAKAWA et al.   Molecular Medicine Reports

Chromatin architecture reorganization during stem cell differentiation

(2015) Jesse R. Dixon et al.   NATURE

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

(2015) Sarah C. Petersen et al.   NEURON

Wnt/β-catenin pathway involvement in ionizing radiation-induced invasion of U87 glioblastoma cells

(2015) Zhen Dong et al.   STRAHLENTHERAPIE UND ONKOLOGIE

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

(2015) Zhipeng Meng et al.   Nature Communications

Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells

(2015) Haiying Cheng et al.   Oncotarget

The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation

(2015) Nicole Scholz et al.   Cell Reports

Shear Stress-Induced Alteration of Epithelial Organization in Human Renal Tubular Cells

(2015) Damien Maggiorani et al.   PLoS One

GSK3β and β-Catenin Modulate Radiation Cytotoxicity in Pancreatic Cancer

(2015) Richard L. Watson et al.   NEOPLASIA

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Shear Stress–Initiated Signaling and Its Regulation of Endothelial Function

(2014) Jing Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Radiation sensitization of tumor cells induced by shear stress: The roles of integrins and FAK

(2014) Chi-Wen Luo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling

(2014) Veronica A. Codelia et al.   CURRENT BIOLOGY

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

(2014) Boon Chuan Low et al.   FEBS LETTERS

Yes-Associated Protein (YAP) Modulates Oncogenic Features and Radiation Sensitivity in Endometrial Cancer

(2014) Masahiro Tsujiura et al.   PLoS One

Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia

(2014) V. Raghavan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow shear stress regulates endothelial barrier function and expression of angiogenic factors in a 3D microfluidic tumor vascular model

(2014) Cara F Buchanan et al.   Cell Adhesion & Migration

A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels

(2013) Sviatoslav N. Bagriantsev et al.   ACS Chemical Biology

Integrins in mechanotransduction

(2013) Tyler D Ross et al.   CURRENT OPINION IN CELL BIOLOGY

A novel panel of biomarkers predicts radioresistance in patients with squamous cell carcinoma of the head and neck

(2013) Jan Akervall et al.   EUROPEAN JOURNAL OF CANCER

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Fluid-Flow Induced Wall Shear Stress and Epithelial Ovarian Cancer Peritoneal Spreading

(2013) Liron Avraham-Chakim et al.   PLoS One

Lung Cancer Cells That Survive Ionizing Radiation Show Increased Integrin α2β1- and EGFR-Dependent Invasiveness

(2013) Xue Li et al.   PLoS One

Chromatin Compaction Protects Genomic DNA from Radiation Damage

(2013) Hideaki Takata et al.   PLoS One

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

(2013) Thibaut Brunet et al.   Nature Communications

Ionizing radiation, ion transports, and radioresistance of cancer cells

(2013) Stephan M. Huber et al.   Frontiers in Physiology

β1 Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

(2012) Iris Eke et al.   JOURNAL OF CLINICAL INVESTIGATION

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Cancer-associated adipocytes promotes breast tumor radioresistance

(2011) Ludivine Bochet et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation

(2011) A Fernandez-L et al.   ONCOGENE

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity

(2011) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification

(2010) K. Storch et al.   CANCER RESEARCH

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

The extracellular matrix in development and morphogenesis: A dynamic view

(2009) Tania Rozario et al.   DEVELOPMENTAL BIOLOGY

Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells

(2009) Yoon Jung Choi et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Low-Dose Radiation-Induced Senescent Stromal Fibroblasts Render Nearby Breast Cancer Cells Radioresistant

(2009) Kelvin K. C. Tsai et al.   RADIATION RESEARCH

Chromatin structure influences the sensitivity of DNA to γ-radiation

(2008) Martin Falk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

 1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts

(2008) C. C. Park et al.   CANCER RESEARCH

Mechanisms by which E-Selectin Regulates Diapedesis of Colon Cancer Cells under Flow Conditions

(2008) P.-L. Tremblay et al.   CANCER RESEARCH

Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad

(2008) S.-F. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA