- Home
- Publications
- Publication Search
- Publication Details
Title
Integrin-mediated mechanotransduction
Authors
Keywords
-
Journal
JOURNAL OF CELL BIOLOGY
Volume 215, Issue 4, Pages 445-456
Publisher
Rockefeller University Press
Online
2016-11-08
DOI
10.1083/jcb.201609037
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Investigating piconewton forces in cells by FRET-based molecular force microscopy
- (2017) Andrea Freikamp et al. JOURNAL OF STRUCTURAL BIOLOGY
- Integrin signalling regulates YAP and TAZ to control skin homeostasis
- (2016) Ahmed Elbediwy et al. DEVELOPMENT
- Kindlin-2 directly binds actin and regulates integrin outside-in signaling
- (2016) Kamila Bledzka et al. JOURNAL OF CELL BIOLOGY
- Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity
- (2016) Abhishek Kumar et al. JOURNAL OF CELL BIOLOGY
- The FAK–Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin
- (2016) Vinay Swaminathan et al. MOLECULAR BIOLOGY OF THE CELL
- Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation
- (2016) Zhiqi Sun et al. NATURE CELL BIOLOGY
- The molecular clutch model for mechanotransduction evolves
- (2016) Vinay Swaminathan et al. NATURE CELL BIOLOGY
- Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity
- (2016) Alberto Elosegui-Artola et al. NATURE CELL BIOLOGY
- Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment
- (2016) Huy Quang Le et al. NATURE CELL BIOLOGY
- Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression
- (2016) Hanane Laklai et al. NATURE MEDICINE
- Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
- (2016) Hong Jiang et al. NATURE MEDICINE
- Measuring cell-generated forces: a guide to the available tools
- (2016) William J Polacheck et al. NATURE METHODS
- Relating conformation to function in integrin α5β1
- (2016) Yang Su et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The mechanical response of talin
- (2016) Mingxi Yao et al. Nature Communications
- Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions
- (2016) Benjamin P Bouchet et al. eLife
- Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin
- (2016) Marina Theodosiou et al. eLife
- Modeling Active Mechanosensing in Cell–Matrix Interactions
- (2015) Bin Chen et al. Annual Review of Biophysics
- Rap1 and its effector RIAM are required for lymphocyte trafficking
- (2015) W. Su et al. BLOOD
- Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired 2 integrin function in mice
- (2015) S. Klapproth et al. BLOOD
- Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity
- (2015) Alan Serrels et al. CELL
- Nuclear F-actin Formation and Reorganization upon Cell Spreading
- (2015) Matthias Plessner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse
- (2015) William A. Comrie et al. JOURNAL OF CELL BIOLOGY
- Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway
- (2015) Nam-Gyun Kim et al. JOURNAL OF CELL BIOLOGY
- KANK deficiency leads to podocyte dysfunction and nephrotic syndrome
- (2015) Heon Yung Gee et al. JOURNAL OF CLINICAL INVESTIGATION
- Visualizing the Interior Architecture of Focal Adhesions with High-Resolution Traction Maps
- (2015) Masatoshi Morimatsu et al. NANO LETTERS
- Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly
- (2015) Edward R. Horton et al. NATURE CELL BIOLOGY
- Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions
- (2015) Lindsay B. Case et al. NATURE CELL BIOLOGY
- Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
- (2015) Francesca Zanconato et al. NATURE CELL BIOLOGY
- Extracellular rigidity sensing by talin isoform-specific mechanical linkages
- (2015) Katharina Austen et al. NATURE CELL BIOLOGY
- Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments
- (2015) Brendon M. Baker et al. NATURE MATERIALS
- Hydrogels with tunable stress relaxation regulate stem cell fate and activity
- (2015) Ovijit Chaudhuri et al. NATURE MATERIALS
- Three-dimensional force microscopy of cells in biopolymer networks
- (2015) Julian Steinwachs et al. NATURE METHODS
- Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer
- (2015) Ruchi Malik et al. TRENDS IN BIOTECHNOLOGY
- Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force
- (2015) Cheng-han Yu et al. Nature Communications
- PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence
- (2015) Chiara Bonfanti et al. Nature Communications
- Cyclic stretching of soft substrates induces spreading and growth
- (2015) Yidan Cui et al. Nature Communications
- Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions
- (2015) Andrew D. Doyle et al. Nature Communications
- Vinculin controls talin engagement with the actomyosin machinery
- (2015) Paul Atherton et al. Nature Communications
- Mechanism of Focal Adhesion Kinase Mechanosensing
- (2015) Jing Zhou et al. PLoS Computational Biology
- Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension
- (2015) Joanna P Rys et al. eLife
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling
- (2014) Veronica A. Codelia et al. CURRENT BIOLOGY
- Integrin-Associated Complexes Form Hierarchically with Variable Stoichiometry in Nascent Adhesions
- (2014) Alexia I. Bachir et al. CURRENT BIOLOGY
- Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts
- (2014) C. Esnault et al. GENES & DEVELOPMENT
- The cancer glycocalyx mechanically primes integrin-mediated growth and survival
- (2014) Matthew J. Paszek et al. NATURE
- CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover
- (2014) Samantha J. Stehbens et al. NATURE CELL BIOLOGY
- Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus
- (2014) Christophe Guilluy et al. NATURE CELL BIOLOGY
- Mechanical memory and dosing influence stem cell fate
- (2014) Chun Yang et al. NATURE MATERIALS
- A DNA-based molecular probe for optically reporting cellular traction forces
- (2014) Brandon L Blakely et al. NATURE METHODS
- Extracellular matrix assembly: a multiscale deconstruction
- (2014) Janna K. Mouw et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The integrin adhesome: from genes and proteins to human disease
- (2014) Sabina E. Winograd-Katz et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structural and Mechanistic Insights into the Recruitment of Talin by RIAM in Integrin Signaling
- (2014) Yu-Chung Chang et al. STRUCTURE
- DNA-based digital tension probes reveal integrin forces during early cell adhesion
- (2014) Yun Zhang et al. Nature Communications
- Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation
- (2014) Mingxi Yao et al. Scientific Reports
- Biophysical Cues and Cell Behavior: The Big Impact of Little Things
- (2013) Joshua Z. Gasiorowski et al. Annual Review of Biomedical Engineering
- Mechanobiology and Developmental Control
- (2013) Tadanori Mammoto et al. Annual Review of Cell and Developmental Biology
- The Yin-Yang of Rigidity Sensing: How Forces and Mechanical Properties Regulate the Cellular Response to Materials
- (2013) Ingmar Schoen et al. Annual Review of Materials Research
- A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors
- (2013) Mariaceleste Aragona et al. CELL
- Nuclear Mechanics and Mechanotransduction in Health and Disease
- (2013) Philipp Isermann et al. CURRENT BIOLOGY
- Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos
- (2013) Yoshikazu Hirate et al. CURRENT BIOLOGY
- Cell-Fibronectin Interactions Propel Vertebrate Trunk Elongation via Tissue Mechanics
- (2013) Nicolas Dray et al. CURRENT BIOLOGY
- FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration
- (2013) Thomas Iskratsch et al. DEVELOPMENTAL CELL
- CFEOM1-Associated Kinesin KIF21A Is a Cortical Microtubule Growth Inhibitor
- (2013) Babet van der Vaart et al. DEVELOPMENTAL CELL
- Mechanosensitivity and compositional dynamics of cell–matrix adhesions
- (2013) Herbert B Schiller et al. EMBO REPORTS
- Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth
- (2013) Ingo Thievessen et al. JOURNAL OF CELL BIOLOGY
- Cyclic Mechanical Reinforcement of Integrin–Ligand Interactions
- (2013) Fang Kong et al. MOLECULAR CELL
- Molecular Tension Sensors Report Forces Generated by Single Integrin Molecules in Living Cells
- (2013) Masatoshi Morimatsu et al. NANO LETTERS
- A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway
- (2013) Morvarid Mohseni et al. NATURE CELL BIOLOGY
- Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
- (2013) Fernando Calvo et al. NATURE CELL BIOLOGY
- β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments
- (2013) Herbert B. Schiller et al. NATURE CELL BIOLOGY
- Quantifying cell-generated mechanical forces within living embryonic tissues
- (2013) Otger Campàs et al. NATURE METHODS
- Talins and kindlins: partners in integrin-mediated adhesion
- (2013) David A. Calderwood et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds
- (2013) C.-y. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integrin-dependent force transmission to the extracellular matrix by -actinin triggers adhesion maturation
- (2013) P. Roca-Cusachs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling
- (2013) X. Wang et al. SCIENCE
- Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
- (2013) J. Swift et al. SCIENCE
- Nuclear Actin Network Assembly by Formins Regulates the SRF Coactivator MAL
- (2013) C. Baarlink et al. SCIENCE
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration
- (2012) Sergey V. Plotnikov et al. CELL
- Focal adhesion size uniquely predicts cell migration
- (2012) Dong-Hwee Kim et al. FASEB JOURNAL
- Tension is required but not sufficient for focal adhesion maturation without a stress fiber template
- (2012) Patrick W. Oakes et al. JOURNAL OF CELL BIOLOGY
- Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
- (2012) Olivier Rossier et al. NATURE CELL BIOLOGY
- Extracellular-matrix tethering regulates stem-cell fate
- (2012) Britta Trappmann et al. NATURE MATERIALS
- Dynamic force sensing of filamin revealed in single-molecule experiments
- (2012) L. Rognoni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamic force-induced direct dissociation of protein complexes in a nuclear body in living cells
- (2012) Yeh-Chuin Poh et al. Nature Communications
- ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma
- (2011) Victoria Sanz-Moreno et al. CANCER CELL
- The Single-Molecule Mechanics of the Latent TGF-β1 Complex
- (2011) Lara Buscemi et al. CURRENT BIOLOGY
- Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2synthesis
- (2011) Kyle R Legate et al. EMBO JOURNAL
- Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins
- (2011) Herbert B Schiller et al. EMBO REPORTS
- Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A
- (2011) A. J. Ehrlicher et al. NATURE
- Role of YAP/TAZ in mechanotransduction
- (2011) Sirio Dupont et al. NATURE
- Dynamic molecular processes mediate cellular mechanotransduction
- (2011) Brenton D. Hoffman et al. NATURE
- Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
- (2011) Jean-Cheng Kuo et al. NATURE CELL BIOLOGY
- The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins
- (2011) Christophe Guilluy et al. NATURE CELL BIOLOGY
- Recreation of the terminal events in physiological integrin activation
- (2010) Feng Ye et al. JOURNAL OF CELL BIOLOGY
- αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration
- (2010) Daniel C. Worth et al. JOURNAL OF CELL BIOLOGY
- Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
- (2010) Carsten Grashoff et al. NATURE
- Nanoscale architecture of integrin-based cell adhesions
- (2010) Pakorn Kanchanawong et al. NATURE
- Linking actin dynamics and gene transcription to drive cellular motile functions
- (2010) Eric N. Olson et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Soft Matrices Suppress Cooperative Behaviors among Receptor-Ligand Bonds in Cell Adhesion
- (2010) Jin Qian et al. PLoS One
- Advances and perspectives of the architecture of hemidesmosomes: Lessons from structural biology
- (2010) José M. de Pereda et al. Cell Adhesion & Migration
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
- (2009) Kandice R. Levental et al. CELL
- The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!
- (2009) Sara A Wickström et al. EMBO JOURNAL
- Demonstration of catch bonds between an integrin and its ligand
- (2009) Fang Kong et al. JOURNAL OF CELL BIOLOGY
- Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells
- (2009) Ellen J. Ezratty et al. JOURNAL OF CELL BIOLOGY
- Stretching Single Talin Rod Molecules Activates Vinculin Binding
- (2009) A. del Rio et al. SCIENCE
- Mechanically Activated Integrin Switch Controls 5 1 Function
- (2009) J. C. Friedland et al. SCIENCE
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Multi-level molecular clutches in motile cell processes
- (2009) Grégory Giannone et al. TRENDS IN CELL BIOLOGY
- Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate
- (2009) Matthew J. Paszek et al. PLoS Computational Biology
- Catch Bonds in Adhesion
- (2008) Wendy Thomas Annual Review of Biomedical Engineering
- The Origins of Multicellularity and the Early History of the Genetic Toolkit For Animal Development
- (2008) Antonis Rokas Annual Review of Genetics
- The role of integrin binding sites in fibronectin matrix assembly in vivo
- (2008) Michael Leiss et al. CURRENT OPINION IN CELL BIOLOGY
- Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation
- (2008) Esen Goksoy et al. MOLECULAR CELL
- Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces
- (2008) Jianghai Zhu et al. MOLECULAR CELL
- Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner
- (2008) Colin K. Choi et al. NATURE CELL BIOLOGY
- Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
- (2008) Ning Wang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Comparative Dynamics of Retrograde Actin Flow and Focal Adhesions: Formation of Nascent Adhesions Triggers Transition from Fast to Slow Flow
- (2008) Antonina Y. Alexandrova et al. PLoS One
- Rapid signal transduction in living cells is a unique feature of mechanotransduction
- (2008) S. Na et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Traction Dynamics of Filopodia on Compliant Substrates
- (2008) C. E. Chan et al. SCIENCE
- Matrix Elasticity, Cytoskeletal Tension, and TGF- : The Insoluble and Soluble Meet
- (2008) R. G. Wells et al. Science Signaling
- Structure and Function of the Cell Surface (Tethered) Mucins
- (2007) Christine L. Hattrup et al. Annual Review of Physiology
- Kank proteins: A new family of ankyrin-repeat domain-containing proteins
- (2007) Yun Zhu et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started