Article
Cell Biology
Bei Tao, Yi Song, Yao Wu, Xiaobo Yang, Tangming Peng, Lilei Peng, Kaiguo Xia, Xiangguo Xia, Ligang Chen, Chuanhong Zhong
Summary: This study found that a stiffer matrix can promote the stemness of glioma cells by activating the BCL9L/Wnt/beta-catenin signaling pathway. Additionally, gigantol can enhance the effectiveness of traditional chemotherapy and radiotherapy by inhibiting Wnt/beta-catenin signaling, providing a potential strategy for clinical treatment of gliomas.
Article
Medicine, Research & Experimental
Fengge Liu, Xiangfeng Kong, Hui Kong
Summary: The study revealed that subconjunctival fibrosis induced by ethylparaben is the result of extra extracellular matrix generation by conjunctival fibroblasts via the Wnt/beta-catenin axis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Morgan K. K. Penny, Antonio M. M. Lerario, Kaitlin J. J. Basham, Sahiti Chukkapalli, Dipika R. R. Mohan, Chris LaPensee, Kimber Converso-Baran, Mark J. J. Hoenerhoff, Laura Suarez-Fernandez, Carmen Gonzalez del Rey, Thomas J. J. Giordano, Ruolan Han, Erika A. A. Newman, Gary D. D. Hammer
Summary: Adrenocortical carcinoma (ACC) is a rare and aggressive cancer with limited treatment options. This study identified a novel Wnt/β-catenin-associated signature enriched in ECM, which was predictive of poor survival in ACC patients. Inhibition of Wnt/β-catenin signaling reduced ECM expression and cancer cell viability, suggesting it as a potential therapeutic strategy for ACC.
Article
Multidisciplinary Sciences
Abhishek Sinha, Vinson B. Fan, Aravinda-Bharathi Ramakrishnan, Nicole Engelhardt, Jennifer Kennell, Ken M. Cadigan
Summary: SOX9 promotes turnover of β-catenin independently of the destruction complex and proteasome in mammalian cell culture. This requires the activation of MAML2, which acts as a coactivator for SOX9 in antagonizing the Wnt/β-catenin pathway. This newly identified pathway provides a parallel mechanism for restricting Wnt/β-catenin signaling.
Article
Medicine, Research & Experimental
Vamshikrishna Malyla, Keshav Raj Paudel, Gabriele De Rubis, Nicole G. Hansbro, Philip M. Hansbro, Kamal Dua
Summary: Lung cancer has the highest mortality rate worldwide, and cigarette smoking is a major etiological factor. This study found that cigarette smoke extract treatment can upregulate WNT/ss-β-catenin signaling and induce tumorigenesis in healthy human bronchial epithelial cells. Furthermore, extracellular vesicles obtained from cigarette smoke exposed cells were found to induce migration and upregulate oncology proteins in recipient cells.
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Abdulkhaliq Alsaadi, Mara Artibani, Zhiyuan Hu, Nina Wietek, Matteo Morotti, Laura Santana Gonzalez, Moiad Alazzam, Jason Jiang, Beena Abdul, Hooman Soleymani Majd, Levi L. Blazer, Jarret Adams, Francesca Silvestri, Sachdev S. Sidhu, Joan S. Brugge, Ahmed Ashour Ahmed
Summary: The study addresses the limited knowledge about fallopian tube (FT) stem cells and lack of in vitro models for their renewal and differentiation. It identifies the importance of WNT/β-catenin signaling for FT stem cell renewal and the critical role of an endogenous hormone-regulated WNT7A-FZD5 signaling axis in this process.
Article
Cell & Tissue Engineering
Mikayla L. Hall, Sophie Givens, Natasha Santosh, Michelina Iacovino, Michael Kyba, Brenda M. Ogle
Summary: In this study, it was found that Laminin 411 alone can enhance endothelial differentiation, and ECM contributes to endothelial differentiation through multiple signaling pathways.
Article
Biochemistry & Molecular Biology
Xichao Xu, Yi Zhang, Xing Wang, Shun Li, Liling Tang
Summary: In liver cancer, higher liver tissue stiffness enhances malignant cell phenotypes and promotes G1/S transition. NEAT1 is identified as a matrix stiffness-responsive lncRNA regulating proliferation and EMT. The activation of the WNT/beta-catenin pathway by NEAT1 in response to increasing matrix stiffness drives EMT and proliferation in liver cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xiaobin Shang, Kai Oliver Boeker, Shahed Taheri, Thelonius Hawellek, Wolfgang Lehmann, Arndt F. Schilling
Summary: Osteoarthritis is a chronic disease that lacks disease-modifying treatment, with the Wnt/beta-catenin pathway playing a key role in its pathophysiology. Both excessive stimulation and suppression of this pathway can contribute to the development of OA. MicroRNAs have been found to regulate various cellular processes in different diseases, offering potential insights for the development of miRNA-based therapeutics for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
David Buechel, Nami Sugiyama, Natalia Rubinstein, Meera Saxena, Ravi K. R. Kalathur, Fabiana Luond, Vida Vafaizadeh, Tomas Valenta, George Hausmann, Claudio Cantu, Konrad Basler, Gerhard Christofori
Summary: The transcriptional activity of beta-catenin plays a crucial role in the malignant progression of breast cancer, affecting tumor growth, invasion, and metastasis formation. This contrasts its adhesion function, highlighting the importance of Wnt/beta-catenin-dependent transcription in cancer progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Jian Chen, Jia Liu, Shimin Chen, Ruijun Lai, Chuanchuan Zheng, Jialiang Lu, Xinshao Jiang, Feng He, Chengliang Yang, Kai Li, Kegong Xie, Yujin Tang, Liqiang Wang
Summary: Salinomycin may be a promising therapeutic drug for osteoarthritis (OA) as it has shown protective effects on cartilage cells, reduces disease-associated changes, and delays cartilage destruction and osteophyte formation. Its mechanism of action may involve regulating cell synthesis and inhibiting degradation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Qi Zhou, Xiaoyan Ren, Michelle K. Oberoi, Meiwand Bedar, Rachel M. Caprini, Marley J. Dewey, Vasiliki Kolliopoulos, Dean T. Yamaguchi, Brendan A. C. Harley, Justine C. Lee
Summary: The nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) scaffold promotes skull regeneration in vivo without exogenous growth factors or progenitor cells. Modulation of MC-GAG stiffness affects the expression of primary human bone marrow-derived mesenchymal stem cells (hMSCs) and canonical Wnt (cWnt) signaling. Stiffness-induced activation of the Wnt and mechanotransduction pathways promotes osteogenesis on MC-GAG, while activated beta-catenin serves as a limiting agent and a potential target for optimal modulation of stiffness in skeletal regenerative materials.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Article
Biochemical Research Methods
Jila N. Ajeian, Edward R. Horton, Pablo Astudillo, Adam Byron, Janet A. Askari, Angelique Millon-Fremillon, David Knight, Susan J. Kimber, Martin J. Humphries, Jonathan D. Humphries
PROTEOMICS CLINICAL APPLICATIONS
(2016)
Review
Oncology
Edward R. Horton, Pablo Astudillo, Martin J. Humphries, Jonathan D. Humphries
EXPERIMENTAL CELL RESEARCH
(2016)
Article
Nutrition & Dietetics
Manuel Olivares, Marco A. Mendez, Pablo A. Astudillo, Fernando Pizarro
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2008)
Article
Medicine, Research & Experimental
P. Astudillo, J. Larrain
CURRENT MOLECULAR MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Pablo Astudillo, Hector Carrasco, Juan Larrain
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2014)
Article
Endocrinology & Metabolism
Ana Maria Pino, Susana Rios, Pablo Astudillo, Mireya Fernandez, Paula Figueroa, German Seitz, J. Pablo Rodriguez
JOURNAL OF BONE AND MINERAL RESEARCH
(2010)
Article
Biochemistry & Molecular Biology
Pablo Astudillo, Susana Rios, Luis Pastenes, Ana Maria Pino, J. Pablo Rodriguez
JOURNAL OF CELLULAR BIOCHEMISTRY
(2008)
Review
Cell & Tissue Engineering
J. Pablo Rodriguez, Pablo Astudillo, Susana Rios, Ana Maria Pino
CURRENT STEM CELL RESEARCH & THERAPY
(2008)
Review
Cell Biology
Pablo Astudillo
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Pablo Astudillo
Summary: This article explores the relationship between the Wnt signaling pathway and the YAP/TAZ transcriptional coactivators, with a focus on the non-canonical Wnt pathway and its connection to YAP/TAZ. Analysis of publicly available ChIP-Seq, gene expression, and protein expression data suggests that WNT5A may be a target gene of YAP/TEAD, and that the crosstalk between YAP/TAZ and the Wnt pathway is more intricate in specific cancer types.
Article
Cell Biology
Pablo Astudillo
Summary: This study analyzed the role of the Wnt signaling pathways in gastric cancer and identified a WNT5A/FZD2/FZD7/ROR2 signature associated with tumor-infiltrating and mesenchymal cell marker expression. High expression of FZD7 and ROR2 correlated with a shared gene and protein expression profile, which in turn correlated with poor prognosis. Overall, the findings provide an updated perspective on the contributions of the Wnt/beta-catenin and non-canonical Wnt pathways in gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Pablo Astudillo
Summary: Wnt5a plays various roles in cancer, and our understanding of its precise involvement is still incomplete. In addition to its binding to receptors, Wnt5a interacts with β-catenin, YAP/TAZ, and LATS1/2, forming a larger regulatory circuit. Therefore, a systems biology perspective is needed to understand the roles of Wnt5a and YAP in cancer.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Letter
Multidisciplinary Sciences
Pablo Astudillo
Review
Medicine, General & Internal
Juan Pablo Rodriguez, Pablo Astudillo, Susana Rios, German Seitz, Ana Maria Pino
REVISTA MEDICA DE CHILE
(2009)