Mechanical Control of Cell Proliferation Increases Resistance to Chemotherapeutic Agents

Niche stiffness underlies the ageing of central nervous system progenitor cells

(2019) Michael Segel et al.   NATURE

Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27Kip1 signaling axis

(2019) Sungmin Nam et al.   Science Advances

Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression

(2019) Maria Kalli et al.   Frontiers in Oncology

Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration

(2018) Maria Kalli et al.   ANNALS OF BIOMEDICAL ENGINEERING

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium

(2018) Giorgio Seano et al.   Nature Biomedical Engineering

Evaluating the influence of mechanical stress on anticancer treatments through a multiphase porous media model

(2017) Pietro Mascheroni et al.   JOURNAL OF THEORETICAL BIOLOGY

Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification

(2017) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

SCWISh network is essential for survival under mechanical pressure

(2017) Morgan Delarue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy

(2016) Chrysovalantis Voutouri et al.   NEOPLASIA

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment

(2016) Daniel Zeitouni et al.   Cancers

Solid stress and elastic energy as measures of tumour mechanopathology

(2016) Hadi T. Nia et al.   Nature Biomedical Engineering

Stemness and chemoresistance in epithelial ovarian carcinoma cells under shear stress

(2016) Carman K. M. Ip et al.   Scientific Reports

Force production and mechanical accommodation during convergent extension

(2015) J. Zhou et al.   DEVELOPMENT

Compressive Stress Inhibits Proliferation in Tumor Spheroids through a Volume Limitation

(2014) Morgan Delarue et al.   BIOPHYSICAL JOURNAL

Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer

(2014) Lucas de Sousa Cavalcante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Stress distributions and cell flows in a growing cell aggregate

(2014) M. Delarue et al.   Interface Focus

Mechanical Control of Cell flow in Multicellular Spheroids

(2013) Morgan Delarue et al.   PHYSICAL REVIEW LETTERS

Multicellular Tumor Spheroids for Evaluation of Cytotoxicity and Tumor Growth Inhibitory Effects of Nanomedicines In Vitro: A Comparison of Docetaxel-Loaded Block Copolymer Micelles and Taxotere®

(2013) Andrew S. Mikhail et al.   PLoS One

Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro

(2013) K. Alessandri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

(2012) Maria Vinci et al.   BMC BIOLOGY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Isotropic stress reduces cell proliferation in tumor spheroids

(2012) Fabien Montel et al.   NEW JOURNAL OF PHYSICS

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress Clamp Experiments on Multicellular Tumor Spheroids

(2011) Fabien Montel et al.   PHYSICAL REVIEW LETTERS

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

(2010) Yohannes Mebratu et al.   CELL CYCLE

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

(2009) Gang Cheng et al.   PLoS One