The Role of Mechanical Forces in Tumor Growth and Therapy

An Indirect Way to Tame Cancer

(2014) Rakesh K. Jain   SCIENTIFIC AMERICAN

Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy

(2013) Y. Huang et al.   CANCER RESEARCH

Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse

(2013) Triantafyllos Stylianopoulos et al.   CANCER RESEARCH

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy

(2013) Kyrre E Emblem et al.   NATURE MEDICINE

Buckling Instability in Growing Tumor Spheroids

(2013) P. Ciarletta   PHYSICAL REVIEW LETTERS

Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation

(2013) T. T. Batchelor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining two strategies to improve perfusion and drug delivery in solid tumors

(2013) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

Vascular Hyperpermeability, Angiogenesis, and Stroma Generation

(2013) J. A. Nagy et al.   Cold Spring Harbor Perspectives in Medicine

Cationic Nanoparticles Have Superior Transvascular Flux into Solid Tumors: Insights from a Mathematical Model

(2012) Triantafyllos Stylianopoulos et al.   ANNALS OF BIOMEDICAL ENGINEERING

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

The effect of interstitial pressure on tumor growth: Coupling with the blood and lymphatic vascular systems

(2012) Min Wu et al.   JOURNAL OF THEORETICAL BIOLOGY

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

(2012) G. S. Karagiannis et al.   MOLECULAR CANCER RESEARCH

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue deformation spatially modulates VEGF signaling and angiogenesis

(2012) N. C. Rivron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-  blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma

(2012) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The buckling of capillaries in solid tumours

(2012) J. MacLaurin et al.   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Continuum- and particle-based modeling of shapes and dynamics of red blood cells in health and disease

(2012) Xuejin Li et al.   Soft Matter

Lymphatic vessels in health and disease

(2012) Cristina T. Kesler et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Biomechanical Forces Shape the Tumor Microenvironment

(2011) Adrian C. Shieh   ANNALS OF BIOMEDICAL ENGINEERING

The Fluid Mechanics of Cancer and Its Therapy

(2011) Petros Koumoutsakos et al.   Annual Review of Fluid Mechanics

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

(2011) A. G. Sorensen et al.   CANCER RESEARCH

Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: A retrospective examination

(2011) Daniel Keizman et al.   EUROPEAN JOURNAL OF CANCER

Multiscale modeling of lymphatic drainage from tissues using homogenization theory

(2011) Tiina Roose et al.   JOURNAL OF BIOMECHANICS

Coupled modelling of tumour angiogenesis, tumour growth and blood perfusion

(2011) Yan Cai et al.   JOURNAL OF THEORETICAL BIOLOGY

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired lymphatic contraction associated with immunosuppression

(2011) S. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaling rules for diffusive drug delivery in tumor and normal tissues

(2011) James W. Baish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

(2011) Vikash P. Chauhan et al.   Annual Review of Chemical and Biomolecular Engineering

Gene Expression Profiles in 3D Tumor Analogs Indicate Compressive Strain Differentially Enhances Metastatic Potential

(2010) Zoe N. Demou   ANNALS OF BIOMEDICAL ENGINEERING

Diffusion Anisotropy in Collagen Gels and Tumors: The Effect of Fiber Network Orientation

(2010) Triantafyllos Stylianopoulos et al.   BIOPHYSICAL JOURNAL

Inhibition of renin–angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine

(2010) Y Nakai et al.   BRITISH JOURNAL OF CANCER

Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium

(2010) Dimana O. Miteva et al.   CIRCULATION RESEARCH

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks

(2010) Walid S Kamoun et al.   NATURE METHODS

A Role for Fibrillar Collagen Deposition and the Collagen Internalization Receptor Endo180 in Glioma Invasion

(2010) Ivo J. Huijbers et al.   PLoS One

Cell adhesion mechanisms and stress relaxation in the mechanics of tumours

(2009) Davide Ambrosi et al.   Biomechanics and Modeling in Mechanobiology

A “Vascular Normalization Index” as Potential Mechanistic Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent Glioblastoma Patients

(2009) A. Gregory Sorensen et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Image-based biomechanics of collagen-based tissue equivalents

(2009) E.A. Sander et al.   IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE

Cells in 3D matrices under interstitial flow: Effects of extracellular matrix alignment on cell shear stress and drag forces

(2009) John A. Pedersen et al.   JOURNAL OF BIOMECHANICS

Impact of angiotensin I converting enzyme inhibitors and angiotensin II type 1 receptor blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapy

(2009) Stefan Wilop et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study

(2009) Christopher G. Willett et al.   JOURNAL OF CLINICAL ONCOLOGY

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

(2009) Benjamin J Vakoc et al.   NATURE MEDICINE

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

(2009) Gang Cheng et al.   PLoS One

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Structural Adaptation and Heterogeneity of Normal and Tumor Microvascular Networks

(2009) Axel R. Pries et al.   PLoS Computational Biology

Darcy Permeability of Agarose-Glycosaminoglycan Gels Analyzed Using Fiber-Mixture and Donnan Models

(2008) Kristin J. Mattern et al.   BIOPHYSICAL JOURNAL

The role of endothelial-to-mesenchymal transition in cancer progression

(2008) S Potenta et al.   BRITISH JOURNAL OF CANCER

Accurate Coarse-Grained Modeling of Red Blood Cells

(2008) Igor V. Pivkin et al.   PHYSICAL REVIEW LETTERS

Permeability calculations in three-dimensional isotropic and oriented fiber networks

(2008) Triantafyllos Stylianopoulos et al.   PHYSICS OF FLUIDS

Nitric oxide mediates lymphatic vessel activation via soluble guanylate cyclase α1β1-impact on inflammation

(2007) Kentaro Kajiya et al.   FASEB JOURNAL

Emergent vascular network inhomogeneities and resulting blood flow patterns in a growing tumor

(2007) M. Welter et al.   JOURNAL OF THEORETICAL BIOLOGY