YAP/TAZ functions and their regulation at a glance

F-actin dynamics regulates mammalian organ growth and cell fate maintenance

(2019) Arianna Pocaterra et al.   JOURNAL OF HEPATOLOGY

YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo

(2019) Tanner O. Monroe et al.   DEVELOPMENTAL CELL

Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity

(2019) Peng Xia et al.   CELL

Tissue Patterning: The Winner Takes It All, the Losers Standing Small

(2019) Sirio Dupont et al.   CURRENT BIOLOGY

Vgll3 operates via Tead1, Tead3 and Tead4 to influence myogenesis in skeletal muscle

(2019) Nicolas Figeac et al.   JOURNAL OF CELL SCIENCE

A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling

(2019) Weiping Li et al.   Cell Stem Cell

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

(2019) Edwin A. Rosado-Olivieri et al.   Nature Communications

The Hippo Signaling Pathway in Development and Disease

(2019) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Nuclear envelope deformation controls cell cycle progression in response to mechanical force

(2019) Julien Aureille et al.   EMBO REPORTS

Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer

(2018) Xuxu Sun et al.   CANCER CELL

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

(2018) Shiro Yui et al.   Cell Stem Cell

Mechanical cell competition

(2018) Catarina Brás-Pereira et al.   CURRENT OPINION IN CELL BIOLOGY

dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene‐induced senescence

(2018) Giulia Santinon et al.   EMBO JOURNAL

PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia

(2018) Wenying Angela Liu et al.   GENES & DEVELOPMENT

Crosstalk between YAP/TAZ and Notch Signaling

(2018) Antonio Totaro et al.   TRENDS IN CELL BIOLOGY

Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export

(2018) Nil Ege et al.   Cell Systems

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

(2018) Francesca Zanconato et al.   NATURE MEDICINE

The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration

(2018) Jun Wang et al.   Nature Reviews Cardiology

A feed forward loop enforces YAP/TAZ signaling during tumorigenesis

(2018) Mandeep K. Gill et al.   Nature Communications

TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells

(2018) Dana Elster et al.   Nature Communications

Zebrafish mutants and TEAD reporters reveal essential functions for Yap and Taz in posterior cardinal vein development

(2018) Matteo Astone et al.   Scientific Reports

The Hippo Pathway: Biology and Pathophysiology

(2018) Shenghong Ma et al.   Annual Review of Biochemistry

Hippo pathway inhibition by blocking the YAP/TAZ–TEAD interface: a patent review

(2018) James J. Crawford et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

(2018) Lei Chang et al.   NATURE

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

(2018) Anant Mamidi et al.   NATURE

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

(2018) Iván M. Moya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NUAK2 is a critical YAP target in liver cancer

(2018) Wei-Chien Yuan et al.   Nature Communications

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

(2017) Charles T. Foster et al.   GENES & DEVELOPMENT

Transcriptional integration of mitogenic and mechanical signals by Myc and YAP

(2017) Ottavio Croci et al.   GENES & DEVELOPMENT

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

(2017) Jongshin Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation

(2017) Yuka Morikawa et al.   NATURE

A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination

(2017) Yaqi Deng et al.   Nature Communications

YAP regulates cell mechanics by controlling focal adhesion assembly

(2017) Giorgia Nardone et al.   Nature Communications

YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis

(2017) Yiting Qiao et al.   Cell Reports

YAP/TAZ initiate and maintain Schwann cell myelination

(2017) Matthew Grove et al.   eLife

Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion

(2017) Julia E. Sero et al.   Cell Systems

Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway

(2017) Jie Liu et al.   Scientific Reports

Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex

(2017) Hung Yi Kristal Kaan et al.   Scientific Reports

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration

(2016) Xuxu Sun et al.   Cell Stem Cell

Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ

(2016) Tito Panciera et al.   Cell Stem Cell

Roles and regulations of Hippo signaling during preimplantation mouse development

(2016) Hiroshi Sasaki   DEVELOPMENT GROWTH & DIFFERENTIATION

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2

(2016) Julian Kwan et al.   GENES & DEVELOPMENT

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

(2016) Peng Li et al.   GENES & DEVELOPMENT

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells

(2016) Yannick Poitelon et al.   NATURE NEUROSCIENCE

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

(2016) Kuei-Chun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP

(2016) Duyen Amy Bui et al.   Science Signaling

New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics

(2016) Mingjing He et al.   Cell Division

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP

(2016) Duyen Amy Bui et al.   Science Signaling

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap

(2015) Aleksander D. Szymaniak et al.   DEVELOPMENTAL CELL

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction

(2015) X.-B. Lv et al.   EMBO REPORTS

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis

(2015) Jing Cai et al.   GENES & DEVELOPMENT

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

(2015) Inge Mannaerts et al.   JOURNAL OF HEPATOLOGY

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

(2015) Giorgio G. Galli et al.   MOLECULAR CELL

YAP is essential for tissue tension to ensure vertebrate 3D body shape

(2015) Sean Porazinski et al.   NATURE

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

(2015) Alex Gregorieff et al.   NATURE

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

Inactivation of a Gα s –PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

(2015) Ramiro Iglesias-Bartolome et al.   NATURE CELL BIOLOGY

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

(2015) Jung-Soon Mo et al.   NATURE CELL BIOLOGY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ

(2015) Minchul Kim et al.   Cell Reports

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

(2015) Claudia Stein et al.   PLoS Genetics

Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma

(2015) Jia-Zhu Fang et al.   PLoS One

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Merlin/NF2 Loss-Driven Tumorigenesis Linked to CRL4DCAF1-Mediated Inhibition of the Hippo Pathway Kinases Lats1 and 2 in the Nucleus

(2014) Wei Li et al.   CANCER CELL

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

(2014) Shi Jiao et al.   CANCER CELL

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

(2014) Avnish Kapoor et al.   CELL

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

(2014) Wenjing Zhang et al.   CELL RESEARCH

Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model

(2014) Zhiqiang Lin et al.   CIRCULATION RESEARCH

Sensing the local environment: actin architecture and Hippo signalling

(2014) Pedro Gaspar et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

(2014) Ning Liang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment

(2014) Adam Skibinski et al.   Cell Reports

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

(2014) Michael DeRan et al.   Cell Reports

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis

(2013) Yi Tang et al.   DEVELOPMENTAL CELL

cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

(2013) Minchul Kim et al.   EMBO JOURNAL

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

YAP and TAZ Regulate Skin Wound Healing

(2013) Min-Jung Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

(2013) Morvarid Mohseni et al.   NATURE CELL BIOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo pathway effector Yap promotes cardiac regeneration

(2013) Mei Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense

(2013) Hongtan Wu et al.   Cell Reports

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

(2013) Antoine Reginensi et al.   PLoS Genetics

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

Hippo Signaling Regulates Pancreas Development through Inactivation of Yap

(2012) N. M. George et al.   MOLECULAR AND CELLULAR BIOLOGY

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

(2012) Dahu Chen et al.   NATURE MEDICINE

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integration of intercellular signaling through the Hippo pathway

(2012) Kenneth D. Irvine   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

 -Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

(2011) M. R. Silvis et al.   Science Signaling

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

Structural insights into the YAP and TEAD complex

(2010) Z. Li et al.   GENES & DEVELOPMENT

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Structural and functional analysis of the YAP-binding domain of human TEAD2

(2010) W. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms

(2009) Fangfang Ren et al.   DEVELOPMENTAL BIOLOGY

TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation

(2009) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

(2009) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling

(2008) M. Ota et al.   DEVELOPMENT

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

(2008) Shian Wu et al.   DEVELOPMENTAL CELL

The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control

(2008) Lei Zhang et al.   DEVELOPMENTAL CELL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY