Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation

YAP: At the crossroad between transformation and tumor suppression

(2011) Efrem Bertini et al.   CELL CYCLE

The Hippo in the room: A new look at a key pathway in cell growth and transformation

(2010) Africa Fernandez-L et al.   CELL CYCLE

Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2

(2010) Naihan Xu et al.   JOURNAL OF CELL BIOLOGY

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

Developmental and oncogenic effects of Insulin-like Growth Factor-I in Ptc1+/- mouse cerebellum

(2010) Mirella Tanori et al.   Molecular Cancer

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastoma

(2010) B Bhatia et al.   ONCOGENE

The miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog-Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehog-Treated Cerebellar Neural Precursors

(2009) P. A. Northcott et al.   CANCER RESEARCH

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

(2009) A. Fernandez-L et al.   GENES & DEVELOPMENT

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

(2009) Paul A Northcott et al.   NATURE GENETICS

Pediatric brain tumors: Current treatment strategies and future therapeutic approaches

(2009) Sabine Mueller et al.   Neurotherapeutics

Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency

(2009) Pierre-Olivier Frappart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

(2008) Vincent Duronio   BIOCHEMICAL JOURNAL

Even Cancers Want Commitment: Lineage Identity and Medulloblastoma Formation

(2008) Charles G. Eberhart   CANCER CELL

The Emerging Role of the Hippo Pathway in Cell Contact Inhibition, Organ Size Control, and Cancer Development in Mammals

(2008) Qi Zeng et al.   CANCER CELL

Insulin-like Growth Factor 2Is Required for Progression to Advanced Medulloblastoma inpatched1Heterozygous Mice

(2008) Ryan B. Corcoran et al.   CANCER RESEARCH

AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

(2008) I. Plo et al.   CANCER RESEARCH

The Smo/Smo Model: Hedgehog-Induced Medulloblastoma with 90% Incidence and Leptomeningeal Spread

(2008) B. A. Hatton et al.   CANCER RESEARCH

PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma

(2008) Mirella Tanori et al.   CARCINOGENESIS

Yes-associated protein (YAP) functions as a tumor suppressor in breast

(2008) M Yuan et al.   CELL DEATH AND DIFFERENTIATION

Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors

(2008) S. R. Parathath et al.   DEVELOPMENT

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

(2008) D. Hambardzumyan et al.   GENES & DEVELOPMENT

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

CD36-dependent Regulation of Muscle FoxO1 and PDK4 in the PPARδ/β-mediated Adaptation to Metabolic Stress

(2008) Zaher Nahlé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability

(2008) Jennifer M. Leonard et al.   JOURNAL OF CELL BIOLOGY

Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

(2008) Marcel Kool et al.   PLoS One