Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators

Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging

(2022) Anita V. Kumar et al.   Frontiers in Cell and Developmental Biology

GMAP is an Atg8a-interacting protein that regulates Golgi turnover in Drosophila

(2022) Ashrafur Rahman et al.   Cell Reports

Mitophagy and Neurodegeneration: Between the Knowns and the Unknowns

(2022) Cuckoo Teresa Jetto et al.   Frontiers in Cell and Developmental Biology

Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage

(2021) Yibin Pan et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

(2021) Mathieu Bourdenx et al.   CELL

Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy

(2021) Thaddaeus Mutugi Nthiga et al.   JOURNAL OF CELL BIOLOGY

The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor

(2021) Thaddaeus Mutugi Nthiga et al.   Autophagy

All cells are created equal in the sight of autophagy: selective autophagy maintains homeostasis in senescent cells

(2021) Jaejin Kim et al.   Autophagy

Autophagy in metabolism and quality control: opposing, complementary or interlinked functions?

(2021) Vojo Deretic et al.   Autophagy

Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse

(2021) Hallie Morton et al.   FREE RADICAL BIOLOGY AND MEDICINE

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

(2021) Nils C. Gassen et al.   Nature Communications

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

Glucocorticoid-induced autophagy and apoptosis in bone

(2020) Tiantian Wang et al.   APOPTOSIS

Therapeutic approaches of trophic factors in animal models and in patients with spinal cord injury

(2020) María del Carmen Díaz-Galindo et al.   GROWTH FACTORS

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Autophagy as a decisive process for cell death

(2020) Seonghee Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Dual role of oxidative stress-JNK activation in autophagy and apoptosis induced by nickel oxide nanoparticles in human cancer cells

(2020) Yik-Lam Cho et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of the Golgi apparatus via GOLPH3-mediated new selective autophagy

(2020) Li-qun Lu et al.   LIFE SCIENCES

Canonical and Noncanonical Autophagy as Potential Targets for COVID-19

(2020) Melissa Bello-Perez et al.   Cells

Autophagy-related MicroRNAs in chronic lung diseases and lung cancer

(2020) Samaneh Rezaei et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Microautophagy – distinct molecular mechanisms handle cargoes of many sizes

(2020) Sebastian Schuck   JOURNAL OF CELL SCIENCE

Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion

(2020) Kazuaki Matoba et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases

(2020) Xinnan Li et al.   PHARMACOLOGICAL RESEARCH

Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas

(2020) Janaki N. Sudhakar et al.   Nature Communications

The Roles of Ubiquitin in Mediating Autophagy

(2020) Zhangyuan Yin et al.   Cells

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy

(2019) Subhash Mehto et al.   MOLECULAR CELL

High-Mobility Group Box 1 (HMGB1) and Autophagy in Acute Lung Injury (ALI): A Review

(2019) Lihua Qu et al.   MEDICAL SCIENCE MONITOR

Autophagy in liver diseases: Time for translation?

(2019) Manon Allaire et al.   JOURNAL OF HEPATOLOGY

Autophagy in the Heart

(2019) Osamu Yamaguchi   CIRCULATION JOURNAL

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy

(2019) Zhanying Hu et al.   Biology Open

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

(2019) Anaïs Larabi et al.   Autophagy

An update on the interactions between Alzheimer's disease, autophagy and inflammation

(2019) Mehmet Bostancıklıoğlu   GENE

Activation of the p38/MAPK pathway regulates autophagy in response to the CYPOR-dependent oxidative stress induced by zearalenone in porcine intestinal epithelial cells

(2019) Tongtong Shen et al.   FOOD AND CHEMICAL TOXICOLOGY

Mechanisms of Autophagy in Metabolic Stress Response

(2019) Angelina S. Gross et al.   JOURNAL OF MOLECULAR BIOLOGY

SHH signaling mediated by a prechordal and brain enhancer controls forebrain organization

(2019) Tomoko Sagai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of autophagy under nitrosative stress: A complex regulatory interplay between SIRT1 and AMPK in MCF7 cells

(2019) Subhamoy Chakraborty et al.   CELLULAR SIGNALLING

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

(2019) Nils C. Gassen et al.   Nature Communications

Autophagy and Age-Related Eye Diseases

(2019) Xue Yang et al.   Biomed Research International

The Role of Autophagy in the Heart

(2018) Sebastiano Sciarretta et al.   Annual Review of Physiology

Mechanisms and function of autophagy in intestinal disease

(2018) Kara G. Lassen et al.   Autophagy

Autophagy and inflammation in chronic respiratory disease

(2018) Alexandra C. Racanelli et al.   Autophagy

Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss

(2018) Huixia Li et al.   Autophagy

Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention

(2018) Thomas Briston et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries

(2018) Masahide Oku et al.   BIOESSAYS

Autophagy in health and disease: A comprehensive review

(2018) Sarbari Saha et al.   BIOMEDICINE & PHARMACOTHERAPY

Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies

(2018) Yu Gao et al.   Current Alzheimer Research

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Role of Autophagy in Parkinson’s Disease

(2018) Silvia Cerri et al.   CURRENT MEDICINAL CHEMISTRY

Neuronal autophagy and intercellular regulation of homeostasis in the brain

(2018) Aditi Kulkarni et al.   CURRENT OPINION IN NEUROBIOLOGY

Autophagy in stem cells: repair, remodelling and metabolic reprogramming

(2018) Patricia Boya et al.   DEVELOPMENT

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

(2018) Plamena R. Angelova et al.   FEBS LETTERS

Reactive nitrogen species control apoptosis and autophagy in K562 cells: implication of TAp73α induction in controlling autophagy

(2018) Sampurna Datta et al.   FREE RADICAL RESEARCH

Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models

(2018) Gyorgy Biczo et al.   GASTROENTEROLOGY

Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease

(2018) P Hemachandra Reddy et al.   HUMAN MOLECULAR GENETICS

Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17

(2018) Takahide Matsui et al.   JOURNAL OF CELL BIOLOGY

Role and mechanisms of autophagy in acetaminophen-induced liver injury

(2018) Xiaojuan Chao et al.   LIVER INTERNATIONAL

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impaired Autophagy in Motor Neurons: A Final Common Mechanism of Injury and Death

(2018) Maria A. Gonzalez Porras et al.   PHYSIOLOGY

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Neurotrophic factors in enteric physiology and pathophysiology

(2018) Sumei Liu   NEUROGASTROENTEROLOGY AND MOTILITY

The role of autophagy in morphogenesis and stem cell maintenance

(2018) Eric Bekoe Offei et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle

(2018) Yan Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and liver cancer

(2018) Yunus Akkoc et al.   Turkish Journal of Gastroenterology

EBV and KSHV Infection Dysregulates Autophagy to Optimize Viral Replication, Prevent Immune Recognition and Promote Tumorigenesis

(2018) Mara Cirone   Viruses-Basel

On the Role of Basal Autophagy in Adult Neural Stem Cells and Neurogenesis

(2018) Lucía Casares-Crespo et al.   Frontiers in Cellular Neuroscience

Autophagy: A necessary process during the Trypanosoma cruzi life-cycle

(2018) Betiana Nebaí Salassa et al.   Virulence

The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System

(2018) Qiuhong Xiong et al.   Cells

Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis

(2017) Anna S. Gukovskaya et al.   GASTROENTEROLOGY

Ubiquitin signaling and autophagy

(2017) Paolo Grumati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin

(2017) Bin Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

(2017) Kumsal Tekirdag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux

(2017) Laura Pontano Vaites et al.   MOLECULAR AND CELLULAR BIOLOGY

C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy

(2017) S. Salcher et al.   Molecular Cancer

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

(2017) Ilija Melentijevic et al.   NATURE

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

Mitophagy in neurodegeneration and aging

(2017) Elayne M. Fivenson et al.   NEUROCHEMISTRY INTERNATIONAL

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Phosphorylated CAV1 activates autophagy through an interaction with BECN1 under oxidative stress

(2017) Jihoon Nah et al.   Cell Death & Disease

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease

(2017) Gargi Ganguly et al.   Drug Design Development and Therapy

Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge

(2017) Javier H. Hervás et al.   Scientific Reports

DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy

(2017) Chuan-Ying Xu et al.   Frontiers in Aging Neuroscience

FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury

(2017) Chonghui Tang et al.   Stem Cells International

Bortezomib initiates endoplasmic reticulum stress, elicits autophagy and death in Echinococcus granulosus larval stage

(2017) María Celeste Nicolao et al.   PLoS One

The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases?

(2016) Paula Garcia-Huerta et al.   BRAIN RESEARCH

Unraveling the roles of Atg4 proteases from autophagy modulation to targeted cancer therapy

(2016) Lan Zhang et al.   CANCER LETTERS

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

(2016) Cindy Puente et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

(2016) Krisztina Hegedűs et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms of FGF gradient formation during embryogenesis

(2016) Revathi Balasubramanian et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis

(2016) Xiaoting Wu et al.   Nature Communications

Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging

(2015) Jaime L. Schneider et al.   AGING CELL

Neurotrophic Factors and Their Potential Applications in Tissue Regeneration

(2015) Nan Xiao et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Atg1 family kinases in autophagy initiation

(2015) Nobuo N. Noda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy, Metabolism, and Cancer

(2015) E. White et al.   CLINICAL CANCER RESEARCH

Interdigital tissue regression in the developing limb of vertebrates

(2015) Carlos I. Lorda-Diez et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Nitric Oxide Induction of Parkin Translocation in PTEN-induced Putative Kinase 1 (PINK1) Deficiency

(2015) Ji-Young Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

(2015) C. K. Domigan et al.   JOURNAL OF CELL SCIENCE

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

(2015) Esperanza Arias et al.   MOLECULAR CELL

FGF signalling regulates bone growth through autophagy

(2015) Laura Cinque et al.   NATURE

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

(2015) Jiajie Diao et al.   NATURE

ATG12–ATG3 interacts with Alix to promote basal autophagic flux and late endosome function

(2015) Lyndsay Murrow et al.   NATURE CELL BIOLOGY

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy

(2015) Yuchen Feng et al.   TRENDS IN CELL BIOLOGY

Compartment-dependent mitochondrial alterations in experimental ALS, the effects of mitophagy and mitochondriogenesis

(2015) Gianfranco Natale et al.   Frontiers in Cellular Neuroscience

Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

(2015) Caroline Park et al.   Nature Communications

The Role of Tau Oligomers in the Onset of Alzheimer's Disease Neuropathology

(2014) María del Carmen Cárdenas-Aguayo et al.   ACS Chemical Neuroscience

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

(2014) Juliana Navarro-Yepes et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium

(2014) Francesco Fornai et al.   Autophagy

Dissecting the localization and function of Atg18, Atg21 and Ygr223c

(2014) Roswitha Krick et al.   Autophagy

Autophagy in osteoblasts is involved in mineralization and bone homeostasis

(2014) Marie Nollet et al.   Autophagy

The yeast autophagy protease Atg4 is regulated by thioredoxin

(2014) María Esther Pérez-Pérez et al.   Autophagy

Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation

(2014) Jaime L. Schneider et al.   Cell Metabolism

Autophagy eliminates cytoplasmic β-catenin and NICD to promote the cardiac differentiation of P19CL6 cells

(2014) Zhuqing Jia et al.   CELLULAR SIGNALLING

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

(2014) Rut Valdor et al.   NATURE IMMUNOLOGY

Structural basis of starvation-induced assembly of the autophagy initiation complex

(2014) Yuko Fujioka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway

(2014) Giuseppina Amadoro et al.   Frontiers in Aging Neuroscience

Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunity

(2014) Xiaojuan Chen et al.   Protein & Cell

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Autophagy during Mycobacterium tuberculosis infection and implications for future tuberculosis medications

(2013) Xiaowen Yu et al.   CELLULAR SIGNALLING

TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3

(2013) Emilio Boada-Romero et al.   EMBO JOURNAL

FIP200 regulates targeting of Atg16L1 to the isolation membrane

(2013) Taki Nishimura et al.   EMBO REPORTS

p38MAPK-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2–antioxidant signaling

(2013) Noemí Rubio et al.   FREE RADICAL BIOLOGY AND MEDICINE

The LC3 interactome at a glance

(2013) P. Wild et al.   JOURNAL OF CELL SCIENCE

The Mechanism and Physiological Function of Macroautophagy

(2013) Daniel J. Klionsky et al.   Journal of Innate Immunity

Kaposi's Sarcoma-Associated Herpesvirus K7 Modulates Rubicon-Mediated Inhibition of Autophagosome Maturation

(2013) Q. Liang et al.   JOURNAL OF VIROLOGY

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atg12–Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site

(2013) Machiko Sakoh-Nakatogawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurogenic and Neurotrophic Effects of BDNF Peptides in Mouse Hippocampal Primary Neuronal Cell Cultures

(2013) Maria del Carmen Cardenas-Aguayo et al.   PLoS One

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

(2013) D. N. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

Structure of the autophagic E2 enzyme Atg10

(2012) Seung Beom Hong et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The fibroblast growth factor signaling axis controls cardiac stem cell differentiation through regulating autophagy

(2012) Jue Zhang et al.   Autophagy

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells

(2012) Patricia Vázquez et al.   Autophagy

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

The lack of autophagy triggers precocious activation of Notch signaling during Drosophila oogenesis

(2012) Julia MI Barth et al.   BMC DEVELOPMENTAL BIOLOGY

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

(2012) Michael H. Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications

(2012) Alicja Kalinowska-Lyszczarz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure-based Analyses Reveal Distinct Binding Sites for Atg2 and Phosphoinositides in Atg18

(2012) Yasunori Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal cell survival

(2012) Eisuke Dohi et al.   NEUROCHEMISTRY INTERNATIONAL

The Hedgehog signalling pathway regulates autophagy

(2012) Maria Jimenez-Sanchez et al.   Nature Communications

The TGFbeta Superfamily Signaling Pathway

(2012) Alexander Weiss et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

A Tecpr1-Dependent Selective Autophagy Pathway Targets Bacterial Pathogens

(2011) Michinaga Ogawa et al.   Cell Host & Microbe

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

FRS2α-Mediated FGF Signals Suppress Premature Differentiation of Cardiac Stem Cells Through Regulating Autophagy Activity

(2011) Jue Zhang et al.   CIRCULATION RESEARCH

Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors

(2011) Vojo Deretic   CURRENT OPINION IN IMMUNOLOGY

Programmed cell death during postnatal development of the rodent nervous system

(2011) Woon Ryoung Kim et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

Role and regulation of autophagy in the development of acinar structures formed by bovine BME-UV1 mammary epithelial cells

(2011) Agnieszka Sobolewska et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Autophagy in Stem Cell Maintenance and Differentiation

(2011) Alexandre Teixeira Vessoni et al.   STEM CELLS AND DEVELOPMENT

A photoconvertible fluorescent reporter to track chaperone-mediated autophagy

(2011) Hiroshi Koga et al.   Nature Communications

Autophagosome Formation and Molecular Mechanism of Autophagy

(2010) Isei Tanida   ANTIOXIDANTS & REDOX SIGNALING

Regulation of autophagy by transforming growth factor-β (TGF-β) signaling

(2010) Hiroshi I. Suzuki et al.   Autophagy

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death

(2010) Lilliana Radoshevich et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

The Expanding Universe of Neurotrophic Factors: Therapeutic Potential in Aging and Age-Associated Disorders

(2010) C. Lanni et al.   CURRENT PHARMACEUTICAL DESIGN

Protein homeostasis and synaptic plasticity

(2010) Iván J Cajigas et al.   EMBO JOURNAL

Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress

(2010) Yongjun Wang et al.   HEPATOLOGY

Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses

(2010) Fabien P. Blanchet et al.   IMMUNITY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis

(2010) Muriel Mari et al.   JOURNAL OF CELL BIOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

Expression and Functions of Fibroblast Growth Factor 2 (FGF-2) in Hippocampal Formation

(2010) Sabrina Zechel et al.   NEUROSCIENTIST

Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism

(2010) Akiko Kuma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Localized accumulation of oxidative stress causes muscle atrophy through activation of an autophagic pathway

(2009) Michela Aucello et al.   Autophagy

Atg101, a novel mammalian autophagy protein interacting with Atg13

(2009) Nao Hosokawa et al.   Autophagy

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

(2009) Mary Y. Wu et al.   DEVELOPMENTAL CELL

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

(2009) Cole J. Ferguson et al.   HUMAN MOLECULAR GENETICS

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian macroautophagy at a glance

(2009) B. Ravikumar et al.   JOURNAL OF CELL SCIENCE

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy

(2009) J. S. Stephan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallization of the coiled-coil domain of Atg16 essential for autophagy

(2008) Yuko Fujioka et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

How autophagy is related to programmed cell death during the development of the nervous system

(2008) Patricia Boya et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death

(2008) Francesco Cecconi et al.   DEVELOPMENTAL CELL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function

(2008) Keisuke Obara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo reconstitution of autophagy inSaccharomyces cerevisiae

(2008) Yang Cao et al.   JOURNAL OF CELL BIOLOGY

Differential Activities of the Ubiquitin-Proteasome System in Neurons versus Glia May Account for the Preferential Accumulation of Misfolded Proteins in Neurons

(2008) S. Tydlacka et al.   JOURNAL OF NEUROSCIENCE

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation

(2008) Tomoko Kawamata et al.   MOLECULAR BIOLOGY OF THE CELL

The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice

(2008) Yu-shin Sou et al.   MOLECULAR BIOLOGY OF THE CELL

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Lithium delays progression of amyotrophic lateral sclerosis

(2008) F. Fornai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I

(2007) Mordhwaj S. Parihar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS