Autophagy and inflammation in chronic respiratory disease

Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis

(2018) Neeraj Vij et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines—2016 revision

(2017) Jan L. Brożek et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis inPseudomonasSepsis

(2017) Qinqin Pu et al.   JOURNAL OF IMMUNOLOGY

Adipose tissue inflammation by intermittent hypoxia: mechanistic link between obstructive sleep apnoea and metabolic dysfunction

(2017) Silke Ryan   JOURNAL OF PHYSIOLOGY-LONDON

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis

(2017) Haijun Liu et al.   Cell Death & Disease

High intensity aerobic exercise training improves chronic intermittent hypoxia-induced insulin resistance without basal autophagy modulation

(2017) Marion Pauly et al.   Scientific Reports

Autophagy plays an essential role in cigarette smoke-induced expression of MUC5AC in airway epithelium

(2016) Jie-Sen Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro

(2016) Saket Ahuja et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis

(2016) David N. O'Dwyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Chronic intermittent hypoxia induces cardiac hypertrophy by impairing autophagy through the adenosine 5′-monophosphate-activated protein kinase pathway

(2016) Sheng Xie et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma

(2016) D. L. Pham et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis

(2016) Jennifer L. Larson-Casey et al.   IMMUNITY

Cigarette Smoke-Induced Pulmonary Inflammation and Autophagy Are Attenuated in Ephx2-Deficient Mice

(2016) Yunxiao Li et al.   INFLAMMATION

Lack of autophagy induces steroid-resistant airway inflammation

(2016) Yuzo Suzuki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis

(2016) Kenji Kobayashi et al.   JOURNAL OF IMMUNOLOGY

MiR-449a regulates autophagy to inhibit silica-induced pulmonary fibrosis through targeting Bcl2

(2016) Ruhui Han et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure

(2016) Forrest Jessop et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

(2016) Rossana G. Iannitti et al.   Nature Communications

Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma

(2016) Duy Le Pham et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Autophagy induction targeting mTORC1 enhances Mycobacterium tuberculosis replication in HIV co-infected human macrophages

(2016) Anna-Maria Andersson et al.   Scientific Reports

Silymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK/p38 MAPK pathway in human bronchial epithelial cells

(2016) Diandian Li et al.   Scientific Reports

Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1

(2015) Meredith L. Sosulski et al.   AGING CELL

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice

(2015) Fadila Telarevic Cero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of Cigarette Smoke–Induced Aggresome Formation in Chronic Obstructive Pulmonary Disease–Emphysema Pathogenesis

(2015) Ian Tran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lactosylceramide-accumulation in lipid-rafts mediate aberrant-autophagy, inflammation and apoptosis in cigarette smoke induced emphysema

(2015) Manish Bodas et al.   APOPTOSIS

IL13 activates autophagy to regulate secretion in airway epithelial cells

(2015) John D Dickinson et al.   Autophagy

PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis

(2015) Saburo Ito et al.   Autophagy

Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis

(2015) Sandra Cabrera et al.   Autophagy

Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5′ adenosine monophosphate-activated protein kinase pathway

(2015) Sheng Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alternaria extract activates autophagy that induces IL-18 release from airway epithelial cells

(2015) Hiroki Murai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Five-Year Outcomes of Patients Enrolled in the REVEAL Registry

(2015) Harrison W. Farber et al.   CHEST

Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target

(2015) G.-Y. Ban et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Global and regional trends in COPD mortality, 1990–2010

(2015) Peter G.J. Burney et al.   EUROPEAN RESPIRATORY JOURNAL

Tuberculosis and chronic respiratory disease: a systematic review

(2015) Anthony L. Byrne et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

The Lung Is Protected from Spontaneous Inflammation by Autophagy in Myeloid Cells

(2015) Masashi Kanayama et al.   JOURNAL OF IMMUNOLOGY

Critical Role for IL-18 in Spontaneous Lung Inflammation Caused by Autophagy Deficiency

(2015) Elmoataz Abdel Fattah et al.   JOURNAL OF IMMUNOLOGY

Association of Egr-1 and autophagy-related gene polymorphism in men with chronic obstructive pulmonary disease

(2015) Chiung-Zuei Chen et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice

(2015) Yosuke Yamada et al.   LABORATORY INVESTIGATION

Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1

(2015) M Reed et al.   Mucosal Immunology

Autophagy is not the answer

(2015) Samuel M. Behar et al.   NATURE

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection

(2015) Jacqueline M. Kimmey et al.   NATURE

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Contribution of metabolic reprogramming to macrophage plasticity and function

(2015) Karim C. EL Kasmi et al.   SEMINARS IN IMMUNOLOGY

Epithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary Fibrosis

(2015) Avignat S. Patel et al.   PLoS One

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis

(2015) Yao-Song Gui et al.   PLoS One

Elastase induces lung epithelial cell autophagy through placental growth factor

(2014) Hsin-Han Hou et al.   Autophagy

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil extracellular traps promote differentiation and function of fibroblasts

(2014) Akrivi Chrysanthopoulou et al.   JOURNAL OF PATHOLOGY

IPF Fibroblasts Are Desensitized to Type I Collagen Matrix-Induced Cell Death by Suppressing Low Autophagy via Aberrant Akt/mTOR Kinases

(2014) Richard Seonghun Nho et al.   PLoS One

Everolimus in Patients with Severe Pulmonary Hypertension: A Safety and Efficacy Pilot Trial

(2014) Hans-Jürgen Seyfarth et al.   Pulmonary Circulation

Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages

(2013) Souhaila Al-Khodor et al.   CELLULAR MICROBIOLOGY

Chloroquine Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Lysosomal Bone Morphogenetic Protein Type II Receptor Degradation

(2013) Lu Long et al.   CIRCULATION RESEARCH

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

(2013) Edda Spiekerkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

(2013) Hilaire C. Lam et al.   JOURNAL OF CLINICAL INVESTIGATION

CaMKI  Regulates AMP Kinase-Dependent, TORC-1-Independent Autophagy during Lipopolysaccharide-Induced Acute Lung Neutrophilic Inflammation

(2013) L. Guo et al.   JOURNAL OF IMMUNOLOGY

Autophagy-Inducing Protein Beclin-1 in Dendritic Cells Regulates CD4 T Cell Responses and Disease Severity during Respiratory Syncytial Virus Infection

(2013) M. Reed et al.   JOURNAL OF IMMUNOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Cigarette Smoke (CS)-Induced Autophagy by Nrf2

(2013) Lingxiang Zhu et al.   PLoS One

Autophagy Enhances Bacterial Clearance during P. aeruginosa Lung Infection

(2013) Robert D. Junkins et al.   PLoS One

Acute cigarette smoke exposure impairs proteasome function in the lung

(2012) Sabine H. van Rijt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema

(2012) Chang Hyeok An et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cross talk between NADPH oxidase and autophagy in pulmonary artery endothelial cells with intrauterine persistent pulmonary hypertension

(2012) Ru-Jeng Teng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Insufficient autophagy in idiopathic pulmonary fibrosis

(2012) Jun Araya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lc3 Over-Expression Improves Survival and Attenuates Lung Injury Through Increasing Autophagosomal Clearance in Septic Mice

(2012) Steven Lo et al.   ANNALS OF SURGERY

ATG5, autophagy and lung function in asthma

(2012) Audrey Poon et al.   Autophagy

The Emerging Importance of Autophagy in Pulmonary Diseases

(2012) Kenji Mizumura et al.   CHEST

The pathogenesis of pulmonary fibrosis: a moving target

(2012) Wim A. Wuyts et al.   EUROPEAN RESPIRATORY JOURNAL

Rescue of Dysfunctional Autophagy Attenuates Hyperinflammatory Responses from Cystic Fibrosis Cells

(2012) M. L. Mayer et al.   JOURNAL OF IMMUNOLOGY

Functional Variant in the Autophagy-Related 5 Gene Promotor is Associated with Childhood Asthma

(2012) Lisa J. Martin et al.   PLoS One

Autophagy in Idiopathic Pulmonary Fibrosis

(2012) Avignat S. Patel et al.   PLoS One

Regulatory T Cells and Pulmonary Hypertension

(2012) Rasa Tamosiuniene et al.   TRENDS IN CARDIOVASCULAR MEDICINE

The pathophysiology of bronchiectasis

(2012) Paul King   International Journal of Chronic Obstructive Pulmonary Disease

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

(2012) Satoko Fujii et al.   OncoImmunology

Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis

(2011) Seon-Jin Lee et al.   Autophagy

Autophagy stimulation by rapamycin suppresses lung inflammation and infection byBurkholderia cenocepaciain a model of cystic fibrosis

(2011) Basant A. Abdulrahman et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

HIV and Tuberculosis: a Deadly Human Syndemic

(2011) C. K. Kwan et al.   CLINICAL MICROBIOLOGY REVIEWS

Genetic and histologic evidence for autophagy in asthma pathogenesis

(2011) Audrey H. Poon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Blocking IL-17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via TGF- 1-Dependent and -Independent Mechanisms

(2011) S. Mi et al.   JOURNAL OF IMMUNOLOGY

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

Obstructive sleep apnea and inflammation: Relationship to cardiovascular co-morbidity

(2011) Brian D. Kent et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis

(2011) MONIQUE A. MALOUF et al.   RESPIROLOGY

Pathology of post primary tuberculosis of the lung: An illustrated critical review

(2011) Robert L. Hunter   TUBERCULOSIS

Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophages

(2011) K Guzik et al.   Cell Death & Disease

Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium?

(2011) Smitha J. Sasindran et al.   Frontiers in Microbiology

Autophagic Protein LC3B Confers Resistance against Hypoxia-induced Pulmonary Hypertension

(2010) Seon-Jin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of an Autophagy Defect in Smokers' Alveolar Macrophages

(2010) M. M. Monick et al.   JOURNAL OF IMMUNOLOGY

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

(2010) Toshinori Yoshida et al.   NATURE MEDICINE

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

(2010) Z.-H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

British Thoracic Society guideline for non-CFbronchiectasis

(2010) M. C. Pasteur et al.   THORAX

Autophagy, Immunity, and Microbial Adaptations

(2009) Vojo Deretic et al.   Cell Host & Microbe

Interleukin-6 Overexpression Induces Pulmonary Hypertension

(2008) M. Kathryn Steiner et al.   CIRCULATION RESEARCH

Pathogenesis of Asthma

(2008) STEPHEN T. HOLGATE   CLINICAL AND EXPERIMENTAL ALLERGY

To Die or Not to Die: That is the Autophagic Question

(2008) Maria Maiuri et al.   CURRENT MOLECULAR MEDICINE

Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

(2008) Zhi-Hua Chen et al.   PLoS One