Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging

Disrupted autophagy and neuronal dysfunction in C. elegans knockin models of FUS amyotrophic lateral sclerosis

(2022) Saba N. Baskoylu et al.   Cell Reports

p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response

(2021) Shun Kageyama et al.   Nature Communications

Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells

(2021) Sabrina Robichaud et al.   Autophagy

UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy

(2021) Min Ji Yoon et al.   Nature Communications

TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins

(2021) Lin Lyu et al.   Autophagy

Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production

(2021) Xing Li et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

p62-containing, proteolytically active nuclear condensates, increase the efficiency of the ubiquitin–proteasome system

(2021) Afu Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

(2021) Eleonora Turco et al.   Nature Communications

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death

(2021) A. D. Foster et al.   Scientific Reports

Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression

(2021) Xiaoyan Yuan et al.   Cell and Bioscience

p62 Overexpression Promotes Bone Metastasis of Lung Adenocarcinoma out of LC3-Dependent Autophagy

(2021) Dongqi Li et al.   Frontiers in Oncology

The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer

(2021) Paulina Hennig et al.   Biomedicines

NBR 1‐mediated p62‐liquid droplets enhance the Keap1‐Nrf2 system

(2020) Pablo Sánchez‐Martín et al.   EMBO REPORTS

Pexophagy: A Model for Selective Autophagy

(2020) Kyla Germain et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake

(2020) Arjen J. Jakobi et al.   Nature Communications

Lysosome biology in autophagy

(2020) Willa Wen-You Yim et al.   Cell Discovery

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

(2020) Guo Chen et al.   Frontiers in Cell and Developmental Biology

p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus Roles

(2020) Sonia Emanuele et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes

(2020) Won Hoon Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Quality Control and Lipid Droplet Metabolism

(2020) Melissa A. Roberts et al.   Annual Review of Cell and Developmental Biology

A role for the autophagic receptor, SQSTM1/p62, in trafficking NF-κB/RelA to nucleolar aggresomes

(2020) Ian T Lobb et al.   MOLECULAR CANCER RESEARCH

Structure and function of p62/SQSTM1 in the emerging framework of phase separation

(2020) Sabrina Berkamp et al.   FEBS Journal

SQSTM1/p62: a potential target for neurodegenerative disease

(2019) Shifan Ma et al.   ACS Chemical Neuroscience

Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration

(2019) Janusz Blasiak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy

(2019) Rastislav Horos et al.   CELL

Autophagy in aging and longevity

(2019) Shi Q. Wong et al.   HUMAN GENETICS

HDAC6 regulates lipid droplet turnover in response to nutrient deprivation via p62-mediated selective autophagy

(2019) Yan Yan et al.   Journal of Genetics and Genomics

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

(2019) Zhiqiang Deng et al.   Autophagy

SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy

(2019) Tatsuya Yamada et al.   Autophagy

A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

(2019) Qiyao Chai et al.   Nature Communications

Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila

(2019) Ricardo Aparicio et al.   Cell Reports

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence

(2019) Gloria Salazar et al.   Autophagy

Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response

(2019) Yi Yang et al.   Nature Communications

Autophagy Deficiency Leads to Impaired Antioxidant Defense via p62-FOXO1/3 Axis

(2019) Lin Zhao et al.   Oxidative Medicine and Cellular Longevity

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

(2019) Caroline Kumsta et al.   Nature Communications

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

(2018) Tatsuya Yamada et al.   Cell Metabolism

Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation

(2018) Daxiao Sun et al.   CELL RESEARCH

p62 filaments capture and present ubiquitinated cargos for autophagy

(2018) Gabriele Zaffagnini et al.   EMBO JOURNAL

Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation

(2018) Zhe Sha et al.   JOURNAL OF CELL BIOLOGY

Aberrant subcellular localization of SQSTM1/p62 contributes to increased vulnerability to proteotoxic stress recovery in Huntington's disease

(2018) Ningjing Huang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan

(2018) Melissa J. Silvestrini et al.   Cell Reports

p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy

(2018) Megumi Tsuchiya et al.   FEBS Open Bio

Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter

(2018) Do Hoon Kwon et al.   Nature Communications

ZZ-dependent regulation of p62/SQSTM1 in autophagy

(2018) Yi Zhang et al.   Nature Communications

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

(2017) Hyunjoo Cha-Molstad et al.   Nature Communications

Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells

(2017) Lin Wang et al.   Scientific Reports

p62 in Cancer: Signaling Adaptor Beyond Autophagy

(2016) Jorge Moscat et al.   CELL

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

(2016) Chrisovalantis Papadopoulos et al.   EMBO JOURNAL

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

(2016) Alice Goode et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models

(2016) Mitchell S. Wold et al.   Molecular Neurodegeneration

Autophagic Turnover of Inactive 26S Proteasomes in Yeast Is Directed by the Ubiquitin Receptor Cue5 and the Hsp42 Chaperone

(2016) Richard S. Marshall et al.   Cell Reports

Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy

(2016) Sangwook Park et al.   PLoS One

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

The Implications of the Sequestosome 1 Mutation P392L in Patients with Paget’s Disease in a United States Cohort

(2015) Margaret Seton et al.   CALCIFIED TISSUE INTERNATIONAL

Distinct requirements of Autophagy-related genes in programmed cell death

(2015) T Xu et al.   CELL DEATH AND DIFFERENTIATION

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

(2015) Elizabeth M. Selleck et al.   mBio

The Selective Autophagy Receptor p62 Forms a Flexible Filamentous Helical Scaffold

(2015) Rodolfo Ciuffa et al.   Cell Reports

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

(2015) Junghyun Lim et al.   PLoS Genetics

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

(2015) Koray Kırlı et al.   eLife

Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy

(2015) Bettina Wurzer et al.   eLife

p62/SQSTM1 at the interface of aging, autophagy, and disease

(2014) Alessandro Bitto et al.   AGE

PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding

(2014) Frank Christian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice

(2014) Masaru Kurosawa et al.   HUMAN MOLECULAR GENETICS

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Interaction Domains of p62: A Bridge Between p62 and Selective Autophagy

(2013) Xiaolong Lin et al.   DNA AND CELL BIOLOGY

Sequestosome-1 (SQSTM1) sequence variants in ALS cases in the UK: prevalence and coexistence of SQSTM1 mutations in ALS kindred with PDB

(2013) Chun T Kwok et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1

(2013) Tiziana Zotti et al.   MOLECULAR IMMUNOLOGY

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease

(2013) Laura Rué et al.   NEUROBIOLOGY OF DISEASE

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade

(2012) Jeongho Kwon et al.   EMBO REPORTS

NBR1 acts as an autophagy receptor for peroxisomes

(2012) E. Deosaran et al.   JOURNAL OF CELL SCIENCE

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

(2012) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

p62/SQSTM1/A170: Physiology and pathology

(2012) Masaaki Komatsu et al.   PHARMACOLOGICAL RESEARCH

p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS

(2011) Safa Al-Sarraj et al.   ACTA NEUROPATHOLOGICA

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

Feedback on Fat: p62-mTORC1-Autophagy Connections

(2011) Jorge Moscat et al.   CELL

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy

(2011) Natura Myeku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Ubiquitin-associated (UBA) Domain of p62 and Its Interaction with Ubiquitin

(2011) Shin Isogai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

(2011) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation

(2011) David G. McEwan et al.   TRENDS IN CELL BIOLOGY

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy

(2010) Weiliang Fan et al.   Autophagy

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

(2009) Serhiy Pankiv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation

(2009) Kazuhiro Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease

(2008) Yifeng Du et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis

(2008) M. A. King et al.   MOLECULAR PHARMACOLOGY