The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System

Crosstalk between lysine methylation and phosphorylation of ATG16L1 dictates the apoptosis of hypoxia/reoxygenation-induced cardiomyocytes

(2018) Huiwen Song et al.   Autophagy

The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes

(2018) Katherine Fletcher et al.   EMBO JOURNAL

ATG5 is required for B cell polarization and presentation of particulate antigens

(2018) Florent Arbogast et al.   Autophagy

ATG16 mediates the autophagic degradation of the 19S proteasomal subunits PSMD1 and PSMD2

(2018) Qiuhong Xiong et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis

(2018) Shashank Rai et al.   Autophagy

An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread

(2018) Joel M. J. Tan et al.   Nature Microbiology

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

Molecular control of chaperone-mediated autophagy

(2017) Steve Catarino et al.   Essays in Biochemistry

Autophagic clearance of proteasomes in yeast requires the conserved sorting nexin Snx4

(2017) Antonia A. Nemec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LC3-Associated Phagocytosis Is Required for Dendritic Cell Inflammatory Cytokine Response to Gut Commensal Yeast Saccharomyces cerevisiae

(2017) Dimitra Lamprinaki et al.   Frontiers in Immunology

It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin

(2016) Martina P. Liebl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model

(2016) Ana Mesquita et al.   Autophagy

Connexins: substrates and regulators of autophagy

(2016) Jegan Iyyathurai et al.   BMC CELL BIOLOGY

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation

(2016) Francesca Nazio et al.   JOURNAL OF CELL BIOLOGY

p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome

(2016) Victoria Cohen-Kaplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell death

(2016) Jia Hu et al.   Cell Death & Disease

The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1

(2016) Emilio Boada-Romero et al.   Nature Communications

Loss of Atg16 delays the alcohol-induced sedation response via regulation of Corazonin neuropeptide production in Drosophila

(2016) Kata Varga et al.   Scientific Reports

ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation

(2015) Huiwen Song et al.   Autophagy

TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy inDictyosteliumand human HeLa cells

(2015) Sandra Muñoz-Braceras et al.   Autophagy

Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles

(2015) Kenrick A. Waite et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

(2015) Tomonori Kimura et al.   JOURNAL OF CELL BIOLOGY

Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis

(2015) Richard S. Marshall et al.   MOLECULAR CELL

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Annexin A2 promotes phagophore assembly by enhancing Atg16L+ vesicle biogenesis and homotypic fusion

(2015) Kateryna Morozova et al.   Nature Communications

The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions

(2015) Q. Xiong et al.   Open Biology

Direct link between Atg protein and small GTPase Rab: Atg16L functions as a potential Rab33 effector in mammals

(2014) Mitsunori Fukuda et al.   Autophagy

Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners

(2014) Jun Hoe Kim et al.   Autophagy

ATG16L1contributes to Crohn's disease susceptibility in Koreans: overmuch concern for ethnic difference?: Table 1

(2014) Suk-Kyun Yang et al.   GUT

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

Connexins modulate autophagosome biogenesis

(2014) Eloy Bejarano et al.   NATURE CELL BIOLOGY

Autophagy-related gene16L2, a potential serum biomarker of multiple sclerosis evaluated by bead-based proteomic technology

(2014) Linlin Yin et al.   NEUROSCIENCE LETTERS

The twoC. elegansATG-16 homologs have partially redundant functions in the basal autophagy pathway

(2013) Hui Zhang et al.   Autophagy

ATG16L1 meets ATG9 in recycling endosomes

(2013) Claudia Puri et al.   Autophagy

A novel crosstalk between two major protein degradation systems

(2013) Xiao J Wang et al.   Autophagy

Substrate recognition in selective autophagy and the ubiquitin–proteasome system

(2013) Anne Schreiber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes

(2013) Claudia Puri et al.   CELL

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3

(2013) Emilio Boada-Romero et al.   EMBO JOURNAL

FIP200 regulates targeting of Atg16L1 to the isolation membrane

(2013) Taki Nishimura et al.   EMBO REPORTS

Biology and trafficking of ATG9 and ATG16L1, two proteins that regulate autophagosome formation

(2013) Eszter Zavodszky et al.   FEBS LETTERS

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection

(2013) Kara L. Conway et al.   GASTROENTEROLOGY

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations

(2013) Suk-Kyun Yang et al.   GUT

Ubiquitin Regulates Caspase Recruitment Domain-mediated Signaling by Nucleotide-binding Oligomerization Domain-containing Proteins NOD1 and NOD2

(2013) Aaron M. Ver Heul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

(2013) Naonobu Fujita et al.   JOURNAL OF CELL BIOLOGY

Three isoforms of the Atg16L1 protein contribute different autophagic properties

(2013) Tao Jiang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Crohn's disease: associated ATG16L1 variant andSalmonellainvasion

(2013) Jeannette S Messer et al.   BMJ Open

ATG16L1 and pathogenesis of urinary tract infections

(2012) Caihong Wang et al.   Autophagy

Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation

(2012) Julia Romanov et al.   EMBO JOURNAL

Ubiquitin receptors and protein quality control

(2012) Xuejun Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity

(2012) Koutaro Ishibashi et al.   MOLECULAR BIOLOGY OF THE CELL

Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex–dependent and –independent autophagy

(2012) Noor Gammoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heteromeric p97/p97R155C Complexes Induce Dominant Negative Changes in Wild-Type and Autophagy 9-Deficient Dictyostelium strains

(2012) Khalid Arhzaouy et al.   PLoS One

Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo

(2012) C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex

(2011) Koutaro Ishibashi et al.   Autophagy

ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation

(2011) Theo S. Plantinga et al.   Autophagy

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation

(2011) Christelle En Lin Chua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2

(2011) T. S. Plantinga et al.   GUT

Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways

(2011) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma membrane helps autophagosomes grow

(2010) Brinda Ravikumar et al.   Autophagy

Processing of autophagic protein LC3 by the 20S proteasome

(2010) Zhonghua Gao et al.   Autophagy

C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms

(2010) Ye Tian et al.   CELL

Loss of Dictyostelium ATG9 results in a pleiotropic phenotype affecting growth, development, phagocytosis and clearance and replication of Legionella pneumophila

(2010) Sze Man Tung et al.   CELLULAR MICROBIOLOGY

WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins

(2010) Natasha Pashkova et al.   MOLECULAR CELL

The plasma membrane brings autophagosomes to life

(2010) Ana Maria Cuervo   NATURE CELL BIOLOGY

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Rab33b and Rab6 are Functionally Overlapping Regulators of Golgi Homeostasis and Trafficking

(2010) Tregei Starr et al.   TRAFFIC

Crohn's disease-associated adherent-invasiveE. coliare selectively favoured by impaired autophagy to replicate intracellularly

(2009) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Molecular basis of canonical and bactericidal autophagy

(2009) T. Noda et al.   INTERNATIONAL IMMUNOLOGY

Dimeric Coiled-coil Structure ofSaccharomyces cerevisiaeAtg16 and Its Functional Significance in Autophagy

(2009) Yuko Fujioka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Involvement of Atg16L1 in Crohn Disease and Canonical Autophagy

(2009) Naonobu Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

Inhibition of lysosomal functions reduces proteasomal activity

(2009) Liyan Qiao et al.   NEUROSCIENCE LETTERS

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation

(2008) Takashi Itoh et al.   MOLECULAR BIOLOGY OF THE CELL

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

(2008) Petric Kuballa et al.   PLoS One

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

(2008) Liyan Qiao et al.   Molecular Brain