New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy

(2019) Subhash Mehto et al.   MOLECULAR CELL

The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

(2019) Sydney Lavoie et al.   eLife

Roles of Autophagy-Related Genes in the Pathogenesis of Inflammatory Bowel Disease

(2019) Sup Kim et al.   Cells

miR-346 functions as a pro-survival factor under ER stress by activating mitophagy

(2018) Junfei Guo et al.   CANCER LETTERS

TNF-α induces autophagy through ERK1/2 pathway to regulate apoptosis in neonatal necrotizing enterocolitis model cells IEC-6

(2018) Yuhang Yuan et al.   CELL CYCLE

Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice

(2018) Johanna Pott et al.   Cell Host & Microbe

ER-stress mobilization of death-associated protein kinase-1–dependent xenophagy counteracts mitochondria stress–induced epithelial barrier dysfunction

(2018) Fernando Lopes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

(2018) Mohammad Samie et al.   NATURE IMMUNOLOGY

An increase in LRRK2 suppresses autophagy and enhances Dectin-1–induced immunity in a mouse model of colitis

(2018) Tetsuya Takagawa et al.   Science Translational Medicine

Paneth Cells during Viral Infection and Pathogenesis

(2018) Mayumi Holly et al.   Viruses-Basel

Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes

(2018) Sylwia Gradzka et al.   Cell Death & Disease

PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer

(2018) Marianne R. Spalinger et al.   Cell Reports

Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major

(2018) Shanshan Hu et al.   Frontiers in Immunology

Ginsenoside Rd ameliorates colitis by inducing p62-driven mitophagy-mediated NLRP3 inflammasome inactivation in mice

(2018) Chao Liu et al.   BIOCHEMICAL PHARMACOLOGY

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

(2018) Konrad Aden et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation

(2018) Alexis Bretin et al.   Scientific Reports

Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota

(2018) Patricia K. Martin et al.   Nature Microbiology

An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread

(2018) Joel M. J. Tan et al.   Nature Microbiology

Fecal Microbiota Transplantation Beneficially Regulates Intestinal Mucosal Autophagy and Alleviates Gut Barrier Injury

(2018) Saisai Cheng et al.   mSystems

The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagosome Induction and the Metabolic Transition of Activated T Cells

(2017) Michael I. Whang et al.   IMMUNITY

The protection role of Atg16l1 in CD11c + dendritic cells in murine colitis

(2017) Hong Zhang et al.   IMMUNOBIOLOGY

Autophagy limits activation of the inflammasomes

(2017) Michihiro Takahama et al.   IMMUNOLOGICAL REVIEWS

Inhibition of Autophagic Degradation Process Contributes to Claudin-2 Expression Increase and Epithelial Tight Junction Dysfunction in TNF-α Treated Cell Monolayers

(2017) Cong Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TREM-1 Inhibition Restores Impaired Autophagy Activity and Reduces Colitis in Mice

(2017) Tunay Kökten et al.   Journal of Crohns & Colitis

Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease

(2017) Wiebe Vanhove et al.   Journal of Crohns & Colitis

Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis

(2017) Markus Tschurtschenthaler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation

(2017) Michaela A. Diamanti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloid ATG16L1 Facilitates Host–Bacteria Interactions in Maintaining Intestinal Homeostasis

(2017) Hong Zhang et al.   JOURNAL OF IMMUNOLOGY

L’autophagie garante de l’immunité et de l’inflammation

(2017) Pierre Lapaquette et al.   M S-MEDECINE SCIENCES

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

(2017) Shai Bel et al.   SCIENCE

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

(2017) Jesus Cosin-Roger et al.   Nature Communications

Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy

(2017) Xiaodong Li et al.   Nutrients

Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration

(2017) Jumpei Asano et al.   Cell Reports

Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasiveEscherichia coliinfection

(2016) Alexis Bretin et al.   Autophagy

Impaired autophagy in macrophages promotes inflammatory eye disease

(2016) Andrea Santeford et al.   Autophagy

Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages

(2016) Jacinta P. W. Lee et al.   Autophagy

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Links of Autophagy Dysfunction to Inflammatory Bowel Disease Onset

(2016) Faris El-Khider et al.   DIGESTIVE DISEASES

Death in the intestinal epithelium-basic biology and implications for inflammatory bowel disease

(2016) J. Magarian Blander   FEBS Journal

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

(2016) Floris Imhann et al.   GUT

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

(2016) Tobias Schwerd et al.   GUT

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

(2016) Kara G. Lassen et al.   IMMUNITY

Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway

(2016) SHOUYU GUO et al.   Molecular Medicine Reports

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

(2016) Rajesh Ravindran et al.   NATURE

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

(2016) H. Chu et al.   SCIENCE

The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1

(2016) Emilio Boada-Romero et al.   Nature Communications

The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

(2016) Agnieszka M Kabat et al.   eLife

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

(2015) T. S. Chew et al.   Disease Models & Mechanisms

Endoplasmic Reticulum Stress and Unfolded Protein Response in Inflammatory Bowel Disease

(2015) Stewart S. Cao   INFLAMMATORY BOWEL DISEASES

Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy

(2015) Jie Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Autophagy Enhances Intestinal Epithelial Tight Junction Barrier Function by Targeting Claudin-2 Protein Degradation

(2015) Prashant K. Nighot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus

(2015) Koichiro Tsuboi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Contributes to the Induction of Anti-TNF Induced Macrophages

(2015) Alon D. Levin et al.   Journal of Crohns & Colitis

Survival of Effector CD8+T Cells during Influenza Infection Is Dependent on Autophagy

(2015) Katrin Schlie et al.   JOURNAL OF IMMUNOLOGY

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

Commensal bacteria direct selective cargo sorting to promote symbiosis

(2015) Qin Zhang et al.   NATURE IMMUNOLOGY

MTMR3risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation

(2015) Amit Lahiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

(2015) Daniela Senft et al.   TRENDS IN BIOCHEMICAL SCIENCES

Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

(2014) Wenjie Guo et al.   Autophagy

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Activating Cannabinoid Receptor 2 Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis Via Activation of Autophagy and Inhibiting NLRP3 Inflammasome

(2014) Bo-Zong Shao et al.   CNS Neuroscience & Therapeutics

TheATG16L1–T300Aallele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients

(2014) Mehdi Sadaghian Sadabad et al.   GUT

Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

(2014) Shaoping Wu et al.   GUT

Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients

(2014) Andrew M. Smith et al.   IMMUNOLOGY

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

Autophagy is essential for effector CD8+ T cell survival and memory formation

(2014) Xiaojin Xu et al.   NATURE IMMUNOLOGY

Infectious etiopathogenesis of Crohn’s disease

(2014) Jessica Carrière   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy is a critical regulator of memory CD8+ T cell formation

(2014) Daniel J Puleston et al.   eLife

Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

(2013) Bo Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Innate and adaptive immunity in inflammatory bowel disease

(2013) Alessandra Geremia et al.   AUTOIMMUNITY REVIEWS

A Deficiency in the Autophagy Gene Atg16L1 Enhances Resistance to Enteric Bacterial Infection

(2013) Amanda M. Marchiando et al.   Cell Host & Microbe

Crohn's Disease–Associated Adherent Invasive Escherichia coli Modulate Levels of microRNAs in Intestinal Epithelial Cells to Reduce Autophagy

(2013) Hang Thi Thu Nguyen et al.   GASTROENTEROLOGY

MIR106B and MIR93 Prevent Removal of Bacteria From Epithelial Cells by Disrupting ATG16L1-Mediated Autophagy

(2013) Changming Lu et al.   GASTROENTEROLOGY

Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease

(2013) J Jasper Deuring et al.   GUT

Autophagy and Cellular Immune Responses

(2013) Yuting Ma et al.   IMMUNITY

Autophagy and Crohn's Disease

(2013) Hang Thi Thu Nguyen et al.   Journal of Innate Immunity

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Autophagy: a new target or an old strategy for the treatment of Crohn's disease?

(2013) Kris Nys et al.   Nature Reviews Gastroenterology & Hepatology

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammasome Components Coordinate Autophagy and Pyroptosis as Macrophage Responses to Infection

(2013) B. G. Byrne et al.   mBio

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

(2012) Yue Shen et al.   Cell Host & Microbe

Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse

(2012) Manon E. Wildenberg et al.   GASTROENTEROLOGY

Subversion of Autophagy in Adherent Invasive Escherichia coli-Infected Neutrophils Induces Inflammation and Cell Death

(2012) Abderrahman Chargui et al.   PLoS One

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

(2011) J R Kovacs et al.   CELL DEATH AND DIFFERENTIATION

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Temporal Regulation of Intracellular Organelle Homeostasis in T Lymphocytes by Autophagy

(2011) W. Jia et al.   JOURNAL OF IMMUNOLOGY

Involvement of ROS in Curcumin-induced Autophagic Cell Death

(2011) Youn Ju Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

The complex interplay of NOD-like receptors and the autophagy machinery in the pathophysiology of Crohn disease

(2010) Susanne Billmann-Born et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine Increases Autophagy Under Basal and Stressed Conditions in Intestinal Epithelial Cells

(2008) Toshio Sakiyama et al.   GASTROENTEROLOGY

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

(2008) D C O Massey et al.   GUT

Everolimus for refractory Crohnʼs disease: A case report

(2008) Jérôme Dumortier et al.   INFLAMMATORY BOWEL DISEASES

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE