Identification of Serum Exosome-Derived circRNA-miRNA-TF-mRNA Regulatory Network in Postmenopausal Osteoporosis Using Bioinformatics Analysis and Validation in Peripheral Blood-Derived Mononuclear Cells

Exploring the relationship between systemic lupus erythematosus and osteoporosis based on bioinformatics

(2022) Jie Han et al.   LUPUS

Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model

(2022) Zhipeng Chen et al.   Stem Cells International

Longitudinal Changes of Circulating miRNAs During Bisphosphonate and Teriparatide Treatment in an Animal Model of Postmenopausal Osteoporosis

(2021) Moritz Weigl et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Exosomal hsa_circ_0006859 is a potential biomarker for postmenopausal osteoporosis and enhances adipogenic versus osteogenic differentiation in human bone marrow mesenchymal stem cells by sponging miR-431-5p

(2021) Feng Zhi et al.   Stem Cell Research & Therapy

Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/β ‐catenin pathway

(2021) Yu‐ying Yang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

POU2F2 regulates glycolytic reprogramming and glioblastoma progression via PDPK1-dependent activation of PI3K/AKT/mTOR pathway

(2021) Rui Yang et al.   Cell Death & Disease

Interleukin 19 suppresses RANKL-induced osteoclastogenesis via the inhibition of NF-κB and p38MAPK activation and c-Fos expression in RAW264.7 cells

(2021) Masanobu Tsubaki et al.   CYTOKINE

The PPAR-γ/SFRP5/Wnt/β-catenin signal axis regulates the dexamethasone-induced osteoporosis

(2021) Hai-Peng He et al.   CYTOKINE

Emerging roles of circular RNAs in osteoporosis

(2021) Weichun Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Validating HMMR Expression and Its Prognostic Significance in Lung Adenocarcinoma Based on Data Mining and Bioinformatics Methods

(2021) Xia Li et al.   Frontiers in Oncology

A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis

(2021) Yongzhi Cui et al.   Bioactive Materials

Circular RNAs in osteoporosis: expression, functions and roles

(2021) Yinzhou Luo et al.   Cell Death Discovery

CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer

(2021) Tao Jiang et al.   Molecular Cancer

Investigation of anti-osteoporosis mechanisms of Rehmanniae Radix Preparata based on network pharmacology and experimental verification

(2021) Li Ou et al.   Journal of Orthopaedic Surgery and Research

Circular RNA CircPVT1 Inhibits 5-Fluorouracil Chemosensitivity by Regulating Ferroptosis Through MiR-30a-5p/FZD3 Axis in Esophageal Cancer Cells

(2021) Wenjian Yao et al.   Frontiers in Oncology

Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis

(2021) Shengbai Sun et al.   Frontiers in Cell and Developmental Biology

Circular RNAs as potential regulators in bone remodeling: a narrative review

(2021) Xuefeng Pan et al.   Annals of Translational Medicine

Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss

(2020) Zu-Guo Zheng et al.   CELL DEATH AND DIFFERENTIATION

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

A broader strategy for osteoporosis interventions

(2020) Ian R. Reid   Nature Reviews Endocrinology

Network-based Transcriptome-wide Expression Study for Postmenopausal Osteoporosis

(2020) Lan Zhang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology

(2020) Le Chang et al.   NUCLEIC ACIDS RESEARCH

Long non-coding RNA MIR22HG promotes osteogenic differentiation of bone marrow mesenchymal stem cells via PTEN/ AKT pathway

(2020) Chanyuan Jin et al.   Cell Death & Disease

Identification of circRNA-associated ceRNA network in BMSCs of OVX models for postmenopausal osteoporosis

(2020) Huichao Wang et al.   Scientific Reports

Molecular Mechanisms and Emerging Therapeutics for Osteoporosis

(2020) Ji-Yoon Noh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CircFOXP1/FOXP1 promotes osteogenic differentiation in adipose‐derived mesenchymal stem cells and bone regeneration in osteoporosis via miR‐33a‐5p

(2020) Wanxiang Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts

(2020) Hung Ho-Xuan et al.   NUCLEIC ACIDS RESEARCH

Comparative Toxicogenomics Database (CTD): update 2021

(2020) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

Identification of Aberrantly Expressed Long Non-Coding RNAs and Nearby Targeted Genes in Male Osteoporosis

(2020) Qi Fei et al.   Clinical Interventions in Aging

High-Throughput Metabolomics Method for Discovering Metabolic Biomarkers and Pathways to Reveal Effects and Molecular Mechanism of Ethanol Extract From Epimedium Against Osteoporosis

(2020) Jun-feng Zhao et al.   Frontiers in Pharmacology

Involvement of circRNA_0007059 in the regulation of postmenopausal osteoporosis by promoting the microRNA‐378/BMP‐2 axis

(2020) Shu Liu et al.   CELL BIOLOGY INTERNATIONAL

Research Progress on circRNA in Nervous System Diseases

(2020) Nana Ma et al.   Current Alzheimer Research

LincSNP 3.0: an updated database for linking functional variants to human long non-coding RNAs, circular RNAs and their regulatory elements

(2020) Yue Gao et al.   NUCLEIC ACIDS RESEARCH

Investigation of transcriptome mechanism associated with osteoporosis explored by microarray analysis

(2019) Yan Liu et al.   Experimental and Therapeutic Medicine

Screening pathways and hub genes involved in osteoclastogenesis by gene expression analysis of circulating monocytes based on Gibbs sampling

(2019) Yu Xiao et al.   Experimental and Therapeutic Medicine

Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor α

(2019) Young Jae Moon et al.   CELL DEATH AND DIFFERENTIATION

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Comprehensive circular RNA profiling reveals circ_0002060 as a potential diagnostic biomarkers for osteoporosis

(2019) Yongping Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CircRNA_28313/miR-195a/CSF1 axis modulates osteoclast differentiation to affect OVX-induced bone absorption in mice

(2019) Xia Chen et al.   RNA Biology

Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4

(2019) Hui Li et al.   CARDIOVASCULAR RESEARCH

Circular RNA circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels via directly sponging miR-103 in Alzheimer’s disease

(2019) Hui Yang et al.   CELL CYCLE

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Prediction of Potential miRNA–Disease Associations Through a Novel Unsupervised Deep Learning Framework with Variational Autoencoder

(2019) Li Zhang et al.   Cells

Overexpressing of POU2F2 accelerates fracture healing via regulating HMGA1/Wnt/β-catenin signaling pathway

(2019) Wei Zhang et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Circulating miR-181c-5p and miR-497-5p are potential biomarkers for prognosis and diagnosis of osteoporosis

(2019) Jianhua Ma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hsa_Circ_0001275: A Potential Novel Diagnostic Biomarker for Postmenopausal Osteoporosis

(2018) Kewei Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Transplantation of Hepatocyte Growth Factor–Modified Dental Pulp Stem Cells Prevents Bone Loss in the Early Phase of Ovariectomy-Induced Osteoporosis

(2018) Fanxuan Kong et al.   HUMAN GENE THERAPY

Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma

(2018) Jian Yu et al.   JOURNAL OF HEPATOLOGY

Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function

(2018) Ana Alonso-Pérez et al.   Frontiers in Physiology

Therapeutic potential of microRNAs in osteoporosis function by regulating the biology of cells related to bone homeostasis

(2018) Wenhua Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Investigation of candidate genes and mechanisms underlying postmenopausal osteoporosis using bioinformatics analysis

(2017) Xiaozhong Zhu et al.   Molecular Medicine Reports

TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions

(2017) Heonjong Han et al.   NUCLEIC ACIDS RESEARCH

Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis

(2017) Xin Xu et al.   Bone Research

Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells

(2017) Carmen Streicher et al.   Scientific Reports

Predicting the 10-year risk of hip and major osteoporotic fracture in rheumatoid arthritis and in the general population: an independent validation and update of UK FRAX without bone mineral density

(2016) Corinne Klop et al.   ANNALS OF THE RHEUMATIC DISEASES

MiR-27a is Essential for the Shift from Osteogenic Differentiation to Adipogenic Differentiation of Mesenchymal Stem Cells in Postmenopausal Osteoporosis

(2016) Li You et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Circular RNAs are miRNA sponges and can be used as a new class of biomarker

(2016) Franceli Rodrigues Kulcheski et al.   JOURNAL OF BIOTECHNOLOGY

Postmenopausal Osteoporosis

(2016) Dennis M. Black et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling

(2016) Chen Xu et al.   Nature Communications

Gene expression profiling suggests a pathological role of human bone marrow-derived mesenchymal stem cells in aging-related skeletal diseases

(2016) Shih Sheng Jiang et al.   Aging-US

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

(2015) Yan Li et al.   CELL RESEARCH

NFI-C Regulates Osteoblast Differentiation via Control of Osterix Expression

(2014) Dong-Seol Lee et al.   STEM CELLS

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

Tumor-Induced Osteoclast miRNA Changes as Regulators and Biomarkers of Osteolytic Bone Metastasis

(2013) Brian Ell et al.   CANCER CELL

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis

(2012) Silvia Affò et al.   GUT

RWRMDA: predicting novel human microRNA–disease associations

(2012) Xing Chen et al.   Molecular BioSystems

The twilight zone of cis element alignments

(2012) Alvaro Sebastian et al.   NUCLEIC ACIDS RESEARCH

Identification of Genes for Complex Diseases Using Integrated Analysis of Multiple Types of Genomic Data

(2012) Hongbao Cao et al.   PLoS One

IMiD immunomodulatory compounds block C/EBP  translation through eIF4E down-regulation resulting in inhibition of MM

(2011) S. Li et al.   BLOOD

Rapamycin and the transcription factor C/EBPβ as a switch in osteoclast differentiation: implications for lytic bone diseases

(2009) Jeske J. Smink et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Osteoporosis and Inflammation

(2008) Gregory R. Mundy   NUTRITION REVIEWS