Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function

TLR4 Inactivation in Myeloid Cells Accelerates Bone Healing of a Calvarial Defect Model in Mice

(2017) Dan Wang et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Toll-Like Receptor Function in Acute Wounds

(2017) Lin Chen et al.   Advances in Wound Care

rhHMGB1 drives osteoblast migration in a TLR2/TLR4- and NF- B-dependent manner

(2016) M.-J. Li et al.   BIOSCIENCE REPORTS

High-mobility group box-B1 (HMGB1) mediates the hypoxia-induced mesenchymal transition of osteoblast cells via activating ERK/JNK signaling

(2016) Yiyan Qiu et al.   CELL BIOLOGY INTERNATIONAL

Toll-like receptor-4-dependence of the lipopolysaccharide-mediated inhibition of osteoblast differentiation

(2016) Y.H. Liu et al.   GENETICS AND MOLECULAR RESEARCH

Anti-citrullinated protein antibodies promote apoptosis of mature human Saos-2 osteoblasts via cell-surface binding to citrullinated heat shock protein 60

(2016) Ming-Chi Lu et al.   IMMUNOBIOLOGY

Understanding the regulation of pattern recognition receptors in inflammatory diseases - a ‘Nod’ in the right direction

(2016) Claire L. Feerick et al.   IMMUNOLOGY

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

(2016) Mikaël M. Martino et al.   Nature Communications

TLR4 Activation Promotes Bone Marrow MSC Proliferation and Osteogenic Differentiation via Wnt3a and Wnt5a Signaling

(2016) Xiaoqing He et al.   PLoS One

The role of Toll-like receptor 3 and 4 in regulating the function of mesenchymal stem cells isolated from umbilical cord

(2015) LI ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Exposure of periodontal ligament progenitor cells to lipopolysaccharide from Escherichia coli changes osteoblast differentiation pattern

(2015) Mayra Laino ALBIERO et al.   Journal of Applied Oral Science

Strain differences in the attenuation of bone accrual in a young growing mouse model of insulin resistance

(2015) Elizabeth Rendina-Ruedy et al.   JOURNAL OF BONE AND MINERAL METABOLISM

TLR4 stimulation by LPS enhances angiogenesis in a co-culture system consisting of primary human osteoblasts and outgrowth endothelial cells

(2015) Bin Ma et al.   Journal of Tissue Engineering and Regenerative Medicine

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

(2015) Rinaldo Florencio-Silva et al.   Biomed Research International

Possible involvement of PI3K-dependent pathways in the increased VEGF120 release from osteoblastic cells preloaded with palmitate in vitro

(2014) Rie Moriya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of mesenchymal stem cells under the stimulation of Toll-like receptor agonists

(2014) Xi Chen et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs

(2014) Rodolfo Gómez et al.   Nature Reviews Rheumatology

Osteoclasts: more than ‘bone eaters’

(2014) Julia F. Charles et al.   TRENDS IN MOLECULAR MEDICINE

A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species

(2014) Céline Vaure et al.   Frontiers in Immunology

Free fatty acids: potential proinflammatory mediators in rheumatic diseases

(2013) Klaus W Frommer et al.   ANNALS OF THE RHEUMATIC DISEASES

Low-intensity pulsed ultrasound (LIPUS) inhibits LPS-induced inflammatory responses of osteoblasts through TLR4–MyD88 dissociation

(2013) Juna Nakao et al.   BONE

Methionine down-regulates TLR4/MyD88/NF-κB signalling in osteoclast precursors to reduce bone loss during osteoporosis

(2013) V Vijayan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MyD88 is essential for alveolar bone loss induced byAggregatibacter actinomycetemcomitanslipopolysaccharide in mice

(2013) M.F.M. Madeira et al.   Molecular Oral Microbiology

Acute-Phase Serum Amyloid A in Osteoarthritis: Regulatory Mechanism and Proinflammatory Properties

(2013) Dominique de Seny et al.   PLoS One

LPS-Stimulated Inflammatory Environment Inhibits BMP-2-Induced Osteoblastic Differentiation Through Crosstalk Between TLR4/MyD88/NF-κB and BMP/Smad Signaling

(2013) Ru-Lin Huang et al.   STEM CELLS AND DEVELOPMENT

A critical role for suppressors of cytokine signaling 3 in regulating LPS-induced transcriptional activation of matrix metalloproteinase-13 in osteoblasts

(2013) Anqi Gao et al.   PeerJ

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

Fracture healing under healthy and inflammatory conditions

(2012) Lutz Claes et al.   Nature Reviews Rheumatology

Inflammation and Toll-Like Receptor Ligation Differentially Affect the Osteogenic Potential of Human Mesenchymal Stromal Cells Depending on Their Tissue Origin

(2012) Gordana Raicevic et al.   TISSUE ENGINEERING PART A

Plasma proteins take their toll on the joint in osteoarthritis

(2012) Steven R Goldring et al.   ARTHRITIS RESEARCH & THERAPY

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4

(2011) Rik F. P. Schelbergen et al.   ARTHRITIS AND RHEUMATISM

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1

(2011) Pu Wang et al.   FASEB JOURNAL

Angiogenesis in bone regeneration

(2011) Kurt D. Hankenson et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Porphyromonas endodontalis Lipopolysaccharides Induce RANKL by Mouse Osteoblast in a Way Different from That of Escherichia coli Lipopolysaccharide

(2011) Yin Tang et al.   JOURNAL OF ENDODONTICS

Different dimerisation mode for TLR4 upon endosomal acidification?

(2011) Monique Gangloff   TRENDS IN BIOCHEMICAL SCIENCES

Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium

(2011) Shahla Abdollahi-Roodsaz et al.   ARTHRITIS RESEARCH & THERAPY

Effects of obesity on bone metabolism

(2011) Jay J Cao   Journal of Orthopaedic Surgery and Research

Exploring the Human Leukocyte Phosphoproteome Using a Microfluidic Reversed-Phase−TiO2−Reversed-Phase High-Performance Liquid Chromatography Phosphochip Coupled to a Quadrupole Time-of-Flight Mass Spectrometer

(2010) Reinout Raijmakers et al.   ANALYTICAL CHEMISTRY

Chondrocyte innate immune MyD88-dependent signaling drives pro-catabolic effects of the endogenous TLR2/TLR4 ligands LMW-HA and HMGB1

(2010) Ru Liu-Bryan et al.   ARTHRITIS AND RHEUMATISM

Molecular mechanisms of the inhibitory effect of lipopolysaccharide (LPS) on osteoblast differentiation

(2010) Kenjiro Bandow et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells

(2010) H. Tsukamoto et al.   INTERNATIONAL IMMUNOLOGY

Interleukin-6 expression and histomorphometry of bones from mice deficient in receptors for interleukin-1 or tumor necrosis factor

(2010) Socorro J. Vargas et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Toll-like receptor triggering in cord blood mesenchymal stem cells

(2010) Lieke C.J. van den Berk et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomodulatory Properties of Mesenchymal Stem Cells Derived from Dental Pulp and Dental Follicle are Susceptible to Activation by Toll-Like Receptor Agonists

(2010) Sergej Tomic et al.   STEM CELLS AND DEVELOPMENT

High Levels of Tumor Necrosis Factor-α Contribute to Accelerated Loss of Cartilage in Diabetic Fracture Healing

(2009) Jazia Alblowi et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased circulating heat shock protein 60 induced by menopause, stimulates apoptosis of osteoblast-lineage cells via up-regulation of toll-like receptors

(2009) Yang Soon Kim et al.   BONE

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Lipopolysaccharides can protect mesenchymal stem cells (MSCs) from oxidative stress-induced apoptosis and enhance proliferation of MSCs via Toll-like receptor(TLR)-4 and PI3K/Akt

(2009) Zhao-jun Wang et al.   CELL BIOLOGY INTERNATIONAL

Molecular Mechanism of the Bifunctional Role of Lipopolysaccharide in Osteoclastogenesis

(2009) Jianzhong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

(2009) Precious G. Motshwene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone loss in inflammatory disorders

(2009) R Hardy et al.   JOURNAL OF ENDOCRINOLOGY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

How Location Governs Toll-Like Receptor Signaling

(2009) Akanksha Chaturvedi et al.   TRAFFIC

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

(2008) Natsuko Tanimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prolonged exposure to bacterial toxins downregulated expression of toll-like receptors in mesenchymal stromal cell-derived osteoprogenitors

(2008) Irene Mo et al.   BMC CELL BIOLOGY

The cell biology of bone metabolism

(2008) H K Datta et al.   JOURNAL OF CLINICAL PATHOLOGY

Expression of functional Toll-like receptors and nucleotide-binding oligomerization domain proteins in murine cementoblasts and their upregulation during cell differentiation

(2008) E. Nemoto et al.   JOURNAL OF PERIODONTAL RESEARCH

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Human Protein Reference Database--2009 update

(2008) T. S. Keshava Prasad et al.   NUCLEIC ACIDS RESEARCH

Lack of Toll-like receptor 4 decreases lipopolysaccharide-induced bone resorption in C3H/HeJ mice in vivo

(2008) H. Nakamura et al.   Oral microbiology and immunology

Nitric oxide production by a human osteoblast cell line stimulated withAggregatibacter actinomycetemcomitanslipopolysaccharide

(2008) W. Sosroseno et al.   Oral microbiology and immunology