Article
Endocrinology & Metabolism
Zora Messner, David Carro-Vazquez, Judith Haschka, Johannes Grillari, Heinrich Resch, Christian Muschitz, Peter Pietschmann, Jochen Zwerina, Matthias Hackl, Roland Kocijan
Summary: This study investigated circulating miRNAs as potential biomarkers for monitoring treatment response in women with postmenopausal osteoporosis on denosumab therapy. The results showed significant changes in expression of seven miRNAs after two years of treatment, which correlated with changes in bone mineral density and bone turnover markers.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hongli Shi, Xin Jiang, Cuidi Xu, Qun Cheng
Summary: This study investigated the differences in miRNA expression profiles in postmenopausal osteoporosis patients with fragility fractures and identified several miRNAs associated with bone mineral density. The study also explored the potential role of these miRNAs in the pathophysiology of postmenopausal osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Moritz Weigl, Roland Kocijan, James Ferguson, Gabriele Leinfellner, Patrick Heimel, Xaver Feichtinger, Peter Pietschmann, Johannes Grillari, Jochen Zwerina, Heinz Redl, Matthias Hackl
Summary: MicroRNAs play a regulatory role in bone homeostasis, and circulating microRNAs are considered as potential biomarkers for bone health. This study investigated the impact of anti-osteoporotic treatments on circulating microRNAs in OVX and SHAM rats, revealing that these treatments can reverse bone loss and modulate specific miRNA expressions. The findings suggest that bone-related miRNAs could serve as promising biomarkers for monitoring treatment efficacy in osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
K. Kerschan-Schindl, M. Hackl, E. Boschitsch, U. Foeger-Samwald, O. Naegele, S. Skalicky, M. Weigl, J. Grillari, P. Pietschmann
Summary: This study aimed to investigate and evaluate the diagnostic accuracy of osteomiRs for osteoporosis, revealing their potential application in the prevention and diagnosis of osteoporosis.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Orthopedics
Zhibang Sun, Junjie Shi, Chenyang Yang, Xukun Chen, Jiaqi Chu, Jing Chen, Yuan Wang, Chenxin Zhu, Jinze Xu, Guozhen Tang, Song Shao
Summary: This study aims to identify PMOP-associated circulating exosomal miRNAs and evaluate their diagnostic performance. The results suggest that plasma exosomal miRNAs have the potential to serve as noninvasive diagnostic biomarkers for PMOP.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Medicine, Research & Experimental
Zhen-zhong Zheng, Jing-hong Xu, Yuliang Dai, Bin Jiang, Zhi-ming Tu, Lei Li, Yawei Li, Bing Wang
Summary: This study aimed to identify key circulating microRNAs (miRNAs) in osteoporotic vertebral compression fracture and assess their potential as diagnostic biomarkers and therapeutic targets. Weighted gene co-expression network analysis (WGCNA) was used to identify hub miRNAs, and their diagnostic value was assessed using plasma samples from 144 patients. In vitro and in vivo experiments confirmed the function of the target miRNA in promoting bone formation and improving bone parameters. The findings suggest that circulating miR-107 may serve as a diagnostic biomarker and therapeutic target for osteoporosis.
Article
Cell Biology
Pernille B. Udesen, Anja E. Sorensen, Rikke Svendsen, Nanna L. S. Frisk, Anne L. Hess, Mubeena Aziz, Marie Louise M. Wissing, Anne Lis M. Englund, Louise T. Dalgaard
Summary: In a 6-year follow-up study, it was found that the levels of certain miRNAs in women with PCOS changed, indicating a shift towards a less hyperandrogenic profile. These findings contribute to our understanding of PCOS and provide potential biomarkers for future research.
Article
Immunology
Peng Yin, Yuan Xue
Summary: Hsa_circ_0006859 has been identified as a potential biomarker and therapeutic target for postmenopausal osteoporosis (PMOP). The study reveals that hsa_circ_0006859 affects the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through the regulation of miRNAs and their target genes. The findings suggest that hsa_circ_0006859 may play a crucial role in the pathogenesis of PMOP and could serve as a novel therapeutic target and biomarker for this condition.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Amila Iriskic Atic, Maja Thiele, Alexander Munk, Louise Torp Dalgaard
Summary: MicroRNAs (miRNAs) secreted by the liver have the potential to be important biomarkers for nonalcoholic liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Several miRNAs, including miR-122, miR-21, miR-34a, miR-192, miR-193, and the miR-17-92 miRNA-cluster, are consistently associated with NAFLD/NASH. These miRNAs show potential as diagnostic markers for NAFLD/NASH, although more research is needed to understand their specificity and regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Jacopo Antonino Vitale, Veronica Sansoni, Martina Faraldi, Carmelo Messina, Chiara Verdelli, Giovanni Lombardi, Sabrina Corbetta
Summary: The study investigated the relationship between osteocalcin (OC) and body composition, risk of fall, and bone-muscle crosstalk in osteoporotic postmenopausal women. Results showed that serum cOC levels correlated with skeletal muscle mass and function, acting as a mediator in the bone-muscle crosstalk. Circulating levels of cOC and uOC may be differentially regulated in fractured and unfractured osteoporotic women, indicating potential differences in bone metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Regina Dantas Jales de Oliveira, Raphael Goncalves de Oliveira, Lais Campos de Oliveira, Sebastiao David Santos-Filho, Danubia Cunha Sa-Caputo, Mario Bernardo-Filho
Summary: This study observed significant effects of whole-body vibration (WBV) on bone mineral density (BMD) in postmenopausal women, with high-quality evidence for high-frequency, low-magnitude, and high-cumulative-dose use. The updated systematic review and meta-analysis found that WBV with high frequency (approximately 30 Hz), low magnitude (approximately 0.3 g), and high cumulative dose (approximately 7000 min) can improve lumbar spine BMD in postmenopausal women.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Orthopedics
Lu Li, Xin Zhou, Jun-tao Zhang, Ai-feng Liu, Chao Zhang, Jin-chang Han, Xiao-qing Zhang, Si Wu, Xiao-yu Zhang, Fu-quan Lv
Summary: Exosomal miR-186 from human bone marrow mesenchymal stem cells can promote osteogenesis in ovariectomy (OVX) rats through the Hippo signaling pathway. This study identified the upregulation of miR-186 in a PMO + Exo treatment group and verified interactions between miR-186 and Mob1. The Hippo signaling pathway was confirmed to play a significant role in osteogenesis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ciro Menale, Gaia Tabacco, Anda Mihaela Naciu, Maria Lucia Schiavone, Francesca Cannata, Emanuela Morenghi, Cristina Sobacchi, Andrea Palermo
Summary: The study aimed to assess the association between Dpp3 activity and bone fragility in postmenopausal osteoporosis, as well as the impact of denosumab on the enzymatic activity. The results showed that serum Dpp3 activity was significantly reduced in patients with severe osteoporosis compared to controls and was associated with bone mass. Additionally, there was a negative correlation between Dpp3 activity and specific bone metabolism markers. Dpp3 activity did not change after denosumab injection.
Article
Medicine, General & Internal
Hae-Sang Park, Ga-Young Kim, Jong-Ah Lo, Jin-Sun Kim, Shin-Young Ahn, Gang-Jee Ko, Young-Joo Kwon, Ji-Eun Kim
Summary: This study identified urine uric acid levels as potential early markers for the development of osteoporosis in women, especially after menopause, through longitudinal and cross-sectional analyses of biochemical measurements from serum and urine.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Fan Zhao, Xiaoli Ma, Wuxia Qiu, Pai Wang, Ru Zhang, Zhihao Chen, Peihong Su, Yan Zhang, Dijie Li, Jianhua Ma, Chaofei Yang, Lei Chen, Chong Yin, Ye Tian, Lifang Hu, Yu Li, Ge Zhang, Xiaoyang Wu, Airong Qian
Review
Biochemistry & Molecular Biology
Xiao Lin, Kewen Zhang, Daixu Wei, Ye Tian, Yongguang Gao, Zhihao Chen, Airong Qian
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Cell Biology
Shujing Liang, Lifang Hu, Zixiang Wu, Zhihao Chen, Shuyu Liu, Xia Xu, Airong Qian
Review
Cell Biology
Shuyu Liu, Xia Xu, Shujing Liang, Zhihao Chen, Yan Zhang, Airong Qian, Lifang Hu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Lifang Hu, Chong Yin, Dong Chen, Zixiang Wu, Shujing Liang, Yu Zhang, Zizhan Huang, Shuyu Liu, Xia Xu, Zhihao Chen, Yi Zhang, Airong Qian
Summary: MACF1 plays a crucial role in osteoblast differentiation by modulating transcriptome dynamics and interacting with various proteins that inhibit osteoblast differentiation. MACF1 regulates cytoplasmic-nuclear localization of itself and other factors, while also controlling the expression of transcription factors driving osteoblast differentiation.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Engineering, Aerospace
Zhihao Chen, Yan Zhang, Fan Zhao, Chong Yin, Chaofei Yang, Ying Huai, Shujing Liang, Shuyu Liu, Xia Xu, Zixiang Wu, Ye Tian, Yu Li, Lifang Hu, Airong Qian
Summary: With the increase interest in deep-space exploration, investigations into the health and safety issues related to astronauts' bone health under microgravity have become more important. This study utilized mouse models and cell models to simulate the effects of microgravity, revealing that miR-138-5p plays a crucial role in regulating osteoblast differentiation through the Wnt/beta-catenin signaling pathway.
Review
Biochemistry & Molecular Biology
Xia Xu, Shuyu Liu, Hua Liu, Kang Ru, Yunxian Jia, Zixiang Wu, Shujing Liang, Zarnaz Khan, Zhihao Chen, Airong Qian, Lifang Hu
Summary: Piezo channels are mechanosensitive ion channels in cell membrane that convert mechanical stimuli into electrochemical signals, playing a crucial role in bone biology. Research focuses on Piezo1's function in bone cells and its role in bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Aerospace
Xiao Lin, Yunyun Xiao, Kewen Zhang, Dan Yang, Zhiping Miao, Xiaoni Deng, Zhihao Chen, Airong Qian
Summary: In simulated microgravity conditions, MACF1 positively regulates bone loss through promoting migration and cytoskeletal organization of pre-osteoclasts. This research provides evidence for MACF1 to be a potential therapeutic target for treating bone loss induced by microgravity.
Article
Multidisciplinary Sciences
Chong Yin, Ye Tian, Dijie Li, Yang Yu, Shanfeng Jiang, Yimei Hou, Meng Deng, Kaiyuan Zheng, Yan Zhang, Xiaoni Deng, Zhihao Chen, Zhiping Miao, Qiang Hao, Yu Li, Airong Qian
Summary: This study discovered an LncRNA called Lnc-DIF that inhibits bone formation by sequestering miR-489-3p through a repeat sequence. It was found that siRNA targeting Lnc-DIF could rescue bone formation in aging and ovariectomized osteoporosis mice. These findings provide potential therapeutic insights for RNA-based therapy for osteoporosis.
Article
Cell Biology
Xiao Lin, Fang Xu, Ke-Wen Zhang, Wu-Xia Qiu, Hui Zhang, Qiang Hao, Meng Li, Xiao-Ni Deng, Ye Tian, Zhi-Hao Chen, Ai-Rong Qian
Summary: In this study, the function of acacetin on bone remodeling and H type vessel formation was explored. Acacetin was found to inhibit osteoclast formation and bone resorption, as well as promote angiogenesis and migration of endothelial progenitor cells (EPCs). Furthermore, acacetin was shown to prevent bone loss in mice through inhibition of osteoclast function and promotion of type H vessel formation via Akt/GSK3 beta and NF-kappa B signaling pathway, making it a potential therapeutic agent for the treatment of osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Zhihao Chen, Ying Huai, Wenjing Mao, Xuehao Wang, Kang Ru, Airong Qian, Hong Yang
Summary: Liquid-liquid phase separation plays a vital role in the formation of membraneless organelles in eukaryotic cells and the precise regulation of cellular functions. It is also associated with the development of metabolic diseases such as type 2 diabetes mellitus, Alzheimer's disease, and metabolic bone diseases.
Article
Plant Sciences
Zixiang Wu, Lifang Hu, Kang Ru, Wenjuan Zhang, Xia Xu, Shuyu Liu, Hua Liu, Yunxia Jia, Shujing Liang, Zhihao Chen, Airong Qian
Summary: This study investigates the role of cyclin-dependent kinase 12 (CDK12) in osteoporosis induced by simulated microgravity and the therapeutic effect of CDK12-targeted Ellagic Acid (EA) on osteoporosis. The results demonstrate that CDK12-targeted EA efficiently improves osteoporosis by promoting osteoblast differentiation.
Article
Orthopedics
Kewen Zhang, Wuxia Qiu, Hui Li, Jun Li, Pai Wang, Zhihao Chen, Xiao Lin, Airong Qian
Summary: MACF1 plays a positive regulatory role in osteogenesis and bone formation in MSCs through the TCF4/miR-335-5p signaling pathway in SOP, suggesting it as a potential therapeutic target for SOP.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Biochemistry & Molecular Biology
Zhihao Chen, Ying Huai, Gaoyang Chen, Shuyu Liu, Yan Zhang, Dijie Li, Fan Zhao, Xiaofeng Chen, Wenjing Mao, Xuehao Wang, Chong Yin, Chaofei Yang, Xia Xu, Kang Ru, Xiaoni Deng, Lifang Hu, Yu Li, Songlin Peng, Ge Zhang, Xiao Lin, Airong Qian
Summary: It was found that the level of miR-138-5p was negatively correlated with bone mineral density and osteogenic markers in patients with senile osteoporosis. High levels of miR-138-5p aggravated the decrease in aged osteoblast differentiation and led to bone loss. MiR-138-5p was shown to regulate aged osteoblast differentiation by targeting MACF1. Therapeutic inhibition of miR-138-5p counteracted the decrease in bone formation and aging-related bone loss.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Dijie Li, Jin Liu, Chaofei Yang, Ye Tian, Chong Yin, Lifang Hu, Zhihao Chen, Fan Zhao, Ru Zhang, Aiping Lu, Ge Zhang, Airong Qian
Summary: The study found that long noncoding RNA PMIF was highly expressed in bone marrow mesenchymal stem cells (BMSCs) from aged mice, responsible for reduced migration capacity of aged osteoprogenitor cells (OPCs) to bone formation surface. Targeting lnc-PMIF to facilitate aged OPCs migrating to bone formation surface could be a brand-new anabolic strategy for aging-related osteoporosis.