Article
Cell Biology
Shreya Udawant, Carl Litif, Alma Lopez, Bonnie Gunn, Erin Schuenzel, Megan Keniry
Summary: The study compared the role of the PI3K/AKT/mTOR pathway in GBM tumor metabolism, revealing that PI3K-impacted glycolytic genes are over-expressed and associated with poor prognosis in GBM patients.
Article
Biochemistry & Molecular Biology
Ming Wang, Wenyan Zhang, Yibo Liu, Zhigang Ma, Wei Xiang, Yuqi Wen, Dingkun Zhang, Yanling Li, Yeming Li, Tao Li, Ligang Chen, Jie Zhou
Summary: The study reveals that PDIA4 plays a critical role in promoting glioblastoma (GBM). Downregulation of PDIA4 inhibits proliferation and promotes apoptosis of GBM cells, potentially through suppressing protein phosphorylation levels of the PI3K/AKT/mTOR pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xiang Gao, Wenqu Jiang, Zunliang Ke, Qiwei Huang, Liang Chen, Guobin Zhang, Chao Li, Xiaojun Yu
Summary: Molecular biomarker TRAM2 is overexpressed in glioma and associated with malignancy properties and poorer survival. Silencing of TRAM2 inhibits glioma cell proliferation, invasion, migration, and EMT. TRAM2 is positively associated with the activation of the PI3K/AKT/mTOR signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mariam Naveed, Ayesha Malik, Hamza Anjum, Bushra Ijaz
Summary: Breast cancer is a significant health challenge for women globally. This study reveals the important role of lncRNA MALAT1 in the development and metastasis of breast cancer, suggesting it as a potential therapeutic target.
BIOCHEMICAL GENETICS
(2023)
Article
Cell Biology
Boli Hu, Yina Zhang, Tingjuan Deng, Jinyan Gu, Juan Liu, Hui Yang, Yuting Xu, Yan Yan, Fan Yang, Heng Zhang, Yulan Jin, Jiyong Zhou
Summary: This study reveals that PDPK1 is a SUMOylation-regulated kinase that plays a central role in activating macroautophagy. SUMOylation of PDPK1 is a physiological feature in the brain and can be induced by viral infections, regulating its phosphorylation and activation of the AKT1-MTOR pathway.
Article
Oncology
Qiong Wu, Jiali Ma, Jue Wei, Wenying Meng, Yugang Wang, Min Shi
Summary: FOXD1-AS1 aggravates gastric cancer progression and chemoresistance by promoting FOXD1 translation through the PIK3CA/PI3K/AKT/mTOR signaling pathway. These findings offer a potential novel target for treating gastric cancer patients, especially those with cisplatin resistance.
MOLECULAR ONCOLOGY
(2021)
Article
Cell Biology
Zhengxia Zhu, Jianyang Zhang, Peng Wu
Summary: The study revealed that ESM-1 expression was significantly upregulated in cervical cancer tissues and cells. Knockdown of ESM-1 inhibited the activation of the PI3K/Akt/mTOR signaling pathway, thereby suppressing cell proliferation, invasion, and migration of cervical cancer cells, promoting cell apoptosis, and holding potential for the treatment and prognosis of cervical cancer.
ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY
(2021)
Article
Oncology
Danfang Wang, Jianhui Li, Wenhan Li
Summary: This study investigates the role of LHPP in gastric cancer (GC) and finds that LHPP acts as a tumor suppressor gene by inhibiting proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of GC cells. The underlying mechanism involves regulating the PI3K/AKT/mTOR pathway.
Article
Oncology
Beiquan Hu, Chao Qin, Li Li, Lei Wei, Xianlun Mo, Huasheng Fan, Yuanhua Lei, Feng Wei, Donghua Zou
Summary: Our study suggests that MDK promotes GBM by activating the PI3K-Akt signaling pathway, and it describes a potential regulatory network involved. MDK is highly expressed in GBM and is associated with poor prognosis, potentially serving as a promising diagnostic and prognostic biomarker for GBM. Overexpression of MDK enhances proliferation, migration, and invasion of GBM cell lines, while suppression of MDK exerts opposite effects. The study also highlights the involvement of MDK in various cancer-related pathways, such as PI3K-Akt signaling, the cell cycle, and VEGF signaling.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yonghe Li, Yaolin Yin, Yi He, Kun He, Jingdong Li
Summary: This study investigated the influence of son of sevenless homolog 1 (SOS1) on invasion and metastasis of hepatocellular carcinoma (HCC) cells. High expression of SOS1 was observed in most human liver cancers, indicating a worse prognosis. Knockout of SOS1 significantly decreased cell invasion and migration, inhibited the epithelial-mesenchymal transition (EMT), and suppressed the PI3K/AKT/mTOR pathway. These findings suggest that SOS1 may play a role in promoting invasion, migration, and metastasis of HCC cells through the activation of the PI3K/AKT/mTOR pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Peiying Huang, Mengmeng Li, Qinglai Tang, Kang Jiang, Yuchao Luo
Summary: This study investigated the biological functions and mechanisms of circular RNA_0000523 (circ_0000523) in nasopharyngeal carcinoma (NPC). The results showed that circ_0000523 facilitates NPC progression through regulating the miR-1184/COL1A1 axis.
Article
Oncology
Wei Su, Baijie Feng, Lina Hu, Xianzhi Guo, Minghua Yu
Summary: MUC3A promotes the progression of colorectal cancer by activating the PI3K/Akt/mTOR signaling pathway and affects cell proliferation, invasion, and chemotherapy resistance. This study reveals the important role of MUC3A in colorectal cancer.
Article
Medicine, Research & Experimental
Xiaoying Jin, Dandan Wang, Mengxia Lei, Yan Guo, Yuqing Cui, Fengzhi Chen, Weiling Sun, Xuesong Chen
Summary: The study reveals that TPI1 is highly expressed in breast cancer and is associated with clinicopathological characteristics and prognosis. TPI1 promotes breast cancer progression by regulating the PI3K/AKT/mTOR pathway, with CDCA5 and P62 being important mediators.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chao Liu, Yun Wang, Yuyang Dao, Shuting Wang, Fei Hou, Zhixian Yang, Pengjie Liu, Juan Lv, Ling Lv, Gaofeng Li, Youjun Zhou, Zhiyong Deng
Summary: This study found that CENPM is upregulated in LUAD and promotes its progression by facilitating cell cycle progression, cell proliferation, migration, and invasion, while inhibiting cell apoptosis. CENPM also affects the growth and metastasis of LUAD by promoting the phosphorylation of mTOR.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
Eun Jin Sun, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane, Lionel Hebbard
Summary: This review article discusses the pivotal role of the PI3K/Akt/mTOR pathway in HCC, focusing on its impact on cellular processes and providing an update on the ongoing clinical development of therapies targeting this pathway for HCC treatments.
Article
Psychology, Biological
Yingying Wang, Qingchun Ji, Rao Fu, Guanghui Zhang, Yingzhi Lu, Chenglin Zhou
Summary: Athletes use kinematic information for action anticipation, but are also influenced by linguistic information. Table tennis experts show higher accuracy in predictions, but accuracy significantly decreases when memorizing hand-related words. Experts share cognitive resources for action anticipation with semantic representations of verbs.
Article
Peripheral Vascular Disease
Mingli He, Hongrui Wang, Yi Tang, Jin'e Wang, Bing Cui, Bingchao Xu, Yongan Sun, Guanghui Zhang, Xiaobing He, Xiaoqin Niu, Bei Wang, Bei Xu, Zaipo Li, Yu Zhang, Yibo Wang
Summary: This study found that higher blood pressure variability and elevated systolic blood pressure from prior to intravenous thrombolysis (IVT) to 72 hours after IVT were associated with increased risk of stroke outcomes within 3 months.
JOURNAL OF HYPERTENSION
(2022)
Editorial Material
Surgery
Bimei Hu, Guanghui Zhang
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Xiaosong Hu, Dakun Pei, Mingxin Ci, Guanghui Zhang, Benqin Li, Jie Wang, Yue Shen, Xuan Zhai, Ping Liang, Hongjuan Cui
Summary: This study identifies ACTL6A as a critical regulator of DNA replication in glioblastoma, showing that ACTL6A knockdown impairs DNA replication initiation and induces DNA damage and apoptosis. ACTL6A transcriptionally regulates MCM5 expression and diminishes the activity of the ATR-Chk1 pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Li Ma, Meng Zhang, Fangjun Cao, Jincheng Han, Peng Han, Yeting Wu, Renyi Deng, Guanghui Zhang, Xiaopeng An, Lei Zhang, Yuxuan Song, Binyun Cao
Summary: This study found that miR-100-5p plays an important role in the proliferation and apoptosis of goat endometrial stromal cells (ESCs) in vitro and embryo implantation in vivo. miR-100-5p functions in embryo implantation through regulation of the PI3K/AKT/mTOR and ERK1/2 pathways, and interacts with the Circ-9110/miR-100-5p/HOXA1 axis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Guanghui Zhang, Qingzong Zhu, Xiaomin Yan, Mingxin Ci, Erhu Zhao, Jianbing Hou, Sicheng Wan, Muhan Lu, Hongjuan Cui
Summary: This study revealed that HECTD3 is abnormally activated in gastric cancer and facilitates the malignant proliferation of gastric cancer through mediating the polyubiquitination of c-MYC.
CELL DEATH DISCOVERY
(2022)
Correction
Biochemistry & Molecular Biology
Rui Yang, Xiuxiu Li, Yanan Wu, Guanghui Zhang, Xiaoran Liu, Yanping Li, Yonghua Bao, Wancai Yang, Hongjuan Cui
Article
Biochemistry & Molecular Biology
Xiaosong Hu, Ruochen Liu, Jianbing Hou, Wen Peng, Sicheng Wan, Minghao Xu, Yongsen Li, Guanghui Zhang, Xuan Zhai, Ping Liang, Hongjuan Cui
Summary: This study reveals the critical oncogenic role of SMARCE1 gene in neuroblastoma, particularly in cases with MYCN amplification. SMARCE1 interacts with MYCN to mediate transcriptional activation of downstream target genes, promoting neuroblastoma proliferation and tumorigenicity. These findings provide a new potential therapeutic target for neuroblastoma with 17q21-ter gain and MYCN amplification.
Article
Oncology
Guanghui Zhang, Ruoyue Tan, Sicheng Wan, Rui Yang, Xiaosong Hu, Erhu Zhao, Xiangfei Ding, Jingping Zhang, Biao Li, Ping Liang, Hongjuan Cui
Summary: This study reveals the potential role of HECTD3 in glioblastoma, demonstrating that it interacts with PARP1 and regulates its polyubiquitination, leading to the stabilization of PARP1 expression. This has implications for the treatment of glioblastoma.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Rui Yang, Guanghui Zhang, Zhen Dong, Shanshan Wang, Yanping Li, Fuming Lian, Xiaoran Liu, Haibin Li, Xiaonan Wei, Hongjuan Cui
Summary: This study reveals that the transcription factor HOXA3 is highly expressed in glioblastoma patients and promotes cell proliferation and tumor growth through the activation of aerobic glycolysis. Additionally, the study identifies KDM6A as an important cooperator of HOXA3 in regulating aerobic glycolysis. HOXA3 activates the transcription of KDM6A, which then removes suppressive histone modifications to activate the transcription of glycolytic genes.
Article
Cell Biology
Mingli He, Hongrui Wang, Yi Tang, Bing Cui, Bingchao Xu, Xiaoqin Niu, Yongan Sun, Guanghui Zhang, Xiaobing He, Bei Wang, Bei Xu, Zaipo Li, Yu Zhang, Yibo Wang
Summary: This study aimed to investigate the relationship between red blood cell distribution width (RDW) in the thrombolysis period and prognosis in patients with acute ischemic stroke (AIS) undergoing intravenous thrombolysis (IVT). The findings showed that higher RDW levels were associated with an increased risk of hemorrhagic transformation (HT) and recurrent stroke.
Article
Oncology
Qing Zhu, Guanghui Zhang, Mingyang Tang, Ligao Wu
Summary: This study detected the expression of Rsf-1 and P16 in CIN and analyzed their expression and correlation in different stages of CIN. The results showed that Rsf-1 and P16 were highly expressed or over-expressed in high-grade CIN, and their expression increased with the increase in CIN grade.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2022)
Article
Oncology
Yuan-Li Huang, Guang-Hui Zhang, Qing Zhu, Xia Wu, Li-Gao Wu
Summary: The study found that GSDME, caspase-3, and caspase-8 were more highly expressed in tumor tissues than in adjacent normal tissues, and that the expression level of GSDME was positively correlated with the postoperative survival rate of patients with lung cancer, suggesting it may serve as a prognostic factor. Further research is needed to understand the role of GSDME and related proteins in cancer.