Article
Endocrinology & Metabolism
Yan Xie, Jie Zhou, Lijie Tian, Yuan Dong, Hairui Yuan, Endong Zhu, Xiaoxia Li, Baoli Wang
Summary: miR-196b-5p plays a role in various malignancies and has been found to affect bone cells and bone homeostasis by inhibiting osteoblast differentiation and regulating the Wnt/beta-catenin signaling pathway. Inhibition of miR-196b-5p can reduce ovariectomy-induced bone loss.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Cell Biology
Longshuai Lin, Hongjie Wang, Weihong Guo, Enjun He, Kai Huang, Qinghua Zhao
Summary: The research confirmed that osteosarcoma cell-derived exosomes promote osteoclastogenesis and aggravate bone loss through miR-501-3p, potentially regulated via the PTEN/PI3K/Akt signaling pathway.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Jian Zhang, Jiangmei Wu
Summary: This article discusses the role of exosomal miR-214 in bone metastasis of lung adenocarcinoma, suggesting that exosomal miR-214 may disrupt bone homeostasis by enhancing bone resorption, leading to bone metastasis. Furthermore, exosomal miR-214 facilitates intercellular communication between lung adenocarcinoma cells and osteoclasts, promoting the colonization and proliferation of cancer cells in the bone.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Hoang Dong Nguyen, Martine Bisson, Michelle Scott, Gilles Boire, Luigi Bouchard, Sophie Roux
Summary: The study identified six significantly decreased mature miRs in overactive osteoclasts from Paget's disease of bone (PDB) patients, including let7i-3p, miR-15b-5p, -29b1-3p, -181a-5p, -500b-5p, and -1246. Target genes and enriched pathways highlight the importance of apoptotic pathways in the context of PDB.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Oncology
Lijuan Yu, Bingdong Sui, Xin Zhang, Jiayun Liu, Xiaoke Hao, Lei Zheng
Summary: This study demonstrates that miR-92a-1-5p enriched EVs regulate osteoclast function by reducing MAPK1 and FoxO1 expression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Guohua Lai, Renli Zhao, Weida Zhuang, Zuoxu Hou, Zefeng Yang, Peipei He, Jiachang Wu, Hongxun Sang
Summary: In the bone marrow microenvironment of postmenopausal osteoporosis, BMSC-derived exosomal miRNAs, specifically miR-27a-3p and miR-196b-5p, have been found to play an important regulatory role in bone formation and bone resorption. The study suggests that these miRNAs may have therapeutic potential for the treatment of osteoporosis.
Article
Multidisciplinary Sciences
Vishwa Deepak, Shu-Ting Yang, Ziqing Li, Xinhua Li, Andrew Ng, Ding Xu, Yi-Ping Li, Merry Jo Oursler, Shuying Yang
Summary: This study identifies a negative function of IFT80 in osteoclasts by regulating the stabilization and degradation of Cbl-b and TRAF6, thereby affecting osteoclast formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nanoscience & Nanotechnology
Lai Pan, Chenyi Zhang, Haizheng Zhang, Ting Ke, Mengyao Bian, Yuxuan Yang, Lili Chen, Jingyi Tan
Summary: This study found that exosomal miR-5134-5p derived from osteoclasts inhibits osteoblastic proliferation and differentiation via the JAK2/STAT3 pathway, exacerbating periodontal tissue inflammation and alveolar bone resorption in mice with experimental periodontitis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Medicine, Research & Experimental
Okhwa Kim, Phuong Thao Tran, Minju Gal, Se Jin Lee, Sung Hun Na, Cheol Hwangbo, Jeong-Hyung Lee
Summary: The activation of RAS in breast cancer cells plays a crucial role in osteolytic bone metastasis through the exosome-mediated transfer of osteoclastogenic miRNAs. The study identifies miR-494-3p, miR-4508, and miR-6869-5p as osteoclastogenic miRNAs in exosomes secreted by RAS-activated breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Review
Endocrinology & Metabolism
Priyanka Ramesh, Rahul Jagadeesan, Saravanan Sekaran, Anuradha Dhanasekaran, Selvaraj Vimalraj
Summary: Flavonoids are polyphenolic compounds found in various natural products with multiple applications, including anti-inflammatory, anti-oxidative, and anti-carcinogenic properties, as well as the ability to stimulate bone formation. They influence bone remodelling through various signaling pathways and play a crucial role in maintaining bone integrity and structure. Their effects on regulating angiogenesis, decreasing inflammatory cytokine levels, and scavenging reactive oxygen species further underscore their potential as a promising agent in treating bone-related ailments in the future.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Leilei Zhong, Jiawei Lu, Jiankang Fang, Lutian Yao, Wei Yu, Tao Gui, Michael Duffy, Nicholas Holdreith, Catherine A. Bautista, Xiaobin Huang, Shovik Bandyopadhyay, Kai Tan, Chider Chen, Yongwon Choi, Jean X. Jiang, Shuying Yang, Wei Tong, Nathanial Dyment, Ling Qin
Summary: Marrow adipogenic lineage precursors (MALPs) are a type of mesenchymal cell that synthesizes Csf1 to stimulate osteoclastogenesis and regulate bone remodeling and hematopoiesis. Depletion of these cells in mice leads to increased trabecular bone mass but normal cortical bone. Further studies suggest that other mesenchymal subpopulations also secrete Csf1 to control bone resorption.
Article
Endocrinology & Metabolism
Henry C. Hrdlicka, Renata C. Pereira, Bongjin Shin, Siu-Pok Yee, Alix C. Deymier, Sun-Kyeong Lee, Anne M. Delany
Summary: miR-29-3p plays a crucial role in regulating gene expression in osteoblasts and osteoclasts. Inhibition of miR-29-3p can affect bone formation, while miR-29-3p inhibition combined with intermittent PTH treatment can enhance bone anabolism.
Article
Oncology
Siyuan Wang, Xiaorong Yang, Wenjie Xie, Shengqiang Fu, Qiang Chen, Zhilong Li, Zhicheng Zhang, Ting Sun, Binbin Gong, Ming Ma
Summary: Our study identified that GAPLINC is significantly upregulated in RCC tissues and cell lines, and is associated with a poor prognosis in RCC patients. Knockdown of GAPLINC inhibited RCC growth in vitro and in vivo, while overexpression of GAPLINC had the opposite effect. Mechanistically, GAPLINC upregulates the oncogene CSF1 expression by acting as a sponge for miR-135b-5p.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Franco A. Sviercz, Patricio Jarmoluk, Cintia G. Cevallos, Cynthia A. M. Lopez, Rosa N. Freiberger, Alex Guano, Alan Adamczyk, Matias Ostrowski, M. Victoria Delpino, Jorge Quarleri
Summary: This study investigated the effects of HIV infection on osteoclast differentiation and found that it severely impaired the differentiation process, leading to compromised cellular adhesion, cathepsin K expression, and resorptive activity. High inoculum of HIV increased the expression of co-receptor CCR5 and tetraspanins CD9 and CD81, resulting in deficient osteoclastogenesis. Massive HIV infection also affected the transcriptional levels of key factors involved in osteoclastogenesis, including RANK, NFATc1, and DC-STAMP.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
