Review
Biochemistry & Molecular Biology
Anshika Goenka, Deanna Marie Tiek, Xiao Song, Rebeca Piatniczka Iglesia, Minghui Lu, Bo Hu, Shi-Yuan Cheng
Summary: Research in cancer biology has predominantly focused on protein-coding genes, but the discovery of non-coding RNAs (ncRNAs) has shed light on their crucial role in various biological processes and human diseases including cancer. Dysregulated ncRNA expression affects cancer initiation, progression, and therapy resistance. This review emphasizes the recent developments and advances in ncRNA biology relevant to glioma tumorigenesis and therapy response, highlighting the potential of ncRNAs as biomarkers and therapeutic agents in glioma.
Review
Biochemistry & Molecular Biology
Danelda Theron, Lloyd N. Hopkins, Heidi G. Sutherland, Lyn R. Griffiths, Francesca Fernandez
Summary: Alzheimer's disease (AD) is a common form of dementia affecting millions worldwide, with no cure currently available. Early diagnosis is crucial, and the exploration of genetic markers and RNA molecules offers a promising avenue. This article provides an overview of potential genetic markers and RNA changes in peripheral tissues of AD cases, highlighting the importance of biomarker profiling for developing reliable diagnostic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Huiwen Ren, Qiuyue Wang
Summary: Diabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes with a complex pathological process involving multiple factors. Non-coding RNAs, such as micro RNA (miRNA), play a role in disease regulation and may serve as potential biomarkers for disease prediction. The research on long coding RNA (lncRNA) and circular RNA (circRNA) is still challenging and in early stages.
DNA AND CELL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Chengshun Li, Dongxu Wang, Ziping Jiang, Yongjian Gao, Liqun Sun, Rong Li, Minqi Chen, Chao Lin, Dianfeng Liu
Summary: More than 10% of the world's population already suffers from diabetes mellitus (DM) to varying degrees, which can lead to cardiovascular disease (CVD) and become the leading cause of death in diabetes patients. Non-coding RNAs (ncRNAs) have been found to play an important role in DM and CVD, and aberrant ncRNAs may serve as potential biomarkers for diagnosis. Regulation of ncRNA expression levels may also be a key mechanism in future DM treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Melissa M. M. Rowe, Klaus H. H. Kaestner
Summary: Non-coding RNAs (ncRNAs) play important roles in liver disease and regeneration. This review focuses on key microRNAs (miRs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in the liver. Specifically, it highlights the role of miR-122, miR-21, the let-7 family of miRs, miR-451a, miR-144, and MALAT1.
Review
Endocrinology & Metabolism
Guanqing Zhou, Mimi Zhang, Jingzhi Zhang, Yaofeng Feng, Zhishen Xie, Siyi Liu, Detu Zhu, Yumei Luo
Summary: Non-coding RNAs play important roles in cell differentiation, proliferation, apoptosis, and the pathogenesis of various diseases. Especially in non-obstructive azoospermia, the expression of non-coding RNAs is associated with pathological conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chisato Kinoshita, Koji Aoyama
Summary: The establishment of antioxidative defense systems is crucial for organisms with aerobic metabolisms to counter the adverse byproducts of oxygen consumption, known as reactive oxygen species (ROS), which can cause oxidative stress states. Glutathione (GSH) plays key roles in the central nervous system as an antioxidant, enzyme cofactor, cysteine storage form, major redox buffer, and neuromodulator, and its levels are precisely regulated by various factors including non-coding RNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Estefania Lozano-Velasco, Virginio Garcia-Lopez, Amelia Aranega, Diego Franco, Virginio Garcia-Martinez, Carmen Lopez-Sanchez
Summary: Heart failure is a complex clinical syndrome with increasing prevalence, and finding new molecular biomarkers is an interesting tool to improve its prevention, diagnosis, treatment, and prognosis. This review emphasizes the relevance of microRNAs, long non-coding RNAs, and circular RNAs as potential biomarkers in heart failure. Further studies in this field are crucial to support their widespread clinical use.
Review
Biochemistry & Molecular Biology
Qingmin Zeng, Chang-Hai Liu, Dongbo Wu, Wei Jiang, Nannan Zhang, Hong Tang
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Long non-coding RNA (lncRNA) and circular RNA (circRNA) have emerged as potential non-invasive biomarkers for predicting NAFLD. This systematic review highlights the potential of lncRNA and circRNA, such as NEAT1, MEG3, MALAT1, and SCAR, for early diagnosis and progression assessment of NAFLD, NASH, and fibrosis. Large-cohort studies and further exploration of the functional mechanisms are needed to validate their clinical value.
Review
Cell Biology
Nasrin Ahangar Davoodi, Sajad Najafi, Zari Naderi Ghale-Noie, Ashkan Piranviseh, Samaneh Mollazadeh, Sahar Ahmadi Asouri, Zatollah Asemi, Mohammadamin Morshedi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Amirhossein Sheida, Hamed Mirzaei
Summary: Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that can have severe consequences. Non-coding RNAs (ncRNAs) play important roles in the pathogenesis and development of RB, with different ncRNAs acting as either tumor promoters or suppressors. Understanding the regulatory mechanisms of ncRNAs provides new opportunities for RB therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Meng-Lan Li, Wen Wang, Zi-Bing Jin
Summary: Circular RNAs (circRNAs) are endogenous single-stranded RNAs with covalently closed loop structures, playing important biological functions in regulating protein functions and their own translation. They are enriched in the central nervous system (CNS) and play crucial roles in its development and diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Samira Samarfard, Abozar Ghorbani, Thomas P. Karbanowicz, Zhi Xian Lim, Mahshid Saedi, Niloofar Fariborzi, Alistair R. McTaggart, Keramatollah Izadpanah
Summary: This review discusses the importance of non-coding RNAs in plant immunity, particularly the interactions among long-ncRNAs, small-ncRNAs, and circular RNAs. By studying plant ncRNAs, we can better utilize molecular-based technologies for crop protection.
JOURNAL OF BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ligia I. Torsin, George E. D. Petrescu, Alexandru A. Sabo, Baoqing Chen, Felix M. Brehar, Mihnea P. Dragomir, George A. Calin
Summary: The text discusses the dysregulated levels and alterations of non-coding RNAs (ncRNAs) in cancer, as well as the emerging focus on modifications to ncRNAs as a potential part of the tumorigenic process. Understanding this extra regulatory layer is crucial in translating knowledge about ncRNAs and their modifications into clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Juhee Ryu, Youngkeun Ahn, Hyun Kook, Young-Kook Kim
Summary: This article reviews the role and therapeutic implications of non-coding RNAs (ncRNAs) in vascular calcification (VC). Studies suggest that ncRNAs, including miRNAs, lncRNAs, and circRNAs, play important roles in regulating VC and may be useful in clinical diagnosis and treatment.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Ida Manna, Francesco Fortunato, Selene De Benedittis, Ilaria Sammarra, Gloria Bertoli, Angelo Labate, Antonio Gambardella
Summary: Temporal lobe epilepsy is the most common form of focal epilepsy, considered a network disorder associated with structural changes. Non-coding RNAs, acting as epigenetic factors, participate in the regulation of the pathophysiological processes of epilepsy and can be used as biomarkers for diagnosis and treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
