Article
Chemistry, Multidisciplinary
Sha Li, Hong Yang, Wan Li, Jin-yi Liu, Li-wen Ren, Yi-hui Yang, Bin-bin Ge, Yi-zhi Zhang, Wei-qi Fu, Xiang-jin Zheng, Guan-hua Du, Jin-Hua Wang
Summary: Colorectal cancer (CRC) is a common cancer globally, especially among women. In this study, alcohol dehydrogenase 1C (ADH1C) was identified as a potential drug target for CRC. Overexpression of ADH1C inhibited the growth and invasion of CRC cells, indicating its therapeutic potential for CRC.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Endocrinology & Metabolism
Daniela Annibali, Sarah-Maria Fendt
Summary: The study demonstrates the transition of PHGDH to the nucleus following nutrient stress, impacting the activity of c-Jun and contributing to sustained cancer cell proliferation.
Article
Medicine, Research & Experimental
Yajuan Zhang, Hua Yu, Jie Zhang, Hong Gao, Siyao Wang, Shuxian Li, Ping Wei, Ji Liang, Guanzhen Yu, Xiongjun Wang, Xinxiang Li, Dawei Li, Weiwei Yang
Summary: This study revealed a new role of SAM in promoting tumor metastasis through PHGDH activity regulation by monoubiquitination in colorectal cancer cells. The increased levels of SAM led to upregulation of cell adhesion genes, promoting tumor cell migration and CRC metastasis. Interestingly, SAM levels correlated with metastatic recurrence in CRC patients.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Lei Gao, Xiaolong Tang, Qingsi He, Guorui Sun, Chao Wang, Hui Qu
Summary: In this study, we found that the upregulation of circCOG2 in colorectal cancer (CRC) promoted tumor proliferation, migration, and invasion through the miR-1305/TGF-beta 2/SMAD3 pathway. Furthermore, the effect of circCOG2 could be transmitted via exosomes from CRC cells with high metastatic potential to those with low metastatic potential, suggesting a potential therapeutic target for CRC.
CELL DEATH DISCOVERY
(2021)
Review
Genetics & Heredity
Xijia Zhou, Chang Tian, Yingshu Cao, Min Zhao, Ke Wang
Summary: Metabolic reprogramming is an important characteristic of malignant tumors. Serine metabolism plays a crucial role in cell proliferation and forms a metabolic network with other pathways. Abnormal serine metabolism can potentially serve as a biomarker for early diagnosis and typing of tumors. In addition, targeting serine metabolism is important for precision and personalized cancer therapy.
FRONTIERS IN GENETICS
(2023)
Article
Cell Biology
Baoxiang Chen, Yuntian Hong, Rui Gui, Huabin Zheng, Shunhua Tian, Xiang Zhai, Xiaoyu Xie, Quanjiao Chen, Qun Qian, Xianghai Ren, Lifang Fan, Congqing Jiang
Summary: Circular RNAs play a critical regulatory role in colorectal cancer (CRC) by modulating metabolic reprogramming. The circ_0003215 circRNA inhibits cell proliferation, migration, and invasion, and suppresses the malignant phenotype of CRC through the miR-663b/DLG4/G6PD axis.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Matteo Rossi, Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, Anke Vandekeere, Alejandro M. Cuadros, Juan Fernandez-Garcia, Carla Riera-Domingo, Cristina Jauset, Melanie Planque, H. Furkan Alkan, David Nittner, Dongmei Zuo, Lindsay A. Broadfield, Sweta Parik, Antonino Alejandro Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, Shao Thing Teoh, Arin B. Aurora, Panagiotis Karras, Ines Vermeire, Dorien Broekaert, Joke Van Elsen, Maximilian M. L. Knott, Martin F. Orth, Sofie Demeyer, Guy Eelen, Lacey E. Dobrolecki, Ayse Bassez, Thomas Van Brussel, Karl Sotlar, Michael T. Lewis, Harald Bartsch, Manfred Wuhrer, Peter van Veelen, Peter Carmeliet, Jan Cools, Sean J. Morrison, Jean-Christophe Marine, Diether Lambrechts, Massimiliano Mazzone, Gregory J. Hannon, Sophia Y. Lunt, Thomas G. P. Grunewald, Morag Park, Jacco van Rheenen, Sarah-Maria Fendt
Summary: The loss of phosphoglycerate dehydrogenase (PHGDH) has been found to increase cancer metastasis. Heterogeneous or low expression of PHGDH in primary tumors of breast cancer patients is associated with decreased metastasis-free survival time. Loss of PHGDH activates the hexosamine-sialic acid pathway through its interaction with the glycolytic enzyme phosphofructokinase, leading to increased cell migration and invasion.
Article
Cell Biology
Longyang Jin, Chao Han, Tianyu Zhai, Xiaoyu Zhang, Chun Chen, Lei Lian
Summary: The study revealed that Circ_0030998 is upregulated in colorectal cancer tissues and cells, associated with poor prognosis, and promotes cancer cell proliferation and angiogenesis.
CELL DEATH DISCOVERY
(2021)
Article
Endocrinology & Metabolism
Chunmin Ma, Ke Zheng, Kun Jiang, Qin Zhao, Nannan Sha, Wang Wang, Man Yan, Tao Chen, Yuzheng Zhao, Yuhui Jiang
Summary: The study by Ma et al. reveals that PHGDH translocates from the cytoplasm to the nucleus under glucose restriction via phosphorylation by p38 and AMPK, resulting in altered activity that affects NAD(+) levels and PARP1 activity. This novel nutrient-sensing mechanism involving PHGDH highlights its critical role in tumour growth and cell fate decisions.
Article
Oncology
Tiezhu Shi, Zhihao Yuan, Yanying He, Dongliang Zhang, Siteng Chen, Xiongjun Wang, Linli Yao, Jialiang Shao, Xiang Wang
Summary: The study reveals that p53 regulates serine metabolism in bladder cancer cells. TP53 gene mutation is positively correlated with PHGDH expression. WT p53 inhibits PHGDH expression by recruiting SIRT1 to the PHGDH promoter. Additionally, YY1 promotes PHGDH expression and promotes bladder tumorigenesis.
Article
Oncology
Rumi Itoyama, Noriko Yasuda-Yoshihara, Fumimasa Kitamura, Tadahito Yasuda, Luke Bu, Atsuko Yonemura, Tomoyuki Uchihara, Kota Arima, Xichen Hu, Zhang Jun, Yuya Okamoto, Takahiko Akiyama, Kohei Yamashita, Yosuke Nakao, Toshihiko Yusa, Yuki Kitano, Takaaki Higashi, Tatsunori Miyata, Katsunori Imai, Hiromitsu Hayashi, Yo-ichi Yamashita, Takumi Mikawa, Hiroshi Kondoh, Hideo Baba, Takatsugu Ishimoto
Summary: Cancer cells, particularly pancreatic ductal adenocarcinoma cells, adapt their energy metabolism in response to nutrient deprivation in the microenvironment. Serine starvation leads to metabolic reprogramming in PDAC cells, with high plasma serine levels associated with PHGDH overexpression in tumors. Targeting the serine biosynthesis pathway by inhibiting PHGDH shows promise as a therapeutic strategy in nutrient-deprived microenvironments for PDAC.
Article
Biotechnology & Applied Microbiology
Yining Liu, Lei Chen, Tianqi Liu, Xiangqian Su, Lin Peng, Jiangbo Chen, Fei Tan, Pu Xing, Zaozao Wang, Jiabo Di, Beihai Jiang, Hong Qu
Summary: This study identified 694 circRNA-mRNA pairs in colorectal cancer patients, showing the regulatory roles between circular RNAs and their corresponding mRNAs, with some of them associated with patient survival time.
Article
Pharmacology & Pharmacy
Kaixuan Wang, Hao Lu, Xinmiao Wang, Qingxia Liu, Jinxia Hu, Yao Liu, Meihua Jin, Dexin Kong
Summary: Metabolic reprogramming is a characteristic of human cancer. The combination of PKM2-IN-1 and NCT-503 shows significant anti-cancer effects by inhibiting proliferation, inducing cell cycle arrest and apoptosis, and affecting multiple metabolic pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Bin-Lin Yang, Guo-Qiang Liu, Ping Li, Xiao-Hui Li
Summary: The study reveals that circular RNA CUL2 plays an important role in colorectal cancer progression and can inhibit cancer progression via the miR-208a-3p/PPP6C signaling pathway, making it a potential target for the diagnosis and therapy of colorectal cancer.
Article
Cell Biology
Tao He, Wen Tao, Lei-Lei Zhang, Bang-Yu Wang, Ke Li, Hui-Min Lu, Guo-Jun Tang, Ya-Di He, Liao-Yuan Li
Summary: circRNA circSCAF8 in prostate cancer activates the LIF-STAT3 pathway to promote proliferation, migration, and invasion, and its expression is a strong predictor of progression-free survival.
CELL DEATH & DISEASE
(2022)
Article
Gastroenterology & Hepatology
Lihong Mao, Chaoqun Li, Xiaoyu Wang, Mingyu Sun, Yifan Li, Zihan Yu, Binxin Cui, Gaoyue Guo, Wanting Yang, Yangyang Hui, Xiaofei Fan, Jie Zhang, Kui Jiang, Chao Sun
Summary: This study found that in decompensated cirrhosis, low subcutaneous adipose tissue index (SATI) and concurrent total adipose tissue index (TATI) were associated with an increased risk of frailty.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Review
Oncology
Fan Yang, Zehua Bian, Peiwen Xu, Shengbai Sun, Zhaohui Huang
Summary: MiR-204-5p is a non-coding RNA molecule that regulates gene expression and is frequently downregulated in various cancer types. It has been found to suppress tumor proliferation, metastasis, autophagy, and chemoresistance, making it a potential prognostic biomarker and therapeutic target for cancer.
Article
Fisheries
Min Cao, Qi Li, Xiantong Liu, Qiang Fu, Chao Li
Summary: Sebastes schlegelii is a fish species with high economic value, but the outbreak of diseases in its aquaculture industry has caused significant economic losses. Study of the fish immune system, particularly the immunoglobulin genes, can provide insights into the immune response to pathogens and contribute to the development of prevention and control methods. This study successfully identified and cloned the immunoglobulin heavy chain genes (sIgM, mIgM, sIgT, and mIgT) of S. schlegelii, revealing their high conservation during evolution.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Xiaoyan Zhang, Haohui Yu, Ningning Wang, Chao Li
Summary: Evidence suggests that lncRNAs are involved in various immune responses in vertebrates. In the snakehead fish, immune-related lncRNAs play crucial roles in regulating immune responses against Nocardia seriolae infection. This study analyzed the transcription landscapes of lncRNAs and mRNAs in snakehead, revealing potential functions of lncRNAs in modulating mRNA expression levels and regulating downstream immune signaling pathways.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Xin Cai, Chengbin Gao, Alan J. Lymbery, Nicola J. Armstrong, Le Ma, Chao Li
Summary: Recently, the Gram-negative pathogenic bacterium Vibrio anguillarum has become a major obstacle to the turbot aquaculture industry due to its global distribution, wide host range, and potential devastating impacts. This study conducted comprehensive analyses of whole-transcriptome sequencing in turbot liver infected by V. anguillarum and found differential expression of circRNAs, miRNAs, and mRNAs. Interaction pairs between miRNA-circRNA and miRNA-mRNA were predicted and circRNA-related ceRNA regulatory networks were constructed. The study identified novel target genes for disease prevention and control in turbot.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Yiping Liu, Min Cao, Xu Yan, Xin Cai, Yuqing Li, Chao Li, Ting Xue
Summary: Cell-to-cell communication through gap junction channels is essential for coordinating cellular functions in multicellular tissues. This study identified 48 members of the gap junction protein family in Sebastes schlegelii, classifying them into connexin and pannexin types. The connexins were further divided into five subfamilies. The study also revealed the protein structure and interactions of GJs, and showed that GJ proteins were highly expressed in intestinal tissues and regulated after bacterial infection. The findings provide valuable insights for further understanding the function of GJ proteins in S. schlegelii.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tengyu Wang, Qinghao Zhen, Tong Wu, Lan Jin, Surui Yao, Yuyang Feng, Jinghua Chen, Chen Chen, Zhaohui Huang
Summary: GABRP is identified as a potential drug target for mediating oxaliplatin or 5-FU resistance in colorectal cancer.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Pediatrics
Mei Mei, Dan Dai, Zhuoyao Guo, Congcong Zhang, Jing Liu, Yuanyuan Qi, Xiaochuan Wang, Libo Wang, Liling Qian
Summary: This study retrospectively analyzed the clinical characteristics and underlying causes of 551 hospitalized children with recurrent pneumonia from January 2016 to January 2021 at the Children's Hospital of Fudan University. The majority (87.7%) of the children had underlying causes, with recurrent aspiration, primary immunodeficiency, and congenital heart diseases being the most common. Genetic defects were identified in about a quarter of the patients. Primary immunodeficiency, primary ciliary dyskinesia, bronchiolitis obliterans, and the age of >3 years at diagnosis were risk factors for severe outcomes. Aspiration and an abnormal family history were risk factors for rehospitalization.
PEDIATRIC PULMONOLOGY
(2023)
Article
Computer Science, Information Systems
Jian Cheng, Quanyuan Feng, Chao Li, Wenxiu Yang
Summary: In this paper, a new run-time monitoring technique is proposed to detect hardware Trojans (HT) on working field-programmable gate array (FPGA), which can enhance the hardware security of IoT devices. The technique places multiple temperature sensors on FPGA and collects their values at each time interval. A predictive model is constructed to estimate the real-time distribution of sensor frequency. If the difference between the predicted value and the real one exceeds a dynamically updated threshold, an HT activation is reported. The experiment results demonstrate that the technique achieves high detection accuracy (>= 98%), low false negative ratio (<= 1.5%), and zero false positive ratio under various FPGA HT benchmarks.
Article
Respiratory System
Liuying Huang, Yuan Yin, Danqi Qian, Yulin Cao, Duo Wang, Xiaohan Wu, Liang Ming, Zhaohui Huang, Leyuan Zhou
Summary: Lung cancer, especially non-small cell lung cancer (NSCLC), has high morbidity and mortality rates worldwide. Severe pulmonary hemorrhage (PH) is a potential adverse event in the treatment of lung cancer with bevacizumab. This study aimed to investigate the underlying causes for the observed clinical differences between patients with lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) after bevacizumab treatment.
JOURNAL OF THORACIC DISEASE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Xue Wang, Han Cheng, Die Hu, Ying Chen, Waseem Hassan, Jing Zhao, Jiuming Li, Zhaohui Huang
Article
Clinical Neurology
Yan-Yan Chen, Zhi-Cheng Gong, Mei-Mei Zhang, Zhao-Hui Huang
Summary: In this study, emodin was encapsulated in a PEG/cRGD-modified liposome to achieve brain-targeted delivery and maximize therapeutic efficacy. The study revealed that encapsulated emodin significantly enhanced its accumulation in the infarct region and improved its therapeutic efficacy. Furthermore, the critical target of emodin responsible for alleviating ischemic stroke was identified, providing a potential drug delivery strategy for ischemic stroke and other brain injuries.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Pediatrics
Lingyu Lai, Yong Lu, Zhimin Xi, Fang Liu, Liling Qian, Libo Wang, Quming Zhao
Summary: This article reports two cases of bronchial Dieulafoy's disease in children, causing recurrent massive hemoptysis. The disease was diagnosed through imaging examinations and bronchial arteriography, and was successfully treated with bronchial artery embolization, with no recurrence of hemoptysis.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Construction & Building Technology
Youmei Zhou, Hao Lei, Xiyu Zhang, Shan Wang, Yingying Xu, Chao Li, Jie Zhang
Summary: This research explores how to incorporate social attributes and social interaction into scenario simulation in the digital twin city research and development, which is a problem to be addressed in the refinement and planning of future digital platforms and management in terms of decision-making. The findings have important implications for inspiring the application of computational decision-making support in urban governance and enhancing comprehensive and sustainable urban regeneration.
Article
Biochemistry & Molecular Biology
Peng Teng, Kaisa Cui, Surui Yao, Bojian Fei, Feng Ling, Chaoqun Li, Zhaohui Huang
Summary: In this study, researchers found that ME2 is highly expressed in human colorectal cancer (CRC) tissues and its knockdown inhibits CRC cell proliferation. They also discovered that SIRT5 can desuccinylate ME2, activating its enzymatic activity. Activated ME2 enhances mitochondrial respiration, supporting cell proliferation and tumor development. Additionally, the levels of succinylated ME2 and SIRT5 are associated with patient prognosis.
CELL DEATH AND DIFFERENTIATION
(2023)
