Review
Immunology
Jie Xu, Linxin Yu, Feng Liu, Longbiao Wan, Zhenhua Deng
Summary: The complicated connections and cross talk between the skeletal system and the immune system are developing into the field of Osteoimmunology. Cytokines, such as TNF, IL, IFN, and chemokines, play a critical role in bone remodeling, particularly in the pathogenesis and development of osteoporosis. This review summarizes the effects of cytokines on osteoblasts and osteoclasts, offering a reference for the role of immunology in osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Pia Rosgaard Jensen, Thomas Levin Andersen, Pascale Chavassieux, Jean-Paul Roux, Jean-Marie Delaisse
Summary: Bisphosphonates not only strongly inhibit bone resorption, but also negatively affect bone formation, limiting the ability to initiate bone formation. This study reveals a possible mechanism for impeding the recruitment of osteoprogenitor cells, which in turn impacts the process of bone formation.
Article
Chemistry, Medicinal
La Yoon Choi, Mi Hye Kim, Woong Mo Yang
Summary: Phlomis umbrosa, traditionally used for bone diseases in traditional Korean Medicine, contains Sweroside (SOS) which has been found to promote osteoblast differentiation. This study showed that SOS can ameliorate osteoporosis by inducing the formation of mineralized bone matrix and regulating molecules mediated by BMP2 and CBFA1. SOS may be a potential therapeutic compound for osteoporosis by producing new bone matrix.
PHYTOTHERAPY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yongguang Gao, Suryaji Patil, Jingxian Jia
Summary: Osteoporosis is a major bone disorder affecting both men and women, primarily due to an imbalance in bone remodeling. Understanding the effects of molecules produced by different cells on bone can help identify new therapeutic targets and approaches for preventing and treating bone disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Barbara Kolodziejska, Natalia Stepien, Joanna Kolmas
Summary: This study summarizes the role of strontium in the treatment of osteoporosis, highlighting its multidirectional effects on bone tissue and its similarities to calcium. It discusses the unique mechanism of action of strontium ranelate and the increasing interest in using strontium ions in ceramics as bone replacement materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Taruneet Kaur, Aijaz A. John, Chandresh Sharma, N. K. Vashisht, Divya Singh, Rajeev Kapila, Suman Kapila
Summary: The study reveals that miR300 negatively regulates osteoblast differentiation by impacting the signaling pathways associated with it, making it a potential therapeutic target for bone-related disorders. High levels of miR300 suppress the protein levels of Smad3, beta-catenin, and Runx2, indicating its role in osteoblast functioning.
Article
Endocrinology & Metabolism
Su-Qin Shi, Shan-Shan Li, Xiao-Ya Zhang, Zhe Wei, Wen-Zhen Fu, Jin-Wei He, Yun-Qiu Hu, Miao Li, Li-Li Zheng, Zhen-Lin Zhang
Summary: This study found that genetic variations of the LGR4 gene are associated with peak bone mineral density, BMI, and trunk fat mass.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tao Wang, Chao Zhang, Lin Xu, Xingnuan Li
Summary: The process of bone remodeling is regulated by interactions between osteoclasts and osteoblasts. Dysregulation of this balance can contribute to bone metabolic diseases such as osteoporosis. Circular RNAs (circRNAs) can regulate the differentiation of these cells. This review provides an overview of how circRNAs regulate the dynamic balance between osteoblasts and osteoclasts for maintaining bone homeostasis, and sheds light on the pathogenesis of bone metabolic diseases.
Article
Genetics & Heredity
Virginia Veronica Visconti, Chiara Greggi, Ida Cariati, Beatrice Gasperini, Ambra Mastrogregori, Annalisa Botta, Umberto Tarantino
Summary: The study revealed a significantly increased expression level of CLU in osteoporotic patients, suggesting its potential role as a biomarker for the diagnosis and prognosis of osteoporosis progression.
Article
Endocrinology & Metabolism
Yoshimitsu Nakanishi, Sujin Kang, Atsushi Kumanogoh
Summary: This article reviews the recent advances in understanding the molecular mechanism of skeletal-neural interactions in bone homeostasis, with a focus on the functions of axon guidance molecules in the establishment and maintenance of the skeletal system.
Article
Endocrinology & Metabolism
Melanie Haffner-Luntzer, Deniz Ragipoglu, Mubashir Ahmad, Astrid Schoppa, Lena Steppe, Verena Fischer, Julia Luther, Timur Yorgan, Ernesto Bockamp, Michael Amling, Thorsten Schinke, Anita Ignatius
Summary: Despite improvements in fracture care, a percentage of fractures still heal poorly. The study investigated the potential of Wnt1 as a molecule to improve bone fracture healing. The results showed that Wnt1 promotes bone formation during fracture healing through YAP/BMP signaling. This suggests that Wnt1 could be used as a therapeutic agent for orthopedic complications.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Public, Environmental & Occupational Health
Chunlu Yan, Jinlong Zhang, Fangyu An, Jiayu Wang, Yao Shi, Lingqing Yuan, Donghui Lv, Yanzhen Zhao, Yongfeng Wang
Summary: This article summarizes the regulatory network mechanism of ferroptosis on bone remodeling and reveals the role of ferroptosis in osteoporosis.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Sophia Ogechi Ekeuku, Elvy Suhana Mohd Ramli, Norfarahin Abdullah Sani, Norzana Abd Ghafar, Ima Nirwana Soelaiman, Kok-Yong Chin
Summary: Glucocorticoid-induced osteogenic dysfunction is the main pathological mechanism of glucocorticoid-induced osteoporosis. Tocotrienol has been shown to prevent oxidative stress and osteoblast apoptosis, enhance osteogenic differentiation, and improve bone formation.
Review
Cell Biology
Mei Huang, Shaozhe Xu, Lifei Liu, Miao Zhang, Jianmin Guo, Yu Yuan, Jiake Xu, Xi Chen, Jun Zou
Summary: Osteoporosis is a common bone disease in the elderly, characterized by decreased bone mass due to bone metabolism imbalance. The m6A modification, through epigenetic regulation, affects the biological processes of bone-related cells and related signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
T. John Martin
Summary: Communication processes among bone cells are crucial for maintaining the structure and function of the organ. Identified molecular controls include the tumor necrosis factor ligand and receptor families, which regulate the three phases of bone remodeling and can impact how drugs act on bone.
Article
Endocrinology & Metabolism
Jie Hong, Tingting Bo, Liuqing Xi, Xiaoqiang Xu, Naying He, Yafeng Zhan, Wanyu Li, Peiwen Liang, Yufei Chen, Juan Shi, Danjie Li, Fuhua Yan, Weiqiong Gu, Weiqing Wang, Ruixin Liu, Jiqiu Wang, Zheng Wang, Guang Ning
Summary: VSG surgery causes correlated alterations of the gut-brain axis, including changes in Clostridia microbiota, postprandial active glucagon-like peptide-1 (aGLP-1), PUT.R brain activity, and eating habits. Preoperative connectivity of PUT.R may serve as a potential predictive marker of surgical outcomes in obese patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Wei Zhang, Pei Liu, Shifeng Ling, Fuhua Wang, Shaojiao Wang, Tienan Chen, Rujiang Zhou, Xuechun Xia, Zhengju Yao, Ying Fan, Niansong Wang, Jiqiu Wang, Haley O. Tucker, Xizhi Guo
Summary: Bone serves as an endocrine source of adiponectin, with the FOXP1 transcription factor in osteoblasts controlling its production. Adiponectin expression is directly regulated by FOXP1, increasing with bone age, and impacting energy metabolism.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Andrology
Yufei Chen, Ling Zhang, Shaoqian Zhao, Lihui Yuan, Juan Shi, Yifei Zhang, Jiqiu Wang, Weiqiong Gu, Weiqing Wang, Jie Hong
Summary: This study found that short night-time sleep duration was associated with an increased risk of MOSH in young obese Chinese men, while there was no significant association between day napping status and the prevalence of MOSH.
Article
Medicine, General & Internal
Juan Shi, Guoqing Bao, Jie Hong, Simin Wang, Yufei Chen, Shaoqian Zhao, Aibo Gao, Ru Zhang, Jingfen Hu, Wenjie Yang, Fuhua Yan, Ankang Lyu, Ruixin Liu, Bin Cui, Yuhong Chen, Jiabin Jin, Baiyong Shen, Yifei Zhang, Weiqiong Gu, Dagan Feng, Weiqing Wang, Jiqiu Wang, Xiuying Wang, Guang Ning
Summary: Texture features of VAT, extracted from CT scans and analyzed with machine learning, can predict metabolic disorders and estimate surgery-induced weight loss effects. These findings have important implications for understanding the role of visceral adipose tissue in metabolic disorders and surgical interventions.
Article
Immunology
Yuli Lin, Liuling Xiao, Qian Cai, Cuisong Zhu, Shufen Li, Bingji Li, Ting Liu, Qiongyue Zhang, Yi Wang, Yiming Li, Xing He, Dongning Pan, Qiqun Tang, Xiaohui Wu, Weiqing Pan, Jiqiu Wang, Xi Li, Rui He
Summary: Cold exposure reduces chemerin and its receptor CMKLR1 expression in iWAT, enhancing type 2 innate immune responses and promoting thermogenic beige fat formation. The chemerin-CMKLR1 axis plays a key role in regulating adipose-immune communication and is a potential therapeutic target for obesity-related metabolic disorders.
SCIENCE IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Teng-teng Li, Cheng Peng, Ji-qiu Wang, Zhi-jian Xu, Ming-bo Su, Jia Li, Wei-liang Zhu, Jing-ya Li
Summary: The study revealed and confirmed that a mutation of DPP4, V486M, leads to loss of dimerization and enzymatic activity by inducing a local conformational collapse in a flap loop. The open/closed conformational transitions of the flap play a crucial role in the enzymatic activity of DPP4.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Medicine, Research & Experimental
Jian Yu, Xin Chen, Yuanjin Zhang, Xiangdi Cui, Zhe Zhang, Wenxiu Guo, Dongmei Wang, Shengbo Huang, Yanru Chen, Yepeng Hu, Cheng Zhao, Jin Qiu, Yu Li, Meiyao Meng, Mingwei Guo, Fei Shen, Mengdi Zhang, Ben Zhou, Xuejiang Gu, Jiqiu Wang, Xin Wang, Xinran Ma, Lingyan Xu
Summary: This study demonstrates that azithromycin, a type of macrolide antibiotics, inhibits the functionality of brown and beige adipocytes. Azithromycin accumulates in adipose tissue of obese patients and is associated with BMI and body weight. The antibiotic impairs mitochondrial function in brown and beige adipocytes through inhibiting mitochondrial respiratory complex I and increasing ROS levels.
Article
Biochemistry & Molecular Biology
Yu Li, Dongmei Wang, Xiaodan Ping, Yankang Zhang, Ting Zhang, Li Wang, Li Jin, Wenjun Zhao, Mingwei Guo, Fei Shen, Meiyao Meng, Xin Chen, Ying Zheng, Jiqiu Wang, Dali Li, Qiang Zhang, Cheng Hu, Lingyan Xu, Xinran Ma
Summary: This study discovered that local hyperthermia therapy promotes the activation of beige fat and offers a promising strategy against obesity via the HSF1-A2B1 transcriptional axis.
Article
Cardiac & Cardiovascular Systems
Lingfang Zhuang, Kangni Jia, Chen Chen, Zhigang Li, Jiaxin Zhao, Jian Hu, Hang Zhang, Qin Fan, Chunkai Huang, Hongyang Xie, Lin Lu, Weifeng Shen, Guang Ning, Jiqiu Wang, Ruiyan Zhang, Kang Chen, Xiaoxiang Yan
Summary: This study reveals the significant role of DYRK1B in mitochondrial bioenergetics and the progression of cardiac hypertrophy and heart failure. DYRK1B promotes impaired mitochondrial bioenergetics by directly binding with STAT3, leading to the downregulation of PGC-1 alpha. Inhibition of DYRK1B or STAT3 activity restores cardiac performance by rejuvenating mitochondrial bioenergetics. These findings may offer new therapeutic options for heart failure patients.
Article
Developmental Biology
Fuhua Wang, Shuqin Xu, Tienan Chen, Shifeng Ling, Wei Zhang, Shaojiao Wang, Rujiang Zhou, Xuechun Xia, Zhengju Yao, Pengxiao Li, Xiaodong Zhao, Jiqiu Wang, Xizhi Guo
Summary: FOXP4 is a transcription factor that regulates the differentiation and activity of beige adipocytes. Depletion of FOXP4 affects early differentiation of beige cells, but enhances thermogenic capacity of mature adipocytes.
Article
Endocrinology & Metabolism
Yaogan Luo, Jiqiu Wang, Liang Sun, Weiqiong Gu, Geng Zong, Boyu Song, Chongrong Shen, Puchen Zhou, Yufei Chen, Yanpu Wu, Huibin Lin, He Zheng, Mengshan Ni, Xiaowei Yang, Yanru Chen, Xinming Xu, Juan Zhang, Juan Shi, Ru Zhang, Jinfen Hu, Hong Hou, Ling Lu, Xiaoqiang Xu, Liming Liang, Ruixin Liu, Xiaoran Liu, Huaixing Li, Jie Hong, Weiqing Wang, Xu Lin, Guang Ning
Summary: This study compared the effects of a Mediterranean diet and Chinese diets high or low in plants on body weight and glucose homeostasis among high-risk Chinese individuals. The results showed that with a 6-month calorie-restricted feeding, both the Chinese diets and the Mediterranean diet achieved similar weight reduction and improved glucose homeostasis, while the control diet showed a higher risk for hypoglycemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Wen Liu, Danjie Li, Minglan Yang, Long Wang, Yu Xu, Na Chen, Zhiyin Zhang, Juan Shi, Wen Li, Shaoqian Zhao, Aibo Gao, Yufei Chen, Qinyun Ma, Ruizhi Zheng, Shujing Wu, Yifei Zhang, Yuhong Chen, Shuwen Qian, Yufang Bi, Weiqiong Gu, Qiqun Tang, Guang Ning, Ruixin Liu, Weiqing Wang, Jie Hong, Jiqiu Wang
Summary: This study found that GREM2 may function as a circulating protein factor associated with human visceral adiposity, and Grem2 inhibits the browning capacity of visceral preadipocytes partially through the BMP4/7-BMPR2 signaling pathway.
Article
Peripheral Vascular Disease
Huan Yun, Liang Sun, Qingqing Wu, Yaogan Luo, Qibin Qi, Huaixing Li, Weiqiong Gu, Jiqiu Wang, Guang Ning, Rong Zeng, Geng Zong, Xu Lin
Summary: This study identified dairy-related sphingomyelin metabolites and their associations with cardiovascular health factors in a Chinese population. Mendelian randomization analysis further revealed a negative association between one sphingomyelin and blood pressure.
Review
Endocrinology & Metabolism
Ningning Zhang, Mingyang Yuan, Jiqiu Wang
Summary: Classic hormone membrane receptors play crucial roles in endocrinology and metabolism. LGR4, a newly discovered receptor, has similar functions and expression patterns as LGR1/2/3. Recent studies have shown that LGR4 is involved in various endocrine and metabolic diseases, such as osteoporosis, cardiometabolic diseases, and obesity. This review discusses the dysfunction of LGR4 in clinical diseases, animal models, and pathophysiological changes, as well as its ligands and downstream signaling pathways, aiming to identify unresolved questions and future perspectives.
Review
Materials Science, Biomaterials
Ran Wei, Danjie Li, Sheng Jia, Yuhong Chen, Jiqiu Wang
Summary: Obesity has become a critical health burden during the global pandemic, and the melanocortin receptor-4 (MC4R) has been identified as a key genetic factor in severe and early onset obesity. Previous studies have focused on the central role of MC4R in energy intake and expenditure, but evidence suggests its expression in peripheral systems as well. This review aims to provide a comprehensive understanding of the central and peripheral roles of MC4R in energy metabolism and endocrine hormone homeostasis.
