Article
Immunology
Mengjia Shen, Congcong Duan, Changhao Xie, Hongtao Wang, Zhijun Li, Baiqing Li, Tao Wang
Summary: This study identified differentially expressed ISGs in the PBMCs of SLE patients and healthy individuals, including NRIR, RSAD2, USP18, IFI44, and ISG15. These findings may contribute to future diagnosis and new personalized targeted therapies for SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Lu Xiao, Feng Zhan, Shudian Lin
Summary: This study identified biomarkers and mechanisms associated with systemic lupus erythematosus (SLE) at a transcriptome level, demonstrating their clinical value in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Bin Lv, Guangyu Gao, Yuhong Guo, Zhiping Zhang, Renfeng Liu, Zhengzai Dai, Cheng Ju, Yiping Liang, Xiaofeng Tang, Min Tang, Xiao-Bin Lv
Summary: This study utilized the Gene Expression Omnibus (GEO) database to analyze differential regulation in osteosarcoma cells compared to osteoblasts, identifying 341 mRNAs, with Serglycin being highlighted as a key gene influencing invasion and proliferation of osteosarcoma cells.
Article
Medicine, Research & Experimental
Xingwang Zhao, Longlong Zhang, Juan Wang, Min Zhang, Zhiqiang Song, Bing Ni, Yi You
Summary: The study identified IFI27 as a potential key player in the pathogenesis of SLE, and highlighted the important role of immune cell infiltration in the progression of the disease. The research sheds light on new insights into the molecular mechanisms of SLE and provides potential markers for diagnosis and progression monitoring.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Wei Sun, Pengchong Li, Min Wang, Yue Xu, Dan Shen, Xuan Zhang, Yudong Liu
Summary: This study identified key PANoptosis-related genes (PRGs) involved in immune dysregulation in SLE. These genes were associated with memory B cells, neutrophils, and CD8+ T cells, and enriched in interferon and IL-6-JAK-STAT3 signaling pathways. The expression levels of these genes were validated in peripheral blood mononuclear cells of SLE patients. These findings suggest that PANoptosis may be implicated in the immune dysregulation of SLE by regulating interferons and JAK-STAT signaling pathways in memory B cells, neutrophils, and CD8+ T cells.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Haoguang Li, Xiuling Zhang, Jingjing Shang, Xueqin Feng, Le Yu, Jie Fan, Jie Ren, Rongwei Zhang, Xinwang Duan
Summary: This study investigated the molecular characteristics of NETs-related genes (NRGs) in systemic lupus erythematosus (SLE) through bioinformatics analysis. Eight differentially expressed NRGs were identified and HMGB1, ITGB2, and CREB5 were selected as hub genes. These hub genes showed significant diagnostic value for SLE and three distinct NETs-related sub-clusters were identified. This study provides new insights into the molecular characteristics of NRGs in SLE and identifies potential biomarkers and molecular clusters.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yun Yu, Liang Liu, Long-Long Hu, Ling-Ling Yu, Jun-Pei Li, Jing-an Rao, Ling-Juan Zhu, Qian Liang, Rong-Wei Zhang, Hui-Hui Bao, Xiao-Shu Cheng
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. This study used bioinformatics methods to identify potential therapeutic targets for SLE, revealing tissue-specific expression differences in hematological markers and increased expression of CCL2, MMP9, and RSAD2 in SLE samples. These key genes could serve as potential therapeutic targets for treating SLE.
Article
Immunology
Yimin Wang, Wenge Su, Yunlun Li, Jie Yuan, Minghao Yao, Xiaoyi Su, Yifei Wang
Summary: This study investigated the mechanisms of the co-occurrence of systemic lupus erythematosus (SLE) and atherosclerosis (AS). Gene expression profiles were analyzed to identify common differentially expressed genes (DEGs), and enrichment analysis revealed the involvement of the IL-17 signaling pathway. Five key genes (CCR1, CD163, IL1RN, MMP9, and SIGLEC1) were identified as potential drivers of monocyte differentiation into macrophages, and immune cell infiltration analysis showed the importance of monocytes in SLE and M0 macrophages in AS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yi Zhang, FengQi Zhang, YiNi Gao, MeiJiao Wang, Yan Gao, HaiChang Li, Jing Sun, ChengPing Wen, ZhiJun Xie
Summary: Through experimental evidence, it has been found that triptolide (TP) exerts therapeutic effects on SLE by regulating miR-146a expression, inhibiting the TLR7/NF-kappa B signaling pathway, and affecting B cell activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Nasren Eiza, Adi D. Sabag, Ofra Kessler, Gera Neufeld, Zahava Vadasz
Summary: CD72 serves as a ligand and signal transducing receptor for sema3A, independent of neuropilin-1 (NRP-1), in B cells. Sema3A binding to CD72 on B cells inhibits the phosphorylation of STAT-4 and HDAC-1 and induces the phosphorylation of p38-MAPK and PKC-theta. The sema3A-CD72 axis is a crucial regulatory pathway in the pathogenesis of SLE.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Biotechnology & Applied Microbiology
Rui Zhang, Xuan Xu, Xi Chen, Chunshu Hao, Zhenjun Ji, Pengfei Zuo, Mingming Yang, Genshan Ma, Yongjun Li
Summary: This study identified key pathogenic genes in hypertension-induced cardiac hypertrophy through gene expression analysis. The upregulated genes Eln and Tgfb3 were found to be positively correlated with the severity of cardiac hypertrophy, suggesting their potential as therapeutic targets for the disease.
Article
Nanoscience & Nanotechnology
Wenhong Liu, Shiqing Li, Fangfang Tao, Lichao Wu, Fei Luo, Tengfei Sun, Junhui Zhao, Junfeng Li, Changyu Li
Summary: This study aimed to investigate the mechanism and partial material basis of Jieduquyuziyin prescription (JQZP) in reducing systemic lupus erythematosus (SLE) inflammation via regulating Nek7-NLRP3 signaling pathway. The results showed that JQZP ameliorated renal histopathological changes and decreased pro-inflammatory cytokine levels both in vivo and in vitro. Network pharmacology and molecular docking analysis identified salidroside, luteolin, and apigenin as the potential active ingredients in JQZP. Furthermore, Western blot confirmed the regulation of Nek7, NLRP3, and ASC by JQZP. These findings suggest that JQZP has a certain effect in improving excessive inflammation of SLE, with salidroside, luteolin, and apigenin as its potential material basis.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Li Lu, Hailin Wang, Xuan Liu, Liping Tan, Xiaoyue Qiao, Jiali Ni, Yang Sun, Jun Liang, Yayi Hou, Huan Dou
Summary: This study found elevated glycolysis in the hippocampus of NPSLE mice, as well as activation of PKM2 observed in microglia in the hippocampus of lupus mice. PKM2 was found to facilitate microglial activation and over-activated microglial phagocytosis via the beta-catenin signaling pathway. Inhibition of PKM2 led to reduced cognitive impairment and brain damage in NPSLE mice.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Xiao-yun Zhang, Yue-ping Chen, Jie Han, Jian Mo, Pan-feng Dong, Ying-hong Zhuo, Yang Feng
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Integrative & Complementary Medicine
Zhe Feng, Ziyi Feng, Jie Han, Weimin Cheng, Bo Su, Jian Mo, XinJian Feng, Sitan Feng, GuoJian Chen, Peng Huang, Long Huang, Zhenwei Cui
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Integrative & Complementary Medicine
Jie Han, Yuan Chai, Xiao-yun Zhang, Feng Chen, Zhi-wei Xu, Zhe Feng, Qian Yan, Shuai-bo Wen, Yu-kun Wu
Summary: The study revealed that Gujiansan accelerates the formation of new bone, promotes the absorption of damaged bone, inhibits the inflammatory response, and induces autophagy in the femoral head. The therapeutic effect of Gujiansan is dose- and time-dependent.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Guo-wu Ren, Shuai-bo Wen, Jie Han, Zhi-wei Xu, Wen Qi, Yu-zhi Shang, Yu-kun Wu
Summary: This study analyzed the potential mechanism of action of Gujiansan in the treatment of steroid-induced avascular necrosis of the femoral head (SANFH) using network pharmacology, providing a reference for further study of its pharmacological basis and targets.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Immunology
Feng Chen, Yukun Wu, Guowu Ren, Shuaibo Wen
Summary: This study investigates the regulatory role of T helper cells in bone metabolism in SLE patients, providing theoretical support for abnormal bone metabolism in SLE and new prospects for future drug development.
Article
Plant Sciences
Xiaoyun Zhang, Yueping Chen, Chi Zhang, Xuan Zhang, Tian Xia, Jie Han, Shilei Song, Canhong Xu, Feng Chen
Summary: Icariin has been shown to promote fracture healing in both young and old rats by activating the BMP-2/Smad5/Runx2 pathway, indicating its potential for clinical applications and further research.
PHARMACEUTICAL BIOLOGY
(2021)