Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss

Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation

(2019) Lijie Peng et al.   ACS Medicinal Chemistry Letters

Screening for Osteoporosis to Prevent Fractures

(2018) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Coupling of bone resorption and formation by RANKL reverse signalling

(2018) Yuki Ikebuchi et al.   NATURE

Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs

(2018) Sainan An et al.   EBioMedicine

SREBP-2 aggravates breast cancer associated osteolysis by promoting osteoclastogenesis and breast cancer metastasis

(2018) Zhiwei Jie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors

(2018) G. Vargas et al.   ONCOGENE

Anhydroicaritin, a SREBPs inhibitor, inhibits RANKL-induced osteoclastic differentiation and improves diabetic osteoporosis in STZ-induced mice

(2017) Zu-Guo Zheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Carnosic acid alleviates hyperlipidemia and insulin resistance by promoting the degradation of SREBPs via the 26S proteasome

(2017) Zhishen Xie et al.   Journal of Functional Foods

Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation

(2016) Zu-Guo Zheng et al.   BIOCHEMICAL PHARMACOLOGY

Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects

(2016) Wei Wei et al.   Cell Metabolism

Osteocytes: The master cells in bone remodelling

(2016) Matthew Prideaux et al.   CURRENT OPINION IN PHARMACOLOGY

Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation

(2015) Kazuki Inoue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Catalytic in vivo protein knockdown by small-molecule PROTACs

(2015) Daniel P Bondeson et al.   Nature Chemical Biology

Carnosic acid

(2015) Simona Birtić et al.   PHYTOCHEMISTRY

High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms

(2015) Chandi C. Mandal   Frontiers in Endocrinology

Identification of Novel Transcription Factors in Osteoclast Differentiation Using Genome-wide Analysis of Open Chromatin Determined by DNase-seq

(2014) Kazuki Inoue et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cholesterol and breast cancer pathophysiology

(2014) Erik R. Nelson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Carboxyl Terminus of Hsp70-Interacting Protein Regulation of Osteoclast Formation in Mice Through Promotion of Tumor Necrosis Factor Receptor-Associated Factor 6 Protein Degradation

(2014) Shan Li et al.   Arthritis & Rheumatology

Mechanisms of bone anabolism regulated by statins

(2012) Feng Ruan et al.   BIOSCIENCE REPORTS

An energetic orphan in an endocrine tissue: A revised perspective of the function of estrogen receptor-related receptor alpha in bone and cartilage

(2012) Edith Bonnelye et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

(2012) Dennis L. Buckley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of Cholesterol in the Development and Progression of Breast Cancer

(2011) Gemma Llaverias et al.   AMERICAN JOURNAL OF PATHOLOGY

Disorders of Bone Remodeling

(2011) Xu Feng et al.   Annual Review of Pathology-Mechanisms of Disease

Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks

(2011) Lillian J. Eichner et al.   MITOCHONDRION

PGC1β Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss

(2010) Wei Wei et al.   Cell Metabolism

PPARγ in bone homeostasis

(2010) Yihong Wan   TRENDS IN ENDOCRINOLOGY AND METABOLISM

ERR receptors as potential targets in osteoporosis

(2010) Marlène Gallet et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Estrogen and ERα: Culprits in cervical cancer?

(2010) Sang-Hyuk Chung et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lipid Changes During the Menopause Transition in Relation to Age and Weight: The Study of Women's Health Across the Nation

(2009) C. A. Derby et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells

(2009) Rebecca A. Stein et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Transcriptional Control of Skeletogenesis

(2008) Gerard Karsenty   Annual Review of Genomics and Human Genetics

Association between serum cholesterol and bone mineral density

(2008) Joanna Makovey et al.   BONE

The significance of the expression of ERRα as a potential biomarker in breast cancer

(2008) Katarzyna Jarzabek et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY