Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism
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Title
Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism
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Journal
Frontiers in Immunology
Volume 13, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-07-22
DOI
10.3389/fimmu.2022.943321
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Note: Only part of the references are listed.- Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation
- (2022) Danlei Li et al. Frontiers in Pharmacology
- Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis
- (2022) Lin Lin et al. Frontiers in Cell and Developmental Biology
- Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis
- (2022) Jian Yang et al. Frontiers in Cell and Developmental Biology
- Ferroptosis in Parkinson’s disease: glia–neuron crosstalk
- (2022) Zhang-Li Wang et al. TRENDS IN MOLECULAR MEDICINE
- Effects of dietary restriction on neuroinflammation in neurodegenerative diseases
- (2021) Luigi Fontana et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK / SIRT1 signaling pathway
- (2021) Nan Wang et al. PHYTOTHERAPY RESEARCH
- Effects of Physiological Doses of Resveratrol and Quercetin on Glucose Metabolism in Primary Myotubes
- (2021) Itziar Eseberri et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High-Fat Diet: Role of Angiogenesis
- (2021) Shasha Yu et al. Oxidative Medicine and Cellular Longevity
- Quercetin induces pro‐apoptotic autophagy via SIRT1 / AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro
- (2021) Hengjuan Guo et al. Thoracic Cancer
- Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1/CREB/ BDNF signaling pathway
- (2021) Zhong-Xuan Ma et al. BEHAVIOURAL BRAIN RESEARCH
- Effects of quercetin on the alterations of serum elements in chronic unpredictable mild stress-induced depressed rats
- (2021) Tong Guan et al. BIOMETALS
- Reactive microglia enhance the transmission of exosomal alpha-synuclein via toll-like receptor 2
- (2021) Yun Xia et al. BRAIN
- PINK1‐mediated mitophagy maintains pluripotency through optineurin
- (2021) Chaoqun Wang et al. CELL PROLIFERATION
- The Protective Mechanism of SIRT1 in the Regulation of Mitochondrial Biogenesis and Mitochondrial Autophagy in Alzheimer’s Disease
- (2021) Fan Ye et al. JOURNAL OF ALZHEIMERS DISEASE
- Quercetin Attenuates Atherosclerotic Inflammation by Inhibiting Gal‐3‐NLRP3 Signaling Pathway
- (2021) Hongxia Li et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Cocrystal of Apixaban–Quercetin: Improving Solubility and Bioavailability of Drug Combination of Two Poorly Soluble Drugs
- (2021) Li Zhang et al. MOLECULES
- Effect of neuropsychiatric medications on mitochondrial function; for better or for worse
- (2021) Tim L. Emmerzaal et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic Reticulum Stress
- (2021) Xing Chang et al. Oxidative Medicine and Cellular Longevity
- Mitochondrial Dysfunction Contributes to Aging-Related Atrial Fibrillation
- (2021) Chuanbin Liu et al. Oxidative Medicine and Cellular Longevity
- Bone-to-Brain: A Round Trip in the Adaptation to Mechanical Stimuli
- (2021) Laura Gerosa et al. Frontiers in Physiology
- Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective
- (2021) Patrycja Mulica et al. Frontiers in Endocrinology
- Mechanisms and Neuroprotective Activities of Stigmasterol Against Oxidative Stress-Induced Neuronal Cell Death via Sirtuin Family
- (2021) Reny Pratiwi et al. Frontiers in Nutrition
- Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels
- (2021) Barbara J. Bailus et al. Autophagy
- Molecular and cellular pathways contributing to brain aging
- (2021) Aliabbas Zia et al. Behavioral and Brain Functions
- Hippocampal proteomic analysis reveals activation of necroptosis and ferroptosis in a mouse model of chronic unpredictable mild stress-induced depression
- (2021) Huan Cao et al. BEHAVIOURAL BRAIN RESEARCH
- SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18
- (2021) Guangming Su et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mechanistic insights and perspectives involved in neuroprotective action of quercetin
- (2021) Amarjot Kaur Grewal et al. BIOMEDICINE & PHARMACOTHERAPY
- Exploring the Role of Monoamine Oxidase Activity in Aging and Alzheimer’s Disease
- (2021) Md. Sohanur Rahman et al. CURRENT PHARMACEUTICAL DESIGN
- Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats
- (2021) Ran Yang et al. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
- MACF1 alleviates aging‐related osteoporosis via HES1
- (2021) Chong Yin et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Microglial heterogeneity in aging and Alzheimer's disease: Is sex relevant?
- (2021) Charlotte Isabelle Delage et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Extracellular vesicles as a next-generation drug delivery platform
- (2021) Inge Katrin Herrmann et al. Nature Nanotechnology
- Lipopolysaccharide-induced depression is associated with estrogen receptor-α/SIRT1/NF-κB signaling pathway in old female mice
- (2021) Xi Jiang et al. NEUROCHEMISTRY INTERNATIONAL
- Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD
- (2021) Yong Zuo et al. Oxidative Medicine and Cellular Longevity
- Biased and allosteric modulation of bone cell-expressing G protein-coupled receptors as a novel approach to osteoporosis therapy
- (2021) Alexander Kalinkovich et al. PHARMACOLOGICAL RESEARCH
- Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism
- (2021) Xingtao Zhao et al. PHYTOTHERAPY RESEARCH
- Cognitive functions in late life depression
- (2021) Caroline Masse et al. Psychologie & NeuroPsychiatrie du Vieillissement
- Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node
- (2021) Yang Fang et al. Frontiers in Aging Neuroscience
- The Emerging Role of Circular RNAs in Alzheimer’s Disease and Parkinson’s Disease
- (2021) Meng Zhang et al. Frontiers in Aging Neuroscience
- Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus
- (2021) Wenxin Sha et al. Journal of Diabetes Research
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- (2021) Takeshi Terao Brain and Behavior
- Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis
- (2021) Zhihui Yin et al. Frontiers in Pharmacology
- Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy
- (2021) Xiaojuan Han et al. Redox Biology
- Ferroptosis: A Novel Therapeutic Target for Ischemia-Reperfusion Injury
- (2021) Yunqing Chen et al. Frontiers in Cell and Developmental Biology
- Parkinson’s Disease: A Nanotheranostic Approach Targeting Alpha-Synuclein Aggregation
- (2021) Fong LaiGuan Zoey et al. Frontiers in Cell and Developmental Biology
- Ferroptosis, a Potential Therapeutic Target in Alzheimer’s Disease
- (2021) Kai Chen et al. Frontiers in Cell and Developmental Biology
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- (2021) Min-Yen Hsu et al. Antioxidants
- Spatial epidemiology of diabetes: Methods and insights
- (2021) Diego F Cuadros et al. World Journal of Diabetes
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- (2021) Xuan Kang et al. BRAIN RESEARCH BULLETIN
- Attenuation of Pb-induced Aβ generation and autophagic dysfunction via activation of SIRT1: Neuroprotective properties of resveratrol
- (2021) Lin Bai et al. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
- Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease
- (2021) Darius J.R. Lane et al. Essays in Biochemistry
- SIRT1 Regulates Tau Expression and Tau Synaptic Pathology
- (2021) Xiaomin Yin et al. JOURNAL OF ALZHEIMERS DISEASE
- A Review of APOE Genotype-Dependent Autophagic Flux Regulation in Alzheimer’s Disease
- (2021) Huiyi Chen et al. JOURNAL OF ALZHEIMERS DISEASE
- Quercetin-mediated SIRT1 activation attenuates collagen-induced mice arthritis
- (2021) Pan Shen et al. JOURNAL OF ETHNOPHARMACOLOGY
- A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism
- (2021) Shahab Shahgaldi et al. LIFE SCIENCES
- Mitophagy in Huntington's disease
- (2021) I. Šonský et al. NEUROCHEMISTRY INTERNATIONAL
- Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage
- (2021) Yunxiao Dou et al. JOURNAL OF NANOBIOTECHNOLOGY
- Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways
- (2021) Xiang Wang et al. Acta Pharmaceutica Sinica B
- Roles of extracellular vesicles in the aging microenvironment and age‐related diseases
- (2021) Yujia Yin et al. Journal of Extracellular Vesicles
- A Novel Insight Into the Fate of Cardiomyocytes in Ischemia-Reperfusion Injury: From Iron Metabolism to Ferroptosis
- (2021) Jing-yan Li et al. Frontiers in Cell and Developmental Biology
- Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson’s Disease: Roads to Biomarker Discovery
- (2021) Anna Picca et al. Biomolecules
- Pterostilbene Attenuates Particulate Matter-Induced Oxidative Stress, Inflammation and Aging in Keratinocytes
- (2021) Wei-Lin Teng et al. Antioxidants
- Role of Nuclear factor kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach
- (2020) Shareen Singh et al. Current Neuropharmacology
- The ageing epigenome and its rejuvenation
- (2020) Weiqi Zhang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Effects and Mechanism of Quercetin Dietary Supplementation in Streptozotocin-Induced Hyperglycemic Arbor Acre Broilers
- (2020) Linlin Ying et al. Oxidative Medicine and Cellular Longevity
- Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC
- (2020) Fang Ke et al. Frontiers in Pharmacology
- Inhibitory Effect and Mechanism of Action of Quercetin and Quercetin Diels-Alder anti-Dimer on Erastin-Induced Ferroptosis in Bone Marrow-Derived Mesenchymal Stem Cells
- (2020) Xican Li et al. Antioxidants
- Extracellular vesicles as drug delivery systems: Why and how?
- (2020) Omnia M. Elsharkasy et al. ADVANCED DRUG DELIVERY REVIEWS
- Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mfice
- (2020) Tian Hu et al. Aging-US
- Quercetin induces apoptosis and enhances gemcitabine therapeutic efficacy against gemcitabine-resistant cancer cells
- (2020) Zhi-jie Liu et al. ANTI-CANCER DRUGS
- Quantitative Structure-Activity Relationship (QSAR) Studies for the Inhibition of MAOs
- (2020) Muthusamy Ramesh et al. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
- Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation
- (2020) Vivek Singh et al. INFLAMMATION
- Tyrosine mediated conformational change in bone morphogenetic protein – 2: Biophysical implications of protein – phytoestrogen interaction
- (2020) Monidipa Konar et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- SIRT1 and aging related signaling pathways
- (2020) Cui Chen et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Effect of Quercetin on PC12 Alzheimer’s Disease Cell Model Induced by Aβ25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway
- (2020) Xinjun Yu et al. Biomed Research International
- Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence
- (2020) Yue-Hua Jiang et al. Frontiers in Pharmacology
- Quercetin and chloroquine synergistically kill glioma cells by inducing organelle stress and disrupting Ca2+ homeostasis
- (2020) Eunjung Jang et al. BIOCHEMICAL PHARMACOLOGY
- Combination of quercetin and exercise training attenuates depression in rats with 1,2‐dimethylhydrazine‐induced colorectal cancer: Possible involvement of inflammation and BDNF signalling
- (2020) Shirin Sadighparvar et al. EXPERIMENTAL PHYSIOLOGY
- Anti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities
- (2020) Mariarosaria Boccellino et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Spiraeoside protects human cardiomyocytes against high glucose‐induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway
- (2020) Hongyang Liu et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats
- (2020) Alaa M. Ali et al. Oxidative Medicine and Cellular Longevity
- Molecular and Biological Functions of Quercetin as a Natural Solution for Cardiovascular Disease Prevention and Treatment
- (2020) Liaosadat Mirsafaei et al. PLANT FOODS FOR HUMAN NUTRITION
- Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain
- (2020) Jeremy Carlos Burns et al. eLife
- SIRT1 Activation by Natural Phytochemicals: An Overview
- (2020) Concetta Iside et al. Frontiers in Pharmacology
- Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons
- (2020) Lina Shi et al. Frontiers in Pediatrics
- Quercetin alleviates acute kidney injury by inhibiting ferroptosis
- (2020) Yue Wang et al. Journal of Advanced Research
- Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration
- (2020) Anna Picca et al. Antioxidants
- Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity
- (2020) Shin Sato et al. Journal of Inflammation Research
- Protective effect of Vigna unguiculata extract against aging and neurodegeneration
- (2020) Farida Tripodi et al. Aging-US
- Dietary quercetin attenuates depressive-like behaviors by inhibiting astrocyte reactivation in response to stress
- (2020) Jiajia Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Role of Forkhead transcription factors of the O class (FoxO) in development and progression of Alzheimer’s disease
- (2020) Shikha Goswami et al. CNS & Neurological Disorders-Drug Targets
- Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence
- (2020) Sok Kuan Wong et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases
- (2020) Fang Luo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Quercetin and vitamin E alleviate ovariectomy‐induced osteoporosis by modulating autophagy and apoptosis in rat bone cells
- (2020) Sina Vakili et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis
- (2020) Tao Liu et al. LIFE SCIENCES
- Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes
- (2020) Dan Li et al. Nutrients
- Ferroptosis Mechanisms Involved in Neurodegenerative Diseases
- (2020) Cadiele Oliana Reichert et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Iron Status is Associated with Mood, Cognition, and Functional Ability in Older Adults: A Cross-Sectional Study
- (2020) Carlos Portugal-Nunes et al. Nutrients
- Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway
- (2020) Dong Wang et al. Frontiers in Cell and Developmental Biology
- Fibroblast Senescence in Idiopathic Pulmonary Fibrosis
- (2020) Yifan Lin et al. Frontiers in Cell and Developmental Biology
- Quercetin mitigates ethanol-induced hepatic steatosis in zebrafish via P2X7R-mediated PI3K/ Keap1/Nrf2 signaling pathway
- (2020) Xingtao Zhao et al. JOURNAL OF ETHNOPHARMACOLOGY
- Quercetin exerts antidepressant and cardioprotective effects in estrogen receptor α-deficient female mice via BDNF-AKT/ERK1/2 signaling
- (2020) Guoli Wang et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Bioactivity of dietary polyphenols: The role of metabolites
- (2019) Simon Vlad Luca et al. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- Quercetin improve ischemia/reperfusion-induced cardiomyocyte apoptosis in vitro and in vivo study via SIRT1/PGC-1α signaling
- (2019) Jiayou Tang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Nrf2/ARE Pathway as a Therapeutic Target for the Treatment of Parkinson Diseases
- (2019) Artem P. Gureev et al. NEUROCHEMICAL RESEARCH
- Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function
- (2019) Munehiro Kitada et al. Frontiers in Endocrinology
- Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- (2019) Dong Xu et al. MOLECULES
- Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology
- (2019) Scott Ayton et al. MOLECULAR PSYCHIATRY
- SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex
- (2019) Yun Lei et al. MOLECULAR PSYCHIATRY
- Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model
- (2019) Kai Feng et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction
- (2019) Francesca Vinchi et al. EUROPEAN HEART JOURNAL
- Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease
- (2019) Elizabeta Zaplatic et al. LIFE SCIENCES
- A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease
- (2019) Sung Hoon Baik et al. Cell Metabolism
- The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications
- (2019) Jessica Maiuolo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model
- (2019) Pérez-Corredor Paula et al. MOLECULES
- Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis
- (2019) Golnaz Morad et al. ACS Nano
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- (2019) Francisco Rodríguez‐Félix et al. JOURNAL OF FOOD SCIENCE
- Ageing as a risk factor for neurodegenerative disease
- (2019) Yujun Hou et al. Nature Reviews Neurology
- Neuroinflammation as a Common Feature of Neurodegenerative Disorders
- (2019) Leonardo Guzman-Martinez et al. Frontiers in Pharmacology
- The therapeutic potential of quercetin in Parkinson’s disease: Insights into its molecular and cellular regulation
- (2019) Omid Reza Tamtaji et al. CURRENT DRUG TARGETS
- Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling
- (2019) Yuanbo Wu et al. MITOCHONDRION
- Neuroprotective Effect of Quercetin in Combination with Piperine Against Rotenone- and Iron Supplement–Induced Parkinson’s Disease in Experimental Rats
- (2019) Shakshi Sharma et al. NEUROTOXICITY RESEARCH
- Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
- (2019) Elizabeth Spangenberg et al. Nature Communications
- Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans
- (2019) Wijdan M. Dabeek et al. Nutrients
- Pharmacological Inhibitors of the NLRP3 Inflammasome
- (2019) Ayesha Zahid et al. Frontiers in Immunology
- The Role of Signaling Pathways of Inflammation and Oxidative Stress in Development of Senescence and Aging Phenotypes in Cardiovascular Disease
- (2019) John Papaconstantinou Cells
- Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- (2019) Si-Min Tang et al. BIOMEDICINE & PHARMACOTHERAPY
- Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages
- (2019) Yue Hu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells
- (2019) Hui Cao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Green Synthetic Nanoarchitectonics of Gold and Silver Nanoparticles Prepared Using Quercetin and Their Cytotoxicity and Catalytic Applications
- (2019) You Jeong Lee et al. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats
- (2018) Linan Qiu et al. BIOMEDICINE & PHARMACOTHERAPY
- Anti-Diabetic Effect of Cotreatment with Quercetin and Resveratrol in Streptozotocin-Induced Diabetic Rats
- (2018) Dong Kwon Yang et al. Biomolecules & Therapeutics
- Dietary nutraceuticals as backbone for bone health
- (2018) Manoj K. Pandey et al. BIOTECHNOLOGY ADVANCES
- Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults
- (2018) Zhanxin Yao et al. EUROPEAN JOURNAL OF NUTRITION
- Quercetin improves endothelial function in diabetic rats through inhibition of endoplasmic reticulum stress-mediated oxidative stress
- (2018) Natarajan Suganya et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway
- (2018) Chengtai Ma et al. Molecular Medicine Reports
- Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration in experimental rats: Biochemical and neurochemical evidences
- (2018) Shamsher Singh et al. NEUROSCIENCE RESEARCH
- Role and Possible Mechanisms of Sirt1 in Depression
- (2018) Guofang Lu et al. Oxidative Medicine and Cellular Longevity
- The effects of hesperidin and quercetin on serum tumor necrosis factor-alpha and interleukin-6 levels in streptozotocin-induced diabetes model
- (2018) Hatice Iskender et al. Pharmacognosy Magazine
- Ameliorating mitochondrial dysfunction restores carbon ion-induced cognitive deficits via co-activation of NRF2 and PINK1 signaling pathway
- (2018) Yang Liu et al. Redox Biology
- Skeletal muscle mitochondrial remodeling in exercise and diseases
- (2018) Zhenji Gan et al. CELL RESEARCH
- Quercetin preserves redox status and stimulates mitochondrial function in metabolically-stressed HepG2 cells
- (2018) Michael J. Houghton et al. FREE RADICAL BIOLOGY AND MEDICINE
- Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
- (2018) Luigi Ferrucci et al. Nature Reviews Cardiology
- New insights into the complex role of mitochondria in Parkinson’s disease
- (2018) Anne Grünewald et al. PROGRESS IN NEUROBIOLOGY
- Natural compounds acting at P2 receptors alleviate peripheral neuropathy
- (2018) Lifang Zou et al. BRAIN RESEARCH BULLETIN
- An atlas of genetic influences on osteoporosis in humans and mice
- (2018) John A. Morris et al. NATURE GENETICS
- Quercetin attenuates high fat diet-induced atherosclerosis in apolipoprotein E knockout mice: A critical role of NADPH oxidase
- (2017) Lin Xiao et al. FOOD AND CHEMICAL TOXICOLOGY
- Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation
- (2017) David Porras et al. FREE RADICAL BIOLOGY AND MEDICINE
- Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells
- (2017) Xiu‑Yin Shen et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-κB and HO-1/Nrf2 Pathways
- (2017) Entaz Bahar et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
- (2017) Eric Tönnies et al. JOURNAL OF ALZHEIMERS DISEASE
- Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease
- (2017) Muhammet Ay et al. JOURNAL OF NEUROCHEMISTRY
- Therapies targeting DNA and RNA in Huntington's disease
- (2017) Edward J Wild et al. LANCET NEUROLOGY
- Neuropathic pain attenuates ischemia reperfusion injury through β2-adrenergic pathway
- (2017) Shigeaki Kawai et al. LIFE SCIENCES
- Safety Aspects of the Use of Quercetin as a Dietary Supplement
- (2017) Susanne Andres et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
- (2017) Christoph Anacker et al. NATURE REVIEWS NEUROSCIENCE
- New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain
- (2017) Eva L. Feldman et al. NEURON
- Treadmill Exercise Attenuates α-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson’s Disease
- (2017) Jung-Hoon Koo et al. NEUROTOXICITY RESEARCH
- Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus
- (2017) Yi-Fen Cheng et al. Nature Communications
- Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1
- (2017) Jing Peng et al. Journal of Diabetes Research
- Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line
- (2017) R. Dhanya et al. Frontiers in Pharmacology
- Extracellular vesicles for drug delivery
- (2016) Pieter Vader et al. ADVANCED DRUG DELIVERY REVIEWS
- A synopsis on aging—Theories, mechanisms and future prospects
- (2016) João Pinto da Costa et al. AGEING RESEARCH REVIEWS
- Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-κB signaling pathway
- (2016) Shobha Bhaskar et al. CELLULAR IMMUNOLOGY
- The role of mitochondrial sirtuins in health and disease
- (2016) Brenna Osborne et al. FREE RADICAL BIOLOGY AND MEDICINE
- Quercetin attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways
- (2016) Chengqiu Li et al. GENE
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- (2016) B. Li et al. GENETICS AND MOLECULAR RESEARCH
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- (2016) Hemat E. El-Horany et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Quercetin modulates toll-like receptor-mediated protein kinase signaling pathways in oxLDL-challenged human PBMCs and regulates TLR-activated atherosclerotic inflammation in hypercholesterolemic rats
- (2016) Shobha Bhaskar et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
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- (2016) Richa Gupta et al. MOLECULAR NEUROBIOLOGY
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- (2016) Tony Wyss-Coray NATURE
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- (2016) Yan Kong et al. Oncotarget
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- (2016) Catalina Carrasco-Pozo et al. Redox Biology
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- (2016) Kuan Rong Chan et al. Nature Microbiology
- Programmed cell death in aging
- (2015) John Tower AGEING RESEARCH REVIEWS
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- (2015) Kasthuri Bai Magalingam et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
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- (2015) T. K. Y. Lim et al. JOURNAL OF NEUROSCIENCE
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- (2015) J. Chakraborty et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation
- (2015) Ching-Hsia Hung et al. MOLECULAR NUTRITION & FOOD RESEARCH
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
- (2015) Michael Lazarou et al. NATURE
- Quercetin reduces eIF2α phosphorylation by GADD34 induction
- (2015) Miki Hayakawa et al. NEUROBIOLOGY OF AGING
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- (2015) Nataša Mrvová et al. NEUROCHEMISTRY INTERNATIONAL
- Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways
- (2015) Iandra Holzmann et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection
- (2015) Luis Leyton et al. VIRUS RESEARCH
- Trends in Hospitalizations and Outcomes for Acute Cardiovascular Disease and Stroke, 1999–2011
- (2014) Harlan M. Krumholz et al. CIRCULATION
- Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)
- (2014) Teresa Valero CURRENT PHARMACEUTICAL DESIGN
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- (2014) Hui Liu et al. GENE
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- (2014) Rafael Antonio Casuso et al. Genes and Nutrition
- Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1
- (2014) Jing Dong et al. JOURNAL OF LIPID RESEARCH
- Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation
- (2014) Mahdi Garelnabi et al. Journal of the International Society of Sports Nutrition
- Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
- (2014) Edward T. Chouchani et al. NATURE
- Quercetin mitigates Adriamycin-induced anxiety- and depression-like behaviors, immune dysfunction, and brain oxidative stress in rats
- (2014) Sameha Merzoug et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Effects of Long-Term Treatment with Quercetin on Cognition and Mitochondrial Function in a Mouse Model of Alzheimer’s Disease
- (2014) Dong-Mei Wang et al. NEUROCHEMICAL RESEARCH
- Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
- (2014) E. Seto et al. Cold Spring Harbor Perspectives in Biology
- Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells
- (2013) G Bardy et al. BRITISH JOURNAL OF PHARMACOLOGY
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons
- (2013) Ruishan Wang et al. Cell Metabolism
- Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3-Nitropropionic Acid-Induced Rat Model of Huntington's Disease
- (2013) Joy Chakraborty et al. CNS Neuroscience & Therapeutics
- Pink1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced akt and increased p38 mapk activation, and downregulation of egfr
- (2013) Insup Choi et al. GLIA
- A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration
- (2013) J. Graff et al. JOURNAL OF NEUROSCIENCE
- Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson’s disease in rats
- (2013) S.S. Karuppagounder et al. NEUROSCIENCE
- Quercetin suppress microglial neuroinflammatory response and induce antidepressent-like effect in olfactory bulbectomized rats
- (2013) P. Rinwa et al. NEUROSCIENCE
- Quercetin supplementation is effective in improving mitochondrial dysfunctions induced by 3-nitropropionic acid: Implications in Huntington's disease
- (2012) Rajat Sandhir et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Quercetin and Sesamin Protect Dopaminergic Cells from MPP+-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System
- (2012) Julie Bournival et al. Oxidative Medicine and Cellular Longevity
- Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine
- (2011) Napatr Sriraksa et al. Evidence-based Complementary and Alternative Medicine
- Protective effects of baicalin and quercetin on an iron-overloaded mouse: comparison of liver, kidney and heart tissues
- (2011) Yan Zhang et al. NATURAL PRODUCT RESEARCH
- Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
- (2011) Mali Jiang et al. NATURE MEDICINE
- DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
- (2010) Kelly Jean Thomas et al. HUMAN MOLECULAR GENETICS
- Protective Effects of Resveratrol and Quercetin Against MPP+ -Induced Oxidative Stress Act by Modulating Markers of Apoptotic Death in Dopaminergic Neurons
- (2009) Julie Bournival et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures
- (2008) Tiina M. Kääriäinen et al. BRAIN RESEARCH
- Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors
- (2008) Raj N Kalaria et al. LANCET NEUROLOGY
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