Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels

The glucocorticoid receptor–FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder

(2020) Haiyin Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Huntingtin Lowering Strategies

(2020) Franz Marxreiter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Huntingtin-Lowering Therapies for Huntington Disease

(2020) Blair R. Leavitt et al.   JAMA Neurology

Meso scale discovery-based assays for the detection of aggregated huntingtin

(2019) Wolfgang Reindl et al.   PLoS One

Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP+

(2019) Wassamon Boonying et al.   JOURNAL OF NEUROCHEMISTRY

Targeting Huntingtin Expression in Patients with Huntington’s Disease

(2019) Sarah J. Tabrizi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment

(2019) Ellen Quarles et al.   AGING CELL

Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model

(2018) Natalie Matosin et al.   BIOLOGICAL PSYCHIATRY

Self-assembly of Mutant Huntingtin Exon-1 Fragments into Large Complex Fibrillar Structures Involves Nucleated Branching

(2018) Anne S. Wagner et al.   JOURNAL OF MOLECULAR BIOLOGY

High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration

(2018) Ismael Al-Ramahi et al.   Cell Systems

Decrease of the Immunophilin FKBP52 Accumulation in Human Brains of Alzheimer's Disease and FTDP-17

(2018) Julien Giustiniani et al.   JOURNAL OF ALZHEIMERS DISEASE

Proline Residues as Switches in Conformational Changes Leading to Amyloid Fibril Formation

(2017) Ajda Taler-Verčič et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hsp90 and FKBP51: complex regulators of psychiatric diseases

(2017) Marangelie Criado-Marrero et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome

(2017) Gabriela Caraveo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function

(2017) Georgia Balsevich et al.   Nature Communications

Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice

(2016) João Luís Neto et al.   GENETICS

Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA

(2016) Paul J. Kemp et al.   JOURNAL OF PHYSIOLOGY-LONDON

Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice

(2016) Peter Langfelder et al.   NATURE NEUROSCIENCE

Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice

(2016) João Luís Neto et al.   GENETICS

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

(2015) Katherine H. Schreiber et al.   AGING CELL

The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease

(2015) Laura J. Blair et al.   JOURNAL OF NEUROCHEMISTRY

A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies

(2015) Ulrike Schmidt et al.   PSYCHONEUROENDOCRINOLOGY

Schizophrenia in the Spectrum of Gene-Stress Interactions: The FKBP5 Example

(2015) N. P. Daskalakis et al.   SCHIZOPHRENIA BULLETIN

Autophagy in Huntington disease and huntingtin in autophagy

(2015) Dale D.O. Martin et al.   TRENDS IN NEUROSCIENCES

Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect

(2015) Chia-Sui Sun et al.   Scientific Reports

Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington’s Disease Neural Stem Cells

(2015) Karen L. Ring et al.   Stem Cell Reports

Selective inhibitors of the FK506-binding protein 51 by induced fit

(2014) Steffen Gaali et al.   Nature Chemical Biology

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

(2014) Nils C. Gassen et al.   PLOS MEDICINE

FKBPs and the Akt/mTOR pathway

(2013) Felix Hausch et al.   CELL CYCLE

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

(2013) Laura J. Blair et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice

(2013) Stefana Albu et al.   JOURNAL OF SLEEP RESEARCH

An evolutionary conserved pattern of 18S rRNA sequence complementarity to mRNA 5′ UTRs and its implications for eukaryotic gene translation regulation

(2013) Josef Pánek et al.   NUCLEIC ACIDS RESEARCH

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin

(2013) Nicholas Stephane Caron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells

(2012) Mahru C. An et al.   Cell Stem Cell

Physical Chemistry of Polyglutamine: Intriguing Tales of a Monotonous Sequence

(2012) Ronald Wetzel   JOURNAL OF MOLECULAR BIOLOGY

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175

(2012) Liliana B. Menalled et al.   PLoS One

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

(2012) Taneli Heikkinen et al.   PLoS One

FK506 Binding Protein 5 Shapes Stress Responsiveness: Modulation of Neuroendocrine Reactivity and Coping Behavior

(2011) Chadi Touma et al.   BIOLOGICAL PSYCHIATRY

FKBPs in chromatin modification and cancer

(2011) Ya-Li Yao et al.   CURRENT OPINION IN PHARMACOLOGY

Organization and function of the FKBP52 and FKBP51 genes

(2011) Donna L Cioffi et al.   CURRENT OPINION IN PHARMACOLOGY

A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease

(2011) Damian M. Cummings et al.   JOURNAL OF NEUROPHYSIOLOGY

The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress

(2011) Jakob Hartmann et al.   NEUROPHARMACOLOGY

A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

(2011) John C. O'Leary et al.   PLoS One

FKBP51 and FKBP52 in signaling and disease

(2011) Cheryl L. Storer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Broadening the therapeutic scope for rapamycin treatment

(2010) Fiona M. Menzies et al.   Autophagy

Does Huntingtin play a role in selective macroautophagy?

(2010) Joan S. Steffan   CELL CYCLE

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of FK506 Binding Proteins Reduces  -Synuclein Aggregation and Parkinson's Disease-Like Pathology

(2010) M. Gerard et al.   JOURNAL OF NEUROSCIENCE

The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

(2010) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

(2009) Liliana Menalled et al.   NEUROBIOLOGY OF DISEASE

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION