Skeletal muscle mitochondrial remodeling in exercise and diseases

Parkin is required for exercise-induced mitophagy in muscle: impact of aging

(2018) Chris Chin Wah Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity

(2018) Tingting Fu et al.   Cell Reports

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

On the role of Mitofusin 2 in endoplasmic reticulum–mitochondria tethering

(2017) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?

(2017) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria and Epigenetics – Crosstalk in Homeostasis and Stress

(2017) Olli Matilainen et al.   TRENDS IN CELL BIOLOGY

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

(2017) Yunjong Lee et al.   Cell Reports

Slow recovery of the impaired fatigue resistance in postunloading mouse soleus muscle corresponding to decreased mitochondrial function and a compensatory increase in type I slow fibers

(2016) Han-Zhong Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Adult expression of PGC-1α and -1β in skeletal muscle is not required for endurance exercise-induced enhancement of exercise capacity

(2016) Christopher Ballmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation

(2016) Marlou L. Dirks et al.   DIABETES

Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

(2016) David Sebastián et al.   EMBO JOURNAL

Coupling of mitochondrial function and skeletal muscle fiber type by a miR‐499/Fnip1/AMPK circuit

(2016) Jing Liu et al.   EMBO Molecular Medicine

The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function

(2016) Adam J. Santanasto et al.   EXPERIMENTAL GERONTOLOGY

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

(2016) Hyo Kyun Chung et al.   JOURNAL OF CELL BIOLOGY

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

(2016) D. Ryu et al.   Science Translational Medicine

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

(2016) Eoin McDonnell et al.   Cell Reports

CODAS Syndrome Is Associated with Mutations of LONP1, Encoding Mitochondrial AAA+ Lon Protease

(2015) Kevin A. Strauss et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization

(2015) Prashant Mishra et al.   Cell Metabolism

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

(2015) Tatiana Varanita et al.   Cell Metabolism

Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

(2015) Gabriele Civiletto et al.   Cell Metabolism

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

(2015) Changhan Lee et al.   Cell Metabolism

PGC-1α overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization

(2015) Chounghun Kang et al.   FASEB JOURNAL

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis

(2015) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial reticulum for cellular energy distribution in muscle

(2015) Brian Glancy et al.   NATURE

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

(2015) G. Gong et al.   SCIENCE

Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation

(2015) T Touvier et al.   Cell Death & Disease

KLF15 and PPARαCooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation

(2015) Domenick A. Prosdocimo et al.   PPAR Research

Oxidative proteome alterations during skeletal muscle ageing

(2015) Sofia Lourenço dos Santos et al.   Redox Biology

PGC-1α modulates denervation-induced mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   Skeletal Muscle

Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis

(2014) Vladimir Ljubicic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Multilayered Genetic and Omics Dissection of Mitochondrial Activity in a Mouse Reference Population

(2014) Yibo Wu et al.   CELL

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss

(2014) Bryn M. Owen et al.   Cell Metabolism

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Receptor-mediated mitophagy in yeast and mammalian systems

(2014) Lei Liu et al.   CELL RESEARCH

Evidence for a Direct Effect of the NAD+Precursor Acipimox on Muscle Mitochondrial Function in Humans

(2014) Tineke van de Weijer et al.   DIABETES

Aging impairs the recovery in mechanical muscle function following 4days of disuse

(2014) L.G. Hvid et al.   EXPERIMENTAL GERONTOLOGY

Kruppel-like Factor 15 Is a Critical Regulator of Cardiac Lipid Metabolism

(2014) Domenick A. Prosdocimo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Organellophagy: Eliminating cellular building blocks via selective autophagy

(2014) Koji Okamoto   JOURNAL OF CELL BIOLOGY

PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice

(2014) Jessica Cannavino et al.   JOURNAL OF PHYSIOLOGY-LONDON

Skeletal Muscle Mitochondrial Function and Fatigability in Older Adults

(2014) Adam J. Santanasto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Insulin Receptor Substrates Are Essential for the Bioenergetic and Hypertrophic Response of the Heart to Exercise Training

(2014) C. Riehle et al.   MOLECULAR AND CELLULAR BIOLOGY

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Estrogen-Related Receptor-α Coordinates Transcriptional Programs Essential for Exercise Tolerance and Muscle Fitness

(2014) Marie-Claude Perry et al.   MOLECULAR ENDOCRINOLOGY

Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy

(2014) Nicholas L. Reyes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity

(2014) Pedro M. Quirós et al.   Cell Reports

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

(2014) Silvia Carnio et al.   Cell Reports

Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy

(2014) Angeliki Chalkiadaki et al.   PLoS Genetics

Skeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia

(2013) Benjamin T. Wall et al.   AGEING RESEARCH REVIEWS

Perrault Syndrome Is Caused by Recessive Mutations in CLPP, Encoding a Mitochondrial ATP-Dependent Chambered Protease

(2013) Emma M. Jenkinson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

A map of the PPARα transcription regulatory network for primary human hepatocytes

(2013) Patrick D. McMullen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A Role for Peroxisome Proliferator-Activated Receptor γ Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth

(2013) Ola J. Martin et al.   CIRCULATION RESEARCH

Signaling pathways controlling skeletal muscle mass

(2013) Marc A. Egerman et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Estrogen-related receptor-α (ERRα) deficiency in skeletal muscle impairs regeneration in response to injury

(2013) Samuel LaBarge et al.   FASEB JOURNAL

Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans

(2013) Gilles Gouspillou et al.   FASEB JOURNAL

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

(2013) S. Gispert et al.   HUMAN MOLECULAR GENETICS

Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1)- and Estrogen-related Receptor (ERR)-induced Regulator in Muscle 1 (PERM1) Is a Tissue-specific Regulator of Oxidative Capacity in Skeletal Muscle Cells

(2013) Yoshitake Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism

(2013) Zhenji Gan et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging

(2013) Anna-Maria Joseph et al.   PLoS One

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Disconnecting Mitochondrial Content from Respiratory Chain Capacity in PGC-1-Deficient Skeletal Muscle

(2013) Glenn C. Rowe et al.   Cell Reports

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals

(2012) Anna-Maria Joseph et al.   AGING CELL

AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm

(2012) Marion Pauly et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle

(2012) Deborah M. Muoio et al.   Cell Metabolism

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Mitochondrial quality control: a matter of life and death for neurons

(2012) Elena I Rugarli et al.   EMBO JOURNAL

Four days of muscle disuse impairs single fiber contractile function in young and old healthy men

(2012) Lars G. Hvid et al.   EXPERIMENTAL GERONTOLOGY

The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms

(2012) Lorenza Brocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

(2012) Hisashi Hasumi et al.   JNCI-Journal of the National Cancer Institute

Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults

(2012) Paul M. Coen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Defective Mitochondrial Morphology and Bioenergetic Function in Mice Lacking the Transcription Factor Yin Yang 1 in Skeletal Muscle

(2012) S. M. Blattler et al.   MOLECULAR AND CELLULAR BIOLOGY

Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes

(2012) Yanfang Chen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Rescue of Dystrophic Skeletal Muscle by PGC-1α Involves a Fast to Slow Fiber Type Shift in the mdx Mouse

(2012) Joshua T. Selsby et al.   PLoS One

PGC-1α is Dispensable for Exercise-Induced Mitochondrial Biogenesis in Skeletal Muscle

(2012) Glenn C. Rowe et al.   PLoS One

Aging Affects the Transcriptional Regulation of Human Skeletal Muscle Disuse Atrophy

(2012) Charlotte Suetta et al.   PLoS One

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation

(2012) S. M. Haldar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Autophagy as a new therapeutic target in Duchenne muscular dystrophy

(2012) C De Palma et al.   Cell Death & Disease

PGC-1α Promotes Nitric Oxide Antioxidant Defenses and Inhibits FOXO Signaling Against Cardiac Cachexia in Mice

(2011) Tuoyu Geng et al.   AMERICAN JOURNAL OF PATHOLOGY

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Exercise and PGC-1α-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERRγ

(2011) Vihang A. Narkar et al.   Cell Metabolism

The nuclear receptor PPAR /  programs muscle glucose metabolism in cooperation with AMPK and MEF2

(2011) Z. Gan et al.   GENES & DEVELOPMENT

Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle

(2011) V. Ljubicic et al.   HUMAN MOLECULAR GENETICS

Molecular mechanisms and physiologic functions of mitochondrial dynamics

(2011) H. Otera et al.   JOURNAL OF BIOCHEMISTRY

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

(2011) Anu Suomalainen et al.   LANCET NEUROLOGY

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

(2011) Julia Szendroedi et al.   Nature Reviews Endocrinology

AMP-activated protein kinase (AMPK)  1 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

(2011) H. M. O'Neill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity

(2010) Christoph Zechner et al.   Cell Metabolism

Mitochondrial myopathy induces a starvation-like response

(2010) Henna Tyynismaa et al.   HUMAN MOLECULAR GENETICS

Estrogen-related Receptor γ Is a Key Regulator of Muscle Mitochondrial Activity and Oxidative Capacity

(2010) Shamina M. Rangwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

(2010) Jeffrey J. Brault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Profiling of promoter occupancy by PPARα in human hepatoma cells via ChIP-chip analysis

(2010) David L. M. van der Meer et al.   NUCLEIC ACIDS RESEARCH

Aberrant Mitochondrial Homeostasis in the Skeletal Muscle of Sedentary Older Adults

(2010) Adeel Safdar et al.   PLoS One

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver

(2009) Manu V. Chakravarthy et al.   CELL

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance

(2009) Eva van Rooij et al.   DEVELOPMENTAL CELL

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Effects of aging on human skeletal muscle after immobilization and retraining

(2009) C. Suetta et al.   JOURNAL OF APPLIED PHYSIOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

(2008) Vincent Giguère   ENDOCRINE REVIEWS

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ

(2008) Yumiko Oishi et al.   NATURE MEDICINE

Hormesis in aging

(2007) Suresh I.S. Rattan   AGEING RESEARCH REVIEWS

Mitochondrial function and apoptotic susceptibility in aging skeletal muscle

(2007) Béatrice Chabi et al.   AGING CELL

PGC-1α is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle

(2007) Lotte Leick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM