Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson’s Disease: Roads to Biomarker Discovery

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

(2021) Juan Carlos Polanco et al.   ACTA NEUROPATHOLOGICA

Potential of extracellular vesicles in the Parkinson's disease – Pathological mediators and biomarkers

(2021) Yuan Zhao et al.   NEUROCHEMISTRY INTERNATIONAL

Circulating extracellular vesicles: friends and foes in neurodegeneration

(2021) Riccardo Calvani et al.   Neural Regeneration Research

Blood contains circulating cell‐free respiratory competent mitochondria

(2020) Zahra Al Amir Dache et al.   FASEB JOURNAL

CHCHD2 harboring the Parkinson’s disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2

(2020) Tom Cornelissen et al.   HUMAN MOLECULAR GENETICS

Initiation and propagation of α-synuclein aggregation in the nervous system

(2020) Baraa A. Hijaz et al.   Molecular Neurodegeneration

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

(2020) Michael Khalil et al.   Nature Communications

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels

(2020) Ali Manouchehrinia et al.   Annals of Clinical and Translational Neurology

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson’s Disease: Results from the EXosomes in PArkiNson’s Disease (EXPAND) Study

(2020) Anna Picca et al.   Journal of Clinical Medicine

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations

(2020) Yi-Ting Liu et al.   HUMAN MOLECULAR GENETICS

α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease

(2020) Cecilia S. Lindestam Arlehamn et al.   Nature Communications

Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease

(2020) Anna Picca et al.   Journal of Clinical Medicine

A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson’s disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study

(2020) Riccardo Calvani et al.   GeroScience

Mechanisms of mitochondrial DNA escape and its relationship with different metabolic diseases

(2020) Perla Pérez-Treviño et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Peripheral inflammation exacerbates α‐synuclein toxicity and neuropathology in Parkinson's models

(2020) P. La Vitola et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Serum neurofilament light chain predicts long term clinical outcomes in multiple sclerosis

(2020) Simon Thebault et al.   Scientific Reports

Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study

(2020) Stefan Bittner et al.   EBioMedicine

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration

(2020) Anna Picca et al.   Antioxidants

Neurofilaments in motor neuron disorders: towards promising diagnostic and prognostic biomarkers

(2020) Elisabetta Zucchi et al.   Molecular Neurodegeneration

Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy

(2020) Ana Belen Malpartida et al.   TRENDS IN BIOCHEMICAL SCIENCES

Neuropathological and Biomarker Findings in Parkinson’s Disease and Alzheimer’s Disease: From Protein Aggregates to Synaptic Dysfunction

(2020) Yaroslau Compta et al.   Journal of Parkinsons Disease

Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease

(2020) Anna Picca et al.   Frontiers in Immunology

Exosomes in Parkinson’s disease: current perspectives and future challenges

(2019) Lin Yuan et al.   ACS Chemical Neuroscience

α-Synuclein and Glia in Parkinson’s Disease: A Beneficial or a Detrimental Duet for the Endo-Lysosomal System?

(2019) Alice Filippini et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease

(2019) Fiona Bonello et al.   HUMAN MOLECULAR GENETICS

Serum NFL discriminates Parkinson disease from atypical parkinsonisms

(2019) Tainá M. Marques et al.   NEUROLOGY

Longitudinal analysis of serum neurofilament light chain: A potential therapeutic monitoring biomarker for multiple sclerosis

(2019) Jae-Won Hyun et al.   Multiple Sclerosis Journal

Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles

(2019) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10

(2019) Fieke Wauters et al.   Autophagy

Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration

(2019) Valentina Durante et al.   BRAIN

Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study

(2019) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neurofilament light chain as a biomarker in neurological disorders

(2019) Lorenzo Gaetani et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neurofilament Light Chain as a Biomarker in Multiple Sclerosis

(2019) Kristin N. Varhaug et al.   Frontiers in Neurology

Neurofilament light chain in the assessment of patients with multiple sclerosis

(2019) Renan Barros DOMINGUES et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

CSF and blood biomarkers for Parkinson's disease

(2019) Lucilla Parnetti et al.   LANCET NEUROLOGY

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology

(2019) Claire Bridel et al.   JAMA Neurology

Cerebrospinal fluid neurofilament light chain predicts disease activity after the first demyelinating event suggestive of multiple sclerosis

(2019) Lorenzo Gaetani et al.   Multiple Sclerosis and Related Disorders

Insights into ubiquitin chain architecture using Ub-clipping

(2019) Kirby N. Swatek et al.   NATURE

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Association Between Serum Neurofilament Light Chain Levels and Long-term Disease Course Among Patients With Multiple Sclerosis Followed up for 12 Years

(2019) Ester Cantó et al.   JAMA Neurology

The metabolomics side of frailty: Toward personalized medicine for the aged

(2019) Anna Picca et al.   EXPERIMENTAL GERONTOLOGY

Mutations in CHCHD2 cause α-synuclein aggregation

(2019) Aya Ikeda et al.   HUMAN MOLECULAR GENETICS

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease

(2019) Paraskevi Krashia et al.   Nature Communications

Characterization of Parkinson’s disease using blood-based biomarkers: A multicohort proteomic analysis

(2019) Marijan Posavi et al.   PLOS MEDICINE

Circulating amino acid signature in older people with Parkinson's disease: A metabolic complement to the EXosomes in PArkiNson Disease (EXPAND) study

(2019) Anna Picca et al.   EXPERIMENTAL GERONTOLOGY

Molecular biomarkers in multiple sclerosis

(2019) Tjalf Ziemssen et al.   Journal of Neuroinflammation

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

(2018) Xu Hou et al.   Autophagy

Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis

(2018) Christian Barro et al.   BRAIN

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis

(2018) Irene Håkansson et al.   Journal of Neuroinflammation

CSF inflammatory biomarkers responsive to treatment in progressive multiple sclerosis capture residual inflammation associated with axonal damage

(2018) Jeppe Romme Christensen et al.   Multiple Sclerosis Journal

Mechanism of parkin activation by PINK1

(2018) Christina Gladkova et al.   NATURE

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plasma neurofilament light chain concentration in the inherited peripheral neuropathies

(2018) Åsa Sandelius et al.   NEUROLOGY

Neuropathology of Parkinson disease

(2018) Dennis W. Dickson   PARKINSONISM & RELATED DISORDERS

Evolution of cerebrospinal fluid total α-synuclein in Parkinson's disease

(2018) Marthe Gurine Førland et al.   PARKINSONISM & RELATED DISORDERS

TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons

(2018) Layal Maatouk et al.   Nature Communications

CSF inflammatory biomarkers responsive to treatment in progressive multiple sclerosis capture residual inflammation associated with axonal damage

(2018) Jeppe Romme Christensen et al.   Multiple Sclerosis Journal

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

(2018) Serge Grazioli et al.   Frontiers in Immunology

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration

(2018) Veronica Ghiglieri et al.   Frontiers in Neurology

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

(2018) Juan Carlos Polanco et al.   Acta Neuropathologica Communications

Neurofilaments as biomarkers in neurological disorders

(2018) Michael Khalil et al.   Nature Reviews Neurology

REM behavior disorder predicts motor progression and cognitive decline in Parkinson disease

(2018) Gennaro Pagano et al.   NEUROLOGY

Finding useful biomarkers for Parkinson’s disease

(2018) Alice S. Chen-Plotkin et al.   Science Translational Medicine

Parkinson’s Disease: Biomarkers, Treatment, and Risk Factors

(2018) Fatemeh N. Emamzadeh et al.   Frontiers in Neuroscience

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Recent Advances in Biomarkers for Parkinson’s Disease

(2018) Runcheng He et al.   Frontiers in Aging Neuroscience

Potential Modes of Intercellular α-Synuclein Transmission

(2017) Dario Valdinocci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets

(2017) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies

(2017) Richard J. Karpowicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk factors for early psychosis in PD: insights from the Parkinson's Progression Markers Initiative

(2017) Dominic H ffytche et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

CSF biomarkers β-amyloid, tau proteins and a-synuclein in the differential diagnosis of Parkinson-plus syndromes

(2017) Vasilios C. Constantinides et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson's disease: a longitudinal cohort study and validation

(2017) Jeanne C Latourelle et al.   LANCET NEUROLOGY

Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson's disease: a cohort study

(2017) Anette Schrag et al.   LANCET NEUROLOGY

Tau/α-synuclein ratio and inflammatory proteins in Parkinson's disease: An exploratory study

(2017) Manuel Delgado-Alvarado et al.   MOVEMENT DISORDERS

Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients

(2017) Lucilla Parnetti et al.   MOVEMENT DISORDERS

Metabolomic biomarkers as strong correlates of Parkinson disease progression

(2017) Peter A. LeWitt et al.   NEUROLOGY

Monitoring disease activity in multiple sclerosis using serum neurofilament light protein

(2017) Lenka Novakova et al.   NEUROLOGY

Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

(2017) Hongrui Meng et al.   Nature Communications

The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer

(2017) Jie Yin et al.   Journal of Immunology Research

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

(2017) Jennifer Ngolab et al.   Acta Neuropathologica Communications

Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease

(2017) Chelsea Caspell-Garcia et al.   PLoS One

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

(2016) A. Verkhratsky et al.   EMBO JOURNAL

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's Disease

(2016) Sara Hall et al.   MOVEMENT DISORDERS

Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression

(2016) Nour K. Majbour et al.   MOVEMENT DISORDERS

Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis

(2016) Lenka Novakova et al.   Multiple Sclerosis Journal

α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era

(2016) Naomi P. Visanji et al.   TRENDS IN NEUROSCIENCES

Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis

(2016) Lenka Novakova et al.   Multiple Sclerosis Journal

Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study

(2016) Magnus Gisslén et al.   EBioMedicine

Neurofilaments as Biomarkers for Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

(2016) Zhouwei Xu et al.   PLoS One

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

(2015) Marcel Kunadt et al.   ACTA NEUROPATHOLOGICA

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

(2015) Anne Stuendl et al.   BRAIN

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

(2015) F. C. Fiesel et al.   EMBO REPORTS

CSF β-Amyloid 1-42 Predicts Progression to Cognitive Impairment in Newly Diagnosed Parkinson Disease

(2015) Mark Terrelonge et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

(2015) Giulio Disanto et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis

(2015) J. Kuhle et al.   NEUROLOGY

Invited review: Frontotemporal dementia caused bymicrotubule-associated protein taugene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

(2015) Bernardino Ghetti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Amyloid-β and α-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease

(2015) Ane Løvli Stav et al.   PARKINSONISM & RELATED DISORDERS

CSF tau and tau/Aβ42 predict cognitive decline in Parkinson's disease

(2015) Changqin Liu et al.   PARKINSONISM & RELATED DISORDERS

Cerebrospinal Fluid Patterns and the Risk of Future Dementia in Early, Incident Parkinson Disease

(2015) David C. Bäckström et al.   JAMA Neurology

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

(2014) Min Shi et al.   ACTA NEUROPATHOLOGICA

Cerebrospinal Fluid α-Synuclein Predicts Cognitive Decline in Parkinson Disease Progression in the DATATOP Cohort

(2014) Tessandra Stewart et al.   AMERICAN JOURNAL OF PATHOLOGY

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

(2014) Stephanie M.Y. Kong et al.   HUMAN MOLECULAR GENETICS

Acceleration of α-Synuclein Aggregation by Exosomes

(2014) Marie Grey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease

(2014) Lucilla Parnetti et al.   MOVEMENT DISORDERS

Direct and indirect pathways of basal ganglia: a critical reappraisal

(2014) Paolo Calabresi et al.   NATURE NEUROSCIENCE

CSF A 42 predicts early-onset dementia in Parkinson disease

(2014) G. Alves et al.   NEUROLOGY

Natalizumab in progressive MS: Results of an open-label, phase 2A, proof-of-concept trial

(2014) J. Romme Christensen et al.   NEUROLOGY

CSF biomarkers and clinical progression of Parkinson disease

(2014) S. Hall et al.   NEUROLOGY

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

(2014) Vinay K. Godena et al.   Nature Communications

Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers

(2014) Jan O. Aasly et al.   Frontiers in Aging Neuroscience

Differential role of CSF alpha-synuclein species, tau, and Aβ42 in Parkinson's Disease

(2014) Lucilla Parnetti et al.   Frontiers in Aging Neuroscience

Longitudinal assessment of tau and amyloid beta in cerebrospinal fluid of Parkinson disease

(2013) Jing Zhang et al.   ACTA NEUROPATHOLOGICA

Exosomes as a novel way of interneuronal communication

(2013) Mathilde Chivet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Immunosuppressive therapy reduces axonal damage in progressive multiple sclerosis

(2013) Markus Axelsson et al.   Multiple Sclerosis Journal

Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD

(2013) Chongwang Chang et al.   NEUROSCIENCE LETTERS

Combined dementia-risk biomarkers in Parkinson's disease: A prospective longitudinal study

(2013) Yaroslau Compta et al.   PARKINSONISM & RELATED DISORDERS

CSF levels of DJ-1 and tau distinguish MSA patients from PD patients and controls

(2013) Megan K. Herbert et al.   PARKINSONISM & RELATED DISORDERS

Neuropathologic substrates of Parkinson disease dementia

(2012) David J. Irwin et al.   ANNALS OF NEUROLOGY

Accuracy of a Panel of 5 Cerebrospinal Fluid Biomarkers in the Differential Diagnosis of Patients With Dementia and/or Parkinsonian Disorders

(2012) Sara Hall et al.   ARCHIVES OF NEUROLOGY

Neurofilaments at a glance

(2012) A. Yuan et al.   JOURNAL OF CELL SCIENCE

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRI

(2012) Anne Bertrand et al.   NEUROIMAGE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?

(2011) Y. Compta et al.   BRAIN

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

(2011) David Ramonet et al.   HUMAN MOLECULAR GENETICS

α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study

(2011) Brit Mollenhauer et al.   LANCET NEUROLOGY

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

(2011) F. Ros-Bernal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab

(2010) Martin Gunnarsson et al.   ANNALS OF NEUROLOGY

Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression

(2010) Min Shi et al.   ANNALS OF NEUROLOGY

Relationships between age and late progression of Parkinson's disease: a clinico-pathological study

(2010) P. A. Kempster et al.   BRAIN

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease

(2009) Lilia Marinova-Mutafchieva et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

(2009) Aaron D Gitler et al.   NATURE GENETICS

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Striatal β-Amyloid Deposition in Parkinson Disease With Dementia

(2008) Michail E. Kalaitzakis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY