Ferroptosis in Parkinson’s disease: glia–neuron crosstalk

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis

(2021) Jian-Jun Guo et al.   Cell Death & Disease

Regional brain iron and gene expression provide insights into neurodegeneration in Parkinson’s disease

(2021) George E C Thomas et al.   BRAIN

miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease

(2021) Xinrong Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Thioredoxin-1 Rescues MPP+/MPTP-Induced Ferroptosis by Increasing Glutathione Peroxidase 4

(2021) Liping Bai et al.   MOLECULAR NEUROBIOLOGY

Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

(2021) Wan-Yang Sun et al.   Nature Chemical Biology

Parkinson’s Disease: Alterations in Iron and Redox Biology as a Key to Unlock Therapeutic Strategies

(2021) L. Ma et al.   Redox Biology

Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients

(2021) Boyd Kenkhuis et al.   Acta Neuropathologica Communications

The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson’s disease

(2021) Emma Biondetti et al.   BRAIN

Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease

(2021) I. Friedrich et al.   Acta Neuropathologica Communications

Apoferritin improves motor deficits in MPTP-treated mice by regulating brain iron metabolism and ferroptosis

(2021) Li-Mei Song et al.   iScience

Super-enhancer-driven Sorting Nexin 5 expression promotes dopaminergic neuronal ferroptosis in Parkinson's disease models

(2021) Wenwen Si et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-induced senescence of PC12 cells

(2021) Shanshan Li et al.   TOXICOLOGY IN VITRO

Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions

(2021) Di Liu et al.   Translational Neurodegeneration

Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI

(2021) Frédérique Depierreux et al.   npj Parkinsons Disease

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

(2020) Alexandr A. Kapralov et al.   Nature Chemical Biology

Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease

(2020) Costanza L. Vallerga et al.   Nature Communications

DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

(2020) Ji Cao et al.   Nature Communications

Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement

(2020) Jared M. Fine et al.   Brain and Behavior

Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson’s disease increase cellular susceptibility to oxidative stress

(2020) Carlos A. Aguirre et al.   BRAIN BEHAVIOR AND IMMUNITY

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

(2020) Plamena R. Angelova et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease

(2020) Pei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

(2020) Julien Bryois et al.   NATURE GENETICS

Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain

(2020) Chaitali Mukherjee et al.   Cell Metabolism

Parkinson’s disease: etiopathogenesis and treatment

(2020) Joseph Jankovic et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells

(2020) Yiran Sun et al.   MOLECULAR NEUROBIOLOGY

The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis

(2020) Li Jiang et al.   ACTA PHARMACOLOGICA SINICA

Microglia and astrocyte dysfunction in parkinson's disease

(2020) Tae-In Kam et al.   NEUROBIOLOGY OF DISEASE

FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson’s Disease

(2020) Ye Tian et al.   Neurotherapeutics

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

(2020) Devika Agarwal et al.   Nature Communications

Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism

(2020) Cristina Fernández-Mendívil et al.   Redox Biology

Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro

(2019) Young J. Yauger et al.   Journal of Neuroinflammation

Lymphoproliferation Impairment and Oxidative Stress in Blood Cells from Early Parkinson’s Disease Patients

(2019) Carmen Vida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Iron-induced oxidative stress contributes to α-synuclein phosphorylation and up-regulation via polo-like kinase 2 and casein kinase 2

(2019) Ranran Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Microglia-mediated neuroinflammation in neurodegenerative diseases

(2019) Charannya Sozheesvari Subhramanyam et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

N‐Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease

(2019) Daniel A. Monti et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Targeting ferroptosis in rhabdomyosarcoma cells

(2019) Jasmin Dächert et al.   INTERNATIONAL JOURNAL OF CANCER

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

(2019) Caitlin W. Brown et al.   DEVELOPMENTAL CELL

New Progress on the Role of Glia in Iron Metabolism and Iron-Induced Degeneration of Dopamine Neurons in Parkinson’s Disease

(2018) Huamin Xu et al.   Frontiers in Molecular Neuroscience

Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis

(2018) Tetsuro Ishii et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP+ Neurotoxicity

(2018) Jeong Baek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress

(2017) Lisa D. Coles et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis

(2017) Sergei A. Novgorodov et al.   JOURNAL OF LIPID RESEARCH

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment

(2017) Wei Song et al.   NEUROBIOLOGY OF AGING

The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

(2017) Mohsen Taghizadeh et al.   NEUROCHEMISTRY INTERNATIONAL

Iron accumulation and microglia activation contribute to substantia nigra hyperechogenicity in the 6-OHDA-induced rat model of Parkinson's disease

(2017) Yaqin Zhu et al.   PARKINSONISM & RELATED DISORDERS

Phase IIb Study of Intranasal Glutathione in Parkinson’s Disease

(2017) Laurie K. Mischley et al.   Journal of Parkinsons Disease

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

(2017) Jennifer Ngolab et al.   Acta Neuropathologica Communications

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes

(2016) Saïda Abounit et al.   EMBO JOURNAL

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson’s disease and its progression: Disease and staging biomarkers and new drug targets

(2016) Carine Coneglian de Farias et al.   NEUROSCIENCE LETTERS

Direct Observation of α-Synuclein Amyloid Aggregates in Endocytic Vesicles of Neuroblastoma Cells

(2016) Mihaela M. Apetri et al.   PLoS One

Significant glial alterations in response to iron loading in a novel organotypic hippocampal slice culture model

(2016) Sinead Healy et al.   Scientific Reports

Ceruloplasmin is Involved in the Nigral Iron Accumulation of 6-OHDA-Lesioned Rats

(2015) Jun Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes

(2015) Anne Burtey et al.   FASEB JOURNAL

Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson’s Disease Model

(2015) Neha Sharma et al.   MOLECULAR NEUROBIOLOGY

α-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons

(2015) Richard Ortega et al.   MOLECULAR NEUROBIOLOGY

Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson’s disease

(2015) L.-H. You et al.   NEUROSCIENCE

Does High-Dose Coenzyme Q10 Improve Oxidative Damage and Clinical Outcomes in Parkinson's Disease?

(2014) Raymond Chee-Seong Seet et al.   ANTIOXIDANTS & REDOX SIGNALING

Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor inhibit ferrous iron influx via divalent metal transporter 1 and iron regulatory protein 1 regulation in ventral mesencephalic neurons

(2014) Hao-Yun Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

(2014) Scott Ayton et al.   Biomed Research International

A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

(2014) et al.   JAMA Neurology

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Pro-inflammatory cytokines modulate iron regulatory protein 1 expression and iron transportation through reactive oxygen/nitrogen species production in ventral mesencephalic neurons

(2013) Jia Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

N-acetylcysteine Boosts Brain and Blood Glutathione in Gaucher and Parkinson Diseases

(2013) Mary J. Holmay et al.   CLINICAL NEUROPHARMACOLOGY

Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model

(2013) Fabia Febbraro et al.   EXPERIMENTAL NEUROLOGY

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Coenzyme Q10 deficiency in patients with Parkinson's disease

(2012) Laurie K. Mischley et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

α-Synuclein expression is modulated at the translational level by iron

(2012) Fabia Febbraro et al.   NEUROREPORT

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Oxidative Damage and Decreased Antioxidant Function in Aging Human Substantia Nigra Compared to Striatum: Implications for Parkinson’s Disease

(2011) C. Venkateshappa et al.   NEUROCHEMICAL RESEARCH

Correction: Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity

(2010) Ikuko Miyazaki et al.   GLIA

Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease

(2009) Robert A. Hauser et al.   MOVEMENT DISORDERS

The life, death, and replacement of oligodendrocytes in the adult CNS

(2008) Dana M. McTigue et al.   JOURNAL OF NEUROCHEMISTRY

DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone

(2008) Steven J. Mullett et al.   NEUROBIOLOGY OF DISEASE