Review
Biochemistry & Molecular Biology
Hiroki Kitakata, Jin Endo, Hidehiko Ikura, Hidenori Moriyama, Kohsuke Shirakawa, Yoshinori Katsumata, Motoaki Sano
Summary: This review discusses the molecular mechanisms of DOX-induced cardiotoxicity, focusing on apoptosis and ferroptosis as the two forms of programmed cell death. Possible therapeutic strategies to prevent DOX cardiotoxicity are also outlined, along with the significance of mitochondrial homeostasis disruption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bei Wang, Yuxuan Jin, Jiao Liu, Qian Liu, Yujun Shen, Shengkai Zuo, Ying Yu
Summary: Chemotherapeutic agent doxorubicin (DOX) can cause cardiomyopathy and potentially life-threatening arrhythmias in cancer patients. This study reveals that the prostaglandin E2 (PGE2)/EP1 axis plays a critical role in protecting cardiomyocytes from DOX-induced ferroptosis. EP1 activation promotes nuclear factor erythroid 2-related factor 2 (Nrf2)-driven anti-oxidative gene expression and prevents ferroptotic cell death. The findings suggest that activating EP1 may be a promising strategy for preventing and treating DOX-induced cardiomyopathy.
Article
Surgery
Youcheng Zeng, Guodong Cao, Liang Lin, Yixin Zhang, Xiqing Luo, Xiaoyu Ma, Akelibieke Aiyisake, Qinghong Cheng
Summary: This study demonstrated that resveratrol (RSV) can improve cardiac function and reverse abnormalities in sepsis-induced cardiomyopathy (SIC) by inhibiting ferroptosis via upregulation of the Sirt1/Nrf2 signaling pathways. The selective Sirt1 inhibitor, EX527, diminished the therapeutic effects of RSV. These findings suggest that RSV may be an effective therapeutic approach against organ failure in sepsis, particularly SIC.
JOURNAL OF INVESTIGATIVE SURGERY
(2023)
Article
Neurosciences
Chang Li, Ziyi Wu, Hang Xue, Qiushi Gao, Yahan Zhang, Changming Wang, Ping Zhao
Summary: The study investigates the role of ferroptosis in hypoxic-ischemic brain injury (HIBI) and its underlying signaling pathways. It reveals that inhibiting ferroptosis through the SIRT1/Nrf2/GPx4 pathway can alleviate brain damage and improve learning and memory abilities in HIBI.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Zhang Qiongyue, Yang Xin, Peng Meng, Mi Sulin, Wang Yanlin, Li Xinyi, Song Xuemin
Summary: This study demonstrates the involvement of ferroptosis, a new type of cell death, in the pathogenesis of sepsis-associated acute kidney injury (SA-AKI). The results show that post-treatment with irisin can inhibit ferroptosis and alleviate SA-AKI through the activation of the SIRT1/Nrf2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Zhang Wei, Qian Shaohuan, Kang Pinfang, Shi Chao
Summary: This study confirms that curcumin can ameliorate diabetic cardiomyopathy by promoting nuclear translocation of Nrf2, increasing the expression of oxidative scavenging factors, and inhibiting glucose-induced ferroptosis in cardiomyocytes.
CARDIOVASCULAR THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Shihua Deng, Jin Li, Li Li, Sheng Lin, Yueyan Yang, Teng Liu, Ting Zhang, Guangsu Xie, Dongming Wu, Ying Xu
Summary: This study demonstrates that quercetin protects against LPS-induced ALI by inhibiting ferroptosis through the activation of the Sirt1/Nrf2/Gpx4 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Xiang Wang, Xinxin Chen, Wenqian Zhou, Hongbo Men, Terigen Bao, Yike Sun, Quanwei Wang, Yi Tan, Bradley B. Keller, Qian Tong, Yang Zheng, Lu Cai
Summary: The role of ferroptosis in the pathogenesis of diabetic cardiomyopathy (DCM) was investigated, and it was found that ferroptosis plays an essential role in DCM. Sulforaphane was able to prevent ferroptosis and associated pathogenesis, suggesting a potential therapeutic approach.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Immunology
Qing Ruan, Cuijie Wang, Yunfeng Zhang, Jiayang Sun
Summary: This study found that brevilin A can protect mice against osteoarthritis by suppressing inflammatory response and ferroptosis through regulating the SIRT1/Nrf2/GPX4 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Lihua Zhao, Lei Jin, Bin Yang
Summary: The study revealed that saikosaponin A (SSA) protected against Staphylococcus aureus (S. aureus)-induced mastitis by suppressing inflammation and ferroptosis through the activation of the SIRT1/Nrf2 pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Xin Lin, Xiaoxia Zhao, Qingfeng Chen, Xiaoyue Wang, Yongya Wu, Hao Zhao
Summary: This study found that quercetin can inhibit sepsis-induced cardiomyopathy (SIC) by activating the SIRT1/p53/SLC7A11 signaling pathway and reducing ferroptosis. These findings provide a potential therapeutic strategy for the management of SIC.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Piergiorgio La Rosa, Sara Petrillo, Riccardo Turchi, Francesco Berardinelli, Tommaso Schirinzi, Gessica Vasco, Daniele Lettieri-Barbato, Maria Teresa Fiorenza, Enrico S. Bertini, Katia Aquilano, Fiorella Piemonte
Summary: Ferroptosis is a form of iron-dependent cell death that may be involved in Friedreich's Ataxia. Nrf2 signaling plays a crucial role in ferroptosis, suggesting it as a potential target to combat neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Dongxu Wang, Kai Yin, Yue Zhang, Hongmin Lu, Lulu Hou, Hongjing Zhao, Mingwei Xing
Summary: In this study, ferroptosis was identified as a key mechanism of fluoride-induced liver injury, leading to lipid peroxidation and iron accumulation. Activation of the SIRT1/FOXOs pathway was found to activate the Nrf2/HO-1 pathway and the P53-dependent ferroptosis pathway, ultimately causing liver damage. These findings provide insight into the mechanism of fluoride-induced liver injury and offer potential strategies for its treatment.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Zi-Shen Zhou, Chen-Fan Kong, Jian-Rong Sun, Xiang-Ke Qu, Jin-Hui Sun, An-Tao Sun
Summary: This study found that fisetin can prevent alcohol-induced liver toxicity by suppressing the activation of hepatic stellate cells (HSCs), promoting SIRT1-mediated autophagy, and inhibiting Sphk1-mediated endoplasmic reticulum stress (ER stress).
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Bo Wang, Li-na Yang, Le-tian Yang, Yan Liang, Fan Guo, Ping Fu, Liang Ma
Summary: The natural flavonol fisetin has therapeutic effects against fibrotic kidney diseases by inhibiting ACS14-mediated tubular ferroptosis, alleviating inflammation and fibrogenesis, and protecting the kidneys from damage.
ACTA PHARMACOLOGICA SINICA
(2023)