A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism

SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPKα signaling pathway

(2020) Jieyun Hong et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inhibiting protein kinase activity of pyruvate kinase M2 by sirtuin 2 deacetylase attenuates psoriasis

(2020) Lihua Hao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

SIRT6 protects retinal ganglion cells against hydrogen peroxide-induced apoptosis and oxidative stress by promoting Nrf2/ARE signaling via inhibition of Bach1

(2019) Jingni Yu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Succinylation-dependent mitochondrial translocation of PKM2 promotes cell survival in response to nutritional stress

(2019) Hailong Qi et al.   Cell Death & Disease

MHY2233 Attenuates Replicative Cellular Senescence in Human Endothelial Progenitor Cells via SIRT1 Signaling

(2019) Shreekrishna Lamichane et al.   Oxidative Medicine and Cellular Longevity

SIRT2, ERK and Nrf2 Mediate NAD+ Treatment-Induced Increase in the Antioxidant Capacity of PC12 Cells Under Basal Conditions

(2019) Jie Zhang et al.   Frontiers in Molecular Neuroscience

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other’s activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy

(2019) Abhinav Kanwal et al.   FASEB JOURNAL

SIRT3-MEDIATED MACROPHAGE PYRUVATE DEHYDROGENASE ACTIVITY IMPROVES PERIVASCULAR ADIPOSE TISSUE REMODELING IN HYPERTENSIVE MICE

(2019) T. Wei et al.   JOURNAL OF HYPERTENSION

SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170

(2019) Sarallah Rezazadeh et al.   NUCLEIC ACIDS RESEARCH

P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy

(2019) Fuzhe Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy

(2019) Wen-Ning Xu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Resveratrol ameliorates rheumatoid arthritis via activation of SIRT1‐Nrf2 signaling pathway

(2019) Gaoyuan Wang et al.   BIOFACTORS

Sirt7 inhibits Sirt1-mediated activation of Suv39h1

(2018) Poonam Kumari et al.   CELL CYCLE

SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer

(2018) Xiu‐Fei Chen et al.   EMBO REPORTS

SIRT7 functions in redox homeostasis and cytoskeletal organization during oocyte maturation

(2018) Min Gao et al.   FASEB JOURNAL

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy

(2018) Valentina Celestini et al.   Cell Death & Disease

Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress

(2018) Lisha Zhao et al.   Redox Biology

PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis

(2018) Maayan Waldman et al.   EXPERIMENTAL CELL RESEARCH

Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor

(2017) Sun-O Ka et al.   FASEB JOURNAL

Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1ɑ-SOD2-mediated regulation of mitochondrial function

(2017) Yong Ding et al.   International Journal of Biological Sciences

Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis

(2017) Lu Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA-binding Protein Quaking StabilizesSirt2mRNA during Oligodendroglial Differentiation

(2017) Merlin P. Thangaraj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

(2017) Xiaoyan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis

(2017) Young Cha et al.   NATURE CELL BIOLOGY

Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1

(2017) Jian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

(2017) Jun Li et al.   SCIENCE

CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis

(2017) Min Jun Jang et al.   Cell Death & Disease

Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation

(2017) Emeric Limagne et al.   Cell Reports

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

(2017) Fang Wang et al.   Cell Reports

Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency

(2017) Adél Szabó et al.   Scientific Reports

PGC-1α/ERRα-Sirt3 Pathway Regulates DAergic Neuronal Death by Directly Deacetylating SOD2 and ATP Synthase β

(2016) Xuefei Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3α-dependent antioxidant defense mechanisms

(2016) Xiao-Xiao Wang et al.   BASIC RESEARCH IN CARDIOLOGY

AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia

(2016) So Dam Lee et al.   CANCER LETTERS

SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents

(2016) Warren Fiskus et al.   CANCER RESEARCH

SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth

(2016) Seong-Hoon Park et al.   CANCER RESEARCH

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

(2016) Huize Pan et al.   CELL RESEARCH

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense

(2016) Lisha Zhou et al.   EMBO REPORTS

Who watches the watchmen? Regulation of the expression and activity of sirtuins

(2016) Marcin Buler et al.   FASEB JOURNAL

SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells

(2016) Wei Cao et al.   FEBS LETTERS

SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro

(2016) YING-WEI DING et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

SIRT3 participates in glucose metabolism interruption and apoptosis induced by BH3 mimetic S1 in ovarian cancer cells

(2016) Xi-Yan Xiang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The role of sirtuins in cellular homeostasis

(2016) Wioleta Kupis et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity

(2016) J Cai et al.   ONCOGENE

Potential Modulation of Sirtuins by Oxidative Stress

(2016) Leonardo Santos et al.   Oxidative Medicine and Cellular Longevity

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

(2016) Sushabhan Sadhukhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair, Longevity, and Health Span

(2016) Borut Poljsak et al.   REJUVENATION RESEARCH

Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome

(2016) Lianhui Sun et al.   Nature Communications

Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth

(2016) Ye Xiangyun et al.   Oncotarget

Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis

(2016) Sivan Elhanati et al.   Cell Reports

Sirtuins Link Inflammation and Metabolism

(2016) Vidula T. Vachharajani et al.   Journal of Immunology Research

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK

(2016) Linh Ho et al.   Aging-US

SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9–Rad1–Hus1 checkpoint clamp

(2015) Bor-Jang Hwang et al.   BMC MOLECULAR BIOLOGY

SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth

(2015) H. Yang et al.   EMBO JOURNAL

The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells

(2015) Moran Choe et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3

(2015) Pankaj K. Bagul et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation

(2015) Ching-Hsia Hung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

SIRT3 protects cells from hypoxia via PGC-1α- and MnSOD-dependent pathways

(2015) Q. Wang et al.   NEUROSCIENCE

Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization

(2015) L Wei et al.   Cell Death & Disease

E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells

(2015) Minghui Wu et al.   Oncotarget

SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells

(2015) Yang Cui et al.   PLoS One

Oxidative Stress Activates SIRT2 to Deacetylate and Stimulate Phosphoglycerate Mutase

(2014) Y. Xu et al.   CANCER RESEARCH

Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

(2014) Selma Masri et al.   CELL

Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity

(2014) Rommel A. Mathias et al.   CELL

SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway

(2014) Tatsuya Yoshizawa et al.   Cell Metabolism

Ubiquitin-Specific Peptidase USP22 Negatively Regulates the STAT Signaling Pathway by Deubiquitinating SIRT1

(2014) Ning Ao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

(2014) Ozkan Ozden et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents

(2014) Minh Truong Do et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex

(2014) Jun Fan et al.   MOLECULAR CELL

SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation

(2014) K-S Seo et al.   ONCOGENE

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated microRNA-34a in obesity reduces NAD+levels and SIRT1 activity by directly targeting NAMPT

(2013) Sung-E Choi et al.   AGING CELL

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

(2013) Zhi-Feng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: Implications for vascular aging

(2013) María José Zarzuelo et al.   BIOCHEMICAL PHARMACOLOGY

SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1 -Dependent Glycolysis

(2013) G. Liu et al.   CANCER RESEARCH

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT4 Represses Peroxisome Proliferator-Activated Receptor α Activity To Suppress Hepatic Fat Oxidation

(2013) Gaëlle Laurent et al.   MOLECULAR AND CELLULAR BIOLOGY

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

(2013) Ruiting Lin et al.   MOLECULAR CELL

SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

(2013) Gaëlle Laurent et al.   MOLECULAR CELL

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol

(2013) Ning Xia et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

A fluorogenic assay for screening Sirt6 modulators

(2013) Jing Hu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress

(2013) Yusuke S. Hori et al.   PLoS One

Ca2+/calmodulin-dependent protein kinase kinase   phosphorylation of Sirtuin 1 in endothelium is atheroprotective

(2013) L. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

(2013) L Wei et al.   Cell Death & Disease

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

Multiple Regulatory Layers of SREBP1/2 by SIRT6

(2013) Sivan Elhanati et al.   Cell Reports

Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1

(2013) Judith Katto et al.   Clinical Epigenetics

Grape Seed Proanthocyanidin Extracts Enhance Endothelial Nitric Oxide Synthase Expression through 5^|^#8242;-AMP Activated Protein Kinase/Surtuin 1^|^#8211;Kr^|^uuml;pple Like Factor 2 Pathway and Modulate Blood Pressure in Ouabain Induced Hypertensive Rats

(2012) Xiaopei Cui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Inhibition of the human deacylase Sirtuin 5 by the indole GW5074

(2012) Benjamin Suenkel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Dietary obesity-associated Hif1  activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system

(2012) J. Krishnan et al.   GENES & DEVELOPMENT

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

(2012) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

(2012) John E. Dominy et al.   MOLECULAR CELL

Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions

(2012) Alexander Laemmle et al.   PLoS One

Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition

(2012) Frank Fischer et al.   PLoS One

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

(2012) Melanie Gertz et al.   PLoS One

Regulation of Sirtuin Function by Posttranslational Modifications

(2012) Franziska Flick et al.   Frontiers in Pharmacology

Sirtuin 1 in lipid metabolism and obesity

(2011) Thaddeus T. Schug et al.   ANNALS OF MEDICINE

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

(2011) H. Yuan et al.   BLOOD

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Cancer Cell Survival Following DNA Damage-mediated Premature Senescence Is Regulated by Mammalian Target of Rapamycin (mTOR)-dependent Inhibition of Sirtuin 1

(2011) Jung Ho Back et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation

(2011) William C. Hallows et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1

(2011) Na Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Stabilization of Suv39H1 by SirT1 Is Part of Oxidative Stress Response and Ensures Genome Protection

(2011) Laia Bosch-Presegué et al.   MOLECULAR CELL

Peptide Switch Is Essential for Sirt1 Deacetylase Activity

(2011) Hyeog Kang et al.   MOLECULAR CELL

Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase

(2011) Wenqing Jiang et al.   MOLECULAR CELL

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

Activation of Peroxisome Proliferator-Activated Receptor Gamma by Rosiglitazone Increases Sirt6 Expression and Ameliorates Hepatic Steatosis in Rats

(2011) Soo Jin Yang et al.   PLoS One

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol

(2010) Gnanapragasam Arunachalam et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of the p65/RelA subunit of NF-κB in TNF-α-induced SIRT1 expression in vascular smooth muscle cells

(2010) Hui-Na Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver

(2010) Joo-Man Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

(2010) A. K. Walker et al.   GENES & DEVELOPMENT

SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells

(2010) Nargis Nasrin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1

(2010) Xiumei Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

(2010) Limin Han et al.   NUCLEIC ACIDS RESEARCH

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

The ageing epigenome: Damaged beyond repair?

(2009) David A. Sinclair et al.   AGEING RESEARCH REVIEWS

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1

(2009) S. B. Rajamohan et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity

(2009) Nargis Nasrin et al.   PLoS One

SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

(2008) Myung-Kwan Han et al.   Cell Stem Cell

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

Necdin Regulates p53 Acetylation via Sirtuin1 to Modulate DNA Damage Response in Cortical Neurons

(2008) K. Hasegawa et al.   JOURNAL OF NEUROSCIENCE

SIRT2 Suppresses Adipocyte Differentiation by Deacetylating FOXO1 and Enhancing FOXO1's Repressive Interaction with PPARγ

(2008) Fei Wang et al.   MOLECULAR BIOLOGY OF THE CELL

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE

DBC1 is a negative regulator of SIRT1

(2008) Ja-Eun Kim et al.   NATURE

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA