Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk

(2021) Zihao Li et al.   Oxidative Medicine and Cellular Longevity

miR-107 affects cartilage matrix degradation in the pathogenesis of knee osteoarthritis by regulating caspase-1

(2021) Jiatian Qian et al.   Journal of Orthopaedic Surgery and Research

Amelioration of diabetes‐induced inflammation mediated pyroptosis, sarcopenia, and adverse muscle remodelling by bone morphogenetic protein‐7

(2021) Chandrakala Aluganti Narasimhulu et al.   Journal of Cachexia Sarcopenia and Muscle

Co-treatment with disulfiram and glycyrrhizic acid suppresses the inflammatory response of chondrocytes

(2021) Chao Li et al.   Journal of Orthopaedic Surgery and Research

USP7 Inhibition Alleviates H2O2-Induced Injury in Chondrocytes via Inhibiting NOX4/NLRP3 Pathway

(2021) Gang Liu et al.   Frontiers in Pharmacology

The P2X7 Receptor in Osteoarthritis

(2021) Zihao Li et al.   Frontiers in Cell and Developmental Biology

RIP1 Perturbation Induces Chondrocyte Necroptosis and Promotes Osteoarthritis Pathogenesis via Targeting BMP7

(2021) Jin Cheng et al.   Frontiers in Cell and Developmental Biology

G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1

(2021) Yi Sun et al.   MOLECULAR MEDICINE

Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration

(2021) Y. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus

(2021) Wenxin Sha et al.   Journal of Diabetes Research

Exogenous stromal cell-derived factor-1 (SDF-1) suppresses the NLRP3 inflammasome and inhibits pyroptosis in synoviocytes from osteoarthritic joints via activation of the AMPK signaling pathway

(2021) Shuya Wang et al.   INFLAMMOPHARMACOLOGY

D‐mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF‐2α‐dependent manner

(2021) Xueman Zhou et al.   CELL PROLIFERATION

Chronic Ethanol Consumption Induces Osteopenia via Activation of Osteoblast Necroptosis

(2021) Man Guo et al.   Oxidative Medicine and Cellular Longevity

LINC00623/miR-101/HRAS axis modulates IL-1β-mediated ECM degradation, apoptosis and senescence of osteoarthritis chondrocytes

(2020) Guohua Lü et al.   Aging-US

Implication of cell migration inducing hyaluronidase 1 (CEMIP) in hyaluronan degradation by synovial fibroblasts in patients with knee osteoarthritis

(2020) Jun Shiozawa et al.   AMERICAN JOURNAL OF PATHOLOGY

Notch Signaling in Skeletal Development, Homeostasis and Pathogenesis

(2020) Jennifer T. Zieba et al.   Biomolecules

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis

(2020) Yingying Yu et al.   BLOOD

TNF‐α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury

(2020) Yao Wang et al.   CELL PROLIFERATION

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

LncRNA PVT1 induces chondrocyte apoptosis through upregulation of TNF-α in synoviocytes by sponging miR-211-3p

(2020) Kai Xu et al.   MOLECULAR AND CELLULAR PROBES

MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis

(2020) L. Xu et al.   OSTEOARTHRITIS AND CARTILAGE

COVID-19: Melatonin as a potential adjuvant treatment

(2020) Rui Zhang et al.   LIFE SCIENCES

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

(2020) Holly Anderton et al.   Nature Reviews Rheumatology

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

Baicalin Protects Human OA Chondrocytes Against IL-1β-Induced Apoptosis and ECM Degradation by Activating Autophagy via MiR-766-3p/AIFM1 Axis

(2020) Zhi Li et al.   Drug Design Development and Therapy

TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis

(2020) Jimin Jeon et al.   ANNALS OF THE RHEUMATIC DISEASES

Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases

(2020) Fang Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation

(2020) Zijian Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes

(2020) Jian Tian et al.   Pain Research & Management

LncRNA SNHG7 alleviates IL-1β-induced osteoarthritis by inhibiting miR-214-5p-mediated PPARGC1B signaling pathways

(2020) Junkui Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Relationship between the pyroptosis of fibroblast‑like synoviocytes and HMGB1 secretion in knee osteoarthritis

(2020) Yancheng Xiao et al.   Molecular Medicine Reports

Icariin enhances cell survival in lipopolysaccharide‑induced synoviocytes by suppressing ferroptosis via the Xc‑/GPX4 axis

(2020) Huasong Luo et al.   Experimental and Therapeutic Medicine

PLCγ1 inhibition combined with inhibition of apoptosis and necroptosis increases cartilage matrix synthesis in IL‐1β‐treated rat chondrocytes

(2020) Xiaolei Chen et al.   FEBS Open Bio

Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling

(2020) Huan Yu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chondrocyte ferroptosis contribute to the progression of osteoarthritis

(2020) Xudong Yao et al.   Journal of Orthopaedic Translation

Increased HIF-1α in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis

(2019) Li Zhang et al.   Oxidative Medicine and Cellular Longevity

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

(2019) Scott Ayton et al.   MOLECULAR PSYCHIATRY

Ligustilide attenuates nitric oxide-induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways

(2019) Yan Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Excessive mechanical stress induces chondrocyte apoptosis through TRPV4 in an anterior cruciate ligament-transected rat osteoarthritis model

(2019) Bo Xu et al.   LIFE SCIENCES

MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling

(2019) Chen Cai et al.   Aging-US

Low dose of indomethacin and Hedgehog signaling inhibitor administration synergistically attenuates cartilage damage in osteoarthritis by controlling chondrocytes pyroptosis

(2019) Qingbai Liu et al.   GENE

Inhibition of Synovial Macrophage Pyroptosis Alleviates Synovitis and Fibrosis in Knee Osteoarthritis

(2019) Li Zhang et al.   MEDIATORS OF INFLAMMATION

Evidence of necroptosis in osteoarthritic disease: investigation of blunt mechanical impact as possible trigger in regulated necrosis

(2019) Jana Riegger et al.   Cell Death & Disease

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

(2019) Yan Zu et al.   Journal of Orthopaedic Surgery and Research

MIR-140-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting HMGB1 in osteoarthritis

(2019) Yingjie Wang et al.   INFLAMMATION RESEARCH

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

(2019) Kajarabille et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The potential role of necroptosis in inflammaging and aging

(2019) Gordon H. Royce et al.   GeroScience

Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes

(2019) Jiaming Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Melatonin Prevents Osteoarthritis-Induced Cartilage Degradation via Targeting MicroRNA-140

(2019) Yijian Zhang et al.   Oxidative Medicine and Cellular Longevity

Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis

(2018) Songfeng Chen et al.   APOPTOSIS

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

(2018) Yubin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

4-Phenylbutyric acid presents therapeutic effect on osteoarthritis via inhibiting cell apoptosis and inflammatory response induced by endoplasmic reticulum stress

(2018) Yang-hua Tang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Melatonin Suppresses Estrogen Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the NLRP3 Inflammasome

(2018) Lijun Xu et al.   CALCIFIED TISSUE INTERNATIONAL

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

(2018) Francine F.S. Ke et al.   CELL

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

(2018) Shouya Feng et al.   JOURNAL OF MOLECULAR BIOLOGY

Recent Advances in the Molecular Mechanisms Underlying Pyroptosis in Sepsis

(2018) Yu-Lei Gao et al.   MEDIATORS OF INFLAMMATION

NLRP1 and NLRP3 inflammasomes mediate LPS/ATP‑induced pyroptosis in knee osteoarthritis

(2018) Ling‑Rui Zhao et al.   Molecular Medicine Reports

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

(2018) Jie Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice

(2018) Bao-Shu Xie et al.   CNS Neuroscience & Therapeutics

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Estradiol inhibits NLRP3 inflammasome in fibroblast-like synoviocytes activated by lipopolysaccharide and adenosine triphosphate

(2017) Jianfeng Shi et al.   International Journal of Rheumatic Diseases

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

(2017) Yves Dondelinger et al.   NATURE CELL BIOLOGY

Mechanical force-mediated pathological cartilage thinning is regulated by necroptosis and apoptosis

(2017) C. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis

(2017) Sefi Zargarian et al.   PLOS BIOLOGY

Necroptosis and Inflammation

(2016) Kim Newton et al.   Annual Review of Biochemistry

Iron depletion enhances the effect of sorafenib in hepatocarcinoma

(2016) Shinichi Urano et al.   CANCER BIOLOGY & THERAPY

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Inflammatory cytokines induce caveolin-1/β-catenin signalling in rat nucleus pulposus cell apoptosis through the p38 MAPK pathway

(2016) Jianxi Wang et al.   CELL PROLIFERATION

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease

(2016) Hao Zhou et al.   HEPATOLOGY

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

(2016) Azam Hosseinzadeh et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Herniated Lumbar Intervertebral Disk

(2016) Richard A. Deyo et al.   NEW ENGLAND JOURNAL OF MEDICINE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

The RIP1–RIP3 Complex Mediates Osteocyte Necroptosis after Ovariectomy in Rats

(2016) Hongwang Cui et al.   PLoS One

Necrostatin-1 treatment inhibits osteocyte necroptosis and trabecular deterioration in ovariectomized rats

(2016) Hongwang Cui et al.   Scientific Reports

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

(2015) Zhaoyang Liu et al.   Science Signaling

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

(2015) Zhaoyang Liu et al.   Science Signaling

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The individual and socioeconomic impact of osteoarthritis

(2014) David J. Hunter et al.   Nature Reviews Rheumatology

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

RBPjκ-dependent Notch signaling is required for articular cartilage and joint maintenance

(2013) Anthony J. Mirando et al.   ARTHRITIS AND RHEUMATISM

Mechanisms of apoptotic phosphatidylserine exposure

(2013) Guillermo Mariño et al.   CELL RESEARCH

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

(2013) Jianfeng Wu et al.   CELL RESEARCH

Immunopathogenesis of osteoarthritis

(2013) Abdul Haseeb et al.   CLINICAL IMMUNOLOGY

Caspase-11: The driving factor for noncanonical inflammasomes

(2013) Elena Viganò et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling

(2013) Wanze Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

(2013) Y. Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Response to 'TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro' - authors' reply

(2013) Jun Qin et al.   ARTHRITIS RESEARCH & THERAPY

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

(2013) Juan Lin et al.   Cell Reports

Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis

(2013) Xavier Houard et al.   Current Rheumatology Reports

Recognition of Bacteria by Inflammasomes

(2012) Jakob von Moltke et al.   Annual Review of Immunology

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Cartilage-specific RBPj -dependent and -independent Notch signals regulate cartilage and bone development

(2012) A. Kohn et al.   DEVELOPMENT

Tyrosine-phosphorylated Caveolin-1 (Tyr-14) Increases Sensitivity to Paclitaxel by Inhibiting BCL2 and BCLxL Proteins via c-Jun N-terminal Kinase (JNK)

(2012) Ayesha N. Shajahan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway

(2012) Hyun-Dae Lim et al.   JOURNAL OF PINEAL RESEARCH

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

(2012) Andreas Linkermann et al.   KIDNEY INTERNATIONAL

HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module

(2012) Ren-Xian Tang   WORLD JOURNAL OF GASTROENTEROLOGY

Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study

(2011) F. W. Roemer et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of subchondral bone osteoblast metabolism by cyclic compression

(2011) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Many stimuli pull the necrotic trigger, an overview

(2011) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Desperately looking for the right target in osteoarthritis: the anti-IL-1 strategy

(2011) Xavier Chevalier et al.   ARTHRITIS RESEARCH & THERAPY

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences

Relation of synovitis to knee pain using contrast-enhanced MRIs

(2010) K. Baker et al.   ANNALS OF THE RHEUMATIC DISEASES

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

Tumor necrosis factor-mediated cell death: to break or to burst, that’s the question

(2010) Franky Van Herreweghe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Migratory Chondrogenic Progenitor Cells from Repair Tissue during the Later Stages of Human Osteoarthritis

(2009) Sebastian Koelling et al.   Cell Stem Cell

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

Notch1, Jagged1, and HES5 Are Abundantly Expressed in Osteoarthritis

(2008) C. Karlsson et al.   CELLS TISSUES ORGANS

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

(2008) S. L. Fink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Bone in Osteoarthritis Pathogenesis

(2008) Steven R. Goldring   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA