Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 13, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-06-09
DOI
10.3389/fphar.2022.924817
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Comprehensive analysis of INHBA: A biomarker for anti-TGFβ treatment in head and neck cancer
- (2022) Shunhao Zhang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Fumonisin B1 alters global m6A RNA methylation and epigenetically regulates Keap1-Nrf2 signaling in human hepatoma (HepG2) cells
- (2021) Thilona Arumugam et al. ARCHIVES OF TOXICOLOGY
- The Intricacies of NRF2 Regulation in Cancer
- (2021) Cody J. Schmidlin et al. SEMINARS IN CANCER BIOLOGY
- De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis
- (2021) Sara Zocher et al. EMBO JOURNAL
- Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90
- (2021) Ping Liu et al. MOLECULAR MEDICINE
- Corosolic acid reduces A549 and PC9 cell proliferation, invasion, and chemoresistance in NSCLC via inducing mitochondrial and liposomal oxidative stress
- (2021) Mingming Jin et al. BIOMEDICINE & PHARMACOTHERAPY
- Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy
- (2021) Silvia Bono et al. Molecular Neurodegeneration
- Methylation Modification, Alternative Splicing, and Noncoding RNA Play a Role in Cancer Metastasis through Epigenetic Regulation
- (2021) Bin Yu et al. Biomed Research International
- The DNA methylation landscape in cancer
- (2020) Ksenia Skvortsova et al. Essays in Biochemistry
- MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress
- (2020) Milad Ashrafizadeh et al. LIFE SCIENCES
- Epigenetic modulations of noncoding RNA: a novel dimension of Cancer biology
- (2020) Xiao Yang et al. Molecular Cancer
- NFκB promotes oxidative stress-induced necrosis and ischemia/reperfusion injury by inhibiting Nrf2-ARE pathway
- (2020) Xiaoyun Guo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight
- (2020) Terence C. S. Ho et al. JOURNAL OF MEDICINAL CHEMISTRY
- Technologies for targeted DNA methylation modifications in cancer:Mechanism and application
- (2020) Jie Wang et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Beyond regulations at DNA levels: A review of epigenetic therapeutics targeting cancer stem cells
- (2020) Shunhao Zhang et al. CELL PROLIFERATION
- Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma
- (2020) Zhaoming Lu et al. Acta Pharmaceutica Sinica B
- Safety and Tolerability of Histone Deacetylase (HDAC) Inhibitors in Oncology
- (2019) Rashmi R. Shah DRUG SAFETY
- Role of histone acetylation in gastric cancer: implications of dietetic compounds and clinical perspectives
- (2019) Danielle Q Calcagno et al. Epigenomics
- NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
- (2019) Matthew Dodson et al. Redox Biology
- Epigenetic modifications but not genetic polymorphisms regulate KEAP1 expression in colorectal cancer
- (2019) Linbo Gao et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Nrf2 promotes breast cancer cell migration via up-regulation of G6PD/HIF-1α/Notch1 axis
- (2019) Hong-Sheng Zhang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- HDAC Inhibitors: Therapeutic Potential in Fibrosis-Associated Human Diseases
- (2019) Somy Yoon et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- NRF2 Activation in Cancer: From DNA to Protein
- (2019) Erica W. Cloer et al. CANCER RESEARCH
- The function of histone acetylation in cervical cancer development
- (2019) Shanshan Liu et al. BIOSCIENCE REPORTS
- Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
- (2019) Kyoung Ah Kang et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- p53 at the Crossroads between Different Types of HDAC Inhibitor-Mediated Cancer Cell Death
- (2019) Maria Mrakovcic et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice
- (2019) Qiuchen Zhao et al. Journal of Neuroinflammation
- Potential Applications of NRF2 Inhibitors in Cancer Therapy
- (2019) Emiliano Panieri et al. Oxidative Medicine and Cellular Longevity
- Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway
- (2019) Hsiao-Chen Dina Kuo et al. AAPS Journal
- Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1
- (2019) Luca Lignitto et al. CELL
- Chemical aspects of biological activity of isothiocyanates and indoles, the products of glucosinolate decomposition
- (2019) Dominik Kołodziejski et al. CURRENT PHARMACEUTICAL DESIGN
- DNA methylation in thyroid cancer
- (2019) Carles Zafon et al. ENDOCRINE-RELATED CANCER
- Impairment of HIF-1α-mediated metabolic adaption by NRF2-silencing in breast cancer cells
- (2019) Sujin Lee et al. Redox Biology
- Pelargonidin reduces the TPA induced transformation of mouse epidermal cells –potential involvement of Nrf2 promoter demethylation
- (2019) Shanyi Li et al. CHEMICO-BIOLOGICAL INTERACTIONS
- DNA Methylation in Epidermal Differentiation, Aging, and Cancer
- (2019) Florian Köhler et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- DNA Methylation: Shared and Divergent Features across Eukaryotes
- (2019) Robert J. Schmitz et al. TRENDS IN GENETICS
- The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer
- (2019) Raheleh Amirkhah et al. Cells
- Tanshinone IIA prevents rifampicin‐induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2
- (2019) Yujie Yang et al. LIVER INTERNATIONAL
- Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms
- (2019) Jinlong Wei et al. Oxidative Medicine and Cellular Longevity
- The Role of Nrf2 Activity in Cancer Development and Progression
- (2019) Alina-Andreea Zimta et al. Cancers
- Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer – contradictory effects and future perspectives
- (2019) Parham Jabbarzadeh Kaboli et al. BIOMEDICINE & PHARMACOTHERAPY
- Fucoxanthin Elicits Epigenetic Modifications, Nrf2 Activation and Blocking Transformation in Mouse Skin JB6 P+ Cells
- (2018) Yuqing Yang et al. AAPS Journal
- NRF2 and the Hallmarks of Cancer
- (2018) Montserrat Rojo de la Vega et al. CANCER CELL
- Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells
- (2018) Wenji Li et al. CHEMICAL RESEARCH IN TOXICOLOGY
- ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications
- (2018) N. T. Moldogazieva et al. FREE RADICAL RESEARCH
- Treating cancer with microRNA replacement therapy: A literature review
- (2018) Nayer Hosseinahli et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells
- (2018) Jie Yang et al. MOLECULAR CARCINOGENESIS
- Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells
- (2018) Chao Wang et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs
- (2018) F. P. Fabrizio et al. Oxidative Medicine and Cellular Longevity
- Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway
- (2018) Xuling Su et al. Oxidative Medicine and Cellular Longevity
- The Histone Acetylation Modifications of Breast Cancer and their Therapeutic Implications
- (2018) Pingping Guo et al. PATHOLOGY & ONCOLOGY RESEARCH
- Nucleosidic DNA demethylating epigenetic drugs – A comprehensive review from discovery to clinic
- (2018) Khushboo Agrawal et al. PHARMACOLOGY & THERAPEUTICS
- The role of DNA methylation in ageing and cancer
- (2018) A. E. Morgan et al. PROCEEDINGS OF THE NUTRITION SOCIETY
- Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
- (2018) Xiao-Juan Zhao et al. Redox Biology
- The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells
- (2018) Qian Zuo et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Histone deacetylase 6 in cancer
- (2018) Ting Li et al. Journal of Hematology & Oncology
- Regulation of microRNA biogenesis and its crosstalk with other cellular pathways
- (2018) Thomas Treiber et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries
- (2018) Zsofia Kutil et al. FASEB JOURNAL
- An overview of microRNAs: Biology, functions, therapeutics, and analysis methods
- (2018) Kioomars Saliminejad et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy
- (2018) Yepeng Luan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers
- (2018) Prabhakaran Soundararajan et al. MOLECULES
- Integrative regulation of physiology by histone deacetylase 3
- (2018) Matthew J. Emmett et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells
- (2017) Mario Negrette-Guzmán et al. FOOD AND CHEMICAL TOXICOLOGY
- Taxifolin Activates the Nrf2 Anti-Oxidative Stress Pathway in Mouse Skin Epidermal JB6 P+ Cells through Epigenetic Modifications
- (2017) Haixue Kuang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Histone Lysine Methylation and Neurodevelopmental Disorders
- (2017) Jeong-Hoon Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2
- (2017) Md. Morshedul Alam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epigenetics in cancer stem cells
- (2017) Tan Boon Toh et al. Molecular Cancer
- The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer
- (2017) Shasha Tao et al. MOLECULAR CARCINOGENESIS
- A functional pseudogene,NMRAL2P, is regulated by Nrf2 and serves as a coactivator ofNQO1in sulforaphane-treated colon cancer cells
- (2017) Gavin S. Johnson et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Histone methylation and the DNA damage response
- (2017) Fade Gong et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- A CRISPR screen identifies a pathway required for paraquat-induced cell death
- (2017) Colleen R Reczek et al. Nature Chemical Biology
- MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
- (2017) Rajesha Rupaimoole et al. NATURE REVIEWS DRUG DISCOVERY
- TET-mediated active DNA demethylation: mechanism, function and beyond
- (2017) Xiaoji Wu et al. NATURE REVIEWS GENETICS
- Mitochondrial ROS control of cancer
- (2017) María del Pilar Sosa Idelchik et al. SEMINARS IN CANCER BIOLOGY
- Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway
- (2017) Ai-Mei Gao et al. Oncotarget
- Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
- (2017) Anna Lewinska et al. Theranostics
- Stressing the (Epi)Genome: Dealing with Reactive Oxygen Species in Cancer
- (2017) Akshay V. Bhat et al. ANTIOXIDANTS & REDOX SIGNALING
- Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway
- (2016) Bo Hong et al. AAPS Journal
- Epigenetic CpG Methylation of the Promoter and Reactivation of the Expression of GSTP1 by Astaxanthin in Human Prostate LNCaP Cells
- (2016) Yuqing Yang et al. AAPS Journal
- Activation of apoptosis signalling pathways by reactive oxygen species
- (2016) Maureen Redza-Dutordoir et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers
- (2016) Ching-Yu Yen et al. CANCER LETTERS
- Dietary Phytochemicals and Cancer Chemoprevention: A Perspective on Oxidative Stress, Inflammation, and Epigenetics
- (2016) Wenji Li et al. CHEMICAL RESEARCH IN TOXICOLOGY
- MicroRNA-153 Regulates NRF2 Expression and is Associated with Breast Carcinogenesis
- (2016) Bo Wang et al. Clinical Laboratory
- MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer
- (2016) B. Zhang et al. CURRENT MOLECULAR MEDICINE
- Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters
- (2016) Xupeng Bai et al. DRUG METABOLISM REVIEWS
- Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1expression
- (2016) Tsui-Hwa Tseng et al. ENVIRONMENTAL TOXICOLOGY
- Role of TET enzymes in DNA methylation, development, and cancer
- (2016) Kasper Dindler Rasmussen et al. GENES & DEVELOPMENT
- Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells
- (2016) Hyuck Kim et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
- (2016) Joshua D Campbell et al. NATURE GENETICS
- Cognitive deficits triggered by early life stress: The role of histone deacetylase 1
- (2016) Samantha M. Adler et al. NEUROBIOLOGY OF DISEASE
- The Tumorigenic Roles of the Cellular REDOX Regulatory Systems
- (2016) Stéphanie Anaís Castaldo et al. Oxidative Medicine and Cellular Longevity
- NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis
- (2016) Hui Wang et al. Science Translational Medicine
- The Dual Roles of NRF2 in Cancer
- (2016) Silvia Menegon et al. TRENDS IN MOLECULAR MEDICINE
- NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction
- (2016) Chao Zhang et al. Oncotarget
- DNA Methyltransferase Activity Assays: Advances and Challenges
- (2016) Wan Jun Poh et al. Theranostics
- HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases
- (2016) Elizabeth E. Hull et al. Biomed Research International
- Keap1-Nrf2 Interaction Suppresses Cell Motility in Lung Adenocarcinomas by Targeting the S100P Protein
- (2015) M.-H. Chien et al. CLINICAL CANCER RESEARCH
- Discovery and development of DNA methyltransferase inhibitors using in silico approaches
- (2015) José L. Medina-Franco et al. DRUG DISCOVERY TODAY
- Epigenetic regulation of Keap1-Nrf2 signaling
- (2015) Yue Guo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
- (2015) Lauren E. Tebay et al. FREE RADICAL BIOLOGY AND MEDICINE
- Molecular basis of the Keap1–Nrf2 system
- (2015) Takafumi Suzuki et al. FREE RADICAL BIOLOGY AND MEDICINE
- The Role of Sulforaphane in Epigenetic Mechanisms, Including Interdependence between Histone Modification and DNA Methylation
- (2015) Agnieszka Kaufman-Szymczyk et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression
- (2015) Hiroki Sekine et al. MOLECULAR AND CELLULAR BIOLOGY
- MicroRNA-101 suppresses migration and invasion via targeting vascular endothelial growth factor-C in hepatocellular carcinoma cells
- (2015) ZHENYU LIU et al. Oncology Letters
- Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic Reactivation of Nrf2 Antioxidative Stress Pathway
- (2014) Ling Wang et al. AAPS Journal
- Development and classes of epigenetic drugs for cancer
- (2014) Dashyant Dhanak et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Requirement and Epigenetics Reprogramming of Nrf2 in Suppression of Tumor Promoter TPA-Induced Mouse Skin Cell Transformation by Sulforaphane
- (2014) Z.-Y. Su et al. Cancer Prevention Research
- Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways
- (2014) Bhupendra Singh et al. CARCINOGENESIS
- The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2
- (2014) Ziming Li et al. FEBS LETTERS
- Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
- (2014) T. Wu et al. GENES & DEVELOPMENT
- Cancer epigenetics drug discovery and development: the challenge of hitting the mark
- (2014) Robert M. Campbell et al. JOURNAL OF CLINICAL INVESTIGATION
- Effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1- and DNMT3a-mediated cytosine methylation
- (2014) Debin Ji et al. Molecular BioSystems
- Therapeutic Delivery of miR-200c Enhances Radiosensitivity in Lung Cancer
- (2014) Maria Angelica Cortez et al. MOLECULAR THERAPY
- The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
- (2014) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors
- (2013) Tien-Yuan Wu et al. AAPS Journal
- Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation
- (2013) Chengyue Zhang et al. BIOCHEMICAL PHARMACOLOGY
- The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts
- (2013) Richard D.W. Kelly et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- RXR Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
- (2013) H. Wang et al. CANCER RESEARCH
- MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis
- (2013) B. Singh et al. CARCINOGENESIS
- Epigenetic impact of dietary isothiocyanates in cancer chemoprevention
- (2013) Clarissa Gerhauser CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-β1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis
- (2013) Lei Jiang et al. KIDNEY INTERNATIONAL
- Toward clinical application of the Keap1–Nrf2 pathway
- (2013) Takafumi Suzuki et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer
- (2012) Bhupendra Singh et al. CARCINOGENESIS
- Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
- (2012) Marcin Imielinski et al. CELL
- Cancer epigenomics: beyond genomics
- (2012) Juan Sandoval et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- AberrantKeap1methylation in breast cancer and association with clinicopathological features
- (2012) Raffaela Barbano et al. Epigenetics
- Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition
- (2012) Marc Kästle et al. FREE RADICAL BIOLOGY AND MEDICINE
- A γ-Tocopherol-Rich Mixture of Tocopherols Maintains Nrf2 Expression in Prostate Tumors of TRAMP Mice via Epigenetic Inhibition of CpG Methylation
- (2012) Ying Huang et al. JOURNAL OF NUTRITION
- The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains
- (2012) J-H Kim et al. ONCOGENE
- Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
- (2012) S Chowdhry et al. ONCOGENE
- Bioactive Dietary Supplements Reactivate ER Expression in ER-Negative Breast Cancer Cells by Active Chromatin Modifications
- (2012) Syed M. Meeran et al. PLoS One
- Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells
- (2012) Madhusudhanan Narasimhan et al. PLoS One
- miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein
- (2012) Jing Xiao et al. PROSTATE
- Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation
- (2011) Tin Oo Khor et al. BIOCHEMICAL PHARMACOLOGY
- Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer
- (2011) B. Singh et al. CARCINOGENESIS
- Unraveling the Biological Roles of Reactive Oxygen Species
- (2011) Michael P. Murphy et al. Cell Metabolism
- Transforming growth factor-β/Smad signalling in diabetic nephropathy
- (2011) Hui Yao Lan CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Regulation ofKEAP1expression by promoter methylation in malignant gliomas and association with patient’s outcome
- (2011) Lucia Anna Muscarella et al. Epigenetics
- Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer
- (2011) Lucia Anna Muscarella et al. Epigenetics
- Berberine induces heme oxygenase-1 up-regulation through phosphatidylinositol 3-kinase/AKT and NF-E2-related factor-2 signaling pathway in astrocytes
- (2011) Jia-Hong Chen et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
- (2011) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study
- (2011) Mitali Pandey et al. MOLECULAR CARCINOGENESIS
- Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells
- (2011) John D. Clarke et al. MOLECULAR NUTRITION & FOOD RESEARCH
- miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response
- (2011) Bogdan Mateescu et al. NATURE MEDICINE
- A SILAC-Based Screen for Methyl-CpG Binding Proteins Identifies RBP-J as a DNA Methylation and Sequence-Specific Binding Protein
- (2011) Stefanie J. J. Bartels et al. PLoS One
- Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells
- (2010) Sujit Nair et al. ACTA PHARMACOLOGICA SINICA
- Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway
- (2010) John D. Hayes et al. ANTIOXIDANTS & REDOX SIGNALING
- The cap’n’collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics
- (2010) Larry G. Higgins et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features
- (2010) L. M. Solis et al. CLINICAL CANCER RESEARCH
- Expression of ABCG2 (BCRP) Is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemoresistance Phenotype
- (2010) Anju Singh et al. MOLECULAR CANCER THERAPEUTICS
- Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane
- (2010) Constance L. Saw et al. MOLECULAR CARCINOGENESIS
- The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
- (2010) Masaaki Komatsu et al. NATURE CELL BIOLOGY
- Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts
- (2010) Insa M.A. Ernst et al. PHARMACOLOGICAL RESEARCH
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
- (2010) M. McMahon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
- (2010) T. Ogura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epigenetic modifications and human pathologies: cancer and CVD
- (2010) Susan J. Duthie PROCEEDINGS OF THE NUTRITION SOCIETY
- Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- (2010) Syed M. Meeran et al. Clinical Epigenetics
- Oxidative stress in prostate cancer
- (2009) Lakshmipathi Khandrika et al. CANCER LETTERS
- Vitamin C and -naphthoflavone prevent estrogen-induced mammary tumors and decrease oxidative stress in female ACI rats
- (2009) S. M. Mense et al. CARCINOGENESIS
- Epigenetic regulation of microRNA expression in colorectal cancer
- (2009) Eva Bandres et al. INTERNATIONAL JOURNAL OF CANCER
- Critical Cysteine Residues of Kelch-Like ECH-Associated Protein 1 in Arsenic Sensing and Suppression of Nuclear Factor Erythroid 2-Related Factor 2
- (2009) X. He et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation
- (2009) X. He et al. MOLECULAR PHARMACOLOGY
- Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents
- (2009) Larry G. Higgins et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
- (2009) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- Epigenetic Changes in Cancer
- (2008) Christine A. Iacobuzio-Donahue Annual Review of Pathology-Mechanisms of Disease
- Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
- (2008) Rui Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity
- (2008) T. Yamamoto et al. MOLECULAR AND CELLULAR BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More