Review
Biochemistry & Molecular Biology
Sonali Bahl, Edward Seto
Summary: Histone deacetylases (HDACs) are enzymes that regulate cellular processes by removing acetyl groups from proteins. HDAC activities are regulated by various mechanisms, including posttranslational modifications like reversible phosphorylation. Dysregulation of HDACs can contribute to disease development, making it important to understand how reversible phosphorylation affects their functions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Rodolfo Soria-Castro, Yatsiri G. Meneses-Preza, Gloria M. Rodriguez-Lopez, Alfredo Ibarra-Sanchez, Claudia Gonzalez-Espinosa, Sonia M. Perez-Tapia, Fabian Flores-Borja, Sergio Estrada-Parra, Alma D. Chavez-Blanco, Rommel Chacon-Salinas
Summary: The study found that valproic acid (VPA) inhibits the activation of mast cells (MC) during Listeria monocytogenes (L.m) infection, reducing degranulation and cytokine release. VPA also reduces intracellular calcium increase and phosphorylation of key signaling molecules in MC. These findings suggest that VPA can modulate the functional activity of immune cells involved in controlling L.m infection.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Long Xu, Xiaoyu Yan, Jian Wang, Yuanxin Zhao, Qingqing Liu, Jiaying Fu, Xinyi Shi, Jing Su
Summary: This article provides an overview of ovarian cancer metastasis and the dysregulated expression of HDACs in ovarian cancer. It discusses the roles of HDACs in the regulation of ovarian cancer metastasis and highlights the importance of developing compounds that target HDACs in the future of ovarian cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Ning Xia, Stefan Tenzer, Oleg Lunov, Martin Karl, Thomas Simmet, Andreas Daiber, Thomas Muenzel, Gisela Reifenberg, Ulrich Foerstermann, Huige Li
Summary: The study showed that both SIRT1 and non-sirtuin deacetylases play a role in regulating NADPH oxidase activity, with Rac1 being directly deacetylated by SIRT1 in a cell-free system to inhibit its interaction with p67phox. The downstream targets of non-sirtuin deacetylases remain unknown, and further investigation is needed to understand the in vivo significance of these findings.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova, Gjumrakch Aliev
Summary: Epigenetic changes associated with histone modifications are important in the emergence and maintenance of various cancer types. Inhibitors of enzymes involved in these modifications are promising for anticancer drug development. This review explores the main features of common histone modifications and their role in malignant neoplasms, discussing strategies for inhibitor development and analyzing the use of multitarget drugs as the most promising strategy.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hae Jin Kee, Inkyeom Kim, Myung Ho Jeong
Summary: This article provides an overview of the pathogenesis of hypertension, current anti-hypertensive drugs, and the need for novel drugs. It focuses on the role and regulatory mechanisms of HDACs in hypertension and discusses the progress in developing HDAC inhibitors as potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Gaurav Sarode, Kari Neier, Noreene M. Shibata, Yuanjun Shen, Dmitry A. Goncharov, Elena A. Goncharova, Tagreed A. Mazi, Nikhil Joshi, Matthew L. Settles, Janine M. LaSalle, Valentina Medici
Summary: The study reveals that the pathogenesis of Wilson disease involves copper accumulation in the liver and brain, affecting acetylation levels through changes in histone deacetylase 5. Dietary modulation can regulate the acetylation levels of HDAC4/5 and H3K9/H3K27.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Genetics & Heredity
Eike A. Strathmann, Irmgard Hoelker, Nikolai Tschernoster, Seyyedmohsen Hosseinibatkooie, Julien Come, Cecile Martinat, Janine Altmueller, Brunhilde Wirth
Summary: Dysregulated PLS3 levels are associated with various skeletal and neuromuscular disorders as well as common types of solid and hematopoietic cancer. PLS3 overexpression provides protection against spinal muscular atrophy. However, the mechanisms that regulate PLS3 expression are still unknown. In this study, we found that PLS3 escapes X chromosome inactivation and that the copy number of DXZ4 monomers correlates significantly with PLS3 levels. We also identified CHD4 as an epigenetic transcriptional regulator of PLS3, suggesting a multilevel epigenetic regulation that may contribute to the dysregulation of PLS3 in disease.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Medicine, General & Internal
Yang Sun, Dai Li, Yuqiang Su, Haikang Zhao, Weiwei Pang, Wei Zhao, Shengjun Wu
Summary: Derangements in monoaminergic transmission and disturbed signaling in the hypothalamic-pituitary-adrenal axis are major characteristics of Parkinson's disease (PD). Hydrogen sulfide (H2S) has been reported to have potential therapeutic effects on PD due to its regulatory role in neuronal signals. This study aimed to evaluate the hypothesis that H2S exerts protective action via inhibition of epigenetic histone acetylation.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yiming Chen, Lihui Zhang, Lin Zhang, Qixiao Jiang, Lei Zhang
Summary: Through structural modification, a HDAC inhibitor (I13) with high anticancer activity was discovered, showing promising inhibitory and antiproliferative potencies in in vitro investigations and cancer cell screenings. The compound also demonstrated potential for inhibiting tumor growth in animal models.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Qiao Li, Yan Z. Mach, Munerah Hamed, Saadia Khilji, Jihong Chen
Summary: Histone acetylation and deacetylation play important roles in gene expression during cellular differentiation. The acetyltransferase p300 is essential for muscle gene expression, while histone deacetylases (HDACs) control gene repression in stem cell fate transition. The expression of Hdac11 is enhanced by nuclear receptor signaling, and it may be essential for differential gene expression during myoblast differentiation.
Article
Biochemistry & Molecular Biology
Alvin Susetyo, Sumiyasu Ishii, Yuki Fujiwara, Izuki Amano, Noriyuki Koibuchi
Summary: Perinatal hypothyroidism impairs cerebellar development and motor coordination. Treatment with an HDAC3 inhibitor reverses the developmental defects and increases the transcription levels of thyroid hormone-responsive genes in the cerebellum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Jui-Lin Fan, Patrice Brassard, Caroline A. Rickards, Ricardo C. Nogueira, Nathalie Nasr, Fiona D. McBryde, James P. Fisher, Yu-Chieh Tzeng
Summary: Optimizing cerebral perfusion is crucial for rescuing salvageable ischemic brain tissue, yet there are no effective guidelines for blood pressure management in acute stroke. The control of cerebral blood flow involves complex pathways that are often overlooked in stroke management. The unique anatomy and physiology of cerebrovascular circulation are usually treated as a separate system rather than an integral part of the cardiovascular system.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Urology & Nephrology
Paulina X. Medina X. Rangel, Elizabeth Cross, Chang Liu, Christopher E. E. Pedigo, Xuefei Tian, Elena Gutierrez-Calabres, Soichiro Nagata, Anupama Priyadarshini, Gabriel Lerner, Patricia Bunda, Sudhir Perincheri, Jianlei Gu, Hongyu Zhao, Ying Wang, Kazunori Inoue, Shuta Ishibe
Summary: Loss of Hdac1/2 in podocytes during development leads to sustained DNA damage, senescence, and loss of podocytes. HDACs play a crucial role in maintaining the normal glomerular filtration barrier and preventing premature senescence. The damaged podocytes secrete proinflammatory cytokines, growth factors, and matrix metalloproteinases, resulting in subsequent podocyte detachment and loss.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Meimiao Guo, Shicong Wang, Han Liu, Senyang Yao, Jinjiao Yan, Caixia Wang, Bingjie Miao, Junxing Guo, Fengwang Ma, Qingmei Guan, Jidi Xu
Summary: Understanding the molecular regulation of plant cold response is crucial for improving cold resistance germplasm in apple. In this study, it was found that the histone deacetylase MdHDA6 can deacetylate cold-negative regulator genes and inhibit their expression, thereby positively regulating cold tolerance in apples. Furthermore, MdHDA6 interacts directly with the transcription factor MdTCP15, which has a negative regulatory effect on cold tolerance in apples.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Maria Razzoli, Matthew J. Emmett, Mitchell A. Lazar, Alessandro Bartolomucci
Article
Cell Biology
Victoria L. Nelson, Hoang C. B. Nguyen, Juan C. Garcia-Canaveras, Erika R. Briggs, Wesley Y. Ho, Joanna R. DiSpirito, Jill M. Marinis, David A. Hill, Mitchell A. Lazar
GENES & DEVELOPMENT
(2018)
Article
Multidisciplinary Sciences
David A. Hill, Hee-Woong Lim, Yong Hoon Kim, Wesley Y. Ho, Yee Hoon Foong, Victoria L. Nelson, Hoang C. B. Nguyen, Kavya Chegireddy, Jihoon Kim, Andreas Habertheuer, Prashanth Vallabhajosyula, Taku Kambayashi, Kyoung-Jae Won, Mitchell A. Lazar
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Yinxin Zhang, Olof Stefan Danner, Tomoyoshi Nakadai, Gulya Fayzikhodjaeva, Yi-Hsueh Lu, Mitchell A. Lazar, Robert G. Roeder, Jeffrey M. Friedman
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Yong Hoon Kim, Sajid A. Marhon, Yuxiang Zhang, David J. Steger, Kyoung-Jae Won, Mitchell A. Lazar
Article
Cell & Tissue Engineering
Wenxiang Hu, Chunjie Jiang, Dongyin Guan, Pieterjan Dierickx, Rong Zhang, Arden Moscati, Girish N. Nadkarni, David J. Steger, Ruth J. F. Loos, Cheng Hu, Weiping Jia, Raymond E. Soccio, Mitchell A. Lazar
Article
Cell Biology
Martha V. Koerner, Laura FitzPatrick, Jim Selfridge, Jacky Guy, Dina De Sousa, Rebekah Tillotson, Alastair Kerr, Zheng Sun, Mitchell A. Lazar, Matthew J. Lyst, Adrian Bird
GENES & DEVELOPMENT
(2018)
Article
Biochemistry & Molecular Biology
Olof S. Dallner, Jill M. Marinis, Yi-Hsueh. Lu, Kivanc Birsoy, Emory Werner, Gulya Fayzikhodjaeva, Brian D. Dill, Henrik Molina, Arden Moscati, Zoltan Kutalik, Pedro Marques-Vidal, Tuomas O. Kilpelainen, Niels Grarup, Allan Linneberg, Yinxin Zhang, Roger Vaughan, Ruth J. F. Loos, Mitchell A. Lazar, Jeffrey M. Friedman
Article
Multidisciplinary Sciences
Pieterjan Dierickx, Matthew J. Emmett, Chunjie Jiang, Kahealani Uehara, Manlu Liu, Marine Adlanmerini, Mitchell A. Lazar
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Diego Adhemar Jaitin, Lorenz Adlung, Christoph A. Thaiss, Assaf Weiner, Baoguo Li, Helene Descamps, Patrick Lundgren, Camille Bleriot, Zhaoyuan Liu, Aleksandra Deczkowska, Hadas Keren-Shaul, Eyal David, Niv Zmora, Shai Meron Eldar, Nir Lubezky, Oren Shibolet, David A. Hill, Mitchell A. Lazar, Marco Colonna, Florent Ginhoux, Hagit Shapiro, Eran Elinav, Ido Amit
Article
Multidisciplinary Sciences
Marine Adlanmerini, Bryce J. Carpenter, Jarrett R. Remsberg, Yann Aubert, Lindsey C. Peed, Hannah J. Richter, Mitchell A. Lazar
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Taiyi Kuo, Michael J. Kraakman, Manashree Damle, Richard Gill, Mitchell A. Lazar, Domenico Accili
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Editorial Material
Multidisciplinary Sciences
Dongyin Guan, Mitchell A. Lazar
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Medicine, Research & Experimental
Taiyi Kuo, Manashree Damle, Bryan J. Gonzalez, Dieter Egli, Mitchell A. Lazar, Domenico Accili