Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers

Correction to: Dietary intake of soy and cruciferous vegetables and treatment-related symptoms in Chinese-American and non-Hispanic White breast cancer survivors

(2018) Sarah J. O. Nomura et al.   BREAST CANCER RESEARCH AND TREATMENT

Glucosinolate and isothiocyanate intakes are inversely associated with breast cancer risk: a case–control study in China

(2018) Nai-Qi Zhang et al.   BRITISH JOURNAL OF NUTRITION

Inhibition of Glycolysis in Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate

(2018) Krishna B. Singh et al.   Cancer Prevention Research

Sulforaphane metabolites cause apoptosis via microtubule disruption in cancer

(2018) Yan Zhou et al.   ENDOCRINE-RELATED CANCER

Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo

(2018) Yi-Shih Ma et al.   ENVIRONMENTAL TOXICOLOGY

HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells

(2018) Chunyu Cao et al.   INTERNATIONAL JOURNAL OF CANCER

Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation in rats

(2018) Jeongtae KIM et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate through JAK2/STAT3 pathway in lung cancer cells

(2018) Huimin Wang et al.   MOLECULAR CARCINOGENESIS

Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs

(2018) Adaobi Okonkwo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Lung Cancer Chemopreventive Activity of Patulin Isolated from Penicillium vulpinum

(2018) Aymeric Monteillier et al.   MOLECULES

Usual Cruciferous Vegetable Consumption and Ovarian Cancer: A Case-Control Study

(2018) Hallie McManus et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Extraction, profiling and bioactivity analysis of volatile glucosinolates present in oil extract of Brassica juncea var. raya

(2018) Priyanka Bassan et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention

(2018) Chun Loong Ho et al.   Nature Biomedical Engineering

Methyl-β-cyclodextrin potentiates the BITC-induced anti-cancer effect through modulation of the Akt phosphorylation in human colorectal cancer cells

(2018) Qifu Yang et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Broccoli consumption affects the human gastrointestinal microbiota

(2018) Jennifer L. Kaczmarek et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention

(2018) Besma Abbaoui et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells

(2017) Mario Negrette-Guzmán et al.   FOOD AND CHEMICAL TOXICOLOGY

Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways

(2017) Christine Sturm et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary Phenethyl Isothiocyanate Protects Mice from Colitis Associated Colon Cancer

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells

(2017) Kendra Royston et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

(2017) David Olagnier et al.   MOLECULAR THERAPY

E-Cadherin/β-Catenin Complex: A Target for Anticancer and Antimetastasis Plants/Plant-derived Compounds

(2017) Majid Tafrihi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Epimedium koreanum Nakai inhibits PMA-induced cancer cell migration and invasion by modulating NF-κB/MMP-9 signaling in monomorphic malignant human glioma cells

(2017) Wonil Lee et al.   ONCOLOGY REPORTS

Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor

(2017) Ada Popolo et al.   SEMINARS IN CANCER BIOLOGY

Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study

(2017) Lucília Pereira et al.   Nutrients

Sulforaphane reduces YAP/∆Np63α signaling to reduce cancer stem cell survival and tumor formation

(2017) Matthew L. Fisher et al.   Oncotarget

Benzyl-isothiocyanate Induces Apoptosis and Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells in vitro

(2017) Mingyue Zhu et al.   Journal of Cancer

Expression profiles of BrMYB transcription factors related to glucosinolate biosynthesis and stress response in eight subspecies of Brassica rapa

(2017) Mi-Suk Seo et al.   FEBS Open Bio

Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles

(2017) Jingga Morry et al.   Redox Biology

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015

(2017) et al.   JAMA Oncology

Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes

(2017) Bei Xie et al.   Scientific Reports

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

(2017) Sharadha Dayalan Naidu et al.   Scientific Reports

Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer associated with the inhibition of CRM1-mediated nuclear export and mTOR-STAT3 pathway

(2016) Wen Yu Shao et al.   CANCER BIOLOGY & THERAPY

The cancer stem-cell signaling network and resistance to therapy

(2016) A. Carnero et al.   CANCER TREATMENT REVIEWS

Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth

(2016) M Aggarwal et al.   CELL DEATH AND DIFFERENTIATION

Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer

(2016) Ravi Kasiappan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194

(2016) Chengyue Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells

(2016) Takashi Kasukabe et al.   ONCOLOGY REPORTS

Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells

(2016) NOU-YING TANG et al.   ONCOLOGY REPORTS

Functional analysis of three BrMYB28 transcription factors controlling the biosynthesis of glucosinolates in Brassica rapa

(2016) Mi-Suk Seo et al.   PLANT MOLECULAR BIOLOGY

Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways

(2016) Paul M. Holloway et al.   VASCULAR PHARMACOLOGY

Benzyl isothiocyanate but not benzyl nitrile from Brassicales plants dually blocks the COX and LOX pathway in primary human immune cells

(2016) Corinna Herz et al.   Journal of Functional Foods

Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

(2016) Mi Park et al.   Cells

Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism

(2015) Allison J. Greaney et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

(2015) Yu Sun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression

(2015) CHANG-SU LEE et al.   ONCOLOGY REPORTS

Oxidized low-density lipoprotein is associated with advanced-stage prostate cancer

(2015) Fangning Wan et al.   TUMOR BIOLOGY

Oxidized low-density lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA-210

(2015) Ku-Chung Chen et al.   Oncotarget

CD44v6 Dependence of Premetastatic Niche Preparation by Exosomes

(2015) Thorsten Jung et al.   NEOPLASIA

Potential Mechanisms of Benzyl Isothiocyanate Suppression of Invasion and Angiogenesis by the U87MG Human Glioma Cell Line

(2014) Yu Zhu et al.   Asian Pacific Journal of Cancer Prevention

Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells

(2014) Yue Tang et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Sulforaphane inhibits phorbol ester-stimulated IKK-NF-κB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-κB activating kinase and ERK

(2014) Ha-Na Kim et al.   CANCER LETTERS

A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer

(2014) Joshi J. Alumkal et al.   INVESTIGATIONAL NEW DRUGS

RAS/ERK Signaling Controls Proneural Genetic Programs in Cortical Development and Gliomagenesis

(2014) S. Li et al.   JOURNAL OF NEUROSCIENCE

Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway

(2014) Palanisamy Nallasamy et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Phenethyl isothiocyanate inhibits growth of human chronic myeloid leukemia K562 cells via reactive oxygen species generation and caspases

(2014) YATING WANG et al.   Molecular Medicine Reports

Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease

(2014) Bo-hyun Choi et al.   MOLECULES

Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently

(2014) Doris Lippmann et al.   Food & Function

Mechanisms of cellular fibrosis associated with cancer regimen-related toxicities

(2014) Maria L. Mancini et al.   Frontiers in Pharmacology

SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells

(2014) G W Watson et al.   Oncogenesis

Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation

(2013) Chengyue Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Cancer-associated upregulation of histone H3 lysine 9 trimethylation promotes cell motilityin vitroand drives tumor formationin vivo

(2013) Yuhki Yokoyama et al.   CANCER SCIENCE

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

(2013) Praveen Rajendran et al.   Epigenetics

Sulforaphane inhibits growth of phenotypically different breast cancer cells

(2013) Anna Pawlik et al.   EUROPEAN JOURNAL OF NUTRITION

Heat Shock Factor 1 (HSF1) Controls Chemoresistance and Autophagy through Transcriptional Regulation of Autophagy-related Protein 7 (ATG7)

(2013) Shruti Desai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFκB activation

(2013) Chin-Shiu Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models

(2012) Parul Gupta et al.   BMC Medicine

Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging

(2012) Sarah J. Chapple et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells

(2012) Yujuan Shan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Benzyl Isothiocyanate Causes FoxO1-Mediated Autophagic Death in Human Breast Cancer Cells

(2012) Dong Xiao et al.   PLoS One

Inhibition of EGFR-AKT Axis Results in the Suppression of Ovarian Tumors In Vitro and in Preclinical Mouse Model

(2012) Sivakumar Loganathan et al.   PLoS One

Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures

(2012) Daniel K Chan et al.   Journal of Ovarian Research

Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae ): evidence for TRPA1-independent effects

(2011) Raffaele Capasso et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Pancreatic Tumor Suppression by Benzyl Isothiocyanate Is Associated with Inhibition of PI3K/AKT/FOXO Pathway

(2011) S. R. Boreddy et al.   CLINICAL CANCER RESEARCH

Phenethyl isothiocyanate promotes immune responses in normal BALB/c mice, inhibits murine leukemia WEHI-3 cells, and stimulates immunomodulationsin vivo

(2011) Mei-Fen Tsou et al.   ENVIRONMENTAL TOXICOLOGY

Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic

(2011) Chang-Lin Wu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Dietary Glucosinolate Intake, Polymorphisms in Selected Biotransformation Enzymes, and Risk of Prostate Cancer

(2010) A. Steinbrecher et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

p66Shc Is Indispensable for Phenethyl Isothiocyanate-Induced Apoptosis in Human Prostate Cancer Cells

(2010) D. Xiao et al.   CANCER RESEARCH

Synergistic Activity of Sorafenib and Sulforaphane Abolishes Pancreatic Cancer Stem Cell Characteristics

(2010) Vanessa Rausch et al.   CANCER RESEARCH

NF-κB Signaling Pathway, Inflammation and Colorectal Cancer

(2010) Soly Wang et al.   Cellular & Molecular Immunology

Phenethyl Isothiocyanate Inhibited Tumor Migration and Invasion via Suppressing Multiple Signal Transduction Pathways in Human Colon Cancer HT29 Cells

(2010) Kuang-Chi Lai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Benzyl Isothiocyanate (BITC) Inhibits Migration and Invasion of Human Colon Cancer HT29 Cells by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase Plasminogen (uPA) through PKC and MAPK Signaling Pathway

(2010) Kuang-Chi Lai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Candidate Dietary Phytochemicals Modulate Expression of Phase II Enzymes GSTP1 and NQO1 in Human Lung Cells

(2010) Xiang-Lin Tan et al.   JOURNAL OF NUTRITION

Benzyl Isothiocyanate-Mediated Inhibition of Histone Deacetylase Leads to NF- B Turnoff in Human Pancreatic Carcinoma Cells

(2010) S. Batra et al.   MOLECULAR CANCER THERAPEUTICS

Phenethyl Isothiocyanate Sensitizes Androgen-Independent Human Prostate Cancer Cells to Docetaxel-Induced Apoptosis In Vitro and In Vivo

(2010) Dong Xiao et al.   PHARMACEUTICAL RESEARCH

Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts

(2010) Insa M.A. Ernst et al.   PHARMACOLOGICAL RESEARCH

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

(2009) Jiyoung Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

(2008) D. Trachootham et al.   BLOOD

Consumption of Raw Cruciferous Vegetables is Inversely Associated with Bladder Cancer Risk

(2008) L. Tang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase

(2008) Hong Zhao et al.   CYTOMETRY PART A

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

(2008) J LOPICCOLO et al.   DRUG RESISTANCE UPDATES

Covalent Binding to Tubulin by Isothiocyanates

(2008) Lixin Mi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism

(2008) H Zhang et al.   LEUKEMIA

Glucosinolates in Brassica vegetables: The influence of the food supply chain on intake, bioavailability and human health

(2008) Ruud Verkerk et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Glucosinolates, isothiocyanates and human health

(2008) Maria Traka et al.   PHYTOCHEMISTRY REVIEWS

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY