The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer

Brusatol overcomes chemoresistance through inhibition of protein translation

(2017) Bryan Harder et al.   MOLECULAR CARCINOGENESIS

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth

(2016) H. Satoh et al.   CANCER RESEARCH

Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

(2016) Youngtae Jeong et al.   Cancer Discovery

A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response

(2015) Tao Shen et al.   ANTIOXIDANTS & REDOX SIGNALING

Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8+ T cell function by limiting GSH and Cys availability

(2015) Lisa K. Sha et al.   FREE RADICAL BIOLOGY AND MEDICINE

Roles of Nrf2 in cell proliferation and differentiation

(2015) Shohei Murakami et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells

(2015) In-geun Ryoo et al.   Oncotarget

The Global Burden of Cancer 2013

(2015) Christina Fitzmaurice et al.   JAMA Oncology

Myeloid Lineage-Specific Deletion of Antioxidant System Enhances Tumor Metastasis

(2014) K. Hiramoto et al.   Cancer Prevention Research

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

(2014) S. Tao et al.   CANCER RESEARCH

Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?

(2014) Tongde Wu et al.   MOLECULAR CARCINOGENESIS

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

The Promise and Perils of Antioxidants for Cancer Patients

(2014) Navdeep S. Chandel et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma

(2013) A. Ooi et al.   CANCER RESEARCH

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

(2013) Hironori Satoh et al.   CANCER RESEARCH

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

The Dark Side of Nrf2

(2012) Rachel Grossman et al.   World Neurosurgery

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Targeted Deletion of Nrf2 Reduces Urethane-Induced Lung Tumor Development in Mice

(2011) Alison K. Bauer et al.   PLoS One

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

(2011) D. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

(2008) Rui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer

(2008) T. O. Khor et al.   Cancer Prevention Research

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

(2008) Tatsuhiro Shibata et al.   GASTROENTEROLOGY

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA