Epigenetic modifications but not genetic polymorphisms regulate KEAP1 expression in colorectal cancer

Mutational and Expressional Analyses of NRF2 and KEAP1 in Sarcomas

(2018) Eun Mi Mi Je et al.   TUMORI

Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma

(2017) Federico Pio Fabrizio et al.   Oncotarget

The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer

(2016) Liang-Che Chang et al.   DISEASE MARKERS

A polymorphism rs4705341 in the flanking region of miR-143/145 predicts risk and prognosis of colorectal cancer

(2016) Ruifen Sun et al.   Oncotarget

A functional variant rs353292 in the flanking region of miR-143/145 contributes to the risk of colorectal cancer

(2016) Fang Yuan et al.   Scientific Reports

Dysregulation of the Keap1–Nrf2 pathway in cancer: Figure 1

(2015) Hanna M. Leinonen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Keap1-Nrf2 Interaction Suppresses Cell Motility in Lung Adenocarcinomas by Targeting the S100P Protein

(2015) M.-H. Chien et al.   CLINICAL CANCER RESEARCH

KEAP1 Genetic Polymorphisms Associate with Breast Cancer Risk and Survival Outcomes

(2015) J. M. Hartikainen et al.   CLINICAL CANCER RESEARCH

Polymorphisms of NRF2 and NRF2 target genes in urinary bladder cancer patients

(2014) Edyta Reszka et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

(2014) Zheng-Yu Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genetic polymorphism in the NRF2 gene as a prognosis marker for cancer chemotherapy

(2014) Toshihisa Ishikawa   Frontiers in Genetics

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

SNP (–617C>A) in ARE-Like Loci of the NRF2 Gene: A New Biomarker for Prognosis of Lung Adenocarcinoma in Japanese Non-Smoking Women

(2013) Yasuko Okano et al.   PLoS One

Keap1 mutations in lung cancer patients

(2013) HIDEFUMI SASAKI et al.   Oncology Letters

Immunohistochemical Study of the Nrf2 Pathway in Colorectal Cancer

(2013) Liang-Che Chang et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells

(2012) Duo Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methylation of the KEAP1 gene promoter region in human colorectal cancer

(2012) Naoyuki Hanada et al.   BMC CANCER

Genetic Polymorphisms and Protein Expression of NRF2 and Sulfiredoxin Predict Survival Outcomes in Breast Cancer

(2012) J. M. Hartikainen et al.   CANCER RESEARCH

AberrantKeap1methylation in breast cancer and association with clinicopathological features

(2012) Raffaela Barbano et al.   Epigenetics

Somatic mutations of the KEAP1 gene in common solid cancers

(2012) Nam Jin Yoo et al.   HISTOPATHOLOGY

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

(2012) Yoichiro Mitsuishi et al.   Frontiers in Oncology

Regulation ofKEAP1expression by promoter methylation in malignant gliomas and association with patient’s outcome

(2011) Lucia Anna Muscarella et al.   Epigenetics

Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer

(2011) Lucia Anna Muscarella et al.   Epigenetics

Association of Keap1 and Nrf2 Genetic Mutations and Polymorphisms With Endometrioid Endometrial Adenocarcinoma Survival

(2011) Tze Fang Wong et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

(2010) P. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

(2008) Rui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer

(2008) T. O. Khor et al.   Cancer Prevention Research

A distinct ERCC1 haplotype is associated with mRNA expression levels in prostate cancer patients

(2008) A. Woelfelschneider et al.   CARCINOGENESIS

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma

(2007) B. Saposnik et al.   BLOOD