HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases

Epigenetic Therapeutics: A New Weapon in the War Against Cancer

(2016) Nita Ahuja et al.   Annual Review of Medicine

Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model

(2016) Rosa Di Liddo et al.   AUTOIMMUNITY

Epigenetically maintained SW13+ and SW13- subtypes have different oncogenic potential and convert with HDAC1 inhibition

(2016) McKale R. Davis et al.   BMC CANCER

Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of Histone H3 Lysine 27 (H3K27) Deacetylation and Methylation

(2016) Fenfen Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class I and IIa HDACs Mediate HIF-1α Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc

(2016) Zachary R Schoepflin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Combining targeted therapy with immunotherapy. Can 1+1 equal more than 2?

(2016) Lidia Robert et al.   SEMINARS IN IMMUNOLOGY

Histone deacetylase inhibitors as immunomodulators in cancer therapeutics

(2016) Li Shen et al.   Epigenomics

Regulation of the p19Arf/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence-prone SAMP8 mice

(2015) Raúl Soriano-Cantón et al.   AGING CELL

New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation

(2015) Minghong Ni et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies

(2015) C. M. Adams et al.   CANCER RESEARCH

Biochemical, biological and structural properties of romidepsin (FK228) and its analogs as novel HDAC/PI3K dual inhibitors

(2015) Ken Saijo et al.   CANCER SCIENCE

Histone deacetylase inhibitor valproic acid promotes the induction of pluripotency in mouse fibroblasts by suppressing reprogramming-induced senescence stress

(2015) Yingying Zhai et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA-31 Is a Transcriptional Target of Histone Deacetylase Inhibitors and a Regulator of Cellular Senescence

(2015) Joon-Ho Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models

(2015) Eva Benito et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-221 governs tumor suppressor HDAC6 to potentiate malignant progression of liver cancer

(2015) Hyun Jin Bae et al.   JOURNAL OF HEPATOLOGY

Experience Modulates the Effects of Histone Deacetylase Inhibitors on Gene and Protein Expression in the Hippocampus: Impaired Plasticity in Aging

(2015) Angila S. Sewal et al.   JOURNAL OF NEUROSCIENCE

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation

(2015) K.V. Woan et al.   Molecular Oncology

Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference

(2015) Stella Aslibekyan et al.   Obesity

Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis

(2015) Melissa D. Cantley et al.   RHEUMATOLOGY

Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response

(2015) John A Halsall et al.   Epigenetics & Chromatin

Romidepsin targets multiple survival signaling pathways in malignant T cells

(2015) B C Valdez et al.   Blood Cancer Journal

HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade

(2015) D. M. Woods et al.   Cancer Immunology Research

Valproic Acid Upregulates NKG2D Ligand Expression through an ERK-dependent Mechanism and Potentially Enhances NK Cell-mediated Lysis of Myeloma

(2015) Xiaosong Wu et al.   NEOPLASIA

HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis

(2014) Manjola Balliu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Harnessing the potential of epigenetic therapy to target solid tumors

(2014) Nita Ahuja et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Role for Histone Deacetylase 6 in the Regulation of the Tolerogenic STAT3/IL-10 Pathway in APCs

(2014) Fengdong Cheng et al.   JOURNAL OF IMMUNOLOGY

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells

(2014) Fengdong Cheng et al.   MOLECULAR IMMUNOLOGY

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Decreased GFAP Expression and Improved Functional Recovery in Contused Spinal Cord of Rats Following Valproic Acid Therapy

(2014) Marzieh Darvishi et al.   NEUROCHEMICAL RESEARCH

HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

(2014) Haiqun Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase inhibitors

(2013) Marije Slingerland et al.   ANTI-CANCER DRUGS

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance

(2013) F. Santoro et al.   BLOOD

Effects of treatment with histone deacetylase inhibitors in solid tumors: a review based on 30 clinical trials

(2013) Tianzhu Qiu et al.   Future Oncology

Randomized Phase II, Double-Blind, Placebo-Controlled Study of Exemestane With or Without Entinostat in Postmenopausal Women With Locally Recurrent or Metastatic Estrogen Receptor-Positive Breast Cancer Progressing on Treatment With a Nonsteroidal Aromatase Inhibitor

(2013) Denise A. Yardley et al.   JOURNAL OF CLINICAL ONCOLOGY

Valproic Acid Protects Motor Neuron Death by Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress-Mediated Cytochrome C Release after Spinal Cord Injury

(2013) Jee Y. Lee et al.   JOURNAL OF NEUROTRAUMA

The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity

(2013) David M. Woods et al.   MELANOMA RESEARCH

HDAC Inhibition Suppresses Primary Immune Responses, Enhances Secondary Immune Responses, and Abrogates Autoimmunity During Tumor Immunotherapy

(2013) Byram W Bridle et al.   MOLECULAR THERAPY

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner

(2013) M. Malvaez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC inhibitor therapy in autoimmunity and transplantation

(2012) Wayne W Hancock et al.   ANNALS OF THE RHEUMATIC DISEASES

Romidepsin (FK228) and its analogs directly inhibit phosphatidylinositol 3-kinase activity and potently induce apoptosis as histone deacetylase/phosphatidylinositol 3-kinase dual inhibitors

(2012) Ken Saijo et al.   CANCER SCIENCE

HDAC Inhibitors Augmented Cell Migration and Metastasis through Induction of PKCs Leading to Identification of Low Toxicity Modalities for Combination Cancer Therapy

(2012) K.-T. Lin et al.   CLINICAL CANCER RESEARCH

Histone Deacetylase Inhibitors: New Promise in the Treatment of Immune and Inflammatory Diseases

(2012) Stephen J. Shuttleworth et al.   CURRENT DRUG TARGETS

Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8

(2012) Taeko Wada et al.   EMBO REPORTS

Three Novel Acetylation Sites in the Foxp3 Transcription Factor Regulate the Suppressive Activity of Regulatory T Cells

(2012) H.-S. Kwon et al.   JOURNAL OF IMMUNOLOGY

SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites

(2012) Francesc X. Soriano et al.   JOURNAL OF NEUROCHEMISTRY

Histone deacetylases and cancer

(2012) Bruna Barneda-Zahonero et al.   Molecular Oncology

Histone Deacetylase Inhibitors Globally Enhance H3/H4 Tail Acetylation Without Affecting H3 Lysine 56 Acetylation

(2012) Paul Drogaris et al.   Scientific Reports

Histone deacetylase inhibitors and their potential role in inflammatory bowel diseases: Figure 1

(2011) Alexander J.P. Edwards et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells

(2011) Keita Nakane et al.   INTERNATIONAL JOURNAL OF UROLOGY

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(2011) Charles Dinarello et al.   MOLECULAR MEDICINE

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(2011) Giuseppe Faraco et al.   MOLECULAR MEDICINE

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Epigenetic Regulation of Thy-1 by Histone Deacetylase Inhibitor in Rat Lung Fibroblasts

(2010) Yan Y. Sanders et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Anti-inflammatory Agents: Present and Future

(2010) Charles A. Dinarello   CELL

Epigenetics and depression: current challenges and new therapeutic options

(2010) Marc Schroeder et al.   CURRENT OPINION IN PSYCHIATRY

Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line

(2010) Jennifer S Waby et al.   Molecular Cancer

Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases

(2010) P.-H. Huang et al.   MOLECULAR PHARMACOLOGY

DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines

(2009) Melissa J LaBonte et al.   BMC Medical Genomics

E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex

(2009) Johannes von Burstin et al.   GASTROENTEROLOGY

Epigenetic regulation of microRNA expression in colorectal cancer

(2009) Eva Bandres et al.   INTERNATIONAL JOURNAL OF CANCER

Carboplatin and Paclitaxel in Combination With Either Vorinostat or Placebo for First-Line Therapy of Advanced Non–Small-Cell Lung Cancer

(2009) Suresh S. Ramalingam et al.   JOURNAL OF CLINICAL ONCOLOGY

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

(2009) E J Noonan et al.   ONCOGENE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL

Epigenetic Enhancement of Antigen Processing and Presentation Promotes Immune Recognition of Tumors

(2008) A. F. Setiadi et al.   CANCER RESEARCH

Histone deacetylase 11 regulates oligodendrocyte-specific gene expression and cell development in OL-1 oligodendroglia cells

(2008) Hedi Liu et al.   GLIA

HDAC6 Is Required for Epidermal Growth Factor-induced β-Catenin Nuclear Localization

(2008) Yu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

(2008) M. Fournel et al.   MOLECULAR CANCER THERAPEUTICS

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

(2008) Alejandro Villagra et al.   NATURE IMMUNOLOGY

Repression of E-cadherin by the polycomb group protein EZH2 in cancer

(2008) Q Cao et al.   ONCOGENE

A homogeneous cellular histone deacetylase assay suitable for compound profiling and robotic screening

(2007) Thomas Ciossek et al.   ANALYTICAL BIOCHEMISTRY