Review
Biochemistry & Molecular Biology
Muthu Thiruvengadam, Baskar Venkidasamy, Umadevi Subramanian, Ramkumar Samynathan, Mohammad Ali Shariati, Maksim Rebezov, Shabari Girish, Sivakumar Thangavel, Anand Raj Dhanapal, Natalya Fedoseeva, Joohyun Lee, Ill-Min Chung
Summary: Oxidative stress is caused by an imbalance between oxidants and antioxidant defense systems. NRF2 plays a crucial role in regulating phase II antioxidant enzymes and is considered a promising target against diseases like diabetes, fibrosis, neurotoxicity, and cancer. Dietary phytochemicals can modulate NRF2/ARE signaling and prevent various diseases, with potential mechanisms including inhibiting inflammatory mediators and regulating NRF2 signaling through various kinases and epigenetic modulation. Further investigation into upstream signaling molecules and the effects of phytochemicals are still needed.
Article
Pharmacology & Pharmacy
Nivedita Banerjee, Hui Wang, Gangduo Wang, Paul J. Boor, M. Firoze Khan
Summary: The study focused on the status and contribution of Nrf(2) and MAPK signaling in TCE-mediated inflammatory and autoimmune responses. TCE exposure led to reduction in Nrf(2) expression and increased pro-inflammatory markers, supporting the role of oxidative stress and Nrf(2)/MAPK signaling in TCE-mediated autoimmune response progression. Treatment with SFN or p38 inhibitor attenuated the phosphorylation of p38 MAPK and suppressed downstream pro-inflammatory cytokines IL-12 and TNF-alpha, suggesting potential therapeutic targets against TCE-mediated autoimmunity.
Article
Pharmacology & Pharmacy
Yuanmei Bai, Haimei Wu, Lijie Zheng, Yuhuan Xie, Feifan Liu, Yan Wan, Qiongchao Li, Peixin Guo
Summary: YJSB, a traditional Dai medicine formula, has significant therapeutic effects on liver protection. It can treat CCl4-induced liver fibrosis by regulating the Keap1-Nrf2 signaling pathway and improving liver function.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Food Science & Technology
Amin Gasmi, Asma Gasmi Benahmed, Mariia Shanaida, Salvatore Chirumbolo, Alain Menzel, Wajiha Anzar, Mehreen Arshad, Natalia Cruz-Martins, Roman Lysiuk, Nataliya Beley, Petro Oliinyk, Volodymyr Shanaida, Antonina Denys, Massimiliano Peana, Geir Bjorklund
Summary: The use of natural bioactive constituents from various food sources, such as broccoli, for anticancer purposes is gaining popularity worldwide. Broccoli contains phytochemicals, vitamins, and minerals, which provide strong antioxidant effects and modulate molecules involved in cell cycle regulation and apoptosis, reducing the risk of cancer development.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Marija Petkovic, Ermelindo C. Leal, Ines Alves, Chanda Bose, Philip T. Palade, Preeti Singh, Sanjay Awasthi, Elisabet Borsheim, Louise T. Dalgaard, Sharda P. Singh, Eugenia Carvalho
Summary: The study found that dietary supplementation with SFN increased antioxidant capacities and gene expression related to the Nrf2 pathway in the skin of old mice. Protein levels for Nrf2 were also increased, while ROS and MMP9 levels decreased significantly. Furthermore, collagen deposition was improved in young mice and significantly improved in old mice with SFN treatment, indicating that SFN can ameliorate skin aging.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Souparnika H. Manjunath, Prabhakaran Nataraj, Vikas H. Swamy, Kavya Sugur, Sumit K. Dey, Veena Ranganathan, Shyni Daniel, Zonunsiami Leihang, Veronica Sharon, Sandeep Chandrashekharappa, Nithin Sajeev, Venkataramana G. Venkatareddy, Anil Chuturgoon, Gowthamarajan Kuppusamy, SubbaRao V. Madhunapantula, Rajesh K. Thimmulappa
Summary: Pharmacological activation of NRF2 provides protection against environmental diseases. Moringa oleifera leaves contain bioactive compounds that can activate NRF2. Therefore, they can be developed as a functional food for targeting NRF2 signaling.
Article
Critical Care Medicine
Yulin Li, Minfei Yang, Lutao Xie, Gongping Zhang, Jiefeng Xu, Shanxiang Xu
Summary: The present study found that Sulforaphane (SFN), known as the activator of the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway, produced effective postresuscitation lung protection through alleviating lung pyroptosis. SFN reduced lung injury score, improved oxidative imbalance, decreased pyroptosis-related proinflammatory cytokines, downregulated pyroptosis-related proteins, and activated the Nrf2/HO-1 pathway.
Article
Multidisciplinary Sciences
Badi Sri Sailaja, Rohit Aita, Shane Maledatu, David Ribnicky, Michael P. Verzi, Ilya Raskin
Summary: This study documents the dual pharmacological action of MIC-1 in a mouse model of acute inflammation, showing reductions in inflammatory markers, spleen weight, and activation of inflammation, immunity, and oxidative stress pathways. MIC-1 increases nuclear accumulation of Nrf2 and decreases NF-kappa B, leading to reduced ROS, mitochondrial superoxide, and restoration of mitochondrial membrane potential in LPS-induced macrophages, indicating its potential in addressing chronic diseases involving inflammation and oxidative stress.
Review
Pharmacology & Pharmacy
Shunhao Zhang, Sining Duan, Zhuojun Xie, Wanlin Bao, Bo Xu, Wenbin Yang, Lingyun Zhou
Summary: The NRF2/KEAP1 signaling pathway plays a key role in cellular physiology by protecting cells from stress conditions. However, recent studies have shown that this pathway may have oncogenic effects and contribute to therapy resistance. This article investigates the role of epigenetic modifications in regulating the NRF2/KEAP1 signaling pathway and its impact on cancer development, and explores the potential of targeting epigenetic changes as therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yanyan Wang, Yanan Xu, Qingzhu Wang, Feng Guo, Yi Song, Xunjie Fan, Mingwei Shao, Duo Chen, Wei Zhang, Guijun Qin
Summary: The study found that sulforaphane (SFN) alleviates podocyte injury in diabetic kidney disease (DKD) by activating the Nrf2/PINK1 signaling pathway and balancing mitophagy. SFN can activate mitophagy in podocytes, restore urine albumin to creatinine ratio, and prevent glomerular hypertrophy and foot process fusion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Environmental Sciences
Nasreddine El Omari, Mohamed Bakha, Hamada Imtara, Fatima-Ezzahrae Guaouguaoua, Abdelaali Balahbib, Gokhan Zengin, Abdelhakim Bouyahya
Summary: Epigenetic dysregulation plays a crucial role in cell transformation and cancer, leading to the development of epidrugs to restore cellular memory. Natural bioactive compounds from medicinal plants have been identified as potential epidrugs for cancer therapy, targeting various epigenetic modulators. This review highlights the pharmacodynamic actions of different chemical classes of natural bioactive compounds in epigenetic medications for cancer treatment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Koji Ishida, Kosuke Kaji, Shinya Sato, Hiroyuki Ogawa, Hirotetsu Takagi, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji
Summary: Sulforaphane has a significant impact on acetaldehyde metabolism and liver fibrosis, alleviating alcoholic liver disease-related fibrosis by activating nuclear factor erythroid 2-related factor 2, and inhibiting the progression of chronic alcoholic liver disease.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Zhiqiang Feng, Tengfei Wang, Yawen Sun, Siying Chen, Haisheng Hao, Weihua Du, Huiying Zou, Dawei Yu, Huabin Zhu, Yunwei Pang
Summary: Sulforaphane (SFN), extracted from cruciferous plants, plays a vital role in eliminating oxidative free radicals and protecting cells through activation of the Nrf2-mediated signaling pathway. This study found that SFN can attenuate paraquat-induced damage to bovine in vitro-matured oocytes and enhance their maturation and fertilization rates. SFN reduces oxidative stress, inhibits cell apoptosis, and activates antioxidative-related genes through the Nrf2 pathway, providing novel evidence for the protective role of SFN against paraquat-induced injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Oncology
Nuria Camina, Trevor M. Penning
Summary: The activation of the NRF2 transcription factor plays a crucial role in detoxifying electrophilic carcinogens and preventing cancer, yet can also potentially exacerbate carcinogenesis in certain contexts. Understanding the activation of the NRF2-KEAP1 signaling pathway, its epigenetic regulation, and its role in oncogenesis is essential for elucidating the mechanisms of cancer development.
BRITISH JOURNAL OF CANCER
(2022)
Article
Neurosciences
Dongyu Hua, Ailin Luo, Zifeng Wu, Chaoli Huang, Shan Li, Xiaolin Xu, Jiali Xu, Chun Yang, Di Wang, Cunming Liu
Summary: Anesthesia and surgery are found to cause cognitive dysfunction in patients, especially the elderly. Decreased Keap1-Nrf2 signaling in the medial prefrontal cortex, hippocampus, and liver may contribute to the onset of post-operative cognitive dysfunction (POCD). Sulforaphane shows potential in improving POCD symptoms by increasing Keap1-Nrf2 signaling.
BRAIN RESEARCH BULLETIN
(2022)
Review
Oncology
Bin Wang, Qin Zhao, Yuyu Zhang, Zijing Liu, Zhuangzhuang Zheng, Shiyu Liu, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Hypoxic tumor microenvironment (TME) may be a major barrier limiting the efficacy of immunotherapy, through inducing immune suppression and resistance. Targeting hypoxia could enhance the efficacy of immunotherapy and provide a promising combinational therapeutic strategy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Jinlong Wei, Qin Zhao, Min Yao, Lingbin Meng, Ying Xin, Xin Jiang
Summary: A 29-year-old male patient with GPA exclusively in the eyelid area underwent successful radiotherapy, leading to a significant reduction of the lesion and obvious symptom relief. This case highlights the importance of considering novel treatments such as radiotherapy for GPA patients when the standard treatment model fails to deliver positive results.
Review
Medicine, Research & Experimental
Zijing Liu, Qin Zhao, Zhuangzhuang Zheng, Shiyu Liu, Lingbin Meng, Lihua Dong, Xin Jiang
Summary: The study focuses on the mechanism of immunotherapy in normalizing tumor blood vessels and proposes a promising prospect for improving hypoxia. Immune checkpoint inhibitors induce the reduction in regulatory T cells and increase in eosinophil levels, playing crucial roles in the process of vascular normalization. This review suggests a new idea for the combined application of immunotherapy and radiotherapy, with the potential to pave the way for a promising strategy for cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Shiyu Liu, Weiyan Shi, Qin Zhao, Zhuangzhuang Zheng, Zijing Liu, Lingbin Meng, Lihua Dong, Xin Jiang
Summary: TTFields is a treatment technology that induces apoptosis of cancer cells by generating an electric field, and is promising for the treatment of glioblastoma with few side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhuangzhuang Zheng, Bin Wang, Qin Zhao, Yuyu Zhang, Jinlong Wei, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Radiotherapy is effective in the treatment of head and neck cancer, but can lead to serious complications such as radiation-induced temporal lobe injury (TLI). Various imaging techniques such as CT and MRI can be used to observe structural changes and dose-dependent alterations in gray and white matter volume. Further advanced imaging modalities like DTI, DKI, SWI, rs-fMRI, MRS, and PET can help in early diagnosis and prognosis evaluation of TLI based on functional, molecular, and cellular processes.
EUROPEAN RADIOLOGY
(2022)
Review
Immunology
Huanhuan Wang, Qin Zhao, Yuyu Zhang, Qihe Zhang, Zhuangzhuang Zheng, Shiyu Liu, Zijing Liu, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Head and neck cancer, primarily head and neck squamous cell carcinoma, is commonly treated with surgery, radiotherapy, chemotherapy, and immunotherapy. Immunotherapy, particularly for HPV-positive patients, has shown promising results possibly due to higher immune cell infiltration and differential expression of immune checkpoints in tumors. Personalized immunotherapy trials are also being conducted in HPV-positive patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Huanhuan Wang, Qin Zhao, Yangyu Zhang, Jinlong Wei, Bin Wang, Zhuangzhuang Zheng, Shiyu Liu, Zijing Liu, Lingbin Meng, Ying Xin, Xin Jiang
Summary: The study found that for recurrent/metastatic head and neck squamous cell carcinoma, chemotherapy regimens such as cetuximab/platinum/5-FU, pembrolizumab/platinum/5-FU or pembrolizumab alone, and nivolumab showed better efficacy with lower rates of adverse events. Immunotherapy has achieved better efficacy in treating the condition.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kunzhi Chen, Zhuangzhuang Zheng, Lijuan Ding, Na Tao, Libo Wang, Wenming Xia, Huidong Wang, Xin Jiang
Summary: A systematic quantitative evaluation of IMRT quality change in modified radical mastectomy using Plan-IQ feasibility tool was conducted. Results showed that the RP group had significantly better OAR dose limits compared to the NP group, with a decrease in total scores. PTV scores decreased in the RP group, while OAR scores improved.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Jing Su, Qin Zhao, Zhuangzhuang Zheng, Huanhuan Wang, Chenbin Bian, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Radiation therapy plays a crucial role in cancer treatment, but the hypoxic microenvironment in solid tumors can affect its effectiveness. Ferroptosis, a newly discovered cell death mechanism, can enhance the radiosensitivity of hypoxic tumor cells by amplifying oxidative stress or inhibiting antioxidant regulation.
Review
Biochemistry & Molecular Biology
Yuan Tian, Ziting Gao, Wenyun Liu, Jinjie Li, Xin Jiang, Ying Xin
Summary: Diabetic cardiomyopathy is a major cause of mortality and morbidity in diabetes patients. Its pathogenesis involves multiple factors, and recent studies have found that long non-coding RNAs play a critical role in this process, providing insights for the development of diagnostic and therapeutic strategies.
Review
Biochemistry & Molecular Biology
Chenbin Bian, Zhuangzhuang Zheng, Jing Su, Huanhuan Wang, Sitong Chang, Ying Xin, Xin Jiang
Summary: Radiotherapy failure and poor tumor prognosis are mainly caused by radioresistance. The relationship and mechanisms between mitochondrial metabolism and cancer radioresistance are not fully understood. However, mitochondria play a crucial role in regulating various biological reactions and influencing the radiation effects of malignancies. Therefore, targeting mitochondrial signaling pathways for the development of novel anticancer drugs holds promise.
Article
Biochemistry & Molecular Biology
Pinyi Liu, Xiaoming Dong, Chao Dong, Guowen Hou, Wenyun Liu, Xin Jiang, Ying Xin
Summary: MHRT exerts a protective effect against Ang II-induced myocardial injury by reducing oxidative stress and NLRP3 inflammasome activation via Nrf2 activation.
Review
Pharmacology & Pharmacy
Wei Liu, Zining Tan, Mengrou Geng, Xin Jiang, Ying Xin
Summary: This article discusses the relationship between the renin-angiotensin system (RAS) and the gut microbiota, noting that Angiotensin II (Ang II) can lead to an imbalance in the gut microbiota, thereby exacerbating disease progression. In addition, angiotensin converting enzyme 2 can alleviate the deleterious effects of Ang II and regulate gut microbial dysbiosis and immune responses associated with coronavirus disease 19. Deciphering these mechanisms will provide a theoretical basis for novel therapeutic strategies for disease prevention and treatment. Finally, therapies targeting the gut microbiota to treat Ang II-related disorders are discussed.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Bin Wang, Yin Han, Yuyu Zhang, Qin Zhao, Huanhuan Wang, Jinlong Wei, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1/PD-L1 have shown promise in treating various types of malignancies by boosting tumor-specific T cell immunity. However, acquired resistance to ICI therapy remains a major obstacle. In this review, we discuss the mechanisms of acquired resistance to ICIs, including lack of neoantigens, mutations in IFN-γ/JAK signaling, activation of alternate inhibitory immune checkpoints, immunosuppressive tumor microenvironment, epigenetic modification, and dysbiosis of the gut microbiome. Potential therapeutic strategies to reverse ICI resistance are also briefly explored.
CELL AND BIOSCIENCE
(2023)
Review
Oncology
Shiyu Liu, Qin Zhao, Weiyan Shi, Zhuangzhuang Zheng, Zijing Liu, Lingbin Meng, Lihua Dong, Xin Jiang
Summary: High-grade gliomas (HGGs) are the most common primary malignant brain tumors, and treatment plans are personalized based on patient characteristics. The basic treatment plan involves surgery, radiotherapy, and chemotherapy, while comprehensive treatment schemes combine various modalities such as radiotherapy, chemotherapy, molecular targeted therapy, and immunotherapy.
