Harnessing redox signaling to overcome therapeutic-resistant cancer dormancy

Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy

(2022) Zhe Zhang et al.   EMBO Molecular Medicine

Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway

(2022) Nu-Ri Im et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

(2021) Sumaiyah K. Rehman et al.   CELL

The Chitosan/Agarose/NanoHA Bone Scaffold-Induced M2 Macrophage Polarization and Its Effect on Osteogenic Differentiation In Vitro

(2021) Paulina Kazimierczak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-term outcome of imatinib 400 mg compared to imatinib 600 mg or imatinib 400 mg daily in combination with cytarabine or pegylated interferon alpha 2a for chronic myeloid leukaemia: results from the French SPIRIT phase III randomised trial

(2021) Francois Guilhot et al.   LEUKEMIA

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence

(2021) Cihangir Duy et al.   Cancer Discovery

Neutrophils create a fertile soil for metastasis

(2021) Kevin Kos et al.   CANCER CELL

A Malignant Case of Arrested Development: Cancer Cell Dormancy Mimics Embryonic Diapause

(2021) Yu-Hsuan Lin et al.   CANCER CELL

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

Diversity and versatility of p38 kinase signalling in health and disease

(2021) Begoña Canovas et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selenium mediated host plant–mite conflict: defense and adaptation

(2021) Zhifeng Xu et al.   PEST MANAGEMENT SCIENCE

Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans

(2021) Jin Meng et al.   Nature Communications

Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation

(2021) Laure-Anne Ligeon et al.   Nature Communications

Long non-coding RNAs and cancer metastasis: Molecular basis and therapeutic implications

(2021) Hui Ming et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Therapy-Induced Senescence: Opportunities to Improve Anti-Cancer Therapy

(2021) Pataje G Prasanna et al.   JNCI-Journal of the National Cancer Institute

Multifaceted functions of chronic inflammation in regulating tumor dormancy and relapse

(2021) Saeed H. Manjili et al.   SEMINARS IN CANCER BIOLOGY

Slow-cycling (dormant) cancer cells in therapy resistance, cancer relapse and metastasis

(2021) Sukanya Basu et al.   SEMINARS IN CANCER BIOLOGY

Thorny ground, rocky soil: tissue-specific mechanisms of tumor dormancy and relapse

(2021) Andrea R. Lim et al.   SEMINARS IN CANCER BIOLOGY

Enhanced lipid metabolism induces the sensitivity of dormant cancer cells to 5-aminolevulinic acid-based photodynamic therapy

(2021) Taku Nakayama et al.   Scientific Reports

Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells

(2021) Scott Sauer et al.   Frontiers in Oncology

Recurrent human papillomavirus-related head and neck cancer undergoes metabolic re-programming and is driven by oxidative phosphorylation

(2021) Avani Vyas et al.   CLINICAL CANCER RESEARCH

Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK

(2021) Ceryl Tan et al.   DEVELOPMENTAL CELL

A cascaded copper-based nanocatalyst by modulating glutathione and cyclooxygenase-2 for hepatocellular carcinoma therapy

(2021) Hailong Tian et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings

(2021) Ryann E. Shor et al.   Molecular Oncology

Cycling cancer persister cells arise from lineages with distinct programs

(2021) Yaara Oren et al.   NATURE

Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

(2021) Ana Luísa Correia et al.   NATURE

Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications

(2021) Ritama Paul et al.   PHARMACOLOGY & THERAPEUTICS

Cellular stress responses and metabolic reprogramming in cancer progression and dormancy

(2021) Kyle K. Payne   SEMINARS IN CANCER BIOLOGY

Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance

(2021) Haohao Huang et al.   Nature Communications

Single Cell Analysis Unveils the Role of the Tumor Immune Microenvironment and Notch Signaling in Dormant Minimal Residual Disease

(2021) Mahnaz Janghorban et al.   CANCER RESEARCH

Persister cancer cells: Iron addiction and vulnerability to ferroptosis

(2021) Raphaël Rodriguez et al.   MOLECULAR CELL

Diverse alterations associated with resistance to KRAS(G12C) inhibition

(2021) Yulei Zhao et al.   NATURE

Microenvironment-mediated cancer dormancy: Insights from metastability theory

(2021) Sadra Bakhshandeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of tumor microenvironment and exosomes in dormancy and relapse

(2021) Shireen Attaran et al.   SEMINARS IN CANCER BIOLOGY

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

(2021) Chewei Anderson Chang et al.   Cancer Discovery

Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer

(2021) Liyuan Peng et al.   Cell Reports

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

(2021) Bashayer R. Al-Mubarak et al.   Redox Biology

Redox Control of the Dormant Cancer Cell Life Cycle

(2021) Bowen Li et al.   Cells

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

(2020) Kari J. Kurppa et al.   CANCER CELL

Senesce to Survive: YAP-Mediated Dormancy Escapes EGFR/MEK Inhibition

(2020) Igor Bado et al.   CANCER CELL

Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency

(2020) Raymond Liang et al.   Cell Stem Cell

Hypoxia: a barricade to conquer the pancreatic cancer

(2020) Zhen Tan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Roles of FoxO Transcription Factors in Regulation of Bone Cells Function

(2020) Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

Tumour metabolism and its unique properties in prostate adenocarcinoma

(2020) David A. Bader et al.   Nature Reviews Urology

Relapse fated latent diagnosis subclones in acute B lineage leukaemia are drug tolerant and possess distinct metabolic programs

(2020) Stephanie M. Dobson et al.   Cancer Discovery

Epigenetic dynamics in cancer stem cell dormancy

(2020) Alejandra I. Ferrer et al.   CANCER AND METASTASIS REVIEWS

NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma

(2020) Hoi Wing Leung et al.   CANCER LETTERS

Hypoxia-mediated changes in bone marrow microenvironment in breast cancer dormancy

(2020) Alejandra Ferrer et al.   CANCER LETTERS

The Matrix Revolution: Matricellular Proteins and Restructuring of the Cancer Microenvironment

(2020) Casimiro Gerarduzzi et al.   CANCER RESEARCH

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

(2020) Marcus Ruscetti et al.   CELL

Protection of hematopoietic stem cells from stress-induced exhaustion and aging

(2020) Shweta Singh et al.   CURRENT OPINION IN HEMATOLOGY

Hedgehog Signaling Demarcates a Niche of Fibrogenic Peribiliary Mesenchymal Cells

(2020) Vikas Gupta et al.   GASTROENTEROLOGY

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Entry and exit of chemotherapeutically-promoted cellular dormancy in glioblastoma cells is differentially affected by the chemokines CXCL12, CXCL16, and CX3CL1

(2020) Vivian Adamski et al.   ONCOGENE

Oxidative resistance of leukemic stem cells and oxidative damage to hematopoietic stem cells under pro-oxidative therapy

(2020) Yongfeng Chen et al.   Cell Death & Disease

Anti-recurrence/metastasis and chemosensitization therapy with thioredoxin reductase-interfering drug delivery system

(2020) Jichun Yang et al.   BIOMATERIALS

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

Tumour dormancy in inflammatory microenvironment: A promising therapeutic strategy for cancer-related bone metastasis

(2020) Wenhui Hu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Challenges and Opportunities in Cancer Drug Resistance

(2020) Richard A. Ward et al.   CHEMICAL REVIEWS

Adrenergic Blockade Promotes Maintenance of Dormancy in Prostate Cancer Through Upregulation of GAS6

(2020) Ann M. Decker et al.   Translational Oncology

The Complex Interplay between Antioxidants and ROS in Cancer

(2020) Isaac S. Harris et al.   TRENDS IN CELL BIOLOGY

Biomaterial 3D collagen I gel culture model: A novel approach to investigate tumorigenesis and dormancy of bladder cancer cells induced by tumor microenvironment

(2020) Yaqi Qiu et al.   BIOMATERIALS

Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

(2020) Dorian Forte et al.   Cell Metabolism

The role of stress kinases in metabolic disease

(2020) Ivana Nikolic et al.   Nature Reviews Endocrinology

Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds

(2020) Zhaowu Ma et al.   SEMINARS IN CANCER BIOLOGY

Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment

(2020) Ying Ji et al.   Nature Communications

Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification

(2020) Bowen Li et al.   DRUG RESISTANCE UPDATES

The role of hypoxia‐inducible factor 1 in tumor immune evasion

(2020) Li You et al.   MEDICINAL RESEARCH REVIEWS

CSN8 is a key regulator in hypoxia-induced epithelial–mesenchymal transition and dormancy of colorectal cancer cells

(2020) Songwen Ju et al.   Molecular Cancer

ROS and hypoxia signaling regulate periodic metabolic arousal during insect dormancy to coordinate glucose, amino acid, and lipid metabolism

(2020) Chao Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils

(2020) Michela Perego et al.   Science Translational Medicine

Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

(2020) Hailong Tian et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting Cancer Cell Dormancy

(2019) Ariadna Recasens et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cycling Quiescence in Temozolomide Resistant Glioblastoma Cells Is Partly Explained by microRNA-93 and -193-Mediated Decrease of Cyclin D

(2019) Jessian L. Munoz et al.   Frontiers in Pharmacology

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

(2019) Matthew J. Watt et al.   Science Translational Medicine

Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling

(2019) Cindy T.J. van Velthoven et al.   Cell Stem Cell

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

(2019) Tareq Saleh et al.   CANCER RESEARCH

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

(2019) Jonathan Cooper et al.   CANCER CELL

A Niche-Dependent Myeloid Transcriptome Signature Defines Dormant Myeloma Cells

(2019) Weng Hua Khoo et al.   BLOOD

Multiple actions of PTHrP in breast cancer bone metastasis

(2019) T. John Martin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

(2019) Mohamed Elgendy et al.   CANCER CELL

Sodium Selenite Alleviates Breast Cancer-Related Lymphedema Independent of Antioxidant Defense System

(2019) Hye Won Han et al.   Nutrients

NR2F1 contributes to cancer cell dormancy, invasion and metastasis of salivary adenoid cystic carcinoma by activating CXCL12/CXCR4 pathway

(2019) Xiao-lei Gao et al.   BMC CANCER

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The pan-therapeutic resistance of disseminated tumor cells: Role of phenotypic plasticity and the metastatic microenvironment

(2019) Bo Ma et al.   SEMINARS IN CANCER BIOLOGY

The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics

(2019) Debasna P. Panigrahi et al.   SEMINARS IN CANCER BIOLOGY

Fatty-acid receptor CD36 functions as a hydrogen sulfide-targeted receptor with its Cys333-Cys272 disulfide bond serving as a specific molecular switch to accelerate gastric cancer metastasis

(2019) Rui Wang et al.   EBioMedicine

Ovariectomy increases RANKL protein expression in bone marrow adipocytes of C3H/HeJ mice.

(2019) Kerensa M. Beekman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug

(2019) Behrouz Hassannia et al.   BIOCHEMICAL PHARMACOLOGY

Integrin-mediated cell adhesion requires extracellular disulfide exchange regulated by protein disulfide isomerase

(2019) Nurit Rosenberg et al.   EXPERIMENTAL CELL RESEARCH

High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation

(2019) Dunfang Zhang et al.   IMMUNITY

Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment

(2019) Elena Butturini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin

(2019) Li Li Han et al.   MOLECULAR CANCER RESEARCH

Protozoan persister-like cells and drug treatment failure

(2019) Michael P. Barrett et al.   NATURE REVIEWS MICROBIOLOGY

Cancer stem cells and their unique role in metastatic spread

(2019) Teresa Bernadette Steinbichler et al.   SEMINARS IN CANCER BIOLOGY

Dormant disseminated tumor cells and cancer stem/progenitor-like cells: Similarities and opportunities

(2019) Omri Hen et al.   SEMINARS IN CANCER BIOLOGY

Acquired Resistance Is Oncogene and Drug Agnostic

(2019) Robert C. Doebele   CANCER CELL

Detection, identification, and quantification of oxidative protein modifications

(2019) Clare L. Hawkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The great escape: tumour cell plasticity in resistance to targeted therapy

(2019) Soufiane Boumahdi et al.   NATURE REVIEWS DRUG DISCOVERY

Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML

(2019) Alexander E. Perl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function

(2019) Xiaozhen Dai et al.   TRENDS IN MOLECULAR MEDICINE

Comprehensive Analysis of ERK1/2 Substrates for Potential Combination Immunotherapies

(2019) Lei Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

LINC00978 promotes the progression of hepatocellular carcinoma by regulating EZH2-mediated silencing of p21 and E-cadherin expression

(2019) Xueying Xu et al.   Cell Death & Disease

Activity-Based Sensing for Site-Specific Proteomic Analysis of Cysteine Oxidation

(2019) Yunlong Shi et al.   ACCOUNTS OF CHEMICAL RESEARCH

The protease activity of human ATG4B is regulated by reversible oxidative modification

(2019) Xueping Zheng et al.   Autophagy

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis

(2019) Hongfeng Wang et al.   Autophagy

ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α

(2019) Duckgue Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy and Inflammation

(2018) Yu Matsuzawa-Ishimoto et al.   Annual Review of Immunology

Reactive Oxygen Species and Mitochondrial Homeostasis as Regulators of Stem Cell Fate and Function

(2018) Darren Q. Tan et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms and context underlying the role of autophagy in cancer metastasis

(2018) Christopher M. Dower et al.   Autophagy

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases

(2018) Douglas B. Kell et al.   BIOLOGICAL REVIEWS

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Abstract OT2-07-09: Detection and targeting of minimal residual disease in breast cancer to reduce recurrence: The PENN-SURMOUNT and CLEVER trials

(2018) LJ Bayne et al.   CANCER RESEARCH

Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII–p38MAPK–pS249/T252RB Pathway

(2018) Li-Yuan Yu-Lee et al.   CANCER RESEARCH

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling

(2018) Ming Luo et al.   Cell Metabolism

CD150 high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

(2018) Yuichi Hirata et al.   Cell Stem Cell

Chemical methods for mapping cysteine oxidation

(2018) Lisa J. Alcock et al.   CHEMICAL SOCIETY REVIEWS

Redundant angiogenic signaling and tumor drug resistance

(2018) Rajesh N. Gacche et al.   DRUG RESISTANCE UPDATES

Hypoxia, oxidative stress and inflammation

(2018) Trudy McGarry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quiescent Tissue Stem Cells Evade Immune Surveillance

(2018) Judith Agudo et al.   IMMUNITY

Estrogen Deficiency-Mediated M2 Macrophage Osteoclastogenesis Contributes to M1/M2 Ratio Alteration in Ovariectomized Osteoporotic Mice

(2018) Ce Dou et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemotherapy medication errors

(2018) Saul N Weingart et al.   LANCET ONCOLOGY

Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner

(2018) Xiaomin Fu et al.   Molecular Cancer

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

How to pull the blanket off dormant cancer cells

(2018) Vivien Marx   NATURE METHODS

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Duration of Adjuvant Chemotherapy for Stage III Colon Cancer

(2018) Axel Grothey et al.   NEW ENGLAND JOURNAL OF MEDICINE

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

(2018) Andrew M. Kidger et al.   PHARMACOLOGY & THERAPEUTICS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence

(2018) Laura Vera-Ramirez et al.   Nature Communications

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

(2018) Karen Frudd et al.   Nature Communications

DUOX2-mediated production of reactive oxygen species induces epithelial mesenchymal transition in 5-fluorouracil resistant human colon cancer cells

(2018) Kyoung Ah Kang et al.   Redox Biology

Antioxidant response elements: Discovery, classes, regulation and potential applications

(2018) Azhwar Raghunath et al.   Redox Biology

Bone Marrow Adipocyte: An Intimate Partner With Tumor Cells in Bone Metastasis

(2018) Guojing Luo et al.   Frontiers in Endocrinology

Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence

(2018) Samir Tivari et al.   Cell Communication and Signaling

Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy

(2018) Jin-Hwan Kim et al.   CELL DEATH AND DIFFERENTIATION

The p38-activated ER stress-ATF6α axis mediates cellular senescence

(2018) Hee Suk Kim et al.   FASEB JOURNAL

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers

(2018) S. N. Gettinger et al.   Nature Communications

Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer

(2018) François M. Vallette et al.   BIOCHEMICAL PHARMACOLOGY

Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound Healing

(2018) Miranda V. Hunter et al.   DEVELOPMENTAL CELL

Modulating ROS to overcome multidrug resistance in cancer

(2018) Qingbin Cui et al.   DRUG RESISTANCE UPDATES

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

CD150high CD4 T cells and CD150high Tregs regulate hematopoietic stem cell quiescence via CD73

(2018) Yuichi Hirata et al.   HAEMATOLOGICA

The role of cellular reactive oxygen species in cancer chemotherapy

(2018) Haotian Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Dormant tumour cells, their niches and the influence of immunity

(2018) Erica T. Goddard et al.   NATURE CELL BIOLOGY

Redox regulation of cell state and fate

(2018) Bernice Woon Li Lee et al.   Redox Biology

Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress

(2018) Zhe Zhang et al.   Redox Biology

Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals

(2017) Jeremiah D. Keyes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3

(2017) Rekha Bassi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging roles of lipid metabolism in cancer metastasis

(2017) Xiangjian Luo et al.   Molecular Cancer

The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

(2017) Pingting Zhou et al.   Molecular Cancer

METCopy Number Gain Is Associated with Gefitinib Resistance in Leptomeningeal Carcinomatosis ofEGFR-mutant Lung Cancer

(2017) Shigeki Nanjo et al.   MOLECULAR CANCER THERAPEUTICS

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

(2017) Hongchao Pan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

(2017) Jesus Cosin-Roger et al.   Nature Communications

A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes

(2017) Qiuhong Li et al.   Nature Communications

Redox environment in stem and differentiated cells: A quantitative approach

(2017) O.G. Lyublinskaya et al.   Redox Biology

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

(2016) Ji Liang et al.   CELL RESEARCH

DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization

(2016) Alpaslan Tasdogan et al.   Cell Stem Cell

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

(2016) Rachelle W. Johnson et al.   NATURE CELL BIOLOGY

Factor inhibiting HIF1α (FIH-1) functions as a tumor suppressor in human colorectal cancer by repressing HIF1α pathway

(2015) Tao Chen et al.   CANCER BIOLOGY & THERAPY

Mechanisms of Cancer Cell Dormancy--Another Hallmark of Cancer?

(2015) A. C. Yeh et al.   CANCER RESEARCH

SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy

(2015) Anh Thu Bui et al.   CELL CYCLE

Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure

(2015) R. Pagliarini et al.   EMBO REPORTS

Crosstalk between Nrf2 and Notch signaling

(2015) Nobunao Wakabayashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone

(2015) Penelope D. Ottewell et al.   INTERNATIONAL JOURNAL OF CANCER

CD36 Binds Oxidized Low Density Lipoprotein (LDL) in a Mechanism Dependent upon Fatty Acid Binding

(2015) Anthony G. Jay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Participation of TNF-α in Inhibitory Effects of Adipocytes on Osteoblast Differentiation

(2015) Robrigo P.F. Abuna et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis

(2015) J-E Kim et al.   ONCOGENE

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

(2015) Michelle A. Lawson et al.   Nature Communications

Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences

(2015) Kati Richter et al.   Redox Biology

NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation

(2014) Jung-Hyun Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

(2014) Eric M. Pietras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

(2014) Fan Jiang et al.   Redox Biology

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy

(2013) B. Boyerinas et al.   BLOOD

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

(2013) Paloma Bragado et al.   NATURE CELL BIOLOGY

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of the Oxidative Stress Sensor NPGPx Compromises GRP78 Chaperone Activity and Induces Systemic Disease

(2012) Pei-Chi Wei et al.   MOLECULAR CELL

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

(2011) Dipak Panigrahy et al.   JOURNAL OF CLINICAL INVESTIGATION

NOV-002, a Glutathione Disulfide Mimetic, as a Modulator of Cellular Redox Balance

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