Slow-cycling (dormant) cancer cells in therapy resistance, cancer relapse and metastasis

Mechanisms of signalling-memory governing progression through the eukaryotic cell cycle

(2021) Béla Novák et al.   CURRENT OPINION IN CELL BIOLOGY

A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

(2020) Federica Francescangeli et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer

(2020) Dingxiao Zhang et al.   Nature Communications

Systematic Evaluation of PKH Labelling on Extracellular Vesicle Size by Nanoparticle Tracking Analysis

(2020) Mehdi Dehghani et al.   Scientific Reports

Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence

(2020) Andrea Walens et al.   Nature Communications

Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways

(2019) Mingwei Min et al.   PLOS BIOLOGY

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

(2019) Jie-Yu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Niche-Dependent Myeloid Transcriptome Signature Defines Dormant Myeloma Cells

(2019) Weng Hua Khoo et al.   BLOOD

Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells

(2019) Yuxuan Miao et al.   CELL

High density is a property of slow-cycling and treatment-resistant human glioblastoma cells

(2019) Hanna Sabelström et al.   EXPERIMENTAL CELL RESEARCH

GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile

(2019) Patricia Rusu et al.   Cell Stem Cell

LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer

(2019) Qiuhui Li et al.   Nature Communications

PKH26 labeling of extracellular vesicles: Characterization and cellular internalization of contaminating PKH26 nanoparticles

(2018) Pia Pužar Dominkuš et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Quiescent Tissue Stem Cells Evade Immune Surveillance

(2018) Judith Agudo et al.   IMMUNITY

A Precise Cdk Activity Threshold Determines Passage through the Restriction Point

(2018) Clayton Schwarz et al.   MOLECULAR CELL

Cancer stem cells: regulation programs, immunological properties and immunotherapy

(2018) Dingxiao Zhang et al.   SEMINARS IN CANCER BIOLOGY

Prostate Cancer Stem Cells: Current Understanding

(2018) Sergej Skvortsov et al.   STEM CELLS

Histone 2B-GFP Label-Retaining Prostate Luminal Cells Possess Progenitor Cell Properties and Are Intrinsically Resistant to Castration

(2018) Dingxiao Zhang et al.   Stem Cell Reports

Cancer Stem Cells, Bone and Tumor Microenvironment: Key Players in Bone Metastases

(2018) Ilaria Roato et al.   Cancers

TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence

(2018) Isabel Puig et al.   JOURNAL OF CLINICAL INVESTIGATION

Control of the Restriction Point by Rb and p21

(2018) Justin Moser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses

(2018) Qiuhui Li et al.   Nature Communications

Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence

(2018) Iain Miller et al.   Cell Reports

Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention

(2018) Lewis A. Quayle et al.   CLINICAL & EXPERIMENTAL METASTASIS

Infiltrative and drug‐resistant slow‐cycling cells support metabolic heterogeneity in glioblastoma

(2018) Lan B Hoang‐Minh et al.   EMBO JOURNAL

A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy

(2018) Adriana Sánchez-Danés et al.   NATURE

Sympathetic Signaling Reactivates Quiescent Disseminated Prostate Cancer Cells in the Bone Marrow

(2017) Ann M. Decker et al.   MOLECULAR CANCER RESEARCH

The Slow Cycling Phenotype: A Growing Problem for Treatment Resistance in Melanoma

(2017) Antonio Ahn et al.   MOLECULAR CANCER THERAPEUTICS

Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle

(2017) Asako Sakaue-Sawano et al.   MOLECULAR CELL

Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens

(2017) Xuefeng Liu et al.   Nature Protocols

A slow-cycling subpopulation of melanoma cells with highly invasive properties

(2017) M Perego et al.   ONCOGENE

Cellular determinants and microenvironmental regulation of prostate cancer metastasis

(2017) Kiera Rycaj et al.   SEMINARS IN CANCER BIOLOGY

MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

(2017) Can Liu et al.   Nature Communications

Molecular determinants of prostate cancer metastasis

(2017) Kiera Rycaj et al.   Oncotarget

Transgenic overexpression of NanogP8 in the mouse prostate is insufficient to initiate tumorigenesis but weakly promotes tumor development in the Hi-Myc mouse model

(2017) Bigang Liu et al.   Oncotarget

Characterization and functional analysis of a slow-cycling subpopulation in colorectal cancer enriched by cell cycle inducer combined chemotherapy

(2017) Feng-Hua Wu et al.   Oncotarget

NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells

(2016) T. Srinivasan et al.   CANCER RESEARCH

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Defining a Population of Stem-like Human Prostate Cancer Cells That Can Generate and Propagate Castration-Resistant Prostate Cancer

(2016) X. Chen et al.   CLINICAL CANCER RESEARCH

A quantitative FastFUCCI assay defines cell cycle dynamics at a single-cell level

(2016) Siang-Boon Koh et al.   JOURNAL OF CELL SCIENCE

Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy

(2016) Frank C. Cackowski et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche

(2016) Olivier Govaere et al.   JOURNAL OF HEPATOLOGY

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

(2016) Aaron N Hata et al.   NATURE MEDICINE

Fluorescent indicators for simultaneous reporting of all four cell cycle phases

(2016) Bryce T Bajar et al.   NATURE METHODS

Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer

(2016) Dingxiao Zhang et al.   Nature Communications

miR-199a-3p targets stemness-related and mitogenic signaling pathways to suppress the expansion and tumorigenic capabilities of prostate cancer stem cells

(2016) Ruifang Liu et al.   Oncotarget

Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA−/lo castration-resistant cells

(2016) Kiera Rycaj et al.   Oncotarget

Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow

(2016) Younghun Jung et al.   Oncotarget

Developing a Novel Two-Dimensional Culture System to Enrich Human Prostate Luminal Progenitors that Can Function as a Cell of Origin for Prostate Cancer

(2016) Dingxiao Zhang et al.   Stem Cells Translational Medicine

NANOG reprograms prostate cancer cells to castration resistance via dynamically repressing and engaging the AR/FOXA1 signaling axis

(2016) Collene R Jeter et al.   Cell Discovery

Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow

(2016) Kenji Yumoto et al.   Scientific Reports

Tenascin-C Protects Cancer Stem-like Cells from Immune Surveillance by Arresting T-cell Activation

(2015) E. Jachetti et al.   CANCER RESEARCH

Cell-of-Origin of Cancer versus Cancer Stem Cells: Assays and Interpretations

(2015) K. Rycaj et al.   CANCER RESEARCH

Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer

(2015) Michael D. Brooks et al.   Cell Stem Cell

Cancer stem cells and cell size: A causal link?

(2015) Qiuhui Li et al.   SEMINARS IN CANCER BIOLOGY

Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding Questions

(2015) Collene R. Jeter et al.   STEM CELLS

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

(2015) Maria Soledad Sosa et al.   Nature Communications

Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells

(2015) Xin Liu et al.   Oncotarget

A Flexible Reporter System for Direct Observation and Isolation of Cancer Stem Cells

(2015) Binwu Tang et al.   Stem Cell Reports

Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells

(2015) Takuya Nakamura et al.   Oncotarget

Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways

(2015) Lisly Chéry et al.   Oncotarget

TBK1 Regulates Prostate Cancer Dormancy through mTOR Inhibition

(2015) Jin Koo Kim et al.   NEOPLASIA

miRNA-128 Suppresses Prostate Cancer by Inhibiting BMI-1 to Inhibit Tumor-Initiating Cells

(2014) M. Jin et al.   CANCER RESEARCH

Cancer Stem Cells: Constantly Evolving and Functionally Heterogeneous Therapeutic Targets

(2014) T. Yang et al.   CANCER RESEARCH

Fucci2a:A bicistronic cell cycle reporter that allows Cre mediated tissue specific expression in mice

(2014) Richard Lester Mort et al.   CELL CYCLE

Metastatic Stem Cells: Sources, Niches, and Vital Pathways

(2014) Thordur Oskarsson et al.   Cell Stem Cell

Cancer stem cells and radioresistance

(2014) Kiera Rycaj et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Aberrant self-renewal and quiescence contribute to the aggressiveness of glioblastoma

(2014) Benito Campos et al.   JOURNAL OF PATHOLOGY

Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states

(2014) K. W. Overton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

(2014) Wan-Jiun Chen et al.   Nature Communications

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

(2014) Anil M Narasimha et al.   eLife

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

The Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit

(2013) Sabrina L. Spencer et al.   CELL

In vivo functional studies of tumor-specific retrogene NanogP8 in transgenic animals

(2013) Mark A Badeaux et al.   CELL CYCLE

New insights into prostate cancer stem cells

(2013) Xin Chen et al.   CELL CYCLE

p16INK4a reporter mice reveal age-promoting effects of environmental toxicants

(2013) Jessica A. Sorrentino et al.   JOURNAL OF CLINICAL INVESTIGATION

Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling

(2013) J Luo et al.   ONCOGENE

GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation

(2013) Russell S. Taichman et al.   PLoS One

Distinct microRNA Expression Profiles in Prostate Cancer Stem/Progenitor Cells and Tumor-Suppressive Functions of let-7

(2012) C. Liu et al.   CANCER RESEARCH

Understanding cancer stem cell heterogeneity and plasticity

(2012) Dean G Tang   CELL RESEARCH

The PSA−/lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration

(2012) Jichao Qin et al.   Cell Stem Cell

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

PKH26 Staining Defines Distinct Subsets of Normal Human Colon Epithelial Cells at Different Maturation Stages

(2012) Anna Pastò et al.   PLoS One

Loss of integrin  3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells

(2012) N. Sachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bed and the bugs: Interactions between the tumor microenvironment and cancer stem cells

(2012) Zafira Castaño et al.   SEMINARS IN CANCER BIOLOGY

MicroRNA Regulation of Cancer Stem Cells

(2011) C. Liu et al.   CANCER RESEARCH

Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancer's Inflammatory Roots

(2011) H. Korkaya et al.   CLINICAL CANCER RESEARCH

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

(2011) Yusuke Shiozawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production

(2011) Karen McLean et al.   JOURNAL OF CLINICAL INVESTIGATION

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation

(2011) C R Jeter et al.   ONCOGENE

Radiosensitivity of Early and Late M-Phase HeLa Cells Isolated by a Combination of Fluorescent Ubiquitination-Based Cell Cycle Indicator (Fucci) and Mitotic Shake-Off

(2011) Motoshi Nakayama et al.   RADIATION RESEARCH

Slow-Cycling Therapy-Resistant Cancer Cells

(2011) Nathan Moore et al.   STEM CELLS AND DEVELOPMENT

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Cancer stem cells in solid tumors

(2010) Patrick C. Hermann et al.   SEMINARS IN CANCER BIOLOGY

CD44+slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2in gastric tumorigenesis

(2009) Takatsugu Ishimoto et al.   CANCER SCIENCE

Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma

(2009) Jennifer L. Dembinski et al.   CLINICAL & EXPERIMENTAL METASTASIS

Functional Evidence that the Self-Renewal GeneNANOGRegulates Human Tumor Development

(2009) Collene R. Jeter et al.   STEM CELLS

PC3 Human Prostate Carcinoma Cell Holoclones Contain Self-renewing Tumor-Initiating Cells

(2008) H. Li et al.   CANCER RESEARCH

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

Tracking antigen-driven responses by flow cytometry: Monitoring proliferation by dye dilution

(2008) Paul K. Wallace et al.   CYTOMETRY PART A

Identification of local and circulating cancer stem cells in human liver cancer

(2008) Zhen Fan Yang et al.   HEPATOLOGY