Redox Control of the Dormant Cancer Cell Life Cycle

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Nrf2 and β‐catenin coactivation in hepatocellular cancer: Biological and therapeutic implications

(2021) Junyan Tao et al.   HEPATOLOGY

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans

(2021) Jin Meng et al.   Nature Communications

Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation

(2021) Laure-Anne Ligeon et al.   Nature Communications

Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment

(2021) Peijie Wu et al.   Frontiers in Cell and Developmental Biology

Long non-coding RNAs and cancer metastasis: Molecular basis and therapeutic implications

(2021) Hui Ming et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Enhanced lipid metabolism induces the sensitivity of dormant cancer cells to 5-aminolevulinic acid-based photodynamic therapy

(2021) Taku Nakayama et al.   Scientific Reports

A cascaded copper-based nanocatalyst by modulating glutathione and cyclooxygenase-2 for hepatocellular carcinoma therapy

(2021) Hailong Tian et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

(2021) Henry Jay Forman et al.   NATURE REVIEWS DRUG DISCOVERY

Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance

(2021) Haohao Huang et al.   Nature Communications

Effect of Reactive Oxygen Species on the Endoplasmic Reticulum and Mitochondria during Intracellular Pathogen Infection of Mammalian Cells

(2021) Junghwan Lee et al.   Antioxidants

The Roles of FoxO Transcription Factors in Regulation of Bone Cells Function

(2020) Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

Epigenetic therapy inhibits metastases by disrupting premetastatic niches

(2020) Zhihao Lu et al.   NATURE

Relapse fated latent diagnosis subclones in acute B lineage leukaemia are drug tolerant and possess distinct metabolic programs

(2020) Stephanie M. Dobson et al.   Cancer Discovery

Epigenetic dynamics in cancer stem cell dormancy

(2020) Alejandra I. Ferrer et al.   CANCER AND METASTASIS REVIEWS

NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma

(2020) Hoi Wing Leung et al.   CANCER LETTERS

Hypoxia-mediated changes in bone marrow microenvironment in breast cancer dormancy

(2020) Alejandra Ferrer et al.   CANCER LETTERS

AMPK activation by metformin promotes survival of dormant ER+ breast cancer cells

(2020) Riley A Hampsch et al.   CLINICAL CANCER RESEARCH

Protection of hematopoietic stem cells from stress-induced exhaustion and aging

(2020) Shweta Singh et al.   CURRENT OPINION IN HEMATOLOGY

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Entry and exit of chemotherapeutically-promoted cellular dormancy in glioblastoma cells is differentially affected by the chemokines CXCL12, CXCL16, and CX3CL1

(2020) Vivian Adamski et al.   ONCOGENE

Minimal residual disease in advanced or metastatic solid cancers: the G0-G1 state and immunotherapy are key to unwinding cancer complexity

(2020) Andrea Nicolini et al.   SEMINARS IN CANCER BIOLOGY

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut

(2020) Alexandra Vaccaro et al.   CELL

Tumour dormancy in inflammatory microenvironment: A promising therapeutic strategy for cancer-related bone metastasis

(2020) Wenhui Hu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A UPR-Induced Soluble ER-Phagy Receptor Acts with VAPs to Confer ER Stress Resistance

(2020) Dan Zhao et al.   MOLECULAR CELL

Adrenergic Blockade Promotes Maintenance of Dormancy in Prostate Cancer Through Upregulation of GAS6

(2020) Ann M. Decker et al.   Translational Oncology

The Complex Interplay between Antioxidants and ROS in Cancer

(2020) Isaac S. Harris et al.   TRENDS IN CELL BIOLOGY

Biomaterial 3D collagen I gel culture model: A novel approach to investigate tumorigenesis and dormancy of bladder cancer cells induced by tumor microenvironment

(2020) Yaqi Qiu et al.   BIOMATERIALS

Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification

(2020) Bowen Li et al.   DRUG RESISTANCE UPDATES

CSN8 is a key regulator in hypoxia-induced epithelial–mesenchymal transition and dormancy of colorectal cancer cells

(2020) Songwen Ju et al.   Molecular Cancer

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

(2020) Nobuaki Takahashi et al.   MOLECULAR CELL

Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils

(2020) Michela Perego et al.   Science Translational Medicine

Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

(2020) Hailong Tian et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Targeting Cancer Cell Dormancy

(2019) Ariadna Recasens et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

(2019) Matthew J. Watt et al.   Science Translational Medicine

Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling

(2019) Cindy T.J. van Velthoven et al.   Cell Stem Cell

Multiple actions of PTHrP in breast cancer bone metastasis

(2019) T. John Martin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impaired redox regulation of estrogen metabolizing proteins is important determinant of human breast cancers

(2019) Smarajit Maiti et al.   Cancer Cell International

The roles and signaling pathways of prolyl-4-hydroxylase 2 in the tumor microenvironment

(2019) Anqi Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

NR2F1 contributes to cancer cell dormancy, invasion and metastasis of salivary adenoid cystic carcinoma by activating CXCL12/CXCR4 pathway

(2019) Xiao-lei Gao et al.   BMC CANCER

Notch2 pathway mediates breast cancer cellular dormancy and mobilisation in bone and contributes to haematopoietic stem cell mimicry

(2019) Mattia Capulli et al.   BRITISH JOURNAL OF CANCER

Quantitative evidence for early metastatic seeding in colorectal cancer

(2019) Zheng Hu et al.   NATURE GENETICS

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fatty-acid receptor CD36 functions as a hydrogen sulfide-targeted receptor with its Cys333-Cys272 disulfide bond serving as a specific molecular switch to accelerate gastric cancer metastasis

(2019) Rui Wang et al.   EBioMedicine

Ovariectomy increases RANKL protein expression in bone marrow adipocytes of C3H/HeJ mice.

(2019) Kerensa M. Beekman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Integrin-mediated cell adhesion requires extracellular disulfide exchange regulated by protein disulfide isomerase

(2019) Nurit Rosenberg et al.   EXPERIMENTAL CELL RESEARCH

High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation

(2019) Dunfang Zhang et al.   IMMUNITY

Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment

(2019) Elena Butturini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dormant disseminated tumor cells and cancer stem/progenitor-like cells: Similarities and opportunities

(2019) Omri Hen et al.   SEMINARS IN CANCER BIOLOGY

The protease activity of human ATG4B is regulated by reversible oxidative modification

(2019) Xueping Zheng et al.   Autophagy

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis

(2019) Hongfeng Wang et al.   Autophagy

Low side-effect and heat-shock protein-inhibited chemo-phototherapy nanoplatform via co-assembling strategy of biotin-tailored IR780 and quercetin

(2019) Hailong Tian et al.   CHEMICAL ENGINEERING JOURNAL

ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α

(2019) Duckgue Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms and context underlying the role of autophagy in cancer metastasis

(2018) Christopher M. Dower et al.   Autophagy

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII–p38MAPK–pS249/T252RB Pathway

(2018) Li-Yuan Yu-Lee et al.   CANCER RESEARCH

CD150 high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

(2018) Yuichi Hirata et al.   Cell Stem Cell

Prion protein cleavage fragments regulate adult neural stem cell quiescence through redox modulation of mitochondrial fission and SOD2 expression

(2018) Steven J. Collins et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chemical methods for mapping cysteine oxidation

(2018) Lisa J. Alcock et al.   CHEMICAL SOCIETY REVIEWS

Hypoxia, oxidative stress and inflammation

(2018) Trudy McGarry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Estrogen Deficiency-Mediated M2 Macrophage Osteoclastogenesis Contributes to M1/M2 Ratio Alteration in Ovariectomized Osteoporotic Mice

(2018) Ce Dou et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner

(2018) Xiaomin Fu et al.   Molecular Cancer

How to pull the blanket off dormant cancer cells

(2018) Vivien Marx   NATURE METHODS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence

(2018) Laura Vera-Ramirez et al.   Nature Communications

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

(2018) Karen Frudd et al.   Nature Communications

Redox control of cancer cell destruction

(2018) Csaba Hegedűs et al.   Redox Biology

Rethinking Extended Adjuvant Antiestrogen Therapy to Increase Survivorship in Breast Cancer

(2018) Balkees Abderrahman et al.   JAMA Oncology

The p38-activated ER stress-ATF6α axis mediates cellular senescence

(2018) Hee Suk Kim et al.   FASEB JOURNAL

A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2

(2018) Hak Rae Lee et al.   Journal of Biological Engineering

Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer

(2018) François M. Vallette et al.   BIOCHEMICAL PHARMACOLOGY

Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies

(2018) David A. Mahvi et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CD150high CD4 T cells and CD150high Tregs regulate hematopoietic stem cell quiescence via CD73

(2018) Yuichi Hirata et al.   HAEMATOLOGICA

Interleukin-23 receptor signaling mediates cancer dormancy and radioresistance in human esophageal squamous carcinoma cells via the Wnt/Notch pathway

(2018) Yuepeng Zhou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Dormant tumour cells, their niches and the influence of immunity

(2018) Erica T. Goddard et al.   NATURE CELL BIOLOGY

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress

(2018) Zhe Zhang et al.   Redox Biology

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3

(2017) Rekha Bassi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic shifts in residual breast cancer drive tumor recurrence

(2017) Kristina M. Havas et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging roles of lipid metabolism in cancer metastasis

(2017) Xiangjian Luo et al.   Molecular Cancer

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

(2017) Hongchao Pan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

(2017) Jesus Cosin-Roger et al.   Nature Communications

DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization

(2016) Alpaslan Tasdogan et al.   Cell Stem Cell

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

(2016) Rachelle W. Johnson et al.   NATURE CELL BIOLOGY

Treating cancer with selective CDK4/6 inhibitors

(2016) Ben O'Leary et al.   Nature Reviews Clinical Oncology

Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

(2016) Trevor T. Price et al.   Science Translational Medicine

Factor inhibiting HIF1α (FIH-1) functions as a tumor suppressor in human colorectal cancer by repressing HIF1α pathway

(2015) Tao Chen et al.   CANCER BIOLOGY & THERAPY

Mechanisms of Cancer Cell Dormancy--Another Hallmark of Cancer?

(2015) A. C. Yeh et al.   CANCER RESEARCH

SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy

(2015) Anh Thu Bui et al.   CELL CYCLE

Crosstalk between Nrf2 and Notch signaling

(2015) Nobunao Wakabayashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone

(2015) Penelope D. Ottewell et al.   INTERNATIONAL JOURNAL OF CANCER

CD36 Binds Oxidized Low Density Lipoprotein (LDL) in a Mechanism Dependent upon Fatty Acid Binding

(2015) Anthony G. Jay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Participation of TNF-α in Inhibitory Effects of Adipocytes on Osteoblast Differentiation

(2015) Robrigo P.F. Abuna et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy

(2015) Daniel L. Abravanel et al.   JOURNAL OF CLINICAL INVESTIGATION

GLI2 inhibition abrogates human leukemia stem cell dormancy

(2015) Anil Sadarangani et al.   Journal of Translational Medicine

Leptin, adipocytes and breast cancer: Focus on inflammation and anti-tumor immunity

(2015) Laetitia Delort et al.   LIFE SCIENCES

Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis

(2015) J-E Kim et al.   ONCOGENE

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

(2015) Maria Soledad Sosa et al.   Nature Communications

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

(2015) Michelle A. Lawson et al.   Nature Communications

The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

(2014) D. Raha et al.   CANCER RESEARCH

NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation

(2014) Jung-Hyun Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

(2014) Eric M. Pietras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

(2014) Fan Jiang et al.   Redox Biology

Redox-Relevant Aspects of the Extracellular Matrix and Its Cellular Contacts via Integrins

(2013) Johannes A. Eble et al.   ANTIOXIDANTS & REDOX SIGNALING

Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy

(2013) B. Boyerinas et al.   BLOOD

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery

(2013) Candice E. Paulsen et al.   CHEMICAL REVIEWS

Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells

(2013) Lara H. El Touny et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

(2013) Paloma Bragado et al.   NATURE CELL BIOLOGY

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of the Oxidative Stress Sensor NPGPx Compromises GRP78 Chaperone Activity and Induces Systemic Disease

(2012) Pei-Chi Wei et al.   MOLECULAR CELL

ERK1/2 and p38α/β Signaling in Tumor Cell Quiescence: Opportunities to Control Dormant Residual Disease

(2011) Maria Soledad Sosa et al.   CLINICAL CANCER RESEARCH

 1-Integrin: A Potential Therapeutic Target in the Battle against Cancer Recurrence

(2011) D. Barkan et al.   CLINICAL CANCER RESEARCH

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

(2011) Dipak Panigrahy et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

(2009) A. Levoye et al.   BLOOD