Review
Biochemistry & Molecular Biology
Vasilia Tamamouna, Evangelia Pavlou, Christiana M. Neophytou, Panagiotis Papageorgis, Paul Costeas
Summary: Cancer recurrence and metastasis pose a significant threat in clinical oncology, and metastatic tumor dormancy is a crucial stage during cancer progression. Dormant cancer cells enter a state of cell cycle arrest and survival to adapt to new microenvironments, making them resistant to treatment and immune surveillance. Understanding the mechanisms of dormancy induction and escape is important for developing innovative therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Sitaram Harihar, Danny R. Welch
Summary: Current therapeutic approaches for metastatic cancers are ineffective at targeting dormant tumor cells, which are non-proliferative, growth-arrested, or resistant to therapy. The understanding of tumor dormancy has been limited, hindering progress in developing effective approaches. However, recent studies have identified KISS1 as a metastasis suppressor gene that keeps tumor cells in a dormant state. This review explores the mechanisms and potential application of KISS1 as a therapeutic for metastatic cancers by eliminating quiescent cells or inducing long-term dormancy.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Oncology
Manuela Zangrossi, Patrizia Romani, Probir Chakravarty, Colin D. H. Ratcliffe, Steven Hooper, Martina Dori, Mattia Forcato, Silvio Bicciato, Sirio Dupont, Erik Sahai, Marco Montagner
Summary: Many estrogen receptor-positive breast cancer patients experience relapses at the metastatic site even up to 20 years after primary tumor removal, a phenomenon known as metastatic dormancy. The molecule EphB6 has been identified as supporting the survival of disseminated dormant cancer cells, while the TFEB-lysosomal axis plays a crucial role in sustaining the survival of dormant cancer cells.
Article
Medicine, Research & Experimental
Sekaran Balaji, Usha Kim, Veerappan Muthukkaruppan, Ayyasamy Vanniarajan
Summary: The interactions between cancer and non-cancerous cells in the TME through exosomes play a significant role in influencing tumor progression, therapeutic resistance, and metastasis. Wnt signaling, which is often involved in exosomal transport, represents a potential therapeutic target in inhibiting these processes.
Review
Oncology
Scott Sauer, Damon R. Reed, Michael Ihnat, Robert E. Hurst, David Warshawsky, Dalit Barkan
Summary: Cancer recurrence is a great fear for many survivors, as metastasis accounts for a majority of cancer deaths. New strategies are needed to prevent metastatic recurrence, including targeting dormant disseminated tumor cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Xiaoxiao Li, Ling Chen, Xiaobo Peng, Xianbao Zhan
Summary: Tumor is a significant public health problem with high morbidity and mortality worldwide, with metastasis being the major contributor to patient deaths. Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment by interacting with tumor cells and influencing the EMT process of tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Baixue Fu, Junwei Hu, Ao Yu, Yongjian Wang
Summary: In this study, a therapeutic nanovaccine is developed that can remodel the metabolic and immunosuppressive microenvironments in both primary tumors and metastatic lymph nodes. It showed an enhanced anti-tumor immune response and strong anti-metastatic effects in a mouse model of lymph node metastatic hepatocarcinoma.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Oncology
Mostafa M. Nasr, Conor C. Lynch
Summary: Circulating tumor cells (CTCs) are prognostic for metastatic relapse and can exist as solitary cells or cell clusters. Compared to solitary CTCs, CTC clusters have a higher metastatic potential. Differences in invasion, survival, dissemination, dormancy, and reawakening between CTC clusters and solitary CTCs need further investigation. This review discusses the current state of CTC cluster research, their clinical significance, collective invasion by CTC clusters, molecular evidence of cluster survival, and future directions for understanding CTC cluster biology.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Immunology
Shuling Zhang, Jin Geng, Fengping Shan, Yuanye Shan, Noreen Griffin, Bin Wu, Xu Wang
Summary: Metastasis is a major challenge in clinical lung cancer treatment, and the epithelial-mesenchymal transition (EMT) plays a crucial role in this process. Immune cells in the tumor microenvironment, specifically tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), promote EMT of cancer cells. This study investigated the effects of methionine enkephalin (MENK) on EMT in vitro and in vivo, as well as its influence on TAMs, MDSCs, and associated cytokines. The findings suggest that MENK can inhibit the growth, migration, and invasion of lung cancer cells by interacting with opioid growth factor receptor, while also reducing the infiltration of M2 macrophages and MDSCs and downregulating the expression of interleukin-10 and transforming growth factor-beta 1 in primary and metastatic tumors. MENK may therefore be a potential target for suppressing metastasis in lung cancer treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Oncology
Audrey Sirvent, Kevin Espie, Evangelia Papadopoulou, Dana Naim, Serge Roche
Summary: Tumor collagens and their architecture in the tumor microenvironment are crucial for cancer progression and therapeutic resistance. DDR1, as a collagen receptor and tyrosine kinase, plays a significant role in tumor dormancy, immune exclusion, and therapeutic resistance induced by stromal collagens deposition.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Sanne Bootsma, Maarten F. Bijlsma, Louis Vermeulen
Summary: This review provides an overview of the histopathological, genomic, and transcriptomic features of peritoneal metastatic disease (PMD) in gastrointestinal malignancies. It is found that cancers representing the mesenchymal subtype are strongly associated with PMD in various malignancies. The review also discusses the peritoneal niche and the critical role of the peritoneal immune system. Overall, the review emphasizes that PMD should be considered as a distinct disease entity requiring tailored treatment strategies.
EMBO MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Misung Park, Dohee Kim, Sunghyub Ko, Ayoung Kim, Kyumin Mo, Hyunho Yoon
Summary: Breast cancer is the most common malignancy in women worldwide, and metastasis is the leading cause of high mortality. Currently, breast cancer is often discovered or diagnosed after metastasis has occurred, resulting in poor prognosis. Understanding the mechanisms and nature of breast cancer metastasis can facilitate the development of targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Chunning Li, Teizo Yoshimura, Miao Tian, Yuze Wang, Takamasa Kondo, Ken-Ichi Yamamoto, Masayoshi Fujisawa, Toshiaki Ohara, Masakiyo Sakaguchi, Akihiro Matsukawa
Summary: This study demonstrated for the first time that a low metastatic subclone can enhance lung metastasis of highly metastatic subclone via exosomal Wnt7a, proposing Wnt7a as a molecular target to treat TNBC patients.
BREAST CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ming-Yu Chou, Muh-Hwa Yang
Summary: The interplay between EMT and immune metabolic changes in cancer cells during tumor metastasis has gained interest among researchers. Understanding how they influence each other may provide novel explanations for immune surveillance during metastasis. Studying immunometabolism in the regulatory loop between tumor-infiltrating immune cells and EMT is crucial for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Charlise Basson, June Cheptoo Serem, Priyesh Bipath, Yvette Nkondo Hlophe
Summary: This article discusses the pathological characteristics of cutaneous melanoma, which is becoming increasingly prevalent, as well as the use of chemotherapy in the treatment of cutaneous melanoma. It is found that the activation of chemokine axes plays an important role in the metastasis of melanoma, so intervention targeting these axes can be considered in the treatment of melanoma. Experimental results have shown that targeting chemokine axes can inhibit the migration, proliferation, and survival of tumor cells, thereby slowing down the metastasis and progression of melanoma.
Review
Oncology
Colin H. Beckwitt, Amanda M. Clark, Sarah Wheeler, D. Lansing Taylor, Donna B. Stolz, Linda Griffith, Alan Wells
EXPERIMENTAL CELL RESEARCH
(2018)
Article
Biochemical Research Methods
Amanda M. Clark, Manu P. Kumar, Sarah E. Wheeler, Carissa L. Young, Raman Venkataramanan, Donna B. Stolz, Linda G. Griffith, Douglas A. Lauffenburger, Alan Wells
MOLECULAR & CELLULAR PROTEOMICS
(2018)
Article
Oncology
Colin H. Beckwitt, Amanda M. Clark, Bo Ma, Diana Whaley, Zoltan N. Oltvai, Alan Wells
BRITISH JOURNAL OF CANCER
(2018)
Review
Medicine, Research & Experimental
Alan Wells, Amanda Clark, Andrew Bradshaw, Bo Ma, Howard Edington
EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Yuhan Jiang, Alan Wells, Kyle Sylakowski, Amanda M. Clark, Bo Ma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Oncology
Amanda M. Clark, Nancy L. Allbritton, Alan Wells
Summary: The liver is the most commonly involved organ in metastases from various solid tumors, and studying tumor cell behavior in the liver microenvironment has provided unexpected insights into the biology of metastasis. Microphysiological systems linking different organs can help examine the influence of one organ on the function of other tissues, including how the liver environment affects tumor behavior.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Dimitrios Korentzelos, Amanda M. Clark, Alan Wells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, Research & Experimental
Amanda M. Clark, Chandi Magawa, Adriana Pliego-Zamora, Pauline Low, Max Reynolds, Stephen J. Ralph
Summary: MAC exhibits anticancer activity against prostate and breast cancer cells by inducing apoptosis and cell cycle arrest, as well as inducing breast cancer cell death through the mitochondrial apoptotic pathway. It also suppresses tumor progression and promotes infiltration of neutrophils with anticancer cytotoxic activity in breast tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Juan Luis Gomez Marti, Colin H. Beckwitt, Amanda M. Clark, Alan Wells
Summary: The study examined the effects of atorvastatin on chemotherapy for mTNBC through animal models and clinical correlations. Atorvastatin was found to have additive effects with doxorubicin targeting liver metastases, and the combination of atorvastatin and chemotherapy led to increased cell death in dormant cancer cells.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Amanda M. Clark, Haley L. Heusey, Linda G. Griffith, Douglas. A. Lauffenburger, Alan Wells
Summary: Metastatic breast cancer with liver involvement is a largely incurable and fatal disease, with a subset of disseminated tumor cells potentially lying dormant for years before re-emerging. IP-10, a CXCR3 ligand, has been found to be elevated in metastatic TNBC breast cancer cells, triggering their emergence within the liver metastatic niche. This pathway could be a target for maintaining dormancy in breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ahmad S. Khazali, Amanda M. Clark, Alan Wells
BRITISH JOURNAL OF CANCER
(2018)
Meeting Abstract
Pathology
A. M. Clark, N. Dioufa, K. Chan, C. D. Edington, M. Kumar, S. E. Wheeler, R. Venkataramanan, D. B. Stolz, D. Trumper, L. Griffith, D. Lauffenburger, A. Wells
AMERICAN JOURNAL OF PATHOLOGY
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
Colin H. Beckwitt, Amanda M. Clark, Katsuhiko Warita, Zoltan N. Oltvai, Alan Wells
Proceedings Paper
Engineering, Biomedical
Collin D. Edington, Murat Cirit, Wen Li Kelly Chen, Amanda M. Clark, Alan Wells, David L. Trumper, Linda G. Griffith
MICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS XV
(2017)
