Diverse alterations associated with resistance to KRAS(G12C) inhibition

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Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

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SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics

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SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

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V211D mutation in MEK1 causes resistance to MEK inhibitors in colon cancer

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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

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The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

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KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition

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Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

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