Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

(2021) Eugen Dhimolea et al.   CANCER CELL

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

(2021) Sumaiyah K. Rehman et al.   CELL

The role of endolysosomal trafficking in anticancer drug resistance

(2021) Noor A. Hussein et al.   DRUG RESISTANCE UPDATES

Cycling cancer persister cells arise from lineages with distinct programs

(2021) Yaara Oren et al.   NATURE

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

(2020) Jinyun Dong et al.   DRUG RESISTANCE UPDATES

Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors

(2020) Sabrina Dallavalle et al.   DRUG RESISTANCE UPDATES

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

Targeting Cancer Cell Dormancy

(2019) Ariadna Recasens et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Definitions and guidelines for research on antibiotic persistence

(2019) Nathalie Q. Balaban et al.   NATURE REVIEWS MICROBIOLOGY

What sustains the multidrug resistance phenotype beyond ABC efflux transporters? Looking beyond the tip of the iceberg

(2019) Teodora Alexa-Stratulat et al.   DRUG RESISTANCE UPDATES

Adaptive evolution reveals a tradeoff between growth rate and oxidative stress during naphthoquinone-based aerobic respiration

(2019) Amitesh Anand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipids and cholesterol: Inducers of cancer multidrug resistance and therapeutic targets

(2019) Joanna Kopecka et al.   DRUG RESISTANCE UPDATES

Advanced technological tools to study multidrug resistance in cancer

(2019) Luca Andrei et al.   DRUG RESISTANCE UPDATES

An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

(2019) Shensi Shen et al.   Nature Communications

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

(2018) Nobuaki Takahashi et al.   CANCER CELL

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential

(2018) Liqin Wang et al.   CELL

Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

(2018) Hai Wang et al.   Nature Communications

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

(2018) Tyler Risom et al.   Nature Communications

Inhibiting Cholesterol Absorption During Lactation Programs Future Intestinal Absorption of Cholesterol in Adult Mice

(2017) Lidiya G. Dimova et al.   GASTROENTEROLOGY

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts

(2017) Rémy Nicolle et al.   Cell Reports

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

(2016) Maia Vinogradova et al.   Nature Chemical Biology

Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs

(2016) Nisebita Sahu et al.   Nature Communications

The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

(2014) D. Raha et al.   CANCER RESEARCH

Epigenetic Modulation of Intestinal Cholesterol Transporter Niemann-Pick C1-like 1 (NPC1L1) Gene Expression by DNA Methylation

(2014) Pooja Malhotra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1

(2013) Pei-Shan Li et al.   NATURE MEDICINE

Autophagy is differentially induced in prostate cancer LNCaP, DU145 and PC-3 cells via distinct splicing profiles of ATG5

(2012) Dong-Yun Ouyang et al.   Autophagy

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake

(2010) L. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Is resistance useless? Multidrug resistance and collateral sensitivity

(2009) Matthew D. Hall et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Niemann-Pick C1-Like 1 Mediates  -Tocopherol Transport

(2008) K. Narushima et al.   MOLECULAR PHARMACOLOGY