Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment

The roles and signaling pathways of prolyl-4-hydroxylase 2 in the tumor microenvironment

(2019) Anqi Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma

(2018) Galia Tiram et al.   FASEB JOURNAL

Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML

(2018) S. Haubner et al.   LEUKEMIA

A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2

(2018) Hak Rae Lee et al.   Journal of Biological Engineering

Engineered In Vitro Models of Tumor Dormancy and Reactivation

(2018) Shantanu Pradhan et al.   Journal of Biological Engineering

Metastatic Breast Cancer Cells Enter Into Dormant State and Express Cancer Stem Cells Phenotype Under Chronic Hypoxia

(2017) Alessandra Carcereri de Prati et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Tumor cell dormancy

(2017) Roger R. Gomis et al.   Molecular Oncology

Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2 -null cell survival

(2016) Tania Campos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cycling hypoxia: A key feature of the tumor microenvironment

(2016) Carine Michiels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

3D tumor spheroids: an overview on the tools and techniques used for their analysis

(2016) Elisabete C. Costa et al.   BIOTECHNOLOGY ADVANCES

A hypoxic signature marks tumors formed by disseminated tumor cells in the BALB-neuT mammary cancer model

(2016) Aichi Msaki et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Co-Expression of Cancer Stem Cell Markers Corresponds to a Pro-Tumorigenic Expression Profile in Pancreatic Adenocarcinoma

(2016) Jan Skoda et al.   PLoS One

Reactive oxygen species in redox cancer therapy

(2015) Lingying Tong et al.   CANCER LETTERS

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Tissue-engineered models of human tumors for cancer research

(2015) Aranzazu Villasante et al.   Expert Opinion on Drug Discovery

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Microenvironmental regulation of therapeutic response in cancer

(2015) Florian Klemm et al.   TRENDS IN CELL BIOLOGY

Modeling human carcinomas: Physiologically relevant 3D models to improve anti-cancer drug development

(2014) Christine Unger et al.   ADVANCED DRUG DELIVERY REVIEWS

Probing the relevance of 3D cancer models in nanomedicine research

(2014) David T. Leong et al.   ADVANCED DRUG DELIVERY REVIEWS

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

(2014) Joseph C. Walsh et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer Cell Dormancy in Novel Mouse Models for Reversible Pancreatic Cancer: A Lingering Challenge in the Development of Targeted Therapies

(2014) Wan-Chi Lin et al.   CANCER RESEARCH

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Genetic modification of hypoxia signaling in animal models and its effect on cancer

(2014) J. M. García-Heredia et al.   Clinical & Translational Oncology

Cancer stem cell characteristics of circulating tumor cells

(2014) Ingeborg Tinhofer et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Stem cell characteristics of dormant cells and cisplatin-induced effects on the stemness of epithelial ovarian cancer cells

(2014) NAN ZHOU et al.   Molecular Medicine Reports

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Dormancy of Cancer Cells with Suppression of AKT Activity Contributes to Survival in Chronic Hypoxia

(2014) Hiroko Endo et al.   PLoS One

Tumor Bioengineering Using a Transglutaminase Crosslinked Hydrogel

(2014) Josephine Y. Fang et al.   PLoS One

Three-dimensional in vitro cancer models: a short review

(2014) Chengyang Wang et al.   Biofabrication

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs

(2013) Elena Butturini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

(2013) Peter J. Ratcliffe   JOURNAL OF PHYSIOLOGY-LONDON

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

(2013) Paloma Bragado et al.   NATURE CELL BIOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

pH sensing and regulation in cancer

(2013) Mehdi Damaghi et al.   Frontiers in Physiology

The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness

(2012) Bin Bao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Biochemical and biophysical origins of cadherin selectivity and adhesion strength

(2012) Jean Paul Thiery et al.   CURRENT OPINION IN CELL BIOLOGY

Targeting CSCs within the tumor microenvironment for cancer therapy: a potential role of mesenchymal stem cells

(2012) Bin Bao et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Protein Phosphatase 2A Mediates Dormancy of Glioblastoma Multiforme-Derived Tumor Stem-Like Cells during Hypoxia

(2012) Christoph P. Hofstetter et al.   PLoS One

Dormancy Signatures and Metastasis in Estrogen Receptor Positive and Negative Breast Cancer

(2012) Ryung S. Kim et al.   PLoS One

Acute versus chronic hypoxia in tumors

(2012) C. Bayer et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Cancer stem cells, tumor dormancy, and metastasis

(2012) Purvi Patel et al.   Frontiers in Endocrinology

Autophagy and cancer therapy

(2011) Paola Maycotte et al.   CANCER BIOLOGY & THERAPY

VEGFR-1 Expressed by Malignant Melanoma-Initiating Cells Is Required for Tumor Growth

(2011) Natasha Y. Frank et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

(2011) Minna Heikkilä et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ERK1/2 and p38α/β Signaling in Tumor Cell Quiescence: Opportunities to Control Dormant Residual Disease

(2011) Maria Soledad Sosa et al.   CLINICAL CANCER RESEARCH

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development

(2010) Muh-Hwa Yang et al.   CELL CYCLE

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination

(2010) Einar K. Rofstad et al.   INTERNATIONAL JOURNAL OF CANCER

Epithelial-Mesenchymal Transition (EMT) in Tumor-Initiating Cells and Its Clinical Implications in Breast Cancer

(2010) Chad J. Creighton et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity

(2010) Hsieh   ONCOLOGY REPORTS

Emerging strategies for the identification and targeting of cancer stem cells

(2010) Jun Dou et al.   TUMOR BIOLOGY

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

The late stages of autophagy: how does the end begin?

(2009) T Noda et al.   CELL DEATH AND DIFFERENTIATION

Vesicular trafficking and autophagosome formation

(2009) A Longatti et al.   CELL DEATH AND DIFFERENTIATION

Akt-dependent and -independent mechanisms of mTOR regulation in cancer

(2009) Regan M. Memmott et al.   CELLULAR SIGNALLING

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of gene expression by hypoxia

(2008) Niall Steven Kenneth et al.   BIOCHEMICAL JOURNAL

Extracellular matrix regulation of autophagy

(2008) Rebecca Lock et al.   CURRENT OPINION IN CELL BIOLOGY

The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death

(2008) Francesco Cecconi et al.   DEVELOPMENTAL CELL

The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells

(2008) Zhen Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional regulation of cell polarity in EMT and cancer

(2008) G Moreno-Bueno et al.   ONCOGENE

PHDs overactivation during chronic hypoxia "desensitizes" HIF  and protects cells from necrosis

(2008) A. Ginouves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATF6 -Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

(2008) D. M. Schewe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA