Microenvironment-mediated cancer dormancy: Insights from metastability theory

Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells

(2021) K. J. Pienta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation

(2021) Wenying Kang et al.   iScience

Integrin Subtypes and Nanoscale Ligand Presentation Influence Drug Sensitivity in Cancer Cells

(2020) Jennifer L. Young et al.   NANO LETTERS

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

(2020) Marco Montagner et al.   NATURE CELL BIOLOGY

The force awakens: metastatic dormant cancer cells

(2020) So-Yeon Park et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression

(2020) Yi Lu et al.   NATURE CELL BIOLOGY

Tumor cell–organized fibronectin maintenance of a dormant breast cancer population

(2020) Lauren E. Barney et al.   Science Advances

Non-disruptive collagen characterization in clinical histopathology using cross-modality image synthesis

(2020) Adib Keikhosravi et al.   Communications Biology

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency

(2020) Melanie Werner-Klein et al.   Nature Communications

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

Mechanics of Development

(2020) Katharine Goodwin et al.   DEVELOPMENTAL CELL

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

(2019) Patrick Carlson et al.   NATURE CELL BIOLOGY

Tunable hydrogels for controlling phenotypic cancer cell states to model breast cancer dormancy and reactivation

(2019) Shantanu Pradhan et al.   BIOMATERIALS

Tissue rheology in embryonic organization

(2019) Nicoletta I Petridou et al.   EMBO JOURNAL

Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish

(2019) Colin D. Paul et al.   Cell Systems

Surface tension determines tissue shape and growth kinetics

(2019) S. Ehrig et al.   Science Advances

Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27Kip1 signaling axis

(2019) Sungmin Nam et al.   Science Advances

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

(2019) Inês Godet et al.   Nature Communications

Compressive Remodeling Alters Fluid Transport Properties of Collagen Networks – Implications for Tumor Growth

(2019) J. Ferruzzi et al.   Scientific Reports

The Emergence of Complexity from a Simple Model for Tissue Growth

(2019) J. W. C. Dunlop et al.   JOURNAL OF STATISTICAL PHYSICS

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

(2019) Danfeng Cai et al.   NATURE CELL BIOLOGY

Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers

(2018) Ken Takai et al.   GENES & DEVELOPMENT

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization

(2018) Ekrem Emrah Er et al.   NATURE CELL BIOLOGY

A geometrically controlled rigidity transition in a model for confluent 3D tissues

(2018) Matthias Merkel et al.   NEW JOURNAL OF PHYSICS

Tensile forces drive a reversible fibroblast-to-myofibroblast transition during tissue growth in engineered clefts

(2018) Philip Kollmannsberger et al.   Science Advances

Integrin α2β1 decelerates proliferation, but promotes survival and invasion of prostate cancer cells

(2018) Marjaana Ojalill et al.   Oncotarget

Engineered In Vitro Models of Tumor Dormancy and Reactivation

(2018) Shantanu Pradhan et al.   Journal of Biological Engineering

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanobiological free energy: a variational approach to tensional homeostasis in tissue equivalents

(2017) C. J. Cyron et al.   ZAMM-Zeitschrift fur Angewandte Mathematik und Mechanik

Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells

(2017) Aline Roch et al.   Nature Communications

Bone marrow niche-mimetics modulate HSPC function via integrin signaling

(2017) Martin Kräter et al.   Scientific Reports

Marrow-inspired matrix cues rapidly affect early fate decisions of hematopoietic stem and progenitor cells

(2017) Ji Sun Choi et al.   Science Advances

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

(2016) Hua Gao et al.   CELL

Growth and remodeling of load-bearing biological soft tissues

(2016) C. J. Cyron et al.   MECCANICA

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Distinguishing autocrine and paracrine signals in hematopoietic stem cell culture using a biofunctional microcavity platform

(2016) Eike Müller et al.   Scientific Reports

Solid stress and elastic energy as measures of tumour mechanopathology

(2016) Hadi T. Nia et al.   Nature Biomedical Engineering

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Tissue growth controlled by geometric boundary conditions: a simple model recapitulating aspects of callus formation and bone healing

(2015) F. Dieter Fischer et al.   Journal of the Royal Society Interface

A density-independent rigidity transition in biological tissues

(2015) Dapeng Bi et al.   Nature Physics

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

(2015) Michelle A. Lawson et al.   Nature Communications

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division

(2014) A. Grob et al.   GENES & DEVELOPMENT

Vascular homeostasis and the concept of mechanobiological stability

(2014) C.J. Cyron et al.   INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE

Mechanobiological stability: a new paradigm to understand the enlargement of aneurysms?

(2014) C. J. Cyron et al.   Journal of the Royal Society Interface

Information-based fitness and the emergence of criticality in living systems

(2014) J. Hidalgo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Centrosomes are autocatalytic droplets of pericentriolar material organized by centrioles

(2014) David Zwicker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphogenesis at criticality

(2014) D. Krotov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrin-Linked Machinery of Cytoskeletal Regulation that Enables Experimental Tumor Initiation and Metastatic Colonization

(2013) Tsukasa Shibue et al.   CANCER CELL

Modeling Boundary Conditions for Balanced Proliferation in Metastatic Latency

(2013) D. P. Taylor et al.   CLINICAL CANCER RESEARCH

Dormant but migratory tumour cells in desmoplastic stroma of invasive ductal carcinomas

(2012) Vanisri Raviraj et al.   CLINICAL & EXPERIMENTAL METASTASIS

Towards a molecular architecture of centriole assembly

(2012) Pierre Gönczy   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adaptation to Optimal Cell Growth through Self-Organized Criticality

(2012) Chikara Furusawa et al.   PHYSICAL REVIEW LETTERS

Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ

(2011) Nicole Sänger et al.   INTERNATIONAL JOURNAL OF CANCER

Are Biological Systems Poised at Criticality?

(2011) Thierry Mora et al.   JOURNAL OF STATISTICAL PHYSICS

Controversies in clinical cancer dormancy

(2011) J. W. Uhr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer as a dynamical phase transition

(2011) Paul CW Davies et al.   Theoretical Biology and Medical Modelling

Molecular mechanisms underlying tumor dormancy

(2010) Nava Almog   CANCER LETTERS

Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment

(2010) D. Barkan et al.   CANCER RESEARCH

Framework models of tumor dormancy from patient-derived observations

(2010) Christoph A Klein   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mechanical control of tissue and organ development

(2010) T. Mammoto et al.   DEVELOPMENT

Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth

(2010) Dalit Barkan et al.   EUROPEAN JOURNAL OF CANCER

Phase Separation in Confined Geometries

(2010) Kurt Binder et al.   JOURNAL OF STATISTICAL PHYSICS

Fluidization of tissues by cell division and apoptosis

(2010) J. Ranft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dormancy contributes to the maintenance of microbial diversity

(2010) S. E. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

(2010) L. Li et al.   SCIENCE

The challenge of establishing preclinical models for segmental bone defect research

(2009) Johannes C. Reichert et al.   BIOMATERIALS

Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia

(2009) Ilse J. Hoogsteen et al.   EUROPEAN JOURNAL OF CANCER

Homeostatic competition drives tumor growth and metastasis nucleation

(2009) Markus Basan et al.   HFSP Journal

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton

(2008) D. Barkan et al.   CANCER RESEARCH

Gene expression dynamics in the macrophage exhibit criticality

(2008) M. Nykter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA