Effect of Tau Protein on Mitochondrial Functions

Broad activation of the PRKN pathway triggers synaptic failure by disrupting synaptic mitochondrial supply in early tauopathy

(2022) Yu Young Jeong et al.   Autophagy

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

(2022) Tara E. Tracy et al.   CELL

Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis

(2022) Lukasz Samluk et al.   MOLECULAR BIOLOGY OF THE CELL

Mitophagy in Alzheimer’s disease: Molecular defects and therapeutic approaches

(2022) Arnaud Mary et al.   MOLECULAR PSYCHIATRY

Hyperphosphorylated Human Tau Accumulates at the Synapse, Localizing on Synaptic Mitochondrial Outer Membranes and Disrupting Respiration in a Mouse Model of Tauopathy

(2022) Andrew J. Trease et al.   Frontiers in Molecular Neuroscience

Mitochondrial dysfunction, mitophagy, and role of dynamin‐related protein 1 in Alzheimer's disease

(2021) Vijay Krishna Medala et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Tau Deletion Prevents Cognitive Impairment and Mitochondrial Dysfunction Age Associated by a Mechanism Dependent on Cyclophilin-D

(2021) Claudia Jara et al.   Frontiers in Neuroscience

Telomerase in Brain: The New Kid on the Block and Its Role in Neurodegenerative Diseases

(2021) Gabriele Saretzki et al.   Biomedicines

Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse

(2021) Hallie Morton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dysfunction in Alzheimer's disease: Therapeutic implications of lithium

(2021) Monique P. Singulani et al.   NEUROSCIENCE LETTERS

Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy

(2021) Konstantinos Palikaras et al.   Aging-US

Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease

(2021) Marcel V. Alavi   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Stem cells from human exfoliated deciduous teeth affect mitochondria and reverse cognitive decline in a senescence-accelerated mouse prone 8 model

(2021) Wenhuan Guo et al.   CYTOTHERAPY

Disentangling Mitochondria in Alzheimer’s Disease

(2021) Ashu Johri   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Paeonol Ameliorates Cognitive Deficits in Streptozotocin Murine Model of Sporadic Alzheimer’s Disease via Attenuation of Oxidative Stress, Inflammation, and Mitochondrial Dysfunction

(2021) Akram Tayanloo-Beik et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mitophagy enhancers against phosphorylated Tau-induced mitochondrial and synaptic toxicities in Alzheimer disease

(2021) Sudhir Kshirsagar et al.   PHARMACOLOGICAL RESEARCH

Mitochondrial complex I as a therapeutic target for Alzheimer's disease

(2021) Eugenia Trushina et al.   Acta Pharmaceutica Sinica B

Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

(2020) Jin Zheng et al.   Acta Neuropathologica Communications

Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer’s Disease

(2020) Sachchida Nand Rai et al.   MOLECULAR NEUROBIOLOGY

Protective effects of chondroitin sulphate nano-selenium on a mouse model of Alzheimer's disease

(2020) Dongsheng Ji et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Mitochondria as a promising target for developing novel agents for treating Alzheimer's disease

(2020) Elena F. Shevtsova et al.   MEDICINAL RESEARCH REVIEWS

Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells

(2020) Rodrigo A. Quintanilla et al.   Frontiers in Cellular Neuroscience

FGF21 attenuates neurodegeneration through modulating neuroinflammation and oxidant-stress

(2020) Kai Kang et al.   BIOMEDICINE & PHARMACOTHERAPY

The distinctive role of tau and amyloid beta in mitochondrial dysfunction through alteration in Mfn2 and Drp1 mRNA Levels: A comparative study in Drosophila melanogaster

(2020) Seyedeh Leila Abtahi et al.   GENE

Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria

(2020) Albin John et al.   AGEING RESEARCH REVIEWS

Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice

(2020) César Espino de la Fuente-Muñoz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice

(2020) Andrea Stojakovic et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

A hypothetic role of minocycline as a neuroprotective agent against methylphenidate-induced neuronal mitochondrial dysfunction and tau protein hyper-phosphorylation: Possible role of PI3/Akt/GSK3β signaling pathway

(2019) Pegah Salehi et al.   MEDICAL HYPOTHESES

Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin

(2019) Angelique Camilleri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

(2019) Melissa L. Young et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention

(2018) Thomas Briston et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus

(2018) Claudia Jara et al.   Redox Biology

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

(2018) Xiongwei Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

(2018) Nadia Cummins et al.   EMBO JOURNAL

GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

(2018) Huazhang Zhu et al.   Molecular Neurodegeneration

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer’s Disease

(2017) João A. Amorim et al.   JOURNAL OF ALZHEIMERS DISEASE

Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease

(2017) María José Pérez et al.   MOLECULAR NEUROBIOLOGY

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration

(2017) Noemí Esteras et al.   Redox Biology

A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration

(2017) Giuseppina Amadoro et al.   JOURNAL OF ALZHEIMERS DISEASE

An antioxidant specifically targeting mitochondria delays progression of Alzheimer’s disease-like pathology

(2016) Natalia Stefanova et al.   Aging-US

Tau Deletion Prevents Stress-Induced Dendritic Atrophy in Prefrontal Cortex: Role of Synaptic Mitochondria

(2016) Sofia Lopes et al.   CEREBRAL CORTEX

Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer’s disease

(2016) Ramesh Kandimalla et al.   HUMAN MOLECULAR GENETICS

Neuroprotective properties of mitochondria-targeted antioxidants of the SkQ-type

(2016) Nickolay K. Isaev et al.   REVIEWS IN THE NEUROSCIENCES

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

(2016) Yu Hu et al.   Oncotarget

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

(2016) Xia-Chun Li et al.   Scientific Reports

mTor mediates tau localization and secretion: Implication for Alzheimer's disease

(2015) Zhi Tang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease

(2015) V. Corsetti et al.   HUMAN MOLECULAR GENETICS

Tau facilitates Aβ-induced loss of mitochondrial membrane potential independent of cytosolic calcium fluxes in mouse cortical neurons

(2015) Susanne P. Pallo et al.   NEUROSCIENCE LETTERS

Dynamic survey of mitochondria by ubiquitin

(2014) M. Escobar-Henriques et al.   EMBO REPORTS

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway

(2014) Giuseppina Amadoro et al.   Frontiers in Aging Neuroscience

Functional role of cardiolipin in mitochondrial bioenergetics

(2013) Giuseppe Paradies et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols

(2013) Angelique Camilleri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

March separate, strike together — Role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease

(2013) Anne Eckert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons

(2013) Fumika Koyano et al.   GENES TO CELLS

β-Amyloid (Aβ) Oligomers Impair Brain-derived Neurotrophic Factor Retrograde Trafficking by Down-regulating Ubiquitin C-terminal Hydrolase, UCH-L1

(2013) Wayne W. Poon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Cleavage of Polymeric Tau Protein by Caspase-3: Implications for Alzheimer Disease

(2013) Jose J. Jarero-Basulto et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Profiling of Parkin-Binding Partners Using Tandem Affinity Purification

(2013) Alessandra Zanon et al.   PLoS One

Why size matters – balancing mitochondrial dynamics in Alzheimer's disease

(2013) Brian DuBoff et al.   TRENDS IN NEUROSCIENCES

Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation

(2012) Michela Guglielmotto et al.   AGING CELL

Mild uncoupling of respiration and phosphorylation as a mechanism providing nephro- and neuroprotective effects of penetrating cations of the SkQ family

(2012) E. Y. Plotnikov et al.   BIOCHEMISTRY-MOSCOW

Calorie restriction increases cerebral mitochondrial respiratory capacity in a NO•-mediated mechanism: Impact on neuronal survival

(2012) Fernanda M. Cerqueira et al.   FREE RADICAL BIOLOGY AND MEDICINE

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

(2012) K. Shahpasand et al.   JOURNAL OF NEUROSCIENCE

In Vivo Imaging of Disease-Related Mitochondrial Dynamics in a Vertebrate Model System

(2012) G. Plucinska et al.   JOURNAL OF NEUROSCIENCE

Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats

(2011) Rumani Singh et al.   AGE

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease

(2011) Jose L. Chou et al.   Journal of Proteomics

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Convergence of Amyloid-β and Tau Pathologies on Mitochondria In Vivo

(2010) Anne Eckert et al.   MOLECULAR NEUROBIOLOGY

Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction

(2010) F. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis

(2009) Zachary T. Schug et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1

(2009) A. E. Cartier et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

(2008) Rosa Resende et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

(2008) Sara Sanz-Blasco et al.   PLoS One

Altered oxidant-mediated intraneuronal zinc mobilization in a triple transgenic mouse model of Alzheimer’s disease

(2007) Stefano L. Sensi et al.   EXPERIMENTAL GERONTOLOGY