GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

Increased Tau Phosphorylation and Impaired Brain Insulin/IGF Signaling in Mice Fed a High Fat/High Cholesterol Diet

(2018) Narayan R. Bhat et al.   JOURNAL OF ALZHEIMERS DISEASE

Functional Deficits Precede Structural Lesions in Mice With High-Fat Diet–Induced Diabetic Retinopathy

(2016) Rithwick Rajagopal et al.   DIABETES

Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy

(2016) N. Mazzaro et al.   JOURNAL OF NEUROSCIENCE

Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules

(2016) L. Yang et al.   JOURNAL OF NEUROSCIENCE

Tau Accumulation, Altered Phosphorylation, and Missorting Promote Neurodegeneration in Glaucoma

(2016) M. Chiasseu et al.   JOURNAL OF NEUROSCIENCE

Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus

(2016) Elliott H. Sohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury

(2014) B Morquette et al.   CELL DEATH AND DIFFERENTIATION

Inhibitory Act of Selenoprotein P on Cu+/Cu2+-Induced Tau Aggregation and Neurotoxicity

(2014) Xiubo Du et al.   INORGANIC CHEMISTRY

The db/db Mouse: A Useful Model for the Study of Diabetic Retinal Neurodegeneration

(2014) Patricia Bogdanov et al.   PLoS One

Insulin dysfunction and Tau pathology

(2014) Noura B. El Khoury et al.   Frontiers in Cellular Neuroscience

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model

(2013) Manuela Polydoro et al.   ACTA NEUROPATHOLOGICA

Neurodegeneration in the Pathogenesis of Diabetic Retinopathy: Molecular Mechanisms and Therapeutic Implications

(2013) Maxwell Stem et al.   CURRENT MEDICINAL CHEMISTRY

Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by Liver X receptor α through a sterol regulatory element-binding protein 1c-dependent mechanism in mice

(2013) Jing Wu et al.   HEPATOLOGY

Nitrosative Stress Plays an Important Role in Wnt Pathway Activation in Diabetic Retinopathy

(2012) Qiuping Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Diet-induced obesity impairs AKT signalling in the retina and causes retinal degeneration

(2012) Anderson C. Marçal et al.   CELL BIOCHEMISTRY AND FUNCTION

Therapeutic Potential of a Monoclonal Antibody Blocking the Wnt Pathway in Diabetic Retinopathy

(2012) K. Lee et al.   DIABETES

The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion

(2012) Ying Ying et al.   FEBS LETTERS

Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

(2012) K. Shahpasand et al.   JOURNAL OF NEUROSCIENCE

Tau as a therapeutic target in neurodegenerative disease

(2012) Diana S. Himmelstein et al.   PHARMACOLOGY & THERAPEUTICS

Early Distal Axonopathy of the Visual Pathway in Experimental Diabetes

(2011) Diego C. Fernandez et al.   AMERICAN JOURNAL OF PATHOLOGY

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals

(2010) J.M. Gaspar et al.   NEUROSCIENCE

Investigating structural and biochemical correlates of ganglion cell dysfunction in streptozotocin-induced diabetic rats

(2009) Bang V. Bui et al.   EXPERIMENTAL EYE RESEARCH

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Diabetes downregulates presynaptic proteins and reduces basal synapsin I phosphorylation in rat retina

(2008) Heather D. VanGuilder et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma

(2008) B. P. Buckingham et al.   JOURNAL OF NEUROSCIENCE