Mitochondrial dysfunction in Alzheimer's disease: Therapeutic implications of lithium

Glycogen synthase kinase-3 signaling in Alzheimer's disease

(2020) Elisabetta Lauretti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impairment of PGC-1α-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease

(2020) Monique Patricio Singulani et al.   EXPERIMENTAL GERONTOLOGY

Lithium Treatment Over the Lifespan in Bipolar Disorders

(2020) Constantin Volkmann et al.   Frontiers in Psychiatry

Physical exercise protects against mitochondria alterations in the 6-hidroxydopamine rat model of Parkinson’s disease

(2020) Ana Flávia Fernandes Ferreira et al.   BEHAVIOURAL BRAIN RESEARCH

Neuronal–Glial Interaction in a Triple-Transgenic Mouse Model of Alzheimer’s Disease: Gene Ontology and Lithium Pathways

(2020) Nicole Kemberly R. Rocha et al.   Frontiers in Neuroscience

Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial

(2019) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Wnt Signaling Deregulation in the Aging and Alzheimer’s Brain

(2019) Ernest Palomer et al.   Frontiers in Cellular Neuroscience

Lithium as a Treatment for Alzheimer’s Disease: The Systems Pharmacology Perspective

(2019) Harald Hampel et al.   JOURNAL OF ALZHEIMERS DISEASE

Powerhouse of the mind: mitochondrial plasticity at the synapse

(2019) Meghan J Rossi et al.   CURRENT OPINION IN NEUROBIOLOGY

Activities of mitochondrial respiratory chain complexes in platelets of patients with Alzheimer's disease and depressive disorder

(2019) Zdeněk Fišar et al.   MITOCHONDRION

Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update

(2019) Giovanna Cenini et al.   Frontiers in Pharmacology

Mitochondrial Dysfunction as a Predictor and Driver of Alzheimer’s Disease-Like Pathology in OXYS Rats

(2018) Mikhail A. Tyumentsev et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic Lithium Treatment Increases Telomere Length in Parietal Cortex and Hippocampus of Triple-Transgenic Alzheimer’s Disease Mice

(2018) Giancarlo de Mattos Cardillo et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

GSK3β Regulates Brain Energy Metabolism

(2018) Stephen A. Martin et al.   Cell Reports

Long-Term Treatment with Lithium Alleviates Memory Deficits and Reduces Amyloid-β Production in an Aged Alzheimer's Disease Transgenic Mouse Model

(2018) Xin Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

LiCl regulates mitochondrial biogenesis during megakaryocyte development

(2017) Ram Babu Undi et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease

(2017) María J. Pérez et al.   Frontiers in Neuroscience

Increase of BDNF Serum Concentration in Lithium Treated Patients with Early Alzheimer's Disease

(2017) Thomas Leyhe et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-term lithium treatment increases intracellular and extracellular brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons at subtherapeutic concentrations

(2016) Vanessa J. De-Paula et al.   BIPOLAR DISORDERS

Lithium, a Therapy for AD: Current Evidence from Clinical Trials of Neurodegenerative Disorders

(2016) Orestes V. Forlenza et al.   Current Alzheimer Research

Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients

(2015) Serena Guidotti et al.   PLoS One

Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer’s Disease and Related Neurodegenerative Disorders

(2014) O. V. Forlenza et al.   ACS Chemical Neuroscience

NCLX: The mitochondrial sodium calcium exchanger

(2013) Liron Boyman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

RNAi screening identifies GSK3β as a regulator of DRP1 and the neuroprotection of lithium chloride against elevated pressure involved in downregulation of DRP1

(2013) Ji-Hong Wu et al.   NEUROSCIENCE LETTERS

Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration

(2012) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial

(2011) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Lithium increases plasma brain-derived neurotrophic factor in acute bipolar mania: A preliminary 4-week study

(2011) Rafael T. de Sousa et al.   NEUROSCIENCE LETTERS

Does lithium protect against dementia?

(2010) Lars Vedel Kessing et al.   BIPOLAR DISORDERS

Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats

(2010) Wen-Fei Tan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Wnt signaling regulates mitochondrial physiology and insulin sensitivity

(2010) J. C. Yoon et al.   GENES & DEVELOPMENT

Effects of mood stabilizers on mitochondrial respiratory chain activity in brain of rats treated with d-amphetamine

(2010) Samira S. Valvassori et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Convergence of Amyloid-β and Tau Pathologies on Mitochondria In Vivo

(2010) Anne Eckert et al.   MOLECULAR NEUROBIOLOGY

Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage

(2009) Rosilla F. Bachmann et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Lithium Treatment and Risk of Dementia

(2008) Lars Vedel Kessing et al.   ARCHIVES OF GENERAL PSYCHIATRY

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

(2008) Elisabete Ferreiro et al.   NEUROBIOLOGY OF DISEASE

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling

(2007) Min-Huei Liang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE