Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease

Mitochondrial Dysfunction in Alzheimer’s Disease: A Biomarker of the Future?

(2021) Simon M. Bell et al.   Biomedicines

Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

(2021) Che-Wei Chang et al.   SCIENCE

Critical Molecular and Cellular Contributors to Tau Pathology

(2021) Liqing Song et al.   Biomedicines

GSK-3 and Tau: A Key Duet in Alzheimer’s Disease

(2021) Carmen Laura Sayas et al.   Cells

A current view on Tau protein phosphorylation in Alzheimer's disease

(2021) Susanne Wegmann et al.   CURRENT OPINION IN NEUROBIOLOGY

High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts

(2021) Emma Cretin et al.   EMBO Molecular Medicine

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

(2020) Xiaoyan Guo et al.   NATURE

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

(2020) Evelyn Fessler et al.   NATURE

Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1

(2020) Liming Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

(2020) Yifan Ge et al.   eLife

Glycogen synthase kinase-3 signaling in Alzheimer's disease

(2020) Elisabetta Lauretti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites

(2020) Gregory M. Dillon et al.   PLoS One

Reciprocal Regulation of Mitochondrial Fission and Fusion

(2020) Rasha Sabouny et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

(2020) Danyang Zhang et al.   eLife

Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

(2020) Ian W. Weidling et al.   EXPERIMENTAL NEUROLOGY

Altered mitochondrial dynamics and function in APOE4-expressing astrocytes

(2020) Eran Schmukler et al.   Cell Death & Disease

GABAergic Inhibitory Interneuron Deficits in Alzheimer’s Disease: Implications for Treatment

(2020) Yilan Xu et al.   Frontiers in Neuroscience

Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation

(2020) Safak Caglayan et al.   iScience

Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease

(2020) Amy F. T. Arnsten et al.   Alzheimers & Dementia

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

(2020) Alberto Serrano-Pozo et al.   LANCET NEUROLOGY

Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1

(2019) Shiori Sekine et al.   MOLECULAR CELL

Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function

(2019) Adam L. Orr et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeted OMA1 therapies for cancer

(2019) Marcel V. Alavi   INTERNATIONAL JOURNAL OF CANCER

Targeting Apolipoprotein E for Alzheimer’s Disease: An Industry Perspective

(2019) Georgette L. Suidan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way

(2019) Lingzi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dynamics and transport in Alzheimer's disease

(2019) Padraig J. Flannery et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1

(2019) Katja Faelber et al.   NATURE

Dynamics of Dynamin-Related Protein 1 in Alzheimer’s Disease and Other Neurodegenerative Diseases

(2019) Darryll Oliver et al.   Cells

Mitochondrial Dynamics and Its Involvement in Disease

(2019) David C. Chan   Annual Review of Pathology-Mechanisms of Disease

Prohibitin levels regulate OMA1 activity and turnover in neurons

(2019) Corey J. Anderson et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients

(2018) Julian H. Birnbaum et al.   Stem Cell Research

Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation

(2018) Fan Yang et al.   Cell Death & Disease

Unsupervised excitation: GABAergic dysfunctions in Alzheimer’s disease

(2018) Eleonora Ambrad Giovannetti et al.   BRAIN RESEARCH

Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease

(2017) María José Pérez et al.   MOLECULAR NEUROBIOLOGY

Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

(2017) Sabrina Heinz et al.   Scientific Reports

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i ‐AAA protease YME1L

(2016) Timothy Wai et al.   EMBO REPORTS

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria

(2016) Anne Korwitz et al.   JOURNAL OF CELL BIOLOGY

Treatment Options in Alzheimer´s Disease: The GABA Story

(2015) Maite Solas et al.   CURRENT PHARMACEUTICAL DESIGN

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics

(2014) M. J. Baker et al.   EMBO JOURNAL

YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress

(2014) T. K. Rainbolt et al.   EMBO REPORTS

Stress-triggered Activation of the Metalloprotease Oma1 Involves Its C-terminal Region and Is Important for Mitochondrial Stress Protection in Yeast

(2014) Iryna Bohovych et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage

(2013) P. Hemachandra Reddy   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics

(2013) Marcel V Alavi et al.   Molecular Neurodegeneration

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

(2012) Carsten Merkwirth et al.   PLoS Genetics

A mitochondrial etiology of Alzheimer and Parkinson disease

(2011) Pinar Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

(2010) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abnormal mitochondrial dynamics and neurodegenerative diseases

(2009) Bo Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

(2009) Brian Head et al.   JOURNAL OF CELL BIOLOGY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Characterization of OPA1 isoforms isolated from mouse tissues

(2008) Vasudheva Reddy Akepati et al.   JOURNAL OF NEUROCHEMISTRY