Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

(2016) Ramesh Kandimalla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanisms of tau and Aβ-induced excitotoxicity

(2016) Susanne P. Pallo et al.   BRAIN RESEARCH

Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer’s disease

(2016) Ramesh Kandimalla et al.   HUMAN MOLECULAR GENETICS

Co-expression of truncated and full-length tau induces severe neurotoxicity

(2016) S Ozcelik et al.   MOLECULAR PSYCHIATRY

Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

(2016) YoungDoo Kim et al.   NEUROBIOLOGY OF DISEASE

Caspase-3-Dependent Proteolytic Cleavage of Tau Causes Neurofibrillary Tangles and Results in Cognitive Impairment During Normal Aging

(2016) John C. Means et al.   NEUROCHEMICAL RESEARCH

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

(2015) Tatiana Varanita et al.   Cell Metabolism

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

(2015) Keith A. Vossel et al.   JOURNAL OF CELL BIOLOGY

Tau facilitates Aβ-induced loss of mitochondrial membrane potential independent of cytosolic calcium fluxes in mouse cortical neurons

(2015) Susanne P. Pallo et al.   NEUROSCIENCE LETTERS

Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s Disease

(2015) Fabian A. Cabezas-Opazo et al.   Oxidative Medicine and Cellular Longevity

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons

(2014) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF DISEASE

GRK5 dysfunction accelerates tau hyperphosphorylation in APP (swe) mice through impaired cholinergic activity

(2014) Yun Zhang et al.   NEUROREPORT

Mitochondrial Free Ca2+ Levels and Their Effects on Energy Metabolism in Drosophila Motor Nerve Terminals

(2013) Maxim V. Ivannikov et al.   BIOPHYSICAL JOURNAL

OPA1 loss of function affects in vitro neuronal maturation

(2013) Ambre M. Bertholet et al.   BRAIN

Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity

(2012) Pete A. Williams et al.   BRAIN

Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity

(2012) Y E Kushnareva et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage

(2012) Yusuke Kageyama et al.   JOURNAL OF CELL BIOLOGY

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

(2012) Eugenia Trushina et al.   PLoS One

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion

(2012) Vanessa Plouffe et al.   PLoS One

Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

(2011) Magali Dumont et al.   FASEB JOURNAL

Amyloid-β Annular Protofibrils Evade Fibrillar Fate in Alzheimer Disease Brain

(2011) Cristian A. Lasagna-Reeves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

(2011) Susanne M. Pritchard et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

(2011) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF AGING

Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo

(2010) Catherine M. Cowan et al.   ACTA NEUROPATHOLOGICA

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

(2010) P. Hemachandra Reddy et al.   BRAIN RESEARCH REVIEWS

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Truncated tau at D421 is associated with neurodegeneration and tangle formation in the brain of Alzheimer transgenic models

(2009) Qipeng Zhang et al.   ACTA NEUROPATHOLOGICA

Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons

(2009) Rodrigo A. Quintanilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

(2009) Gustavo Basurto-Islas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients

(2008) Xinglong Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death

(2008) Tori A. Matthews-Roberson et al.   BRAIN RESEARCH

Mitochondria Modulate Ca2+-Dependent Glutamate Release from Rat Cortical Astrocytes

(2008) R. C. Reyes et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

(2008) S. Hauptmann et al.   NEUROBIOLOGY OF AGING

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE